LOCUS       NM_007653                918 bp    mRNA    linear   ROD 31-JAN-2024
DEFINITION  Mus musculus CD63 antigen (Cd63), transcript variant 2, mRNA.
ACCESSION   NM_007653
VERSION     NM_007653.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 918)
  AUTHORS   De Silva,N.S., Siewiera,J., Alkhoury,C., Nader,G.P.F., Nadalin,F.,
            de Azevedo,K., Couty,M., Izquierdo,H.M., Bhargava,A., Conrad,C.,
            Maurin,M., Antoniadou,K., Fouillade,C., Londono-Vallejo,A.,
            Behrendt,R., Bertotti,K., Serdjebi,C., Lanthiez,F., Gallwitz,L.,
            Saftig,P., Herrero-Fernandez,B., Saez,A., Gonzalez-Granado,J.M.,
            van Niel,G., Boissonnas,A., Piel,M. and Manel,N.
  TITLE     Nuclear envelope disruption triggers hallmarks of aging in lung
            alveolar macrophages
  JOURNAL   Nat Aging 3 (10), 1251-1268 (2023)
   PUBMED   37723209
REFERENCE   2  (bases 1 to 918)
  AUTHORS   Mowry,F.E., Espejo-Porras,F., Jin,S., Quadri,Z., Wu,L.,
            Bertolio,M., Jarvis,R., Reynolds,C., Alananzeh,R., Bieberich,E. and
            Yang,Y.
  TITLE     Chronic nSMase inhibition suppresses neuronal exosome spreading and
            sex-specifically attenuates amyloid pathology in APP knock-in
            Alzheimer's disease mice
  JOURNAL   Neurobiol Dis 184, 106213 (2023)
   PUBMED   37364689
REFERENCE   3  (bases 1 to 918)
  AUTHORS   Wang,Z.X., Luo,Z.W., Li,F.X., Cao,J., Rao,S.S., Liu,Y.W.,
            Wang,Y.Y., Zhu,G.Q., Gong,J.S., Zou,J.T., Wang,Q., Tan,Y.J.,
            Zhang,Y., Hu,Y., Li,Y.Y., Yin,H., Wang,X.K., He,Z.H., Ren,L.,
            Liu,Z.Z., Hu,X.K., Yuan,L.Q., Xu,R., Chen,C.Y. and Xie,H.
  TITLE     Aged bone matrix-derived extracellular vesicles as a messenger for
            calcification paradox
  JOURNAL   Nat Commun 13 (1), 1453 (2022)
   PUBMED   35304471
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 918)
  AUTHORS   Nie,X., Zheng,J., Cruciger,M., Yang,P. and Mao,J.J.
  TITLE     mTOR plays a pivotal role in multiple processes of enamel organ
            development principally through the mTORC1 pathway and in part via
            regulating cytoskeleton dynamics
  JOURNAL   Dev Biol 467 (1-2), 77-87 (2020)
   PUBMED   32866472
REFERENCE   5  (bases 1 to 918)
  AUTHORS   Men,Y., Yelick,J., Jin,S., Tian,Y., Chiang,M.S.R., Higashimori,H.,
            Brown,E., Jarvis,R. and Yang,Y.
  TITLE     Exosome reporter mice reveal the involvement of exosomes in
            mediating neuron to astroglia communication in the CNS
  JOURNAL   Nat Commun 10 (1), 4136 (2019)
   PUBMED   31515491
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 918)
  AUTHORS   Gwynn,B., Eicher,E.M. and Peters,L.L.
  TITLE     Genetic localization of Cd63, a member of the transmembrane 4
            superfamily, reveals two distinct loci in the mouse genome
  JOURNAL   Genomics 35 (2), 389-391 (1996)
   PUBMED   8661157
REFERENCE   7  (bases 1 to 918)
  AUTHORS   Nagira,M., Imai,T., Ishikawa,I., Uwabe,K.I. and Yoshie,O.
  TITLE     Mouse homologue of C33 antigen (CD82), a member of the
            transmembrane 4 superfamily: complementary DNA, genomic structure,
            and expression
  JOURNAL   Cell Immunol 157 (1), 144-157 (1994)
   PUBMED   8039242
REFERENCE   8  (bases 1 to 918)
  AUTHORS   Nomura,M., Takihara,Y. and Shimada,K.
  TITLE     Isolation and characterization of retinoic acid-inducible cDNA
            clones in F9 cells: one of the early inducible clones encodes a
            novel protein sharing several highly homologous regions with a
            Drosophila polyhomeotic protein
  JOURNAL   Differentiation 57 (1), 39-50 (1994)
   PUBMED   8070621
REFERENCE   9  (bases 1 to 918)
  AUTHORS   Miyamoto,H., Homma,M. and Hotta,H.
  TITLE     Molecular cloning of the murine homologue of CD63/ME491 and
            detection of its strong expression in the kidney and activated
            macrophages
  JOURNAL   Biochim Biophys Acta 1217 (3), 312-316 (1994)
   PUBMED   8148377
REFERENCE   10 (bases 1 to 918)
  AUTHORS   Hotta,H., Ross,A.H., Huebner,K., Isobe,M., Wendeborn,S., Chao,M.V.,
            Ricciardi,R.P., Tsujimoto,Y., Croce,C.M. and Koprowski,H.
  TITLE     Molecular cloning and characterization of an antigen associated
            with early stages of melanoma tumor progression
  JOURNAL   Cancer Res 48 (11), 2955-2962 (1988)
   PUBMED   3365686
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY164291.1, AK151702.1 and BP769648.1.
            
            [WARNING] On Mar 11, 2024 this sequence was replaced by
            NM_007653.4.
            
            On Jul 18, 2006 this sequence version replaced NM_007653.2.
            
            Transcript Variant: This variant (2) has an alternate 5' UTR exon,
            compared to variant 1. Variants 1, 2 and 3 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC008108.1, AK170344.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                BY164291.1         2-37
            37-896              AK151702.1         3-862
            897-918             BP769648.1         1-22                c
FEATURES             Location/Qualifiers
     source          1..918
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 77.19 cM"
     gene            1..918
                     /gene="Cd63"
                     /gene_synonym="ME491; Tspan30"
                     /note="CD63 antigen"
                     /db_xref="GeneID:12512"
                     /db_xref="MGI:MGI:99529"
     exon            1..93
                     /gene="Cd63"
                     /gene_synonym="ME491; Tspan30"
                     /inference="alignment:Splign:2.1.0"
     exon            94..170
                     /gene="Cd63"
                     /gene_synonym="ME491; Tspan30"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..821
                     /gene="Cd63"
                     /gene_synonym="ME491; Tspan30"
                     /note="melanoma 1 antigen"
                     /codon_start=1
                     /product="CD63 antigen"
                     /protein_id="NP_031679.1"
                     /db_xref="CCDS:CCDS24297.1"
                     /db_xref="GeneID:12512"
                     /db_xref="MGI:MGI:99529"
                     /translation="MAVEGGMKCVKFLLYVLLLAFCACAVGLIAIGVAVQVVLKQAIT
                     HETTAGSLLPVVIIAVGAFLFLVAFVGCCGACKENYCLMITFAIFLSLIMLVEVAVAI
                     AGYVFRDQVKSEFNKSFQQQMQNYLKDNKTATILDKLQKENNCCGASNYTDWENIPGM
                     AKDRVPDSCCINITVGCGNDFKESTIHTQGCVETIAIWLRKNILLVAAAALGIAFVEV
                     LGIIFSCCLVKSIRSGYEVM"
     exon            171..359
                     /gene="Cd63"
                     /gene_synonym="ME491; Tspan30"
                     /inference="alignment:Splign:2.1.0"
     exon            360..434
                     /gene="Cd63"
                     /gene_synonym="ME491; Tspan30"
                     /inference="alignment:Splign:2.1.0"
     exon            435..530
                     /gene="Cd63"
                     /gene_synonym="ME491; Tspan30"
                     /inference="alignment:Splign:2.1.0"
     exon            531..671
                     /gene="Cd63"
                     /gene_synonym="ME491; Tspan30"
                     /inference="alignment:Splign:2.1.0"
     exon            672..755
                     /gene="Cd63"
                     /gene_synonym="ME491; Tspan30"
                     /inference="alignment:Splign:2.1.0"
     exon            756..903
                     /gene="Cd63"
                     /gene_synonym="ME491; Tspan30"
                     /inference="alignment:Splign:2.1.0"
     regulatory      872..877
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cd63"
                     /gene_synonym="ME491; Tspan30"
                     /note="putative"
ORIGIN      
        1 ggggccgtgc agcaggcggg gcgcgggcag ggggcacggg agacggcggc tgagccgcgg
       61 caggagagta ctgagaagcg tcggggagcg caggcccaac agccatggcg gtggaaggag
      121 gaatgaagtg tgtcaagttt ttgctctacg ttctcctgct ggccttctgc gcctgtgcag
      181 tgggattgat cgccattggt gtagcggttc aggttgtctt gaagcaggcc attacccatg
      241 agactactgc tggctcgctg ttgcctgtgg tcatcattgc agtgggtgcc ttcctcttcc
      301 tggtggcctt tgtgggctgc tgtggggcct gcaaggagaa ctactgtctc atgattacat
      361 ttgccatctt cctgtctctt atcatgcttg tggaggtggc tgtggccatt gctggctatg
      421 tgtttagaga ccaggtgaag tcagagttta ataaaagctt ccagcagcag atgcagaatt
      481 accttaaaga caacaaaaca gccactattt tggacaaatt gcagaaagaa aataactgct
      541 gtggagcttc taactacaca gactgggaaa acatccccgg catggccaag gacagagtcc
      601 ccgattcttg ctgcatcaac ataactgtgg gctgtgggaa tgatttcaag gaatccacta
      661 tccataccca gggctgcgtg gagactatag caatatggct aaggaagaac atactgctgg
      721 tggctgcagc ggccctgggc attgcttttg tggaggtctt gggaattatc ttctcctgct
      781 gtctggtgaa gagtattcga agtggctatg aagtaatgta ggggtggggg gcgtttggtc
      841 ttttcatgga gtggattctc caggtttttc aattaaacgg attatttttt cagacctaaa
      901 aaaaaaaaaa aaaaaaaa
//
