LOCUS       NM_001033122            1631 bp    mRNA    linear   ROD 26-NOV-2024
DEFINITION  Mus musculus CD69 antigen (Cd69), mRNA.
ACCESSION   NM_001033122 XM_132882 XM_897762 XM_897773 XM_918242 XM_925570
            XM_925572
VERSION     NM_001033122.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1631)
  AUTHORS   Burton,O.T., Bricard,O., Tareen,S., Gergelits,V., Andrews,S.,
            Biggins,L., Roca,C.P., Whyte,C., Junius,S., Brajic,A., Pasciuto,E.,
            Ali,M., Lemaitre,P., Schlenner,S.M., Ishigame,H., Brown,B.D.,
            Dooley,J. and Liston,A.
  TITLE     The tissue-resident regulatory T cell pool is shaped by transient
            multi-tissue migration and a conserved residency program
  JOURNAL   Immunity 57 (7), 1586-1602 (2024)
   PUBMED   38897202
REFERENCE   2  (bases 1 to 1631)
  AUTHORS   Miyahara,A., Umeki,A., Sato,K., Nomura,T., Yamamoto,H.,
            Miyasaka,T., Tanno,D., Matsumoto,I., Zong,T., Kagesawa,T.,
            Oniyama,A., Kawamura,K., Yuan,X., Yokoyama,R., Kitai,Y., Kanno,E.,
            Tanno,H., Hara,H., Yamasaki,S., Saijo,S., Iwakura,Y., Ishii,K. and
            Kawakami,K.
  TITLE     Innate phase production of IFN-gamma by memory and effector T cells
            expressing early activation marker CD69 during infection with
            Cryptococcus deneoformans in the lungs
  JOURNAL   Infect Immun 92 (6), e0002424 (2024)
   PUBMED   38700335
  REMARK    GeneRIF: Innate phase production of IFN-gamma by memory and
            effector T cells expressing early activation marker CD69 during
            infection with Cryptococcus deneoformans in the lungs.
REFERENCE   3  (bases 1 to 1631)
  AUTHORS   Nakai,S., Kume,M., Matsumura,Y., Koguchi-Yoshioka,H., Matsuda,S.,
            Fujimoto,M. and Watanabe,R.
  TITLE     CD69 Is Indispensable for Development of Functional Local Immune
            Memory in Murine Contact Hypersensitivity
  JOURNAL   J Invest Dermatol 144 (6), 1344-1352 (2024)
   PUBMED   38135026
  REMARK    GeneRIF: CD69 Is Indispensable for Development of Functional Local
            Immune Memory in Murine Contact Hypersensitivity.
REFERENCE   4  (bases 1 to 1631)
  AUTHORS   Sallais,J., Park,C., Alahari,S., Porter,T., Liu,R., Kurt,M.,
            Farrell,A., Post,M. and Caniggia,I.
  TITLE     HIF1 inhibitor acriflavine rescues early-onset preeclampsia
            phenotype in mice lacking placental prolyl hydroxylase domain
            protein 2
  JOURNAL   JCI Insight 7 (23), e158908 (2022)
   PUBMED   36227697
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1631)
  AUTHORS   Blanco-Dominguez,R., de la Fuente,H., Rodriguez,C.,
            Martin-Aguado,L., Sanchez-Diaz,R., Jimenez-Alejandre,R.,
            Rodriguez-Arabaolaza,I., Curtabbi,A., Garcia-Guimaraes,M.M.,
            Vera,A., Rivero,F., Cuesta,J., Jimenez-Borreguero,L.J., Cecconi,A.,
            Duran-Cambra,A., Tauron,M., Alonso,J., Bueno,H., Villalba-Orero,M.,
            Enriquez,J.A., Robson,S.C., Alfonso,F., Sanchez-Madrid,F.,
            Martinez-Gonzalez,J. and Martin,P.
  TITLE     CD69 expression on regulatory T cells protects from immune damage
            after myocardial infarction
  JOURNAL   J Clin Invest 132 (21), e152418 (2022)
   PUBMED   36066993
  REMARK    GeneRIF: CD69 expression on regulatory T cells protects from immune
            damage after myocardial infarction.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1631)
  AUTHORS   Simpson,S.J., Mizoguchi,E., Allen,D., Bhan,A.K. and Terhorst,C.
  TITLE     Evidence that CD4+, but not CD8+ T cells are responsible for murine
            interleukin-2-deficient colitis
  JOURNAL   Eur J Immunol 25 (9), 2618-2625 (1995)
   PUBMED   7589135
REFERENCE   7  (bases 1 to 1631)
  AUTHORS   Negishi,I., Motoyama,N., Nakayama,K., Nakayama,K., Senju,S.,
            Hatakeyama,S., Zhang,Q., Chan,A.C. and Loh,D.Y.
  TITLE     Essential role for ZAP-70 in both positive and negative selection
            of thymocytes
  JOURNAL   Nature 376 (6539), 435-438 (1995)
   PUBMED   7630421
REFERENCE   8  (bases 1 to 1631)
  AUTHORS   Morse,H.C. 3rd.
  TITLE     Genetic nomenclature for loci controlling surface antigens of mouse
            hemopoietic cells
  JOURNAL   J Immunol 149 (10), 3129-3134 (1992)
   PUBMED   1431091
  REMARK    Review article
            Erratum:[J Immunol 1993 Mar 15;150(6):2563]
REFERENCE   9  (bases 1 to 1631)
  AUTHORS   Cambiaggi,C., Scupoli,M.T., Cestari,T., Gerosa,F., Carra,G.,
            Tridente,G. and Accolla,R.S.
  TITLE     Constitutive expression of CD69 in interspecies T-cell hybrids and
            locus assignment to human chromosome 12
  JOURNAL   Immunogenetics 36 (2), 117-120 (1992)
   PUBMED   1612643
REFERENCE   10 (bases 1 to 1631)
  AUTHORS   Yokoyama,W.M., Koning,F., Kehn,P.J., Pereira,G.M., Stingl,G.,
            Coligan,J.E. and Shevach,E.M.
  TITLE     Characterization of a cell surface-expressed disulfide-linked dimer
            involved in murine T cell activation
  JOURNAL   J Immunol 141 (2), 369-376 (1988)
   PUBMED   2838547
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK151076.1, BY193860.1 and BE691115.1.
            
            On Feb 16, 2018 this sequence version replaced NM_001033122.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK017979.1, AK151076.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                AK151076.1         2-68
            68-68               BY193860.1         69-69
            69-1620             AK151076.1         70-1621
            1621-1631           BE691115.1         1-11                c
FEATURES             Location/Qualifiers
     source          1..1631
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 63.21 cM"
     gene            1..1631
                     /gene="Cd69"
                     /gene_synonym="5830438K24Rik; AIM; VEA"
                     /note="CD69 antigen"
                     /db_xref="GeneID:12515"
                     /db_xref="MGI:MGI:88343"
     exon            1..148
                     /gene="Cd69"
                     /gene_synonym="5830438K24Rik; AIM; VEA"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..684
                     /gene="Cd69"
                     /gene_synonym="5830438K24Rik; AIM; VEA"
                     /note="Very Early Activation Antigen"
                     /codon_start=1
                     /product="early activation antigen CD69"
                     /protein_id="NP_001028294.1"
                     /db_xref="CCDS:CCDS20582.1"
                     /db_xref="GeneID:12515"
                     /db_xref="MGI:MGI:88343"
                     /translation="MDSENCSITENSSSHLERGQKDHGTSIHFEKHHEGSIQVSIPWA
                     VLIVVLITSLIIALIALNVGKYNCPGLYEKLESSDHHVATCKNEWISYKRTCYFFSTT
                     TKSWALAQRSCSEDAATLAVIDSEKDMTFLKRYSGELEHWIGLKNEANQTWKWANGKE
                     FNSWFNLTGSGRCVSVNHKNVTAVDCEANFHWVCSKPSR"
     exon            149..271
                     /gene="Cd69"
                     /gene_synonym="5830438K24Rik; AIM; VEA"
                     /inference="alignment:Splign:2.1.0"
     exon            272..471
                     /gene="Cd69"
                     /gene_synonym="5830438K24Rik; AIM; VEA"
                     /inference="alignment:Splign:2.1.0"
     exon            472..575
                     /gene="Cd69"
                     /gene_synonym="5830438K24Rik; AIM; VEA"
                     /inference="alignment:Splign:2.1.0"
     exon            576..1621
                     /gene="Cd69"
                     /gene_synonym="5830438K24Rik; AIM; VEA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1599..1604
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cd69"
                     /gene_synonym="5830438K24Rik; AIM; VEA"
                     /note="hexamer: AATAAA"
     polyA_site      1621
                     /gene="Cd69"
                     /gene_synonym="5830438K24Rik; AIM; VEA"
                     /note="major polyA site"
ORIGIN      
        1 actgaacaag acagctccag ctacatctct ccgtggacca cttgagagtc gccagggacc
       61 ttgaggggaa aaaaattaaa aaggatggat tctgaaaact gttctataac ggaaaatagc
      121 tcttcacatc tggagagagg gcagaaggac catggcacca gtatacattt tgagaagcat
      181 catgaaggat ccattcaagt ttctatccct tgggctgtgt taatagtggt cctcatcacg
      241 tccttaataa tagctctcat tgccttaaat gtgggcaagt acaattgccc aggcttgtac
      301 gagaagttgg aatcatctga ccaccatgtt gctacctgca agaatgagtg gatttcatac
      361 aagaggacat gttacttctt ctccaccaca accaagagtt gggccttggc ccaacgctct
      421 tgttctgaag atgctgctac tcttgctgta attgattcag aaaaggacat gacgtttctg
      481 aagcgatatt ctggtgaact ggaacattgg attgggctga aaaatgaagc taatcagaca
      541 tggaaatggg caaatggcaa agaatttaac agctggttca acttgacggg gtctgggagg
      601 tgcgtgtccg tgaaccacaa aaatgttacc gctgtggact gtgaggcaaa cttccactgg
      661 gtctgcagca agccctccag atgacgagga tacatagatg tataaatgac tgtgccatag
      721 caccacagga aagttgtgta actggatact gctctgcagt tgaattttcc acaaagactg
      781 cacaaaccaa ctttacatca tcctggatca actccagata gaactgtggg acatgaggaa
      841 gaagatccag gaagatccct tgaccaggag ctgaaactgt caccaactga ctgctaatca
      901 catcaaggat gagaggatgg ctatgaagcc tcatcaacgc actttatttt tttttaaacc
      961 tagaatgaat agaactgact agctctagag ttactattta ttgccgaatg actgctacag
     1021 ccagtgcctt tacgcatttg cactatttgg aggggtttca gtggtaggaa gagctgaatg
     1081 taggtacagg aagatttgac tgattaatga ttttcttaaa ttcaaaaagc attcacaaat
     1141 agaacaatgc ttatgaaacc aagctttgca gtaactccat ctatttacag aaactttgcc
     1201 tcattatttt gtcaattgtt ctcccccaaa gaataagagt ggccttttct ttaacttcct
     1261 ccgtgtagac agctaatttt caatggtaca tatttcttaa cctttaaaaa cctctgtagc
     1321 gtatttcaag gaagaaaaca aaagcacagc atatgagtaa tatttgtaga gcagatttca
     1381 aagtgctgga aagaaaagtg caatacgtgt agtggcagat ctctgtcagg acacaccctg
     1441 tggtttgacc ttggaataac tccagtcttg tcacataacc tgtttgtgtc tttcccagtc
     1501 ctttgtccaa aatatttccc atgtgcaata aagtgtttat atatttgttt gtgttttaaa
     1561 acccactata aagtttaagc tgtttctatg tatgtgaaaa taaaagaata gataaatggt
     1621 taaaaaaaaa a
//
