LOCUS       NM_001291058            1263 bp    mRNA    linear   ROD 19-NOV-2024
DEFINITION  Mus musculus CD68 antigen (Cd68), transcript variant 1, mRNA.
ACCESSION   NM_001291058 XM_006532109
VERSION     NM_001291058.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1263)
  AUTHORS   McClure,J.J., McIlroy,G.D., Symons,R.A., Clark,S.M., Cunningham,I.,
            Han,W., Kania,K., Colella,F., Rochford,J.J., De Bari,C. and
            Roelofs,A.J.
  TITLE     Disentangling the detrimental effects of local from systemic
            adipose tissue dysfunction on articular cartilage in the knee
  JOURNAL   Osteoarthritis Cartilage 32 (12), 1552-1565 (2024)
   PUBMED   39103079
REFERENCE   2  (bases 1 to 1263)
  AUTHORS   Mao,Y., Meng,Y., Zou,K., Qin,N., Wang,Y., Yan,J., Chen,P.,
            Cheng,Y., Shi,W., Zhou,C., Chen,H., Sheng,J., Liu,X., Pan,J. and
            Huang,H.
  TITLE     Advanced paternal age exacerbates neuroinflammation in offspring
            via m6A modification-mediated intergenerational inheritance
  JOURNAL   J Neuroinflammation 21 (1), 249 (2024)
   PUBMED   39367406
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1263)
  AUTHORS   Williamson,A.E., Liyanage,S., Hassanshahi,M., Dona,M.S.I.,
            Toledo-Flores,D., Tran,D.X.A., Dimasi,C., Schwarz,N., Fernando,S.,
            Salagaras,T., Long,A., Kazenwadel,J., Harvey,N.L., Drummond,G.R.,
            Vinh,A., Chandrakanthan,V., Misra,A., Neufeld,Z., Tan,J.T.M.,
            Martelotto,L., Polo,J.M., Bonder,C.S., Pinto,A.R., Sharma,S.,
            Nicholls,S.J., Bursill,C.A. and Psaltis,P.J.
  TITLE     Discovery of an embryonically derived bipotent population of
            endothelial-macrophage progenitor cells in postnatal aorta
  JOURNAL   Nat Commun 15 (1), 7097 (2024)
   PUBMED   39154007
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1263)
  AUTHORS   Feng,X., Yu,J.-L., Sun,Y.-F., Du,C.-Y., Shen,Y., Zhang,L.,
            Kong,W.-Z., Han,S. and Cheng,Y.
  TITLE     Plasmodium yoelii surface-related antigen (PySRA) modulates the
            host pro-inflammatory responses via binding to CD68 on macrophage
            membrane
  JOURNAL   Infect Immun 92 (5), e0011324 (2024)
   PUBMED   38624215
  REMARK    GeneRIF: Plasmodium yoelii surface-related antigen (PySRA)
            modulates the host pro-inflammatory responses via binding to CD68
            on macrophage membrane.
REFERENCE   5  (bases 1 to 1263)
  AUTHORS   Solon,M., Ge,N., Hambro,S., Haller,S., Jiang,J., Baca,M.,
            Preston,J., Maltzman,A., Wickliffe,K.E., Liang,Y., Reja,R.,
            Nickles,D., Newton,K. and Webster,J.D.
  TITLE     ZBP1 and TRIF trigger lethal necroptosis in mice lacking caspase-8
            and TNFR1
  JOURNAL   Cell Death Differ 31 (5), 672-682 (2024)
   PUBMED   38548850
REFERENCE   6  (bases 1 to 1263)
  AUTHORS   Jones,E., Quinn,C.M., See,C.G., Montgomery,D.S., Ford,M.J.,
            Kolble,K., Gordon,S. and Greaves,D.R.
  TITLE     The linked human elongation initiation factor 4A1 (EIF4A1) and CD68
            genes map to chromosome 17p13
  JOURNAL   Genomics 53 (2), 248-250 (1998)
   PUBMED   9790779
REFERENCE   7  (bases 1 to 1263)
  AUTHORS   Jiang,Z., Shih,D.M., Xia,Y.R., Lusis,A.J., de Beer,F.C., de
            Villiers,W.J., van der Westhuyzen,D.R. and de Beer,M.C.
  TITLE     Structure, organization, and chromosomal mapping of the gene
            encoding macrosialin, a macrophage-restricted protein
  JOURNAL   Genomics 50 (2), 199-205 (1998)
   PUBMED   9653646
REFERENCE   8  (bases 1 to 1263)
  AUTHORS   Li,A.C., Guidez,F.R., Collier,J.G. and Glass,C.K.
  TITLE     The macrosialin promoter directs high levels of transcriptional
            activity in macrophages dependent on combinatorial interactions
            between PU.1 and c-Jun
  JOURNAL   J Biol Chem 273 (9), 5389-5399 (1998)
   PUBMED   9479000
REFERENCE   9  (bases 1 to 1263)
  AUTHORS   Ramprasad,M.P., Terpstra,V., Kondratenko,N., Quehenberger,O. and
            Steinberg,D.
  TITLE     Cell surface expression of mouse macrosialin and human CD68 and
            their role as macrophage receptors for oxidized low density
            lipoprotein
  JOURNAL   Proc Natl Acad Sci U S A 93 (25), 14833-14838 (1996)
   PUBMED   8962141
REFERENCE   10 (bases 1 to 1263)
  AUTHORS   Holness,C.L., da Silva,R.P., Fawcett,J., Gordon,S. and Simmons,D.L.
  TITLE     Macrosialin, a mouse macrophage-restricted glycoprotein, is a
            member of the lamp/lgp family
  JOURNAL   J Biol Chem 268 (13), 9661-9666 (1993)
   PUBMED   8486654
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY210951.1, X68273.1 and AW123877.1.
            
            On Mar 21, 2014 this sequence version replaced XM_006532109.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the functional protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X68273.1, AK002264.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164140
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                BY210951.1         2-18
            18-1246             X68273.1           1-1229
            1247-1263           AW123877.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..1263
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 42.86 cM"
     gene            1..1263
                     /gene="Cd68"
                     /gene_synonym="gp110; Lamp4; Scard1"
                     /note="CD68 antigen"
                     /db_xref="GeneID:12514"
                     /db_xref="MGI:MGI:88342"
     exon            1..151
                     /gene="Cd68"
                     /gene_synonym="gp110; Lamp4; Scard1"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..1089
                     /gene="Cd68"
                     /gene_synonym="gp110; Lamp4; Scard1"
                     /note="macrosialin"
                     /codon_start=1
                     /product="macrosialin precursor"
                     /protein_id="NP_001277987.1"
                     /db_xref="CCDS:CCDS70216.1"
                     /db_xref="GeneID:12514"
                     /db_xref="MGI:MGI:88342"
                     /translation="MRLPVCLILLGPLIAQGTEEDCPHKKAVTLLPSFTMTPTATEST
                     ASPTTSHRPTTTSHGNVTVHTSSGPTTVTHNPATTTSHGNATISHATVSPTTNGTATS
                     PRSSTVGPHPGPPPPSPSPRSKGALGNYTWANGSQPCVQLQAQIQIRILYPIQGGRKA
                     WGISVLNPNKTKVQGGCDGTHPHLSLSFPYGQLTFGFKQDLHQSPSTVYLDYMAVEYN
                     VSFPQAAQWTFMAQNSSLRELQAPLGQSFCCGNASIVLSPAVHLDLLSLRLQAAQLPD
                     KGHFGPCFSCNRDQSLLLPLIIGLVLLGLLTLVLIAFCITRRRQSTYQPL"
     exon            152..585
                     /gene="Cd68"
                     /gene_synonym="gp110; Lamp4; Scard1"
                     /inference="alignment:Splign:2.1.0"
     exon            586..705
                     /gene="Cd68"
                     /gene_synonym="gp110; Lamp4; Scard1"
                     /inference="alignment:Splign:2.1.0"
     exon            706..784
                     /gene="Cd68"
                     /gene_synonym="gp110; Lamp4; Scard1"
                     /inference="alignment:Splign:2.1.0"
     exon            785..955
                     /gene="Cd68"
                     /gene_synonym="gp110; Lamp4; Scard1"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1247
                     /gene="Cd68"
                     /gene_synonym="gp110; Lamp4; Scard1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1224..1229
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cd68"
                     /gene_synonym="gp110; Lamp4; Scard1"
                     /note="hexamer: AATAAA"
     polyA_site      1247
                     /gene="Cd68"
                     /gene_synonym="gp110; Lamp4; Scard1"
                     /note="major polyA site"
ORIGIN      
        1 ttttagttaa gggaagtgag gcttttcatt tcctcttcca agagaaggca aaggggattg
       61 gattgaggaa ggaactggtg tagcctagct ggtctgagca tctctgccat gcggctccct
      121 gtgtgtctga tcttgctagg accgcttata gcccaaggaa cagaggaaga ctgtcctcac
      181 aaaaaggccg ttactctcct gccatccttc acgatgacac ctacagccac agaaagcaca
      241 gccagcccta cgaccagcca caggcccacc accaccagtc acggaaatgt cacagttcac
      301 accagctccg gacccacaac tgtcactcat aaccctgcca ccaccaccag tcatgggaat
      361 gccacaattt ctcatgccac agtttctccc accacaaatg gcactgctac tagtccaaga
      421 tcctccactg ttggccctca ccctggacca cctccaccct cgcctagtcc aaggtccaag
      481 ggggctcttg ggaactacac gtgggccaac ggctcccagc cttgtgttca gctccaagcc
      541 caaattcaaa tccgaatcct atacccaatt cagggtggaa gaaaggcttg gggcatatct
      601 gttttgaatc ccaacaaaac caaggtccag ggaggttgtg acggtaccca tccccacctg
      661 tctctctcat ttccttatgg acagcttacc tttggattca aacaggacct acatcagagc
      721 ccgagtacag tctacctgga ctacatggcg gtggaataca atgtgtcctt cccacaggca
      781 gcacagtgga cattcatggc gcagaattca tctcttcgag agctccaagc tcccttgggc
      841 caaagcttct gctgtggaaa tgcaagcata gttctttctc cagctgttca ccttgacctg
      901 ctctctctaa ggctacaggc tgctcagctg cctgacaagg gacacttcgg gccatgtttc
      961 tcttgcaacc gtgaccagtc cctcttgctg cctctcatca ttggcctggt cctcctcggc
     1021 ctcctcaccc tggtgctcat cgccttctgc atcacccgca gacgacaatc aacctaccag
     1081 cccctctgag catctgcccc agtccactgt gtaagccacc aaggagcgcc tcatctcttc
     1141 accatgccac tgactcaaca gttaccttcc ttctctgtct ttaggaacac aatgaagaga
     1201 ttttataata ggggtgggga atcaataaac atgaatggta cctactaaaa aaaaaaaaaa
     1261 aaa
//
