LOCUS       NM_008339               1249 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus CD79B antigen (Cd79b), transcript variant 1, mRNA.
ACCESSION   NM_008339
VERSION     NM_008339.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1249)
  AUTHORS   Flumann,R., Hansen,J., Meinel,J., Pfeiffer,P., Goldfarb
            Wittkopf,H., Lutz,A., Wirtz,J., Mollmann,M., Zhou,T., Tabatabai,A.,
            Lohmann,T., Jauch,M., Beleggia,F., Pelzer,B., Ullrich,F.,
            Hofmann,S., Arora,A., Persigehl,T., Buttner,R., von Tresckow,B.,
            Klein,S., Jachimowicz,R.D., Reinhardt,H.C. and Knittel,G.
  TITLE     An inducible Cd79b mutation confers ibrutinib sensitivity in mouse
            models of Myd88-driven diffuse large B-cell lymphoma
  JOURNAL   Blood Adv 8 (5), 1063-1074 (2024)
   PUBMED   38060829
REFERENCE   2  (bases 1 to 1249)
  AUTHORS   Pindzola,G.M., Razzaghi,R., Tavory,R.N., Nguyen,H.T., Morris,V.M.,
            Li,M., Agarwal,S., Huang,B., Okada,T., Reinhardt,H.C., Knittel,G.,
            Kashkar,H., Young,R.M., Pittaluga,S. and Muppidi,J.R.
  TITLE     Aberrant expansion of spontaneous splenic germinal centers induced
            by hallmark genetic lesions of aggressive lymphoma
  JOURNAL   Blood 140 (10), 1119-1131 (2022)
   PUBMED   35759728
REFERENCE   3  (bases 1 to 1249)
  AUTHORS   Wemlinger,S.M., Parker Harp,C.R., Yu,B., Hardy,I.R., Seefeldt,M.,
            Matsuda,J., Mingueneau,M., Spilker,K.A., Cameron,T.O.,
            Larrick,J.W., Getahun,A. and Cambier,J.C.
  TITLE     Preclinical Analysis of Candidate Anti-Human CD79 Therapeutic
            Antibodies Using a Humanized CD79 Mouse Model
  JOURNAL   J Immunol 208 (7), 1566-1584 (2022)
   PUBMED   35321883
REFERENCE   4  (bases 1 to 1249)
  AUTHORS   Veselits,M., Tanaka,A., Chen,Y., Hamel,K., Mandal,M., Kandasamy,M.,
            Manicassamy,B., O'Neill,S.K., Wilson,P., Sciammas,R. and Clark,M.R.
  TITLE     Igbeta ubiquitination activates PI3K signals required for endosomal
            sorting
  JOURNAL   J Exp Med 214 (12), 3775-3790 (2017)
   PUBMED   29141870
  REMARK    GeneRIF: ablation of B cell antigen receptor ubiquitination in vivo
            uncouples the receptor from CD19 phosphorylation and
            phosphatidylinositol 3-kinase (PI3K) signals.
REFERENCE   5  (bases 1 to 1249)
  AUTHORS   Song,J., Uyttersprot,N., Classen,S. and Waisman,A.
  TITLE     The IgG1 B-cell receptor provides survival and proliferative
            signals analogue to the Igalpha but not the Igbeta co-receptor
  JOURNAL   Eur J Immunol 46 (8), 1878-1886 (2016)
   PUBMED   27218486
REFERENCE   6  (bases 1 to 1249)
  AUTHORS   Lin,H. and Grosschedl,R.
  TITLE     Failure of B-cell differentiation in mice lacking the transcription
            factor EBF
  JOURNAL   Nature 376 (6537), 263-267 (1995)
   PUBMED   7542362
REFERENCE   7  (bases 1 to 1249)
  AUTHORS   Muller,B., Cooper,L. and Terhorst,C.
  TITLE     Cloning and sequencing of the cDNA encoding the human homologue of
            the murine immunoglobulin-associated protein B29
  JOURNAL   Eur J Immunol 22 (6), 1621-1625 (1992)
   PUBMED   1534761
REFERENCE   8  (bases 1 to 1249)
  AUTHORS   Matsuuchi,L., Gold,M.R., Travis,A., Grosschedl,R., DeFranco,A.L.
            and Kelly,R.B.
  TITLE     The membrane IgM-associated proteins MB-1 and Ig-beta are
            sufficient to promote surface expression of a partially functional
            B-cell antigen receptor in a nonlymphoid cell line
  JOURNAL   Proc Natl Acad Sci U S A 89 (8), 3404-3408 (1992)
   PUBMED   1373499
REFERENCE   9  (bases 1 to 1249)
  AUTHORS   Hermanson,G.G., Briskin,M., Sigman,D. and Wall,R.
  TITLE     Immunoglobulin enhancer and promoter motifs 5' of the B29
            B-cell-specific gene
  JOURNAL   Proc Natl Acad Sci U S A 86 (19), 7341-7345 (1989)
   PUBMED   2508087
REFERENCE   10 (bases 1 to 1249)
  AUTHORS   Hermanson,G.G., Eisenberg,D., Kincade,P.W. and Wall,R.
  TITLE     B29: a member of the immunoglobulin gene superfamily exclusively
            expressed on beta-lineage cells
  JOURNAL   Proc Natl Acad Sci U S A 85 (18), 6890-6894 (1988)
   PUBMED   3137575
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BU695347.1, AK143573.1 and
            BE633998.1.
            
            [WARNING] On Feb 10, 2025 this sequence was replaced by
            NM_008339.4.
            
            On Sep 15, 2015 this sequence version replaced NM_008339.2.
            
            Summary: The B lymphocyte antigen receptor is a multimeric complex
            that includes the antigen-specific component, surface
            immunoglobulin (Ig). Surface Ig non-covalently associates with two
            other proteins, Ig-alpha and Ig-beta, which are necessary for
            expression and function of the B-cell antigen receptor. This gene
            encodes the Ig-beta protein of the B-cell antigen component.
            Alternatively spliced transcript variants encoding different
            isoforms have been described. [provided by RefSeq, Sep 2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: J03857.1, AK143573.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                BU695347.1         1-33
            34-1223             AK143573.1         2-1191
            1224-1249           BE633998.1         383-408
FEATURES             Location/Qualifiers
     source          1..1249
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 68.89 cM"
     gene            1..1249
                     /gene="Cd79b"
                     /gene_synonym="B29; Ig-beta; Igb; Igbeta"
                     /note="CD79B antigen"
                     /db_xref="GeneID:15985"
                     /db_xref="MGI:MGI:96431"
     exon            1..145
                     /gene="Cd79b"
                     /gene_synonym="B29; Ig-beta; Igb; Igbeta"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..765
                     /gene="Cd79b"
                     /gene_synonym="B29; Ig-beta; Igb; Igbeta"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; B-cell antigen receptor complex-associated
                     protein beta chain; B-cell-specific glycoprotein B29;
                     immunoglobulin-associated B29 protein;
                     immunoglobulin-associated beta"
                     /codon_start=1
                     /product="B-cell antigen receptor complex-associated
                     protein beta chain isoform 1 precursor"
                     /protein_id="NP_032365.1"
                     /db_xref="CCDS:CCDS48960.1"
                     /db_xref="GeneID:15985"
                     /db_xref="MGI:MGI:96431"
                     /translation="MATLVLSSMPCHWLLFLLLLFSGEPVPAMTSSDLPLNFQGSPCS
                     QIWQHPRFAAKKRSSMVKFHCYTNHSGALTWFRKRGSQQPQELVSEEGRIVQTQNGSV
                     YTLTIQNIQYEDNGIYFCKQKCDSANHNVTDSCGTELLVLGFSTLDQLKRRNTLKDGI
                     ILIQTLLIILFIIVPIFLLLDKDDGKAGMEEDHTYEGLNIDQTATYEDIVTLRTGEVK
                     WSVGEHPGQE"
     exon            146..196
                     /gene="Cd79b"
                     /gene_synonym="B29; Ig-beta; Igb; Igbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            197..505
                     /gene="Cd79b"
                     /gene_synonym="B29; Ig-beta; Igb; Igbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            506..624
                     /gene="Cd79b"
                     /gene_synonym="B29; Ig-beta; Igb; Igbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            625..666
                     /gene="Cd79b"
                     /gene_synonym="B29; Ig-beta; Igb; Igbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            667..1231
                     /gene="Cd79b"
                     /gene_synonym="B29; Ig-beta; Igb; Igbeta"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1207..1212
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cd79b"
                     /gene_synonym="B29; Ig-beta; Igb; Igbeta"
                     /note="hexamer: AATAAA"
     polyA_site      1231
                     /gene="Cd79b"
                     /gene_synonym="B29; Ig-beta; Igb; Igbeta"
                     /note="major polyA site"
ORIGIN      
        1 caagctgcag cccaggctga catacagtta catgtttcgc ccccaaacct ccttgggctc
       61 agagacagag cagtgaccat ggccacactg gtgctgtctt ccatgccctg ccactggctg
      121 ttgttcctgc tgctgctctt ctcaggtgag ccggtaccag caatgacaag cagtgacctg
      181 ccactgaatt tccaaggaag cccttgttcc cagatctggc agcacccgag gtttgcagcc
      241 aaaaagcgga gctccatggt gaagtttcac tgctacacaa accactcagg tgcactgacc
      301 tggttccgaa agcgagggag ccagcagccc caggaactgg tctcagaaga gggacgcatt
      361 gtgcagaccc agaatggctc tgtctacacc ctcactatcc aaaacatcca gtacgaggat
      421 aatggtatct acttctgcaa gcagaaatgt gacagcgcca accataatgt caccgacagc
      481 tgtggcacgg aacttctagt cttaggattc agcacgttgg accaactgaa gcggcggaac
      541 acactgaaag atggcattat cttgatccag accctcctca tcatcctctt catcattgtg
      601 cccatcttcc tgctacttga caaggatgac ggcaaggctg ggatggagga agatcacacc
      661 tatgagggct tgaacattga ccagacagcc acctatgaag acatagtgac tcttcggaca
      721 ggggaggtaa agtggtcggt aggagagcat ccaggccagg aatgagggtc accttcatcc
      781 tgctcaactc ttgggcctca ctgcttccaa accgcctggc tcacaagccc attccctgct
      841 tcctggatac cccggccagc gtctgaagct ggaccatcaa taccacctct cattctagcc
      901 cctggtcccc agctcttgct gaagggcctg gggtggaagg acaatagggt ggtgacatgg
      961 agtaaggagt tctctgggga tagacttgac ccaaggcttc tgggagtgcc atgtgggatc
     1021 tgtccccatg tttgggacag gaaagcagag acttgttgga atctgcaaat ggactcagaa
     1081 cacactggct tcaagaggag tctaggagga ccatggttca cactgacacc tgaagaagtt
     1141 gccagaatgc catttctctc tcccattcca aggatcaccc aaagcctaca gcccatcctc
     1201 ctgtggaata aataatgtgc ctgacaccag aaaaaaaaaa aaaaaaaaa
//
