LOCUS       NM_181858                603 bp    mRNA    linear   ROD 08-JUN-2024
DEFINITION  Mus musculus CD59b antigen (Cd59b), transcript variant 2, mRNA.
ACCESSION   NM_181858
VERSION     NM_181858.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 603)
  AUTHORS   Liu,F., Sahoo,R., Ge,X., Wu,L., Ghosh,P., Qin,X. and Halperin,J.A.
  TITLE     Deficiency of the complement regulatory protein CD59 accelerates
            the development of diabetes-induced atherosclerosis in mice
  JOURNAL   J Diabetes Complications 31 (2), 311-317 (2017)
   PUBMED   27729184
  REMARK    GeneRIF: Data (including data from studies using knockout mice)
            suggest that CD59a, CD59b, and ApoE are involved in development of
            diabetes-induced atherosclerosis; here, deficiency of CD59a/CD59b
            (in ApoE deficient mice) accelerates development of atherosclerosis
            in mice with type 1 diabetes. (CD59a = CD59a antigen; CD59b = CD59b
            antigen; ApoE = apolipoprotein E)
REFERENCE   2  (bases 1 to 603)
  AUTHORS   Loughner,C.L., Bruford,E.A., McAndrews,M.S., Delp,E.E.,
            Swamynathan,S. and Swamynathan,S.K.
  TITLE     Organization, evolution and functions of the human and mouse
            Ly6/uPAR family genes
  JOURNAL   Hum Genomics 10, 10 (2016)
   PUBMED   27098205
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 603)
  AUTHORS   Lefebvre,J., Clarkson,M., Massa,F., Bradford,S.T., Charlet,A.,
            Buske,F., Lacas-Gervais,S., Schulz,H., Gimpel,C., Hata,Y.,
            Schaefer,F. and Schedl,A.
  TITLE     Alternatively spliced isoforms of WT1 control podocyte-specific
            gene expression
  JOURNAL   Kidney Int 88 (2), 321-331 (2015)
   PUBMED   25993318
REFERENCE   4  (bases 1 to 603)
  AUTHORS   Zhang,J., Hu,W., Xing,W., You,T., Xu,J., Qin,X. and Peng,Z.
  TITLE     The protective role of CD59 and pathogenic role of complement in
            hepatic ischemia and reperfusion injury
  JOURNAL   Am J Pathol 179 (6), 2876-2884 (2011)
   PUBMED   22019898
REFERENCE   5  (bases 1 to 603)
  AUTHORS   Hu,W., Ge,X., You,T., Xu,T., Zhang,J., Wu,G., Peng,Z., Chorev,M.,
            Aktas,B.H., Halperin,J.A., Brown,J.R. and Qin,X.
  TITLE     Human CD59 inhibitor sensitizes rituximab-resistant lymphoma cells
            to complement-mediated cytolysis
  JOURNAL   Cancer Res 71 (6), 2298-2307 (2011)
   PUBMED   21252115
REFERENCE   6  (bases 1 to 603)
  AUTHORS   Turnberg,D. and Botto,M.
  TITLE     The regulation of the complement system: insights from
            genetically-engineered mice
  JOURNAL   Mol Immunol 40 (2-4), 145-153 (2003)
   PUBMED   12914820
  REMARK    Review article
REFERENCE   7  (bases 1 to 603)
  AUTHORS   Qin,X., Krumrei,N., Grubissich,L., Dobarro,M., Aktas,H., Perez,G.
            and Halperin,J.A.
  TITLE     Deficiency of the mouse complement regulatory protein mCd59b
            results in spontaneous hemolytic anemia with platelet activation
            and progressive male infertility
  JOURNAL   Immunity 18 (2), 217-227 (2003)
   PUBMED   12594949
  REMARK    GeneRIF: Cd59b knockout mice present a phenotype characterized by
            hemolytic anemia, platelet activation and a progressive loss of
            fertility associated with immobile dysmorphic and fewer sperm cells
            after 5 months of age.
REFERENCE   8  (bases 1 to 603)
  AUTHORS   Pillebout,E., Burtin,M., Yuan,H.T., Briand,P., Woolf,A.S.,
            Friedlander,G. and Terzi,F.
  TITLE     Proliferation and remodeling of the peritubular microcirculation
            after nephron reduction: association with the progression of renal
            lesions
  JOURNAL   Am J Pathol 159 (2), 547-560 (2001)
   PUBMED   11485913
REFERENCE   9  (bases 1 to 603)
  AUTHORS   Qin,X., Miwa,T., Aktas,H., Gao,M., Lee,C., Qian,Y.M., Morton,C.C.,
            Shahsafaei,A., Song,W.C. and Halperin,J.A.
  TITLE     Genomic structure, functional comparison, and tissue distribution
            of mouse Cd59a and Cd59b
  JOURNAL   Mamm Genome 12 (8), 582-589 (2001)
   PUBMED   11471050
  REMARK    GeneRIF: Genomic structure, functional comparison, and tissue
            distribution of mouse Cd59a and Cd59b.
REFERENCE   10 (bases 1 to 603)
  AUTHORS   Qian,Y.M., Qin,X., Miwa,T., Sun,X., Halperin,J.A. and Song,W.C.
  TITLE     Identification and functional characterization of a new gene
            encoding the mouse terminal complement inhibitor CD59
  JOURNAL   J Immunol 165 (5), 2528-2534 (2000)
   PUBMED   10946279
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX640578.3 and BX813317.11.
            
            On Jan 29, 2019 this sequence version replaced NM_181858.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189685.218717.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on computational evidence
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                BX640578.3         11057-11079         c
            24-102              BX640578.3         3209-3287           c
            103-204             BX640578.3         1047-1148           c
            205-603             BX813317.11        4278-4676
FEATURES             Location/Qualifiers
     source          1..603
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 54.51 cM"
     gene            1..603
                     /gene="Cd59b"
                     /note="CD59b antigen"
                     /db_xref="GeneID:333883"
                     /db_xref="MGI:MGI:1888996"
     exon            1..23
                     /gene="Cd59b"
                     /inference="alignment:Splign:2.1.0"
     exon            24..102
                     /gene="Cd59b"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..431
                     /gene="Cd59b"
                     /note="CD59B glycoprotein; MACIF; MAC-IP; protectin;
                     MAC-inhibitory protein; membrane attack complex inhibition
                     factor"
                     /codon_start=1
                     /product="CD59B glycoprotein precursor"
                     /protein_id="NP_862906.1"
                     /db_xref="CCDS:CCDS16486.1"
                     /db_xref="GeneID:333883"
                     /db_xref="MGI:MGI:1888996"
                     /translation="MRAQRGLILLLLLLAVFCSTAVSLKCYNCLDPVSSCKINTTCSP
                     NLDSCLYAVAGRQVYQQCWKLSDCNSNYIMSRLDVAGIQSKCCQWDLCNKNLDGLEEP
                     NNAETSSLRKTALLGTSVLVAILKFCF"
     exon            103..204
                     /gene="Cd59b"
                     /inference="alignment:Splign:2.1.0"
     exon            205..603
                     /gene="Cd59b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      533..538
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cd59b"
                     /note="hexamer: AATAAA"
     polyA_site      561
                     /gene="Cd59b"
                     /note="major polyA site"
ORIGIN      
        1 actgccctgt tgccttggat cagatttggt ggcccagcac aatgagagct cagaggggac
       61 tcatcttact cctgctgctt ctggctgtct tctgttccac agctgttagc ctcaaatgct
      121 acaactgttt agacccggtt tcttcatgca aaataaacac tacttgctct cctaacctgg
      181 attcctgtct ctatgctgta gccggaaggc aagtgtatca acagtgttgg aaactttcgg
      241 attgtaattc caactatatt atgagccgat tagacgtggc aggcatacaa agcaaatgct
      301 gtcagtggga cttgtgtaac aaaaatcttg acggattaga agagccaaac aacgcagaaa
      361 cttcctcatt gaggaagaca gcattgctgg ggacctcagt tctggtggcc attttgaagt
      421 tttgcttcta agtcatcctg gatgccccgc ccccctctct ctgtctctct tttcctgcta
      481 ctgcagcact ctaaagcctt tattattttc cagctgtatt aatttaggaa agaataaagt
      541 tcacttgaac atcttggata agagggtgga gtttaagcag tgtggaagag caccatgcac
      601 acc
//
