LOCUS       NM_001404959            2125 bp    mRNA    linear   ROD 14-OCT-2024
DEFINITION  Mus musculus CD55 molecule, decay accelerating factor for
            complement (Cd55), transcript variant 2, mRNA.
ACCESSION   NM_001404959 XM_006529115
VERSION     NM_001404959.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2125)
  AUTHORS   Yao,H., Tong,W., Song,Y., Li,R., Xiang,X., Cheng,W., Zhou,Y.,
            He,Y., Yang,Y., Liu,Y., Li,S. and Jin,L.
  TITLE     Exercise training upregulates CD55 to suppress complement-mediated
            synaptic phagocytosis in Parkinson's disease
  JOURNAL   J Neuroinflammation 21 (1), 246 (2024)
   PUBMED   39342308
  REMARK    GeneRIF: Exercise training upregulates CD55 to suppress
            complement-mediated synaptic phagocytosis in Parkinson's disease.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2125)
  AUTHORS   Kang,L., Kohen,M., McCarthy,I., Hammelef,E., Kim,H.S., Bapputty,R.,
            Gubitosi-Klug,R., Orge,F.H., Kern,T. and Medof,M.E.
  TITLE     Critical Role of CD55 in Controlling Wound Healing
  JOURNAL   J Immunol 212 (7), 1142-1149 (2024)
   PUBMED   38372645
  REMARK    GeneRIF: Critical Role of CD55 in Controlling Wound Healing.
REFERENCE   3  (bases 1 to 2125)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 2125)
  AUTHORS   Liu,D., Winer,B.Y., Chou,M.Y., Tam,H., Xu,Y., An,J., Gardner,J.M.
            and Cyster,J.G.
  TITLE     Dynamic encounters with red blood cells trigger splenic marginal
            zone B cell retention and function
  JOURNAL   Nat Immunol 25 (1), 142-154 (2024)
   PUBMED   38049580
REFERENCE   5  (bases 1 to 2125)
  AUTHORS   Budge,K.L., Verlato,A., Bin,S., Salem,F.E., Perin,L., La Manna,G.,
            Zaza,G., Fiaccadori,E., Cantarelli,C. and Cravedi,P.
  TITLE     Decay-Accelerating Factor Restrains Complement Activation and
            Delays Progression of Murine cBSA-Induced Membranous Nephropathy
  JOURNAL   Kidney360 4 (6), e769-e776 (2023)
   PUBMED   37036696
REFERENCE   6  (bases 1 to 2125)
  AUTHORS   Nonaka,M., Takenaka,O., Okada,N. and Okada,H.
  TITLE     A new repetitive sequence uniquely present in the
            decay-accelerating factor genes
  JOURNAL   Immunogenetics 47 (3), 246-255 (1998)
   PUBMED   9435343
REFERENCE   7  (bases 1 to 2125)
  AUTHORS   Song,W.C., Deng,C., Raszmann,K., Moore,R., Newbold,R.,
            McLachlan,J.A. and Negishi,M.
  TITLE     Mouse decay-accelerating factor: selective and tissue-specific
            induction by estrogen of the gene encoding the
            glycosylphosphatidylinositol-anchored form
  JOURNAL   J Immunol 157 (9), 4166-4172 (1996)
   PUBMED   8892654
REFERENCE   8  (bases 1 to 2125)
  AUTHORS   Fukuoka,Y., Yasui,A., Okada,N. and Okada,H.
  TITLE     Molecular cloning of murine decay accelerating factor by
            immunoscreening
  JOURNAL   Int Immunol 8 (3), 379-385 (1996)
   PUBMED   8671624
REFERENCE   9  (bases 1 to 2125)
  AUTHORS   van Denderen,B., Somerville,C., Pearse,M., Nottle,M., Du,Z.T.,
            Shinkel,T. and d'Apice,A.
  TITLE     Expression of functional decay-accelerating factor in transgenic
            mice
  JOURNAL   Transplant Proc 27 (6), 3567-3568 (1995)
   PUBMED   8540104
REFERENCE   10 (bases 1 to 2125)
  AUTHORS   Spicer,A.P., Seldin,M.F. and Gendler,S.J.
  TITLE     Molecular cloning and chromosomal localization of the mouse
            decay-accelerating factor genes. Duplicated genes encode
            glycosylphosphatidylinositol-anchored and transmembrane forms
  JOURNAL   J Immunol 155 (6), 3079-3091 (1995)
   PUBMED   7545711
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC111067.9.
            
            On Apr 15, 2022 this sequence version replaced XM_006529115.5.
            
            Summary: This gene encodes an inhibitor of both the classical and
            the alternative pathways of complement activation. The encoded
            preproprotein undergoes post-translational processing to generate a
            mature polypeptide anchored to the plasma membrane via a
            glycosylphosphatidylinositol moiety. Erythrocytes from mice
            deficient in the encoded protein exhibit impaired regulation of
            complement activation resulting in enhanced complement deposition.
            Mice lacking the encoded protein exhibit enhanced susceptibility to
            experimentally induced myasthenia gravis. This gene is located
            adjacent to a closely related gene on chromosome 1. [provided by
            RefSeq, Nov 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13861890.12782.1,
                                           SRR5189676.76328.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164133, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-162               AC111067.9         66400-66561         c
            163-348             AC111067.9         65652-65837         c
            349-540             AC111067.9         63412-63603         c
            541-640             AC111067.9         61917-62016         c
            641-726             AC111067.9         60651-60736         c
            727-918             AC111067.9         56214-56405         c
            919-1065            AC111067.9         53247-53393         c
            1066-1146           AC111067.9         52158-52238         c
            1147-2125           AC111067.9         50491-51469         c
FEATURES             Location/Qualifiers
     source          1..2125
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 56.89 cM"
     gene            1..2125
                     /gene="Cd55"
                     /gene_synonym="Daf; Daf-GPI; Daf1; GPI-DAF"
                     /note="CD55 molecule, decay accelerating factor for
                     complement"
                     /db_xref="GeneID:13136"
                     /db_xref="MGI:MGI:104850"
     exon            1..162
                     /gene="Cd55"
                     /gene_synonym="Daf; Daf-GPI; Daf1; GPI-DAF"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..1478
                     /gene="Cd55"
                     /gene_synonym="Daf; Daf-GPI; Daf1; GPI-DAF"
                     /note="isoform 2 preproprotein is encoded by transcript
                     variant 2; complement decay-accelerating factor,
                     GPI-anchored; GPI anchor addition signal; decay
                     accelerating factor 1;
                     complement-glycosylphosphatidylinositol; Cromer blood
                     group; CD55 antigen"
                     /codon_start=1
                     /product="complement decay-accelerating factor,
                     GPI-anchored isoform 2 preproprotein"
                     /protein_id="NP_001391888.1"
                     /db_xref="GeneID:13136"
                     /db_xref="MGI:MGI:104850"
                     /translation="MIRGRAPRTRPSPPPPLLPLLSLSLLLLSPTVRGDCGPPPDIPN
                     ARPILGRHSKFAEQSKVAYSCNNGFKQVPDKSNIVVCLENGQWSSHETFCEKSCVAPE
                     RLSFASLKKEYLNMNFFPVGTIVEYECRPGFRKQPPLPGKATCLEDLVWSPVAQFCKK
                     KSCPNPKDLDNGHINIPTGILFGSEINFSCNPGYRLVGVSSTFCSVTGNTVDWDDEFP
                     VCTEIHCPEPPKINNGIMRGESDSYTYSQVVTYSCDKGFILVGNASIYCTVSKSDVGQ
                     WSSPPPRCIEKSKVPTKKPTINVPSTGTPSTPQKPTTESVPNPGDQPTPQKPSTVKVS
                     ATQHVPVTKTTVRHPIRTSTDKGEPNTGGDRYIYGKFDSQGVRRNCHHCGKHSLHFWK
                     RILSYNCLRKTIKMQCFWAPKGRWVNPFNPLVLWTPLGVQYAPSYSQQCSCSQGVLGQ
                     LQVIWPISQVALSARCVSRSL"
     exon            163..348
                     /gene="Cd55"
                     /gene_synonym="Daf; Daf-GPI; Daf1; GPI-DAF"
                     /inference="alignment:Splign:2.1.0"
     exon            349..540
                     /gene="Cd55"
                     /gene_synonym="Daf; Daf-GPI; Daf1; GPI-DAF"
                     /inference="alignment:Splign:2.1.0"
     exon            541..640
                     /gene="Cd55"
                     /gene_synonym="Daf; Daf-GPI; Daf1; GPI-DAF"
                     /inference="alignment:Splign:2.1.0"
     exon            641..726
                     /gene="Cd55"
                     /gene_synonym="Daf; Daf-GPI; Daf1; GPI-DAF"
                     /inference="alignment:Splign:2.1.0"
     exon            727..918
                     /gene="Cd55"
                     /gene_synonym="Daf; Daf-GPI; Daf1; GPI-DAF"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1065
                     /gene="Cd55"
                     /gene_synonym="Daf; Daf-GPI; Daf1; GPI-DAF"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1146
                     /gene="Cd55"
                     /gene_synonym="Daf; Daf-GPI; Daf1; GPI-DAF"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..2125
                     /gene="Cd55"
                     /gene_synonym="Daf; Daf-GPI; Daf1; GPI-DAF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2097..2102
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cd55"
                     /gene_synonym="Daf; Daf-GPI; Daf1; GPI-DAF"
                     /note="hexamer: AATAAA"
     polyA_site      2125
                     /gene="Cd55"
                     /gene_synonym="Daf; Daf-GPI; Daf1; GPI-DAF"
                     /note="major polyA site"
ORIGIN      
        1 aattaactgc ggctcaaaac agctccagcc gcagccgggc aaggtctctt ctacctgggg
       61 ctatgatccg tgggcgggcg cctaggactc ggccatcacc gccgcctccg ctgctgccgt
      121 tgctgtcgct gtctctgttg ctgctgtccc caactgtacg cggagactgc ggcccacctc
      181 cagacattcc taatgccagg ccaatcttgg gcagacactc caagtttgct gagcaaagca
      241 aagtggcata ctcgtgtaat aacggcttta aacaagttcc agacaagtca aacatagttg
      301 tctgtcttga aaatggccaa tggtcgagcc acgaaacatt ctgtgagaaa tcatgtgttg
      361 ctccagaaag actgagtttt gcatccctca aaaaagagta cctcaacatg aattttttcc
      421 cagttggtac tattgtggaa tatgagtgtc ggccaggatt tcgaaaacaa cctccactcc
      481 caggaaaagc aacttgcctt gaggatttag tatggtctcc agttgctcag ttttgtaaaa
      541 aaaaatcatg ccctaatcct aaagatctgg ataatggtca catcaacata ccaaccggca
      601 tattattcgg ttcagaaata aacttctcat gcaacccagg gtacaggcta gtcggtgtct
      661 cctctacttt ctgttctgtc acaggaaata ctgttgattg ggacgatgag tttccagtgt
      721 gcacagaaat acattgtcca gagccaccaa aaatcaacaa tggaataatg cgaggggaaa
      781 gtgactctta tacgtatagc caggtggtca cctattcatg tgacaaaggc ttcatcctgg
      841 ttggaaatgc tagcatttat tgtactgtga gcaagtctga tgtaggacaa tggagcagtc
      901 caccaccccg gtgcatagag aaatccaagg tcccaacgaa gaaaccaaca attaatgttc
      961 caagtacagg aaccccctca acgcctcaga aacccacaac agaaagtgtt ccaaatccag
     1021 gagaccaacc aactcctcag aaaccttcca cagttaaagt ttcagcaacc cagcatgtac
     1081 ctgttaccaa gacaacagta cgtcatccaa taagaacatc tacagacaaa ggagagccta
     1141 acacaggtgg tgaccgttat atatatggta agtttgactc acagggagtt agaagaaatt
     1201 gccatcactg tgggaaacat agtctacatt tctggaagag aatcttatct tataactgtc
     1261 tcaggaaaac gatcaaaatg cagtgtttct gggcacctaa gggaagatgg gtaaatccct
     1321 ttaatccgct tgttttgtgg acaccattag gcgtccagta tgctccttcc tattctcaac
     1381 agtgttcctg ttctcaggga gtcttaggac agcttcaggt catttggcca atcagtcagg
     1441 tagcattgag tgcccgttgt gtcagtcgct cactttaggg acagaagaag cacagaaacg
     1501 gaggtcaaca tggttcttgt ctaaagagct gcatagtcaa ccaactcttt gaccagtttt
     1561 atgtctctgt cataggccaa gtgccagcaa gagtctcagc tttagatata tttgtccttc
     1621 aactctagta acagttttaa gcagagttct gttaaaatgt attctctaca tgctaatatg
     1681 gttggcaaag gtaaaccatg tcttatgttg tgaatccttt tagcatttgg tcagtatatt
     1741 tctatgtaca ttatatttac tgttactcat taataaggtc aacaaacccc cgaacaaaat
     1801 gctaagagac tttgttaaat agaaaaatag caaagaagca tacaaagtca tgtgcaactg
     1861 taaatatcct ttcatgaaaa gatgtgtatt ttaccatttt gtatgaatca gtgatatcac
     1921 cttttcatac atgaatgaat gtattagcta agggacacgc cctgaaaaca ggtactcggt
     1981 ttccaatgtt actcttacgg gtgtttgtca tacttagttt atgtttaagc taaaaattta
     2041 gttagagata tcacagcagg ggcaattgct tttgtacatt ttctaattta aatagaaata
     2101 aatgtattct aagctaatgc aaaaa
//
