LOCUS       NM_001359898            2688 bp    mRNA    linear   ROD 15-OCT-2024
DEFINITION  Mus musculus CD80 antigen (Cd80), transcript variant 1, mRNA.
ACCESSION   NM_001359898 XM_017316857
VERSION     NM_001359898.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2688)
  AUTHORS   Jaggi,U. and Ghiasi,H.
  TITLE     Presence of CD80 and Absence of LAT in Modulating Cellular
            Infiltration and HSV-1 Latency
  JOURNAL   Viruses 16 (9), 1379 (2024)
   PUBMED   39339855
  REMARK    GeneRIF: Presence of CD80 and Absence of LAT in Modulating Cellular
            Infiltration and HSV-1 Latency.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2688)
  AUTHORS   Luan,J., Truong,C., Vuchkovska,A., Guo,W., Good,J., Liu,B.,
            Gang,A., Infarinato,N., Stewart,K., Polak,L., Pasolli,H.A.,
            Andretta,E., Rudensky,A.Y., Fuchs,E. and Miao,Y.
  TITLE     CD80 on skin stem cells promotes local expansion of regulatory T
            cells upon injury to orchestrate repair within an inflammatory
            environment
  JOURNAL   Immunity 57 (5), 1071-1086 (2024)
   PUBMED   38677291
  REMARK    GeneRIF: CD80 on skin stem cells promotes local expansion of
            regulatory T cells upon injury to orchestrate repair within an
            inflammatory environment.
REFERENCE   3  (bases 1 to 2688)
  AUTHORS   Jaggi,U., Matundan,H.H., Oh,J.J. and Ghiasi,H.
  TITLE     Absence of CD80 reduces HSV-1 replication in the eye and delays
            reactivation but not latency levels
  JOURNAL   J Virol 98 (3), e0201023 (2024)
   PUBMED   38376148
  REMARK    GeneRIF: Absence of CD80 reduces HSV-1 replication in the eye and
            delays reactivation but not latency levels.
REFERENCE   4  (bases 1 to 2688)
  AUTHORS   Subileau,M. and Vittet,D.
  TITLE     Ontogenesis of the Mouse Ocular Surface Lymphatic Vascular Network
  JOURNAL   Invest Ophthalmol Vis Sci 64 (15), 7 (2023)
   PUBMED   38054922
REFERENCE   5  (bases 1 to 2688)
  AUTHORS   Zhao,Y., Caron,C., Chan,Y.Y., Lee,C.K., Xu,X., Zhang,J.,
            Masubuchi,T., Wu,C., Bui,J.D. and Hui,E.
  TITLE     cis-B7:CD28 interactions at invaginated synaptic membranes provide
            CD28 co-stimulation and promote CD8+ T cell function and anti-tumor
            immunity
  JOURNAL   Immunity 56 (6), 1187-1203 (2023)
   PUBMED   37160118
  REMARK    GeneRIF: cis-B7:CD28 interactions at invaginated synaptic membranes
            provide CD28 co-stimulation and promote CD8[+] T cell function and
            anti-tumor immunity.
REFERENCE   6  (bases 1 to 2688)
  AUTHORS   Morse,H.C. 3rd.
  TITLE     Genetic nomenclature for loci controlling surface antigens of mouse
            hemopoietic cells
  JOURNAL   J Immunol 149 (10), 3129-3134 (1992)
   PUBMED   1431091
  REMARK    Review article
            Erratum:[J Immunol 1993 Mar 15;150(6):2563]
REFERENCE   7  (bases 1 to 2688)
  AUTHORS   Liu,Y., Jones,B., Brady,W., Janeway,C.A. Jr. and Linsley,P.S.
  TITLE     Co-stimulation of murine CD4 T cell growth: cooperation between B7
            and heat-stable antigen
  JOURNAL   Eur J Immunol 22 (11), 2855-2859 (1992)
   PUBMED   1385153
  REMARK    Erratum:[Eur J Immunol 1993 Mar;23(3):780. Linley PS [corrected to
            Linsley PS]]
REFERENCE   8  (bases 1 to 2688)
  AUTHORS   Larsen,C.P., Ritchie,S.C., Pearson,T.C., Linsley,P.S. and
            Lowry,R.P.
  TITLE     Functional expression of the costimulatory molecule, B7/BB1, on
            murine dendritic cell populations
  JOURNAL   J Exp Med 176 (4), 1215-1220 (1992)
   PUBMED   1328465
REFERENCE   9  (bases 1 to 2688)
  AUTHORS   Razi-Wolf,Z., Freeman,G.J., Galvin,F., Benacerraf,B., Nadler,L. and
            Reiser,H.
  TITLE     Expression and function of the murine B7 antigen, the major
            costimulatory molecule expressed by peritoneal exudate cells
  JOURNAL   Proc Natl Acad Sci U S A 89 (9), 4210-4214 (1992)
   PUBMED   1373896
REFERENCE   10 (bases 1 to 2688)
  AUTHORS   Selvakumar,A., Mohanraj,B.K., Eddy,R.L., Shows,T.B., White,P.C. and
            Dupont,B.
  TITLE     Genomic organization and chromosomal location of the human gene
            encoding the B-lymphocyte activation antigen B7
  JOURNAL   Immunogenetics 36 (3), 175-181 (1992)
   PUBMED   1377173
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC209577.2.
            
            On Jan 18, 2018 this sequence version replaced XM_017316857.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC131959.1, AJ278965.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation,
                                                expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-357               AC209577.2         96844-97200         c
            358-675             AC209577.2         81950-82267         c
            676-957             AC209577.2         76788-77069         c
            958-1071            AC209577.2         73400-73513         c
            1072-1215           AC209577.2         69686-69829         c
            1216-2688           AC209577.2         60175-61647         c
FEATURES             Location/Qualifiers
     source          1..2688
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 26.86 cM"
     gene            1..2688
                     /gene="Cd80"
                     /gene_synonym="B71; Cd28l; Ly-53; Ly53; MIC17; TSA1"
                     /note="CD80 antigen"
                     /db_xref="GeneID:12519"
                     /db_xref="MGI:MGI:101775"
     exon            1..357
                     /gene="Cd80"
                     /gene_synonym="B71; Cd28l; Ly-53; Ly53; MIC17; TSA1"
                     /inference="alignment:Splign:2.1.0"
     CDS             249..1169
                     /gene="Cd80"
                     /gene_synonym="B71; Cd28l; Ly-53; Ly53; MIC17; TSA1"
                     /note="B7 protein; activation B7-1 antigen"
                     /codon_start=1
                     /product="T-lymphocyte activation antigen CD80 precursor"
                     /protein_id="NP_001346827.1"
                     /db_xref="CCDS:CCDS28168.1"
                     /db_xref="GeneID:12519"
                     /db_xref="MGI:MGI:101775"
                     /translation="MACNCQLMQDTPLLKFPCPRLILLFVLLIRLSQVSSDVDEQLSK
                     SVKDKVLLPCRYNSPHEDESEDRIYWQKHDKVVLSVIAGKLKVWPEYKNRTLYDNTTY
                     SLIILGLVLSDRGTYSCVVQKKERGTYEVKHLALVKLSIKADFSTPNITESGNPSADT
                     KRITCFASGGFPKPRFSWLENGRELPGINTTISQDPESELYTISSQLDFNTTRNHTIK
                     CLIKYGDAHVSEDFTWEKPPEDPPDSKNTLVLFGAGFGAVITVVVIVVIIKCFCKHRS
                     CFRRNEASRETNNSLTFGPEEALAEQTVFL"
     exon            358..675
                     /gene="Cd80"
                     /gene_synonym="B71; Cd28l; Ly-53; Ly53; MIC17; TSA1"
                     /inference="alignment:Splign:2.1.0"
     exon            676..957
                     /gene="Cd80"
                     /gene_synonym="B71; Cd28l; Ly-53; Ly53; MIC17; TSA1"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1071
                     /gene="Cd80"
                     /gene_synonym="B71; Cd28l; Ly-53; Ly53; MIC17; TSA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1215
                     /gene="Cd80"
                     /gene_synonym="B71; Cd28l; Ly-53; Ly53; MIC17; TSA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..2688
                     /gene="Cd80"
                     /gene_synonym="B71; Cd28l; Ly-53; Ly53; MIC17; TSA1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1942..1947
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cd80"
                     /gene_synonym="B71; Cd28l; Ly-53; Ly53; MIC17; TSA1"
                     /note="hexamer: AATAAA"
     polyA_site      1968
                     /gene="Cd80"
                     /gene_synonym="B71; Cd28l; Ly-53; Ly53; MIC17; TSA1"
                     /note="major polyA site"
     regulatory      2011..2016
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cd80"
                     /gene_synonym="B71; Cd28l; Ly-53; Ly53; MIC17; TSA1"
                     /note="hexamer: AAGAAA"
     polyA_site      2032
                     /gene="Cd80"
                     /gene_synonym="B71; Cd28l; Ly-53; Ly53; MIC17; TSA1"
     regulatory      2332..2337
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cd80"
                     /gene_synonym="B71; Cd28l; Ly-53; Ly53; MIC17; TSA1"
                     /note="hexamer: AATAAA"
     polyA_site      2353
                     /gene="Cd80"
                     /gene_synonym="B71; Cd28l; Ly-53; Ly53; MIC17; TSA1"
                     /note="major polyA site"
ORIGIN      
        1 gagttttata cctcaataga ctcttactag tttctctttt tcaggttgtg aaactcaacc
       61 ttcaaagaca ctctgttcca tttctgtgga ctaataggat catctttagc atctgccggg
      121 tggatgccat ccaggcttct ttttctacat ctctgtttct cgatttttgt gagcctagga
      181 ggtgcctaag ctccattggc tctagattcc tggctttccc catcatgttc tccaaagcat
      241 ctgaagctat ggcttgcaat tgtcagttga tgcaggatac accactcctc aagtttccat
      301 gtccaaggct cattcttctc tttgtgctgc tgattcgtct ttcacaagtg tcttcagatg
      361 ttgatgaaca actgtccaag tcagtgaaag ataaggtatt gctgccttgc cgttacaact
      421 ctcctcatga agatgagtct gaagaccgaa tctactggca aaaacatgac aaagtggtgc
      481 tgtctgtcat tgctgggaaa ctaaaagtgt ggcccgagta taagaaccgg actttatatg
      541 acaacactac ctactctctt atcatcctgg gcctggtcct ttcagaccgg ggcacataca
      601 gctgtgtcgt tcaaaagaag gaaagaggaa cgtatgaagt taaacacttg gctttagtaa
      661 agttgtccat caaagctgac ttctctaccc ccaacataac tgagtctgga aacccatctg
      721 cagacactaa aaggattacc tgctttgctt ccgggggttt cccaaagcct cgcttctctt
      781 ggttggaaaa tggaagagaa ttacctggca tcaatacgac aatttcccag gatcctgaat
      841 ctgaattgta caccattagt agccaactag atttcaatac gactcgcaac cacaccatta
      901 agtgtctcat taaatatgga gatgctcacg tgtcagagga cttcacctgg gaaaaacccc
      961 cagaagaccc tcctgatagc aagaacacac ttgtgctctt tggggcagga ttcggcgcag
     1021 taataacagt cgtcgtcatc gttgtcatca tcaaatgctt ctgtaagcac agaagctgtt
     1081 tcagaagaaa tgaggcaagc agagaaacaa acaacagcct taccttcggg cctgaagaag
     1141 cattagctga acagaccgtc ttcctttagt tcttctctgt ccatgtggga tacatggtat
     1201 tatgtggctc atgaggtctc atctaccatt tgcaactgac ctcttctgca aaggacttca
     1261 gaaacctagc actaccctgg ctctgcaaac acggttctct aggtgaagcc tctgcagtgg
     1321 tttgcagaag tactcagacg aatgaaccac agtagttctg ctgattctga ggacgtagtt
     1381 tagagactga attctttgga aaggacatag ggacgatttg cacatttgct tgcacatcac
     1441 acacacacac acacacacac acacacacac acccacacac acacactctc tctcgatacc
     1501 ttaggatagg gttctaccct gttgctcagt gacaaagaat cactctgtgg cggaggcagg
     1561 cttcaagctt gcagcaatcc tcctgcacca gtttcctgag tgccagactt ccaggtgtaa
     1621 gctatggcac ttagcagaac actagctgaa tcaatgaaga cactgaggtt ccaagaggga
     1681 acctgaatta tgaaggtgag tcagaatcca gatttcctgg ctctaccact cttaacctgt
     1741 atctgttaga ccccaagctc tgagctcata gacaagctaa tttaaaatgc ttttaataag
     1801 cagaaggctc agttagtacg gggttcagga tactgcttac tggcaatatt tgactagcct
     1861 ctattttgtt tgttttttaa ggcctactga ctgtagtgta atttgtagga aacatgttgc
     1921 tatgtatacc catttgaggg taataaaaat gttggtaatt ttcagccagc actttccagg
     1981 tatttccctt tttatccttc atgtccttaa aagaaaccag agtcaaccag aattaactgc
     2041 ttttgttgtc taagatgaat gtatgccttt tatacttcaa agcaaaagtc aagttggagg
     2101 cacagttcgt aacttactcg ttcatattga acttataatg aatgtcttta ggcaactttg
     2161 cccttttaca cagttcttga tatagttctt atttcaaatg agattattta ctgagtaatc
     2221 atctgtcctc acataaacaa cttaagtgat actagcctta cacagaactt cctcagattc
     2281 ctggaagtgg cttttgctct ttggtataga tctgctacag tggaattgaa aaataaaatg
     2341 tacgttagac acacttgcct gtaatccctg cactcagtat actgaggctg aagaactgaa
     2401 ttccaggtag catggcctgg atagtaagat cctgtctgaa acccactcct ccatcaatgt
     2461 gccccaaaga aatggaaaac aagaagcagc taactgctgc ttctatactg aaggttccct
     2521 tttctctgag atgtaatcca caacctacaa gaccagcagt gagcttaagt caagacaatc
     2581 agatattcta gtctgaattt ataggaggac atcgaatggc agccaaactt ctcaacggga
     2641 ccagaatctg ttgtatgccc aggaaacagg tccattttta tgtgggtg
//
