LOCUS       NM_133655               1534 bp    mRNA    linear   ROD 24-SEP-2024
DEFINITION  Mus musculus CD81 antigen (Cd81), mRNA.
ACCESSION   NM_133655 XM_993688
VERSION     NM_133655.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1534)
  AUTHORS   Cone,A.S., Zhou,Y., McNamara,R.P., Eason,A.B., Arias,G.F.,
            Landis,J.T., Shifflett,K.W., Chambers,M.G., Yuan,R., Willcox,S.,
            Griffith,J.D. and Dittmer,D.P.
  TITLE     CD81 fusion alters SARS-CoV-2 Spike trafficking
  JOURNAL   mBio 15 (9), e0192224 (2024)
   PUBMED   39140770
  REMARK    GeneRIF: CD81 fusion alters SARS-CoV-2 Spike trafficking.
REFERENCE   2  (bases 1 to 1534)
  AUTHORS   Abu-Saleh,N., Kuo,C.C., Jiang,W., Levy,R. and Levy,S.
  TITLE     The molecular mechanism of CD81 antibody inhibition of metastasis
  JOURNAL   Proc Natl Acad Sci U S A 120 (26), e2305042120 (2023)
   PUBMED   37339209
  REMARK    GeneRIF: The molecular mechanism of CD81 antibody inhibition of
            metastasis.
REFERENCE   3  (bases 1 to 1534)
  AUTHORS   Abe,I., Oguri,Y., Verkerke,A.R.P., Monteiro,L.B., Knuth,C.M.,
            Auger,C., Qiu,Y., Westcott,G.P., Cinti,S., Shinoda,K., Jeschke,M.G.
            and Kajimura,S.
  TITLE     Lipolysis-derived linoleic acid drives beige fat progenitor cell
            proliferation
  JOURNAL   Dev Cell 57 (23), 2623-2637 (2022)
   PUBMED   36473459
REFERENCE   4  (bases 1 to 1534)
  AUTHORS   Bahi,A. and Dreyer,J.L.
  TITLE     Chronic knockdown of the tetraspanin gene CD81 in the mouse nucleus
            accumbens modulates anxiety and ethanol-related behaviors
  JOURNAL   Physiol Behav 254, 113894 (2022)
   PUBMED   35764142
  REMARK    GeneRIF: Chronic knockdown of the tetraspanin gene CD81 in the
            mouse nucleus accumbens modulates anxiety and ethanol-related
            behaviors.
REFERENCE   5  (bases 1 to 1534)
  AUTHORS   Lasswitz,L., Zapatero-Belinchon,F.J., Moeller,R., Hulskotter,K.,
            Laurent,T., Carlson,L.A., Goffinet,C., Simmons,G., Baumgartner,W.
            and Gerold,G.
  TITLE     The Tetraspanin CD81 Is a Host Factor for Chikungunya Virus
            Replication
  JOURNAL   mBio 13 (3), e0073122 (2022)
   PUBMED   35612284
  REMARK    GeneRIF: The Tetraspanin CD81 Is a Host Factor for Chikungunya
            Virus Replication.
REFERENCE   6  (bases 1 to 1534)
  AUTHORS   Mordica,W.J., Gallagher,R.J., Kennedy,J.L. and Chapes,S.K.
  TITLE     Male CD81 knockout genotype disrupts Mendelian distribution of
            offspring
  JOURNAL   Comp Med 60 (3), 196-199 (2010)
   PUBMED   20579434
  REMARK    GeneRIF: CD81 gene is maternally imprinted, with preferential
            expression from the paternal allele.
REFERENCE   7  (bases 1 to 1534)
  AUTHORS   Seldin,M.F., Rochelle,J.M., Tomlinson,M.G. and Wright,M.D.
  TITLE     Mapping of the genes for four members of the transmembrane 4
            superfamily: mouse Cd9, Cd63, Cd81, and Cd82
  JOURNAL   Immunogenetics 42 (5), 422-425 (1995)
   PUBMED   7590978
REFERENCE   8  (bases 1 to 1534)
  AUTHORS   Andria,M.L., Barsh,G.S. and Levy,S.
  TITLE     Expression of TAPA-1 in preimplantation mouse embryos
  JOURNAL   Biochem Biophys Res Commun 186 (3), 1201-1206 (1992)
   PUBMED   1380797
REFERENCE   9  (bases 1 to 1534)
  AUTHORS   Andria,M.L., Hsieh,C.L., Oren,R., Francke,U. and Levy,S.
  TITLE     Genomic organization and chromosomal localization of the TAPA-1
            gene
  JOURNAL   J Immunol 147 (3), 1030-1036 (1991)
   PUBMED   1650385
REFERENCE   10 (bases 1 to 1534)
  AUTHORS   Bastian,H. and Gruss,P.
  TITLE     A murine even-skipped homologue, Evx 1, is expressed during early
            embryogenesis and neurogenesis in a biphasic manner
  JOURNAL   EMBO J 9 (6), 1839-1852 (1990)
   PUBMED   1971786
  REMARK    Erratum:[EMBO J 1991 Dec;10(12):3978]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY252638.1, AK166521.1, BQ175800.1 and BQ175686.1.
            
            On Dec 4, 2007 this sequence version replaced NM_133655.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.453457.1, BC011433.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            imprinted gene         :: PMID: 20579434
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                BY252638.1         1-38
            39-1055             AK166521.1         5-1021
            1056-1511           BQ175800.1         24-479              c
            1512-1534           BQ175686.1         1-23                c
FEATURES             Location/Qualifiers
     source          1..1534
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 88.1 cM"
     gene            1..1534
                     /gene="Cd81"
                     /gene_synonym="Tapa-1; Tapa1; Tspan28"
                     /note="CD81 antigen"
                     /db_xref="GeneID:12520"
                     /db_xref="MGI:MGI:1096398"
     exon            1..317
                     /gene="Cd81"
                     /gene_synonym="Tapa-1; Tapa1; Tspan28"
                     /inference="alignment:Splign:2.1.0"
     CDS             252..962
                     /gene="Cd81"
                     /gene_synonym="Tapa-1; Tapa1; Tspan28"
                     /note="26 kDa cell surface protein TAPA-1; target of the
                     antiproliferative antibody 1"
                     /codon_start=1
                     /product="CD81 antigen"
                     /protein_id="NP_598416.1"
                     /db_xref="CCDS:CCDS22038.1"
                     /db_xref="GeneID:12520"
                     /db_xref="MGI:MGI:1096398"
                     /translation="MGVEGCTKCIKYLLFVFNFVFWLAGGVILGVALWLRHDPQTTSL
                     LYLELGNKPAPNTFYVGIYILIAVGAVMMFVGFLGCYGAIQESQCLLGTFFTCLVILF
                     ACEVAAGIWGFVNKDQIAKDVKQFYDQALQQAVMDDDANNAKAVVKTFHETLNCCGSN
                     ALTTLTTTILRNSLCPSGGNILTPLLQQDCHQKIDELFSGKLYLIGIAAIVVAVIMIF
                     EMILSMVLCCGIRNSSVY"
     exon            318..432
                     /gene="Cd81"
                     /gene_synonym="Tapa-1; Tapa1; Tspan28"
                     /inference="alignment:Splign:2.1.0"
     exon            433..530
                     /gene="Cd81"
                     /gene_synonym="Tapa-1; Tapa1; Tspan28"
                     /inference="alignment:Splign:2.1.0"
     exon            531..605
                     /gene="Cd81"
                     /gene_synonym="Tapa-1; Tapa1; Tspan28"
                     /inference="alignment:Splign:2.1.0"
     exon            606..710
                     /gene="Cd81"
                     /gene_synonym="Tapa-1; Tapa1; Tspan28"
                     /inference="alignment:Splign:2.1.0"
     exon            711..812
                     /gene="Cd81"
                     /gene_synonym="Tapa-1; Tapa1; Tspan28"
                     /inference="alignment:Splign:2.1.0"
     exon            813..899
                     /gene="Cd81"
                     /gene_synonym="Tapa-1; Tapa1; Tspan28"
                     /inference="alignment:Splign:2.1.0"
     exon            900..1518
                     /gene="Cd81"
                     /gene_synonym="Tapa-1; Tapa1; Tspan28"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1488..1493
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cd81"
                     /gene_synonym="Tapa-1; Tapa1; Tspan28"
                     /note="hexamer: AATAAA"
     polyA_site      1518
                     /gene="Cd81"
                     /gene_synonym="Tapa-1; Tapa1; Tspan28"
                     /note="major polyA site"
ORIGIN      
        1 gaggtctata aagagtgagg agctaggcgc gcgcgcccgg tccgagcgag cgcgtccttg
       61 cttcaaagag atagtgactc tcgcgcctcc ggctaggcct ccagcccttc tctaccctac
      121 gtctcattct ccgcaacgca gttctccggc ccgcaagcgc tccaggctat ctgccagtcc
      181 cggaccccgg tactgcgtcc ccataccgcc cgctccagga ccaatccaag ctccgcaggc
      241 cgcgcaccgc catgggggtg gagggctgca ccaaatgcat caaatacctg ctcttcgtct
      301 tcaatttcgt cttctggctg gctggaggcg tgatcctagg tgtagctctg tggttgcgtc
      361 atgatccaca gaccaccagc ctgctgtacc tggaactggg aaacaaaccg gcacccaaca
      421 ccttctacgt gggcatctac attctcattg ctgtgggagc tgtgatgatg tttgtaggct
      481 tcctggggtg ctatggggcc atccaggagt cccagtgtct gctggggacg ttcttcacct
      541 gccttgtgat cctgtttgcc tgtgaggtgg ctgcaggcat ctggggcttc gtaaacaaag
      601 accagatcgc caaggatgtg aagcagttct atgaccaggc ccttcagcaa gctgtgatgg
      661 atgatgatgc caacaatgcc aaggctgtgg tgaagacttt ccatgagacg ctcaactgtt
      721 gtggctccaa cgcactgacc acactgacta ccaccatact gaggaacagc ctgtgtccct
      781 caggcggcaa catactcacc cccttactgc agcaagattg tcatcagaaa atcgatgagc
      841 tcttctctgg gaagctgtac ctcattggaa ttgcagccat tgtggtagct gtcattatga
      901 tctttgagat gattctgagc atggtgctgt gctgtggcat ccggaacagc tccgtgtact
      961 gaggcccttt gcattgcacc agaggatccc tggagtgacc agaggccacc ttgggggaca
     1021 tggcctgtgt atataatatt tctgtatcac tctgctacac ttagtctttt tacttttgag
     1081 ttttttgttt tgttttgttt tgtttttgtt ttagtttttt tttttgtcct gaacttttcc
     1141 tgttaccttt tgggagctga catcacacat gggtggcata tgtgggatgt aggggtggag
     1201 ctggccctgg cttgcagggc cctgtacgtc tgggacccct ggagagttct gcctgctgag
     1261 ccaaacctcc tctacagcta cttgcccaga ggctttgtag cctagctaga gggccatgcc
     1321 cacccactca acccactgtg ggtcacattg ctcacatctt tttaatcttt gttcctttcc
     1381 tgcctccatt tcaagagctg ggtttgtaag ccctcttatg ccttcaatgc acttattctt
     1441 tctaacgtgt caccttcaac tgtaattaaa tcttgaaaca gtcatttaat aaaggaggaa
     1501 aaaaatcagg catgctaaaa aaaaaaaaaa aaaa
//
