LOCUS       NM_009852               3034 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus CD6 antigen (Cd6), transcript variant 2, mRNA.
ACCESSION   NM_009852
VERSION     NM_009852.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3034)
  AUTHORS   Ozawa,M., Taguchi,J., Katsuma,K., Ishikawa-Yamauchi,Y., Kikuchi,M.,
            Sakamoto,R., Yamada,Y. and Ikawa,M.
  TITLE     Efficient simultaneous double DNA knock-in in murine embryonic stem
            cells by CRISPR/Cas9 ribonucleoprotein-mediated circular plasmid
            targeting for generating gene-manipulated mice
  JOURNAL   Sci Rep 12 (1), 21558 (2022)
   PUBMED   36513736
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3034)
  AUTHORS   Casado-Llombart,S., Velasco-de Andres,M., Catala,C.,
            Leyton-Pereira,A., Gutierrez-Cozar,R., Suarez,B., Armiger,N.,
            Carreras,E., Esteller,M., Ricart,E., Ordas,I., Gisbert,J.P.,
            Chaparro,M., Esteve,M., Marquez,L., Busquets,D., Iglesias,E.,
            Garcia-Planella,E., Martin-Arranz,M.D., Lohmann,J., Ayata,C.K.,
            Niess,J.H., Engel,P., Panes,J., Salas,A., Domenech,E. and Lozano,F.
  CONSRTM   ENEIDA Project of GETECCU
  TITLE     Experimental and genetic evidence for the impact of CD5 and CD6
            expression and variation in inflammatory bowel disease
  JOURNAL   Front Immunol 13, 966184 (2022)
   PUBMED   36211446
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3034)
  AUTHORS   Catala,C., Velasco-de Andres,M., Leyton-Pereira,A.,
            Casado-Llombart,S., Saez Moya,M., Gutierrez-Cozar,R.,
            Garcia-Luna,J., Consuegra-Fernandez,M., Isamat,M., Aranda,F.,
            Martinez-Florensa,M., Engel,P., Mourglia-Ettlin,G. and Lozano,F.
  TITLE     CD6 deficiency impairs early immune response to bacterial sepsis
  JOURNAL   iScience 25 (10), 105078 (2022)
   PUBMED   36157587
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3034)
  AUTHORS   Chalmers,S.A., Ayilam Ramachandran,R., Garcia,S.J., Der,E.,
            Herlitz,L., Ampudia,J., Chu,D., Jordan,N., Zhang,T., Parodis,I.,
            Gunnarsson,I., Ding,H., Shen,N., Petri,M., Mok,C.C., Saxena,R.,
            Polu,K.R., Connelly,S., Ng,C.T., Mohan,C. and Putterman,C.
  TITLE     The CD6/ALCAM pathway promotes lupus nephritis via T cell-mediated
            responses
  JOURNAL   J Clin Invest 132 (1) (2022)
   PUBMED   34981775
  REMARK    GeneRIF: The CD6/ALCAM pathway promotes lupus nephritis via T
            cell-mediated responses.
REFERENCE   5  (bases 1 to 3034)
  AUTHORS   Li,Y., Ruth,J.H., Rasmussen,S.M., Athukorala,K.S., Weber,D.P.,
            Amin,M.A., Campbell,P.L., Singer,N.G., Fox,D.A. and Lin,F.
  TITLE     Attenuation of Murine Collagen-Induced Arthritis by Targeting CD6
  JOURNAL   Arthritis Rheumatol 72 (9), 1505-1513 (2020)
   PUBMED   32307907
  REMARK    GeneRIF: Attenuation of Murine Collagen-Induced Arthritis by
            Targeting CD6.
REFERENCE   6  (bases 1 to 3034)
  AUTHORS   Starling,G.C., Whitney,G.S., Siadak,A.W., Llewellyn,M.B.,
            Bowen,M.A., Farr,A.G. and Aruffo,A.A.
  TITLE     Characterization of mouse CD6 with novel monoclonal antibodies
            which enhance the allogeneic mixed leukocyte reaction
  JOURNAL   Eur J Immunol 26 (4), 738-746 (1996)
   PUBMED   8625962
REFERENCE   7  (bases 1 to 3034)
  AUTHORS   Lecomte,O., Bock,J.B., Birren,B.W., Vollrath,D. and Parnes,J.R.
  TITLE     Molecular linkage of the mouse CD5 and CD6 genes
  JOURNAL   Immunogenetics 44 (5), 385-390 (1996)
   PUBMED   8781125
REFERENCE   8  (bases 1 to 3034)
  AUTHORS   Robinson,W.H., Prohaska,S.S., Santoro,J.C., Robinson,H.L. and
            Parnes,J.R.
  TITLE     Identification of a mouse protein homologous to the human CD6 T
            cell surface protein and sequence of the corresponding cDNA
  JOURNAL   J Immunol 155 (10), 4739-4748 (1995)
   PUBMED   7594475
REFERENCE   9  (bases 1 to 3034)
  AUTHORS   Whitney,G., Bowen,M., Neubauer,M. and Aruffo,A.
  TITLE     Cloning and characterization of murine CD6
  JOURNAL   Mol Immunol 32 (1), 89-92 (1995)
   PUBMED   7870060
REFERENCE   10 (bases 1 to 3034)
  AUTHORS   Wee,S., Wang,W.C., Farr,A.G., Nelson,A.J., Patel,D.D., Haynes,B.F.,
            Linsley,P.S. and Aruffo,A.
  TITLE     Characterization of a CD6 ligand(s) expressed on human- and
            murine-derived cell lines and murine lymphoid tissues
  JOURNAL   Cell Immunol 158 (2), 353-364 (1994)
   PUBMED   7923388
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK030823.1 and BQ553341.1.
            
            On Mar 2, 2007 this sequence version replaced NM_009852.2.
            
            Transcript Variant: This variant (2) represents the longer
            transcript and encodes the longer protein (isoform 2).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK030823.1, BC014294.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3027              AK030823.1         2-3028
            3028-3034           BQ553341.1         1-7                 c
FEATURES             Location/Qualifiers
     source          1..3034
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 7.16 cM"
     gene            1..3034
                     /gene="Cd6"
                     /note="CD6 antigen"
                     /db_xref="GeneID:12511"
                     /db_xref="MGI:MGI:103566"
     exon            1..251
                     /gene="Cd6"
                     /inference="alignment:Splign:2.1.0"
     exon            252..320
                     /gene="Cd6"
                     /inference="alignment:Splign:2.1.0"
     exon            321..668
                     /gene="Cd6"
                     /inference="alignment:Splign:2.1.0"
     exon            669..980
                     /gene="Cd6"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1283
                     /gene="Cd6"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1346
                     /gene="Cd6"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1487
                     /gene="Cd6"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..1583
                     /gene="Cd6"
                     /inference="alignment:Splign:2.1.0"
     exon            1584..1700
                     /gene="Cd6"
                     /inference="alignment:Splign:2.1.0"
     exon            1701..1772
                     /gene="Cd6"
                     /inference="alignment:Splign:2.1.0"
     exon            1773..2027
                     /gene="Cd6"
                     /inference="alignment:Splign:2.1.0"
     exon            2028..2129
                     /gene="Cd6"
                     /inference="alignment:Splign:2.1.0"
     exon            2130..3034
                     /gene="Cd6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3010..3015
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cd6"
                     /note="hexamer: ATTAAA"
     polyA_site      3032
                     /gene="Cd6"
                     /note="major polyA site"
ORIGIN      
        1 cacaagcaga aggtagaggc gtgagacact cacaggctgg gcctgtgtgt aggagagaga
       61 gtgcgcagca cacagggcac tgagaacaag aacagaaagg gcaccacggg tgagacaagc
      121 catcggtggc acaaccgtct cccggaacca ggatggcact tcctatgggc aggcgtgagt
      181 agcagtggag acagcaccag acatgtggct cttccttggg atcgctggat tgctgacagc
      241 agttctctca ggtctcccat ctccagcccc ctctggccag cacaaaaatg gcaccatccc
      301 gaacatgacc ttggacctag aggagcggct ggggattcgc ctggtgaacg ggagcagtcg
      361 ctgcagcgga tctgtgaagg ttctactgga gtcctgggag cctgtgtgtg cggcacactg
      421 gaacagggct gctacggagg ctgtgtgcaa agcgctgaac tgtggtgatt cgggaaaggt
      481 tacctacctg atgccaccca cctctgagct tccaccagga gccacttctg ggaacacaag
      541 cagcgccggg aatacgacgt gggcgcgggc accaactgag agatgcaggg gagccaattg
      601 gcagttctgc aaggtgcagg accaggagtg tagcagcgac aggcggctgg tgtgggtcac
      661 ctgtgcagag aaccaagcag tgcggttagt ggatggtagc agccgctgtg ctggccgagt
      721 ggagatgctg gagcatggtg aatggggtac cgtgtgcgac gacacgtggg acctgcagga
      781 tgcacacgta gtgtgtaagc aactgaagtg cggctgggca gtgaaggcgc tggccggctt
      841 gcacttcacc ccaggccaag gacccatcca ccgcgatcag gtgaactgct ctgggactga
      901 ggcttacctg tgggactgcc cgggacggcc aggagaccag tactgtggtc acaaggagga
      961 cgcaggagtg gtgtgctcag agcaccagtc ctggcgcctg actggaggca ttgactcctg
     1021 cgaagggcaa gtggaagtgt acttccgggg tgtctggagc acggtgtgtg acagcgagtg
     1081 gtacccatct gaggccaaag tgctctgtcg gtccttgggt tgcggatcag cagtggctcg
     1141 gcccaggggg ctgccacact ccctggacgg tagaatgtac tactcctgca aaggacagga
     1201 gcccgccctc agcacctgtt cctggcggtt caacaactcc aacctgtgca gccagtcgcg
     1261 ggcagccagg gttgtctgct caggctccca gagacatctc aatctgtcta cttctgaagt
     1321 gccttccaga gttccagtca cgatagaatc ttctgtgccg gtgagcgtga aggataagga
     1381 ctcacaaggg ctgacacttc tcattctctg tattgtcctg ggaattctcc tcctcgtctc
     1441 caccatcttc atagttattc ttctcttgag agccaaagga caatacgccc tccctgcttc
     1501 agtgaaccac cagcaactgt ctactgccaa ccaagcaggg atcaataact accatcctgt
     1561 ccctatcacc attgccaaag aagctcctat gctgttcatc cagccccggg tccctgcaga
     1621 ctcggactcc agttctgact ccgactatga gcactatgac ttcagctccc agccacctgt
     1681 ggccctgacc accttctaca attcccagcg acaccgggtc acagaggagg aagctcagca
     1741 gaacaggttt cagatgccac ccttggagga aggacttgaa gagctgcatg tttcccacat
     1801 cccagcggct gaccccagac cctgtgtggc agatgtcccc tctcggggct ctcagtacca
     1861 cgtgaggaac aacagtgatt ccagcacctc ctctgaggag ggctactgca atgatcccag
     1921 cagcaagcca cctccatgga attcccaggc gttttattct gagaagagtc ccctcacaga
     1981 gcagcccccc aacttggaac tggctggctc tccggcagtg ttttcagggc cctcagccga
     2041 tgacagctcc agcacctcat ccggagagtg gtaccagaac ttccagccac caccccagca
     2101 tcctccagca gaacagtttg aatgtccagg accccctggc ccccaaacag actccattga
     2161 tgatgatgag gaggattacg atgacatcgg tgcagcctag cctgggtccc cgaggctcct
     2221 gggtggcccc tccctctgct ctcttgttct agcccctagc agaggtggaa gggtgggcat
     2281 tctcccagcc cctcatcctc cacccattga ttaacctgca ggagcccgga acagaagaca
     2341 aagccagtgg tgtgagagct gagtcctggg ttgaacaaac agggtctggc cacttcttgg
     2401 gagtggtgaa gggtcatgct gggtgaccct gaggccttat ctcactccgt gtctggcact
     2461 ttgatcctaa gcctcaggaa gctgctgaag gggctgagta gcccacccac tgctgaaata
     2521 caggccctgg gccaggggct gccattatca cccaggaagt cagcgatgtc tcaatacaac
     2581 ctggggcctc aatcaatcag agtagcagcc gctttagcac gggcatggcc tccctgggca
     2641 ctgtcaccta agagtaacca tggcgaatac atgcttgctt ccagaggtct ctgagtccac
     2701 cacaggcact agctggactc ctttctctat ccctagacaa ttattctaat tccttgggct
     2761 ttataagagc atccctgccc tgcctgagtc aggggatcca cagccccatt gggacaagaa
     2821 tgcagggacc tgttctggag ggctagaggg caccaaaagc tccgagtccc cacaggtccc
     2881 cttgggttga caggaacact ttgggagagt gtggttattg cagccaagac cttaaacagg
     2941 tcctccccac agcgtcagag aactggaggg tcccagccag gctacagtgg cctgtcctga
     3001 gttccagaga ttaaacgatt actgagtgaa aact
//
