LOCUS       NM_001416925            1845 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus CD59a antigen (Cd59a), transcript variant 5, mRNA.
ACCESSION   NM_001416925
VERSION     NM_001416925.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1845)
  AUTHORS   Modinger,Y., Rapp,A.E., Vikman,A., Ren,Z., Fischer,V., Bergdolt,S.,
            Haffner-Luntzer,M., Song,W.C., Lambris,J.D., Huber-Lang,M.,
            Neidlinger-Wilke,C., Brenner,R.E. and Ignatius,A.
  TITLE     Reduced Terminal Complement Complex Formation in Mice Manifests in
            Low Bone Mass and Impaired Fracture Healing
  JOURNAL   Am J Pathol 189 (1), 147-161 (2019)
   PUBMED   30339839
REFERENCE   2  (bases 1 to 1845)
  AUTHORS   Stauber,M., Weidemann,M., Dittrich-Breiholz,O., Lobschat,K.,
            Alten,L., Mai,M., Beckers,A., Kracht,M. and Gossler,A.
  TITLE     Identification of FOXJ1 effectors during ciliogenesis in the foetal
            respiratory epithelium and embryonic left-right organiser of the
            mouse
  JOURNAL   Dev Biol 423 (2), 170-188 (2017)
   PUBMED   27914912
REFERENCE   3  (bases 1 to 1845)
  AUTHORS   Liu,F., Sahoo,R., Ge,X., Wu,L., Ghosh,P., Qin,X. and Halperin,J.A.
  TITLE     Deficiency of the complement regulatory protein CD59 accelerates
            the development of diabetes-induced atherosclerosis in mice
  JOURNAL   J Diabetes Complications 31 (2), 311-317 (2017)
   PUBMED   27729184
  REMARK    GeneRIF: Data (including data from studies using knockout mice)
            suggest that CD59a, CD59b, and ApoE are involved in development of
            diabetes-induced atherosclerosis; here, deficiency of CD59a/CD59b
            (in ApoE deficient mice) accelerates development of atherosclerosis
            in mice with type 1 diabetes. (CD59a = CD59a antigen; CD59b = CD59b
            antigen; ApoE = apolipoprotein E)
REFERENCE   4  (bases 1 to 1845)
  AUTHORS   Song,D., Wilson,B., Zhao,L., Bhuyan,R., Bandyopadhyay,M.,
            Lyubarsky,A., Yu,C., Li,Y., Kanu,L., Miwa,T., Song,W.C.,
            Finnemann,S.C., Rohrer,B. and Dunaief,J.L.
  TITLE     Retinal Pre-Conditioning by CD59a Knockout Protects against
            Light-Induced Photoreceptor Degeneration
  JOURNAL   PLoS One 11 (11), e0166348 (2016)
   PUBMED   27893831
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1845)
  AUTHORS   Loughner,C.L., Bruford,E.A., McAndrews,M.S., Delp,E.E.,
            Swamynathan,S. and Swamynathan,S.K.
  TITLE     Organization, evolution and functions of the human and mouse
            Ly6/uPAR family genes
  JOURNAL   Hum Genomics 10, 10 (2016)
   PUBMED   27098205
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1845)
  AUTHORS   Holt,D.S., Botto,M., Bygrave,A.E., Hanna,S.M., Walport,M.J. and
            Morgan,B.P.
  TITLE     Targeted deletion of the CD59 gene causes spontaneous intravascular
            hemolysis and hemoglobinuria
  JOURNAL   Blood 98 (2), 442-449 (2001)
   PUBMED   11435315
REFERENCE   7  (bases 1 to 1845)
  AUTHORS   Qian,Y.M., Qin,X., Miwa,T., Sun,X., Halperin,J.A. and Song,W.C.
  TITLE     Identification and functional characterization of a new gene
            encoding the mouse terminal complement inhibitor CD59
  JOURNAL   J Immunol 165 (5), 2528-2534 (2000)
   PUBMED   10946279
REFERENCE   8  (bases 1 to 1845)
  AUTHORS   Holt,D.S., Powell,M.B., Rushmere,N.K. and Morgan,B.P.
  TITLE     Genomic structure and chromosome location of the gene encoding
            mouse CD59
  JOURNAL   Cytogenet Cell Genet 89 (3-4), 264-267 (2000)
   PUBMED   10965140
REFERENCE   9  (bases 1 to 1845)
  AUTHORS   Kent,J., Lee,M., Schedl,A., Boyle,S., Fantes,J., Powell,M.,
            Rushmere,N., Abbott,C., van Heyningen,V. and Bickmore,W.A.
  TITLE     The reticulocalbin gene maps to the WAGR region in human and to the
            Small eye Harwell deletion in mouse
  JOURNAL   Genomics 42 (2), 260-267 (1997)
   PUBMED   9192846
REFERENCE   10 (bases 1 to 1845)
  AUTHORS   Powell,M.B., Marchbank,K.J., Rushmere,N.K., van den Berg,C.W. and
            Morgan,B.P.
  TITLE     Molecular cloning, chromosomal localization, expression, and
            functional characterization of the mouse analogue of human CD59
  JOURNAL   J Immunol 158 (4), 1692-1702 (1997)
   PUBMED   9029105
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX813317.11.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR15390195.409403.1,
                                           SRR5189685.252917.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-105               BX813317.11        16788-16892
            106-225             BX813317.11        17581-17700
            226-304             BX813317.11        24027-24105
            305-409             BX813317.11        30596-30700
            410-1845            BX813317.11        33831-35266
FEATURES             Location/Qualifiers
     source          1..1845
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 54.53 cM"
     gene            1..1845
                     /gene="Cd59a"
                     /gene_synonym="Cd59; MAC-IP; MACIF"
                     /note="CD59a antigen"
                     /db_xref="GeneID:12509"
                     /db_xref="MGI:MGI:109177"
     exon            1..105
                     /gene="Cd59a"
                     /gene_synonym="Cd59; MAC-IP; MACIF"
                     /inference="alignment:Splign:2.1.0"
     exon            106..225
                     /gene="Cd59a"
                     /gene_synonym="Cd59; MAC-IP; MACIF"
                     /inference="alignment:Splign:2.1.0"
     exon            226..304
                     /gene="Cd59a"
                     /gene_synonym="Cd59; MAC-IP; MACIF"
                     /inference="alignment:Splign:2.1.0"
     CDS             244..615
                     /gene="Cd59a"
                     /gene_synonym="Cd59; MAC-IP; MACIF"
                     /note="CD59A glycoprotein; MAC-inhibitory protein;
                     membrane attack complex inhibition factor; CD59 antigen;
                     protectin"
                     /codon_start=1
                     /product="CD59A glycoprotein precursor"
                     /protein_id="NP_001403854.1"
                     /db_xref="GeneID:12509"
                     /db_xref="MGI:MGI:109177"
                     /translation="MRAQRGLILLLLLLAVFCSTAVSLTCYHCFQPVVSSCNMNSTCS
                     PDQDSCLYAVAGMQVYQRCWKQSDCHGEIIMDQLEETKLKFRCCQFNLCNKSDGSLGK
                     TPLLGTSVLVAILNLCFLSHL"
     exon            305..409
                     /gene="Cd59a"
                     /gene_synonym="Cd59; MAC-IP; MACIF"
                     /inference="alignment:Splign:2.1.0"
     exon            410..1845
                     /gene="Cd59a"
                     /gene_synonym="Cd59; MAC-IP; MACIF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1765..1770
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cd59a"
                     /gene_synonym="Cd59; MAC-IP; MACIF"
                     /note="hexamer: ATTAAA"
     polyA_site      1789
                     /gene="Cd59a"
                     /gene_synonym="Cd59; MAC-IP; MACIF"
                     /note="major polyA site"
     regulatory      1825..1830
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cd59a"
                     /gene_synonym="Cd59; MAC-IP; MACIF"
                     /note="hexamer: AATACA"
     polyA_site      1845
                     /gene="Cd59a"
                     /gene_synonym="Cd59; MAC-IP; MACIF"
ORIGIN      
        1 acttttgggg tctgttgtag gcttagctac agcatgtcca agcccgtaag gcccatgaga
       61 ctgctaacac tgggttatgt taagtcactt agcttccaga ccttgggttg aaggtgtctg
      121 tgaagcctgt ggaaactgct gctgttaaaa tcttcaatct ggctggggat gtggctcaag
      181 atagtgctgc atggtggcct ggcttgcgtt cttcatatat taaaaatttg gtagcccagc
      241 acaatgagag ctcagagggg actcatctta ctcctgctgc ttctggctgt gttctgttcc
      301 acagctgtta gcctcacatg ctaccactgt ttccaaccgg tggtttcttc atgcaatatg
      361 aacagcactt gctctcctga ccaggattcc tgtctctatg ctgtagccgg aatgcaagtg
      421 tatcaaaggt gttggaaaca atcagattgt catggtgaga tcattatgga ccaattagaa
      481 gagacaaaat taaaattcag atgctgccag tttaacttgt gtaacaaaag tgacggatcc
      541 ttggggaaga caccattgct ggggacctcg gttctggtgg ccattttgaa tctttgtttc
      601 ttaagtcatc tctaagtcct agatgcctcc tctctctctc tctctctctc tctctctctc
      661 ttttcctgct gctgcagtag tctaaagctt ttattatttt ccatctgtat taatttagga
      721 aagaataaag ttcacttgaa catcttggac aagagggagg agtttaagca gtgtggaaga
      781 gcaccatgca caccaggaga gcccacttgc agttgcagag tgaaggcgga gggtagaaca
      841 cctataggtt atataatctt cctttgcctg actttaagat tcaggttaag tgagttcctg
      901 gcaaccctca gggatagctc tctggttcct gcaatgtagc tgaggagtga gatcagacct
      961 ttaggagtga gtgggccagg aggattctct ttaccactct gacacgctca aaatgctttc
     1021 ataatcttca caggccctga gctggtgtgt gaatgttcca gttgtgagct gtcagttagg
     1081 ggcagtgact gttcacttgc ttaaaaaaac aaaagcaaac ccaaccaacc aaccaaccaa
     1141 ccaaccaacc agtgctggcc atgaagccca gatcttggct tgtaggcgag tgctttaccc
     1201 ttaagcccca gccccagctc aagcagtgaa tgaaccgctg tgctttcagc tttagaaaat
     1261 gtagggaaat gaaacaagct ctgaacccca tgtgatggta cttgcttcct ttgcttagta
     1321 tctcagtact caggaggcag aggcaggagg atggccagaa attgaaggtg gtttccaggc
     1381 cacctaaaac tatatagtaa gagcttgcct caaataaaaa aaaaaaaaaa aaaaaaaagg
     1441 gaaagaaaaa aaaagaaaaa accaggtggg tgttggtgca gttttaatcc cagcactcgg
     1501 gaagtagaag caggcctatg ctgtgaggtg gaagccagcc agttctagga cagccaagga
     1561 cacacagaga aacccgcctc taaataaata aatggaaaag aaaaacctca gaacaaaagc
     1621 aaaacaaaaa agaaaggaaa cacacaaaag tctgtctgtt cttatagaag tactggcggc
     1681 cacaacttgg atgtcccaca tctctgaata ttgcctgggc tctgctagct tttactagaa
     1741 aaatgtaatt accaaaaata attaattaaa gttatttgat ctggaaaaag cagattatct
     1801 tgactctctt ccacatgttg gaataataca cactattcta gatta
//
