LOCUS       NM_009854               1052 bp    mRNA    linear   ROD 19-NOV-2024
DEFINITION  Mus musculus CD7 antigen (Cd7), mRNA.
ACCESSION   NM_009854
VERSION     NM_009854.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1052)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1052)
  AUTHORS   Zhou,H.Y., Feng,X., Wang,L.W., Zhou,R., Sun,H., Chen,X., Lu,R.B.,
            Huang,Y., Guo,Q. and Luo,X.H.
  TITLE     Bone marrow immune cells respond to fluctuating nutritional stress
            to constrain weight regain
  JOURNAL   Cell Metab 35 (11), 1915-1930 (2023)
   PUBMED   37703873
REFERENCE   3  (bases 1 to 1052)
  AUTHORS   Gomes-Silva,D., Srinivasan,M., Sharma,S., Lee,C.M., Wagner,D.L.,
            Davis,T.H., Rouce,R.H., Bao,G., Brenner,M.K. and Mamonkin,M.
  TITLE     CD7-edited T cells expressing a CD7-specific CAR for the therapy of
            T-cell malignancies
  JOURNAL   Blood 130 (3), 285-296 (2017)
   PUBMED   28539325
  REMARK    GeneRIF: CD7 chimeric antigen receptor T cells have robust activity
            against T-cell malignancies in vitro and in vivo.
REFERENCE   4  (bases 1 to 1052)
  AUTHORS   Howie,D., Garcia Rueda,H., Brown,M.H. and Waldmann,H.
  TITLE     Secreted and transmembrane 1A is a novel co-stimulatory ligand
  JOURNAL   PLoS One 8 (9), e73610 (2013)
   PUBMED   24039998
  REMARK    GeneRIF: Data indicate the tissue ligand SECTM1A (Secreted and
            transmembrane1A) as an alternative CD7 ligand.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1052)
  AUTHORS   Howard,B.A., Sempowski,G.D., Scearce,R.M., Liao,H.X., Lee,D.M.,
            Lam,G.K., Chen,H., Fadden,P., Haystead,T. and Haynes,B.F.
  TITLE     Murine CD7 shares antigenic cross-reactivity with HSP-60
  JOURNAL   Hybridoma (Larchmt) 27 (2), 81-89 (2008)
   PUBMED   18642672
  REMARK    GeneRIF: Molecular mimicry of murine CD7 with HSP-60 is
            demonstrated; CD7 may regulate HSP-60 expression in mouse small
            intestine.
REFERENCE   6  (bases 1 to 1052)
  AUTHORS   Bonilla,F.A., Kokron,C.M., Swinton,P. and Geha,R.S.
  TITLE     Targeted gene disruption of murine CD7
  JOURNAL   Int Immunol 9 (12), 1875-1883 (1997)
   PUBMED   9466315
REFERENCE   7  (bases 1 to 1052)
  AUTHORS   Lee,D.M., Schanberg,L.E., Fleenor,D.E., Seldin,M.F., Haynes,B.F.
            and Kaufman,R.E.
  TITLE     The mouse CD7 gene: identification of a new element common to the
            human CD7 and mouse Thy-1 promoters
  JOURNAL   Immunogenetics 44 (2), 108-114 (1996)
   PUBMED   8662072
REFERENCE   8  (bases 1 to 1052)
  AUTHORS   Yoshikawa,K., Seto,M., Ueda,R., Obata,Y., Aoki,S. and Takahashi,T.
  TITLE     Molecular cloning of the gene coding for the mouse T-cell antigen
            CD7
  JOURNAL   Immunogenetics 41 (2-3), 159-161 (1995)
   PUBMED   7528728
REFERENCE   9  (bases 1 to 1052)
  AUTHORS   Lee,D.M., Watson,M.L. and Seldin,M.F.
  TITLE     Mouse Cd7 maps to chromosome 11
  JOURNAL   Immunogenetics 39 (4), 289-290 (1994)
   PUBMED   7509775
REFERENCE   10 (bases 1 to 1052)
  AUTHORS   Yoshikawa,K., Seto,M., Ueda,R., Obata,Y., Fukatsu,H., Segawa,A. and
            Takahashi,T.
  TITLE     Isolation and characterization of mouse CD7 cDNA
  JOURNAL   Immunogenetics 37 (2), 114-119 (1993)
   PUBMED   7678579
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL662887.13, AK136444.1 and AI852832.1.
            
            On Apr 5, 2011 this sequence version replaced NM_009854.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC024376.1, D10329.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849380,
                                           SAMN00849383 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-47                AL662887.13        72573-72619         c
            48-1035             AK136444.1         2-989
            1036-1052           AI852832.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..1052
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 84.85 cM"
     gene            1..1052
                     /gene="Cd7"
                     /note="CD7 antigen"
                     /db_xref="GeneID:12516"
                     /db_xref="MGI:MGI:88344"
     exon            1..186
                     /gene="Cd7"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..746
                     /gene="Cd7"
                     /note="T-cell antigen CD7"
                     /codon_start=1
                     /product="T-cell antigen CD7 precursor"
                     /protein_id="NP_033984.1"
                     /db_xref="CCDS:CCDS25764.1"
                     /db_xref="GeneID:12516"
                     /db_xref="MGI:MGI:88344"
                     /translation="MTQQAVLALLLTLAGILPGPLDAQDVHQSPRLTIASEGDSVNIT
                     CSTRGHLEGILMKKIWPQAYNVIYFEDRQEPTVDRTFSGRINFSGSQKNLTITISSLQ
                     LADTGDYTCEAVRKVSARGLFTTVVVKEKSSQEAYRSQEPLQTSFSFPAAIAVGFFFT
                     GLLLGVVCSMLRKIQIKKLCASGIKESPCVVYEDMSYSNRKTPCIPNQYQ"
     exon            187..501
                     /gene="Cd7"
                     /inference="alignment:Splign:2.1.0"
     exon            502..638
                     /gene="Cd7"
                     /inference="alignment:Splign:2.1.0"
     exon            639..1042
                     /gene="Cd7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1016..1021
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cd7"
                     /note="hexamer: AATAAA"
     polyA_site      1042
                     /gene="Cd7"
                     /note="major polyA site"
ORIGIN      
        1 gccacacccc tgtttcttcc tctcagggtt tttggtgtga actttcacag tgctcagtaa
       61 tgtgttgtag ccagagtggc tgatttggct cagatcacct ggatttgggc gtcatgactc
      121 agcaggcagt gctggctttg ctgcttacac tggccggaat cctgcctggc cccctggatg
      181 cccaagacgt acaccagtcc ccccgactca cgattgcctc tgagggggat tctgtcaaca
      241 tcacctgctc tacaagaggg cacctggaag ggatcttaat gaagaagatc tggcctcagg
      301 cttacaatgt gatttacttt gaagaccggc aggagcccac agtagacagg accttctcag
      361 gccgaattaa tttctctggt tcccagaaga acctgaccat caccataagc tccctccagc
      421 tggcagacac tggagactac acctgcgagg ctgtcaggaa agtcagtgcc cgtggcttgt
      481 tcaccacggt tgtggtgaaa gaaaaatcat cccaagaagc atacagatcc caggaacctc
      541 tgcagacatc attttccttc ccagctgcca ttgctgtagg cttcttcttc accgggctgc
      601 tccttggggt ggtgtgcagc atgctgagga agatacagat caagaaactg tgtgcctcag
      661 ggattaagga atctccgtgc gtagtgtatg aagacatgtc ctacagcaac cgcaagacgc
      721 catgcatccc caaccagtac cagtgaaccc ctctgcctgc agtcccccgt gccttgtttc
      781 agcagagctt acagcagtcc tgctggcccc cacaccccgc ccaactcccc agcactcttc
      841 ctgtggtact caaattcccc cttggtgctt ctgggtgggt gggattcctc ctctgtaagc
      901 tcccccacag ggctctgcaa tctgtcacca accctagcca ggtaccctga catcagaaac
      961 aaagcttggg ggtggggagg tacctgcctt ggagccgcct ggccaggaaa aattaaataa
     1021 acacacaaat acattaacaa aaaaaaaaaa aa
//
