LOCUS       NP_598416                236 aa            linear   ROD 24-SEP-2024
DEFINITION  CD81 antigen [Mus musculus].
ACCESSION   NP_598416 XP_998782
VERSION     NP_598416.1
DBSOURCE    REFSEQ: accession NM_133655.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 236)
  AUTHORS   Cone,A.S., Zhou,Y., McNamara,R.P., Eason,A.B., Arias,G.F.,
            Landis,J.T., Shifflett,K.W., Chambers,M.G., Yuan,R., Willcox,S.,
            Griffith,J.D. and Dittmer,D.P.
  TITLE     CD81 fusion alters SARS-CoV-2 Spike trafficking
  JOURNAL   mBio 15 (9), e0192224 (2024)
   PUBMED   39140770
  REMARK    GeneRIF: CD81 fusion alters SARS-CoV-2 Spike trafficking.
REFERENCE   2  (residues 1 to 236)
  AUTHORS   Abu-Saleh,N., Kuo,C.C., Jiang,W., Levy,R. and Levy,S.
  TITLE     The molecular mechanism of CD81 antibody inhibition of metastasis
  JOURNAL   Proc Natl Acad Sci U S A 120 (26), e2305042120 (2023)
   PUBMED   37339209
  REMARK    GeneRIF: The molecular mechanism of CD81 antibody inhibition of
            metastasis.
REFERENCE   3  (residues 1 to 236)
  AUTHORS   Abe,I., Oguri,Y., Verkerke,A.R.P., Monteiro,L.B., Knuth,C.M.,
            Auger,C., Qiu,Y., Westcott,G.P., Cinti,S., Shinoda,K., Jeschke,M.G.
            and Kajimura,S.
  TITLE     Lipolysis-derived linoleic acid drives beige fat progenitor cell
            proliferation
  JOURNAL   Dev Cell 57 (23), 2623-2637 (2022)
   PUBMED   36473459
REFERENCE   4  (residues 1 to 236)
  AUTHORS   Bahi,A. and Dreyer,J.L.
  TITLE     Chronic knockdown of the tetraspanin gene CD81 in the mouse nucleus
            accumbens modulates anxiety and ethanol-related behaviors
  JOURNAL   Physiol Behav 254, 113894 (2022)
   PUBMED   35764142
  REMARK    GeneRIF: Chronic knockdown of the tetraspanin gene CD81 in the
            mouse nucleus accumbens modulates anxiety and ethanol-related
            behaviors.
REFERENCE   5  (residues 1 to 236)
  AUTHORS   Lasswitz,L., Zapatero-Belinchon,F.J., Moeller,R., Hulskotter,K.,
            Laurent,T., Carlson,L.A., Goffinet,C., Simmons,G., Baumgartner,W.
            and Gerold,G.
  TITLE     The Tetraspanin CD81 Is a Host Factor for Chikungunya Virus
            Replication
  JOURNAL   mBio 13 (3), e0073122 (2022)
   PUBMED   35612284
  REMARK    GeneRIF: The Tetraspanin CD81 Is a Host Factor for Chikungunya
            Virus Replication.
REFERENCE   6  (residues 1 to 236)
  AUTHORS   Mordica,W.J., Gallagher,R.J., Kennedy,J.L. and Chapes,S.K.
  TITLE     Male CD81 knockout genotype disrupts Mendelian distribution of
            offspring
  JOURNAL   Comp Med 60 (3), 196-199 (2010)
   PUBMED   20579434
  REMARK    GeneRIF: CD81 gene is maternally imprinted, with preferential
            expression from the paternal allele.
REFERENCE   7  (residues 1 to 236)
  AUTHORS   Seldin,M.F., Rochelle,J.M., Tomlinson,M.G. and Wright,M.D.
  TITLE     Mapping of the genes for four members of the transmembrane 4
            superfamily: mouse Cd9, Cd63, Cd81, and Cd82
  JOURNAL   Immunogenetics 42 (5), 422-425 (1995)
   PUBMED   7590978
REFERENCE   8  (residues 1 to 236)
  AUTHORS   Andria,M.L., Barsh,G.S. and Levy,S.
  TITLE     Expression of TAPA-1 in preimplantation mouse embryos
  JOURNAL   Biochem Biophys Res Commun 186 (3), 1201-1206 (1992)
   PUBMED   1380797
REFERENCE   9  (residues 1 to 236)
  AUTHORS   Andria,M.L., Hsieh,C.L., Oren,R., Francke,U. and Levy,S.
  TITLE     Genomic organization and chromosomal localization of the TAPA-1
            gene
  JOURNAL   J Immunol 147 (3), 1030-1036 (1991)
   PUBMED   1650385
REFERENCE   10 (residues 1 to 236)
  AUTHORS   Bastian,H. and Gruss,P.
  TITLE     A murine even-skipped homologue, Evx 1, is expressed during early
            embryogenesis and neurogenesis in a biphasic manner
  JOURNAL   EMBO J 9 (6), 1839-1852 (1990)
   PUBMED   1971786
  REMARK    Erratum:[EMBO J 1991 Dec;10(12):3978]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY252638.1, AK166521.1, BQ175800.1 and BQ175686.1.
            
            On May 4, 2006 this sequence version replaced XP_998782.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.453457.1, BC011433.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            imprinted gene         :: PMID: 20579434
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..236
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 88.1 cM"
     Protein         1..236
                     /product="CD81 antigen"
                     /note="26 kDa cell surface protein TAPA-1; target of the
                     antiproliferative antibody 1"
                     /calculated_mol_wt=25684
     Region          10..228
                     /region_name="Tetraspanin"
                     /note="Tetraspanin family; pfam00335"
                     /db_xref="CDD:459767"
     Site            13..33
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P35762.2)"
     Site            64..84
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P35762.2)"
     Site            90..112
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P35762.2)"
     Site            116
                     /site_type="other"
                     /note="Important for interaction with integrin.
                     /evidence=ECO:0000250|UniProtKB:P60033; propagated from
                     UniProtKB/Swiss-Prot (P35762.2)"
     Site            144
                     /site_type="other"
                     /note="Important for interaction with integrin.
                     /evidence=ECO:0000250|UniProtKB:P60033; propagated from
                     UniProtKB/Swiss-Prot (P35762.2)"
     Site            148
                     /site_type="other"
                     /note="Important for interaction with integrin.
                     /evidence=ECO:0000250|UniProtKB:P60033; propagated from
                     UniProtKB/Swiss-Prot (P35762.2)"
     Site            202..224
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P35762.2)"
     CDS             1..236
                     /gene="Cd81"
                     /gene_synonym="Tapa-1; Tapa1; Tspan28"
                     /coded_by="NM_133655.2:252..962"
                     /db_xref="CCDS:CCDS22038.1"
                     /db_xref="GeneID:12520"
                     /db_xref="MGI:MGI:1096398"
ORIGIN      
        1 mgvegctkci kyllfvfnfv fwlaggvilg valwlrhdpq ttsllylelg nkpapntfyv
       61 giyiliavga vmmfvgflgc ygaiqesqcl lgtfftclvi lfacevaagi wgfvnkdqia
      121 kdvkqfydqa lqqavmddda nnakavvktf hetlnccgsn alttltttil rnslcpsggn
      181 iltpllqqdc hqkidelfsg klyligiaai vvavimifem ilsmvlccgi rnssvy
//
