LOCUS       NM_001042605            1431 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus CD74 antigen (invariant polypeptide of major
            histocompatibility complex, class II antigen-associated) (Cd74),
            transcript variant 1, mRNA.
ACCESSION   NM_001042605
VERSION     NM_001042605.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1431)
  AUTHORS   Tang,Z., Hu,J., Li,X.C., Wang,W., Zhang,H.Y., Guo,Y.Y., Shuai,X.,
            Chu,Q., Xie,C., Lin,D. and Zhong,B.
  TITLE     A subset of neutrophils activates anti-tumor immunity and inhibits
            non-small-cell lung cancer progression
  JOURNAL   Dev Cell (2024) In press
   PUBMED   39515330
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 1431)
  AUTHORS   Mori,S., Kohyama,M., Yasumizu,Y., Tada,A., Tanzawa,K., Shishido,T.,
            Kishida,K., Jin,H., Nishide,M., Kawada,S., Motooka,D., Okuzaki,D.,
            Naito,R., Nakai,W., Kanda,T., Murata,T., Terao,C., Ohmura,K.,
            Arase,N., Kurosaki,T., Fujimoto,M., Suenaga,T., Kumanogoh,A.,
            Sakaguchi,S., Ogawa,Y. and Arase,H.
  TITLE     Neoself-antigens are the primary target for autoreactive T cells in
            human lupus
  JOURNAL   Cell 187 (21), 6071-6087 (2024)
   PUBMED   39276775
REFERENCE   3  (bases 1 to 1431)
  AUTHORS   Carabana,C., Sun,W., Veludo Ramos,C., Huyghe,M., Perkins,M.,
            Maillot,A., Journot,R., Hartani,F., Faraldo,M.M., Lloyd-Lewis,B.
            and Fre,S.
  TITLE     Spatially distinct epithelial and mesenchymal cell subsets along
            progressive lineage restriction in the branching embryonic mammary
            gland
  JOURNAL   EMBO J 43 (12), 2308-2336 (2024)
   PUBMED   38760574
REFERENCE   4  (bases 1 to 1431)
  AUTHORS   Bonnin,E., Rodrigo Riestra,M., Marziali,F., Mena Osuna,R.,
            Denizeau,J., Maurin,M., Saez,J.J., Jouve,M., Bonte,P.E., Richer,W.,
            Nevo,F., Lemoine,S., Girard,N., Lefevre,M., Borcoman,E.,
            Vincent-Salomon,A., Baulande,S., Moreau,H.D., Sedlik,C., Hivroz,C.,
            Lennon-Dumenil,A.M., Tosello Boari,J. and Piaggio,E.
  TITLE     CD74 supports accumulation and function of regulatory T cells in
            tumors
  JOURNAL   Nat Commun 15 (1), 3749 (2024)
   PUBMED   38702311
  REMARK    GeneRIF: CD74 supports accumulation and function of regulatory T
            cells in tumors.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1431)
  AUTHORS   Liu,L., Wang,J., Wang,Y., Chen,L., Peng,L., Bin,Y., Ding,P.,
            Zhang,R., Tong,F. and Dong,X.
  TITLE     Blocking the MIF-CD74 axis augments radiotherapy efficacy for brain
            metastasis in NSCLC via synergistically promoting microglia M1
            polarization
  JOURNAL   J Exp Clin Cancer Res 43 (1), 128 (2024)
   PUBMED   38685050
  REMARK    GeneRIF: Blocking the MIF-CD74 axis augments radiotherapy efficacy
            for brain metastasis in NSCLC via synergistically promoting
            microglia M1 polarization.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1431)
  AUTHORS   Kolk,D.P. and Floyd-Smith,G.
  TITLE     The HXY box regulatory element modulates expression of the murine
            IA antigen-associated invariant chain in L fibroblasts
  JOURNAL   DNA Cell Biol 11 (10), 745-754 (1992)
   PUBMED   1457043
REFERENCE   7  (bases 1 to 1431)
  AUTHORS   Mock,B.A., Contente,S., Kenyon,K., Friedman,R.M. and Kozak,C.A.
  TITLE     The gene for lysyl oxidase maps to mouse chromosome 18
  JOURNAL   Genomics 14 (3), 822-823 (1992)
   PUBMED   1358813
REFERENCE   8  (bases 1 to 1431)
  AUTHORS   Justice,M.J., Gilbert,D.J., Kinzler,K.W., Vogelstein,B.,
            Buchberg,A.M., Ceci,J.D., Matsuda,Y., Chapman,V.M., Patriotis,C.,
            Makris,A. et al.
  TITLE     A molecular genetic linkage map of mouse chromosome 18 reveals
            extensive linkage conservation with human chromosomes 5 and 18
  JOURNAL   Genomics 13 (4), 1281-1288 (1992)
   PUBMED   1354644
REFERENCE   9  (bases 1 to 1431)
  AUTHORS   Wegener,A.M., Letourneur,F., Hoeveler,A., Brocker,T., Luton,F. and
            Malissen,B.
  TITLE     The T cell receptor/CD3 complex is composed of at least two
            autonomous transduction modules
  JOURNAL   Cell 68 (1), 83-95 (1992)
   PUBMED   1531041
REFERENCE   10 (bases 1 to 1431)
  AUTHORS   Byrd,L., Grossmann,M., Potter,M. and Shen-Ong,G.L.
  TITLE     Chronic multifocal osteomyelitis, a new recessive mutation on
            chromosome 18 of the mouse
  JOURNAL   Genomics 11 (4), 794-798 (1991)
   PUBMED   1686018
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK002232.1, BG148172.1 and AW123644.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK154096.1, BC003476.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-659               AK002232.1         1-659
            660-851             BG148172.1         328-519
            852-1258            AK002232.1         660-1066
            1259-1431           AW123644.1         1-173               c
FEATURES             Location/Qualifiers
     source          1..1431
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 34.41 cM"
     gene            1..1431
                     /gene="Cd74"
                     /gene_synonym="CLIP; DHLAG; HLADG; Ia-GAMMA; Ii"
                     /note="CD74 antigen (invariant polypeptide of major
                     histocompatibility complex, class II antigen-associated)"
                     /db_xref="GeneID:16149"
                     /db_xref="MGI:MGI:96534"
     exon            1..162
                     /gene="Cd74"
                     /gene_synonym="CLIP; DHLAG; HLADG; Ia-GAMMA; Ii"
                     /inference="alignment:Splign:2.1.0"
     exon            163..332
                     /gene="Cd74"
                     /gene_synonym="CLIP; DHLAG; HLADG; Ia-GAMMA; Ii"
                     /inference="alignment:Splign:2.1.0"
     exon            333..412
                     /gene="Cd74"
                     /gene_synonym="CLIP; DHLAG; HLADG; Ia-GAMMA; Ii"
                     /inference="alignment:Splign:2.1.0"
     exon            413..475
                     /gene="Cd74"
                     /gene_synonym="CLIP; DHLAG; HLADG; Ia-GAMMA; Ii"
                     /inference="alignment:Splign:2.1.0"
     exon            476..568
                     /gene="Cd74"
                     /gene_synonym="CLIP; DHLAG; HLADG; Ia-GAMMA; Ii"
                     /inference="alignment:Splign:2.1.0"
     exon            569..659
                     /gene="Cd74"
                     /gene_synonym="CLIP; DHLAG; HLADG; Ia-GAMMA; Ii"
                     /inference="alignment:Splign:2.1.0"
     exon            660..851
                     /gene="Cd74"
                     /gene_synonym="CLIP; DHLAG; HLADG; Ia-GAMMA; Ii"
                     /inference="alignment:Splign:2.1.0"
     exon            852..914
                     /gene="Cd74"
                     /gene_synonym="CLIP; DHLAG; HLADG; Ia-GAMMA; Ii"
                     /inference="alignment:Splign:2.1.0"
     exon            915..1415
                     /gene="Cd74"
                     /gene_synonym="CLIP; DHLAG; HLADG; Ia-GAMMA; Ii"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1394..1399
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cd74"
                     /gene_synonym="CLIP; DHLAG; HLADG; Ia-GAMMA; Ii"
                     /note="hexamer: AATAAA"
     polyA_site      1413
                     /gene="Cd74"
                     /gene_synonym="CLIP; DHLAG; HLADG; Ia-GAMMA; Ii"
                     /note="major polyA site"
ORIGIN      
        1 agacacacag cagcagcagc agcagcagca gcagcaacag cagcagcagc agcagcgcct
       61 gtgggaaaaa ctagaggcta gagccatgga tgaccaacgc gacctcatct ctaaccatga
      121 acagttgccc atactgggca accgccctag agagccagaa aggtgcagcc gtggagctct
      181 gtacaccggt gtctctgtcc tggtggctct gctcttggct gggcaggcca ccactgctta
      241 cttcctgtac cagcaacagg gccgcctaga caagctgacc atcacctccc agaacctgca
      301 actggagagc cttcgcatga agcttccgaa atctgccaaa cctgtgagcc agatgcggat
      361 ggctactccc ttgctgatgc gtccaatgtc catggataac atgctccttg ggcctgtgaa
      421 gaacgttacc aagtacggca acatgaccca ggaccatgtg atgcatctgc tcacgaggtc
      481 tggacccctg gagtacccgc agctgaaggg gaccttccca gagaatctga agcatcttaa
      541 gaactccatg gatggcgtga actggaagat cttcgagagc tggatgaagc agtggctctt
      601 gtttgagatg agcaagaact ccctggagga gaagaagccc accgaggctc cacctaaagt
      661 actgaccaag tgccaggaag aagtcagcca catccctgcc gtctacccgg gtgcgttccg
      721 tcccaagtgc gacgagaacg gtaactattt gccactccag tgccacggga gcactggcta
      781 ctgctggtgt gtgttcccca acggcactga ggttcctcac accaagagcc gcgggcgcca
      841 taactgcagt gagccactgg acatggaaga cctatcttct ggcctgggag tgaccaggca
      901 ggaactgggt caagtcaccc tgtgaagaca gaggccagct ctgcacagca gcagcgcccc
      961 ctgctctcct gtgcctcagc ccttcttatg ttccctgatg tcacacccca cttcccgtct
     1021 ccctgcaccc tggggcttga gactggtgtc tgtttcatcg tcccaggaca cggcaaatga
     1081 agtcagaaca gaaggaggac gctggagggc cttgctggct accgctatct aaagggaacc
     1141 cccatttctg acccattagt agtcttgaat gtggggctct gagataaagg cccgcagaca
     1201 gggacaaggg atgccctacc cttaacctag gctggacaca tttgctgcct tctcctcaag
     1261 gaagaagaac ccaagcccct cctcccagta acccctcctc acatcctgcc accccccctc
     1321 aagccccacc ccctttcagg ttccttgctc agccaagctt gtcagcagcc tgtaggatca
     1381 tggttcaagt gacaataaag gaagaaagta gaacaaaaaa aaaaaaaaaa a
//
