LOCUS       NM_007827               1368 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus CD55 molecule, decay accelerating factor for
            complement B (Cd55b), transcript variant 1, mRNA.
ACCESSION   NM_007827
VERSION     NM_007827.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1368)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1368)
  AUTHORS   Liu,D., Duan,L., Rodda,L.B., Lu,E., Xu,Y., An,J., Qiu,L., Liu,F.,
            Looney,M.R., Yang,Z., Allen,C.D.C., Li,Z., Marson,A. and
            Cyster,J.G.
  TITLE     CD97 promotes spleen dendritic cell homeostasis through the
            mechanosensing of red blood cells
  JOURNAL   Science 375 (6581), eabi5965 (2022)
   PUBMED   35143305
REFERENCE   3  (bases 1 to 1368)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1368)
  AUTHORS   Aly,M., Wiltshire,S., Chahrour,G., Osti,J.C. and Vidal,S.M.
  TITLE     Complex genetic control of host susceptibility to coxsackievirus
            B3-induced myocarditis
  JOURNAL   Genes Immun 8 (3), 193-204 (2007)
   PUBMED   17287827
REFERENCE   5  (bases 1 to 1368)
  AUTHORS   Hamano,Y., Tsukamoto,K., Abe,M., Sun,G.D., Zhang,D., Fujii,H.,
            Matsuoka,S., Tanaka,M., Ishida-Okawara,A., Tachikawa,H.,
            Nishimura,H., Tokunaka,K., Hirose,S. and Suzuki,K.
  TITLE     Genetic dissection of vasculitis, myeloperoxidase-specific
            antineutrophil cytoplasmic autoantibody production, and related
            traits in spontaneous crescentic glomerulonephritis-forming/Kinjoh
            mice
  JOURNAL   J Immunol 176 (6), 3662-3673 (2006)
   PUBMED   16517735
REFERENCE   6  (bases 1 to 1368)
  AUTHORS   Harris,C.L., Rushmere,N.K. and Morgan,B.P.
  TITLE     Molecular and functional analysis of mouse decay accelerating
            factor (CD55)
  JOURNAL   Biochem J 341 (Pt 3) (Pt 3), 821-829 (1999)
   PUBMED   10417349
REFERENCE   7  (bases 1 to 1368)
  AUTHORS   Sun,X., Funk,C.D., Deng,C., Sahu,A., Lambris,J.D. and Song,W.C.
  TITLE     Role of decay-accelerating factor in regulating complement
            activation on the erythrocyte surface as revealed by gene targeting
  JOURNAL   Proc Natl Acad Sci U S A 96 (2), 628-633 (1999)
   PUBMED   9892684
REFERENCE   8  (bases 1 to 1368)
  AUTHORS   Nonaka,M., Takenaka,O., Okada,N. and Okada,H.
  TITLE     A new repetitive sequence uniquely present in the
            decay-accelerating factor genes
  JOURNAL   Immunogenetics 47 (3), 246-255 (1998)
   PUBMED   9435343
REFERENCE   9  (bases 1 to 1368)
  AUTHORS   Spicer,A.P., Seldin,M.F. and Gendler,S.J.
  TITLE     Molecular cloning and chromosomal localization of the mouse
            decay-accelerating factor genes. Duplicated genes encode
            glycosylphosphatidylinositol-anchored and transmembrane forms
  JOURNAL   J Immunol 155 (6), 3079-3091 (1995)
   PUBMED   7545711
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CJ046619.1, L41365.1,
            AC111067.9 and CJ236680.1.
            
            On Dec 3, 2015 this sequence version replaced NM_007827.2.
            
            Summary: This gene encodes an inhibitor of both the classical and
            the alternative pathways of complement activation. This gene is
            located adjacent to a closely related gene on chromosome 1 and
            preferentially expressed in the spleen and testis. Alternative
            splicing of this gene results in multiple transcript variants
            encoding distinct isoforms. [provided by RefSeq, Dec 2015].
            
            ##Evidence-Data-START##
            Transcript exon combination :: L41365.1, BC115954.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: downstream AUG is associated
                                                with N-terminal localization
                                                signal
            RefSeq Select criteria           :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                CJ046619.1         2-35
            35-154              L41365.1           1-120
            155-155             AC111067.9         26719-26719         c
            156-615             L41365.1           121-580
            616-616             AC111067.9         21979-21979         c
            617-687             L41365.1           582-652
            688-1366            CJ236680.1         1-679
            1367-1368           L41365.1           1329-1330
FEATURES             Location/Qualifiers
     source          1..1368
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 56.89 cM"
     gene            1..1368
                     /gene="Cd55b"
                     /gene_synonym="Daf; Daf-TM; Daf2; TM-DAF"
                     /note="CD55 molecule, decay accelerating factor for
                     complement B"
                     /db_xref="GeneID:13137"
                     /db_xref="MGI:MGI:104849"
     exon            1..179
                     /gene="Cd55b"
                     /gene_synonym="Daf; Daf-TM; Daf2; TM-DAF"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..1288
                     /gene="Cd55b"
                     /gene_synonym="Daf; Daf-TM; Daf2; TM-DAF"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; complement-transmembrane; decay accelerating
                     factor 2"
                     /codon_start=1
                     /product="complement decay-accelerating factor
                     transmembrane isoform isoform 1 precursor"
                     /protein_id="NP_031853.2"
                     /db_xref="CCDS:CCDS35699.1"
                     /db_xref="GeneID:13137"
                     /db_xref="MGI:MGI:104849"
                     /translation="MIPAQAPGTWSSPPLLLVLSLSLVLLFQTVCGDCGPPPDIPNAR
                     PILGRHSKFAEQSKVAYSCNNGFKQVPDKSNIVVCLENGQWSSHETFCEKSCDTPERL
                     SFASLKKEYFNMNFFPVGTIVEYECRPGFRKQPSLSGKSTCLEDLVWSPVAQFCKKKS
                     CPNPKDLDNGHINIPTGILFGSEINFSCNPGYRLVGITSILCTIIGNTVDWDDEFPVC
                     TEIFCPDPPKINNGIMRGESDSYKYSQVVIYSCDKGFILFGNSTIYCTVSKSDVGQWS
                     SPPPQCIEESKVPIKKPVVNVPSTGIPSTPQKPTTESVPNPGDQPTPQKPSTVKVPAT
                     QHEPDTTTRTSTDKGESNSGGDRYIYGFVAVIAMIDSLIIVKTLWTILSPNRRSDFQG
                     KERKDVSK"
     exon            180..365
                     /gene="Cd55b"
                     /gene_synonym="Daf; Daf-TM; Daf2; TM-DAF"
                     /inference="alignment:Splign:2.1.0"
     exon            366..557
                     /gene="Cd55b"
                     /gene_synonym="Daf; Daf-TM; Daf2; TM-DAF"
                     /inference="alignment:Splign:2.1.0"
     exon            558..657
                     /gene="Cd55b"
                     /gene_synonym="Daf; Daf-TM; Daf2; TM-DAF"
                     /inference="alignment:Splign:2.1.0"
     exon            658..743
                     /gene="Cd55b"
                     /gene_synonym="Daf; Daf-TM; Daf2; TM-DAF"
                     /inference="alignment:Splign:2.1.0"
     exon            744..935
                     /gene="Cd55b"
                     /gene_synonym="Daf; Daf-TM; Daf2; TM-DAF"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1082
                     /gene="Cd55b"
                     /gene_synonym="Daf; Daf-TM; Daf2; TM-DAF"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1145
                     /gene="Cd55b"
                     /gene_synonym="Daf; Daf-TM; Daf2; TM-DAF"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1166
                     /gene="Cd55b"
                     /gene_synonym="Daf; Daf-TM; Daf2; TM-DAF"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1368
                     /gene="Cd55b"
                     /gene_synonym="Daf; Daf-TM; Daf2; TM-DAF"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccccgcccg gcctcagctg ctcaattaac catgcctcaa aacagctccg gccaaatcct
       61 ggcatggtct cttccacctg gggctatgat ccccgcgcag gcgccgggga cttggtcatc
      121 accaccactg ctgctggtgc tgtcactatc gctggtgctg ttgttccaaa ctgtgtgcgg
      181 agactgcggc ccacctccag acattcctaa tgccaggcca atcttgggca gacactccaa
      241 gtttgctgag caaagcaaag tggcatactc gtgtaataac ggctttaaac aagttccaga
      301 caagtcaaac atagttgtct gtcttgaaaa tggccaatgg tcgagccacg aaacattctg
      361 tgagaaatca tgtgatactc cagaaagact gagttttgca tccctcaaaa aagagtactt
      421 caacatgaat tttttcccag ttggtactat tgtggaatat gagtgtcggc caggatttcg
      481 aaaacaacct tcactctcag gaaaatcaac ttgccttgag gatttagtat ggtctccagt
      541 tgctcagttt tgtaaaaaaa aatcatgccc taatcctaaa gatctggata atggtcacat
      601 caacatacca accggcatat tattcggttc agaaataaac ttctcatgca acccagggta
      661 caggctagtc ggtatcacct ctattttatg tactattata ggaaatactg ttgattggga
      721 tgatgaattt ccagtgtgca cagaaatatt ttgtccagac ccaccaaaaa tcaacaatgg
      781 aataatgcga ggggaaagcg attcttataa atatagccag gtggtcattt attcatgtga
      841 caaaggcttc atcctgtttg gaaattctac catatattgt actgtgagca agtctgatgt
      901 aggacaatgg agcagtccac caccccagtg tatagaggaa tctaaggtcc caattaagaa
      961 accagtagtt aatgttccaa gtacaggaat cccctcaacg cctcagaaac ccacaacaga
     1021 aagtgttcca aatccaggag accaaccaac tcctcagaaa ccttccacag ttaaagttcc
     1081 agcaacccag catgaacctg ataccacgac aagaacatct acagacaaag gagagtctaa
     1141 ctcaggtggt gaccgttata tatatggatt tgttgctgtt attgcaatga ttgatagcct
     1201 aattatagtc aaaactcttt ggactatttt aagtccaaac agaaggtctg actttcaagg
     1261 aaaggagagg aaggatgtct caaagtaaga agagagcaag aatccagtct ccaccttttc
     1321 aacctgtttg ggtgtgtgct ctatgaatta aatggcagct gcccacat
//
