LOCUS       NM_007651               2802 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus CD53 antigen (Cd53), mRNA.
ACCESSION   NM_007651
VERSION     NM_007651.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2802)
  AUTHORS   Chakraborty,M., Greenberg,Z.J., Dong,Q., Roundy,N., Bednarski,J.J.,
            Paracatu,L.C., Duncavage,E., Li,W. and Schuettpelz,L.G.
  TITLE     Cutting Edge: The Tetraspanin CD53 Promotes CXCR4 Signaling and
            Bone Marrow Homing in B Cells
  JOURNAL   J Immunol 212 (7), 1075-1080 (2024)
   PUBMED   38363205
  REMARK    GeneRIF: Cutting Edge: The Tetraspanin CD53 Promotes CXCR4
            Signaling and Bone Marrow Homing in B Cells.
REFERENCE   2  (bases 1 to 2802)
  AUTHORS   Higgins,C.B., Adams,J.A., Ward,M.H., Greenberg,Z.J., Milewska,M.,
            Sun,J., Zhang,Y., Chiquetto Paracatu,L., Dong,Q., Ballentine,S.,
            Li,W., Wandzik,I., Schuettpelz,L.G. and DeBosch,B.J.
  TITLE     The tetraspanin transmembrane protein CD53 mediates dyslipidemia
            and integrates inflammatory and metabolic signaling in hepatocytes
  JOURNAL   J Biol Chem 299 (2), 102835 (2023)
   PUBMED   36581203
  REMARK    GeneRIF: The tetraspanin transmembrane protein CD53 mediates
            dyslipidemia and integrates inflammatory and metabolic signaling in
            hepatocytes.
REFERENCE   3  (bases 1 to 2802)
  AUTHORS   Dunlock,V.E., Arp,A.B., Singh,S.P., Charrin,S., Nguyen,V.,
            Jansen,E., Schaper,F., Beest,M.T., Zuidscherwoude,M., van
            Deventer,S.J., Nakken,B., Szodoray,P., Demaria,M.C., Wright,M.D.,
            Querol Cano,L., Rubinstein,E. and van Spriel,A.B.
  TITLE     Tetraspanin CD53 controls T cell immunity through regulation of
            CD45RO stability, mobility, and function
  JOURNAL   Cell Rep 39 (13), 111006 (2022)
   PUBMED   35767951
  REMARK    GeneRIF: Tetraspanin CD53 controls T cell immunity through
            regulation of CD45RO stability, mobility, and function.
REFERENCE   4  (bases 1 to 2802)
  AUTHORS   Yeung,L., Gottschalk,T.A., Hall,P., Tsantikos,E., Gallagher,R.H.,
            Kitching,A.R., Hibbs,M.L., Wright,M.D. and Hickey,M.J.
  TITLE     Tetraspanin CD53 modulates lymphocyte trafficking but not systemic
            autoimmunity in Lyn-deficient mice
  JOURNAL   Immunol Cell Biol 99 (10), 1053-1066 (2021)
   PUBMED   34514627
  REMARK    GeneRIF: Tetraspanin CD53 modulates lymphocyte trafficking but not
            systemic autoimmunity in Lyn-deficient mice.
REFERENCE   5  (bases 1 to 2802)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2802)
  AUTHORS   Yokoi,N., Kitada,K., Kuramoto,T., Maihara,T., Andoh,Y., Takami,S.,
            Higaki,J., Miki,T., Ogihara,T., Lathrop,G.M. and Serikawa,T.
  TITLE     Mapping of 20 polymorphic DNA markers in the rat by somatic hybrid
            and linkage analysis
  JOURNAL   Mamm Genome 7 (1), 71-73 (1996)
   PUBMED   8903735
REFERENCE   7  (bases 1 to 2802)
  AUTHORS   Tomlinson,M.G., Hanke,T., Hughes,D.A., Barclay,A.N., Scholl,E.,
            Hunig,T. and Wright,M.D.
  TITLE     Characterization of mouse CD53: epitope mapping, cellular
            distribution and induction by T cell receptor engagement during
            repertoire selection
  JOURNAL   Eur J Immunol 25 (8), 2201-2205 (1995)
   PUBMED   7545113
REFERENCE   8  (bases 1 to 2802)
  AUTHORS   McClive,P.J. and Morahan,G.
  TITLE     Assignment of the mouse homologues of 6 loci from HSA1p to
            chromosomes 3 and 4
  JOURNAL   Genomics 23 (1), 243-246 (1994)
   PUBMED   7829080
REFERENCE   9  (bases 1 to 2802)
  AUTHORS   Wright,M.D., Rochelle,J.M., Tomlinson,M.G., Seldin,M.F. and
            Williams,A.F.
  TITLE     Gene structure, chromosomal localization, and protein sequence of
            mouse CD53 (Cd53): evidence that the transmembrane 4 superfamily
            arose by gene duplication
  JOURNAL   Int Immunol 5 (2), 209-216 (1993)
   PUBMED   8452817
REFERENCE   10 (bases 1 to 2802)
  AUTHORS   Taguchi,T., Bellacosa,A., Zhou,J.Y., Gilbert,D.J., Lazo,P.A.,
            Copeland,N.G., Jenkins,N.A., Tsichlis,P.N. and Testa,J.R.
  TITLE     Chromosomal localization of the Ox-44 (CD53) leukocyte antigen gene
            in man and rodents
  JOURNAL   Cytogenet Cell Genet 64 (3-4), 217-221 (1993)
   PUBMED   8404042
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC117255.3, AA177409.1 and AK160326.1.
            
            On Dec 1, 2007 this sequence version replaced NM_007651.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK156510.1, AK160326.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-112               AC117255.3         97162-97273
            113-640             AA177409.1         1-528
            641-1481            AK160326.1         539-1379
            1482-2802           AC117255.3         127130-128450
FEATURES             Location/Qualifiers
     source          1..2802
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 46.53 cM"
     gene            1..2802
                     /gene="Cd53"
                     /gene_synonym="Ox-44; Tspan25"
                     /note="CD53 antigen"
                     /db_xref="GeneID:12508"
                     /db_xref="MGI:MGI:88341"
     exon            1..183
                     /gene="Cd53"
                     /gene_synonym="Ox-44; Tspan25"
                     /inference="alignment:Splign:2.1.0"
     exon            184..262
                     /gene="Cd53"
                     /gene_synonym="Ox-44; Tspan25"
                     /inference="alignment:Splign:2.1.0"
     CDS             200..859
                     /gene="Cd53"
                     /gene_synonym="Ox-44; Tspan25"
                     /note="cell surface glycoprotein CD53"
                     /codon_start=1
                     /product="leukocyte surface antigen CD53"
                     /protein_id="NP_031677.1"
                     /db_xref="CCDS:CCDS17728.1"
                     /db_xref="GeneID:12508"
                     /db_xref="MGI:MGI:88341"
                     /translation="MGMSSLKLLKYVLFIFNLLFWVCGCCILGFGIYFLVQNTYGVLF
                     RNLPFLTLGNILVIVGSIIMVVAFLGCMGSIKENKCLLMSFFVLLLIILLAEVTIAIL
                     LFVYEQKLNTLVAEGLNDSIQHYHSDNSTMKAWDFIQTQLQCCGVNGSSDWTSGPPSS
                     CPSGADVQGCYNKAKSWFHSNFLYIGIITICVCVIQVLGMSFALTLNCQIDKTSQALG
                     L"
     exon            263..451
                     /gene="Cd53"
                     /gene_synonym="Ox-44; Tspan25"
                     /inference="alignment:Splign:2.1.0"
     exon            452..526
                     /gene="Cd53"
                     /gene_synonym="Ox-44; Tspan25"
                     /inference="alignment:Splign:2.1.0"
     exon            527..622
                     /gene="Cd53"
                     /gene_synonym="Ox-44; Tspan25"
                     /inference="alignment:Splign:2.1.0"
     exon            623..703
                     /gene="Cd53"
                     /gene_synonym="Ox-44; Tspan25"
                     /inference="alignment:Splign:2.1.0"
     exon            704..787
                     /gene="Cd53"
                     /gene_synonym="Ox-44; Tspan25"
                     /inference="alignment:Splign:2.1.0"
     exon            788..2802
                     /gene="Cd53"
                     /gene_synonym="Ox-44; Tspan25"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1709..1714
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cd53"
                     /gene_synonym="Ox-44; Tspan25"
                     /note="hexamer: AATAAA"
     regulatory      1713..1718
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cd53"
                     /gene_synonym="Ox-44; Tspan25"
                     /note="hexamer: AACAAA"
     polyA_site      1733
                     /gene="Cd53"
                     /gene_synonym="Ox-44; Tspan25"
     polyA_site      1742
                     /gene="Cd53"
                     /gene_synonym="Ox-44; Tspan25"
                     /note="major polyA site"
     regulatory      2491..2496
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cd53"
                     /gene_synonym="Ox-44; Tspan25"
                     /note="hexamer: AGTAAA"
     polyA_site      2509
                     /gene="Cd53"
                     /gene_synonym="Ox-44; Tspan25"
ORIGIN      
        1 agtctcactt cctcactctt ctcgcttggg tttcctgtcg tcacagcatg attgtatttt
       61 ttctctcttc acttctcctt ttacacaaat agacatagac ttctgggtta caggctgtgc
      121 tggccaccta aaagataatc agtgaattct acctgaagta ctgagggaca ctgccttcaa
      181 aagggcatac tatcccagca tgggcatgag cagcctgaaa ttgctgaaat atgttctgtt
      241 tatctttaac ttgctttttt gggtctgtgg ctgttgcatt ttgggctttg gcatctattt
      301 cctggtccaa aatacctatg gagtactctt ccgtaacctt cccttcctga cacttggcaa
      361 cattctggtc attgtgggat ccattatcat ggtagttgcc ttcttgggtt gcatgggctc
      421 aatcaaggaa aataagtgcc tgcttatgtc gttctttgtt ctgctgctga ttattctcct
      481 tgctgaggtg accatagcca tcctgctctt tgtgtatgaa caaaaactca acactttagt
      541 ggctgagggt ctgaatgaca gcatccaaca ttatcactct gacaacagca ctatgaaggc
      601 atgggacttc atccagacac aactgcagtg ttgtggtgta aatggctcaa gtgattggac
      661 cagtggtcca ccatcttcct gcccatcagg tgcagatgtt cagggttgct ataataaggc
      721 aaaatcgtgg tttcactcca atttcttgta tattggaatc attaccatct gtgtatgtgt
      781 gatacaggtg ctgggaatgt cctttgcact gacactcaac tgccagattg acaaaacaag
      841 ccaggcttta gggctgtgac ttgcaacttc cccctgctta agtgacttat tcctctctag
      901 aaagtcaaag catccattcc atgagaactt aaacaattac ctgcctgact ggcattttgg
      961 cttcttctta ttccatcttt gactggatct ctgtcttata cacatccact gaagagaata
     1021 tttgtcatgg acttcccata tcaagcagaa gacaaacatt aaccaactga tagcagtaac
     1081 catatccctt aaagatggtg aaacatacct gggtgttttt ggtttttttt ttttttttac
     1141 atacttgggt atttttttta aagagacact gtagcactgg tggcttgaga tccactgcca
     1201 gctgctggtg tggttatttc tcagagtact agcctagcaa atgtgagccc ttgagtttag
     1261 ccccaaatac tacaaaaaag aggtccaagt ttaaatgtta gtctcctaac aactgtcaaa
     1321 tcaatttcta gcctctaaat cttgctactt ccactctaca aagtcacata agagagaagc
     1381 tgatggaaat ttttgagtcc cattcattag ataattgaca tactcagttt ccttttgaac
     1441 acagtccttg gtaataggaa tcatacagaa atcttttatt tctggaaaat attccaattt
     1501 ctttgtctta ttgattttgt tccatccatc catccagaaa agattattcc catcctattg
     1561 ttagtcagtc tggtagcctt gaattacatt gccataaaac aacccagaag tattaatatc
     1621 tccagtgtgt tagctgataa tcacatccat gtctatgttt tatttctcta ttaaataagg
     1681 ttctgttaat gtaccatttt aacctgttaa taaacaaaag tttataatca ctatccatca
     1741 aacatttgac tcattctgat atttctgtta caagccaaat atatgttata tttctgtata
     1801 acaaattagt tcaaaatgta gtggctaaga acctatatat ttgttttata aattgactga
     1861 tttaaagaca gcattttgct atgtagccca ggctgtcttg gaacttacta tatgaccaaa
     1921 gatggcacca aactcatgat taccctgctt ttaacttctg aatattagaa ttacagttaa
     1981 gtgctactaa gtcagaacaa acatttattg tctgatggct ttatgtaatc aggagtgtgg
     2041 aagtagctta gaaaaatgat tatagatagt tgtttcttgc atatagtgat taagtggtca
     2101 gccatatctt ccatcatctc atgtctcatt ggaaaattaa tccattgtca tgttctcata
     2161 tagttgtaat gaacctcata taatggccac acataagttt atatgggtag tttcgtgaat
     2221 aatgagacag gtaagacata aaatgatagg tagcatccaa gacaaaagtc atagcacttt
     2281 tataacttaa cccagaaatg atggcatcag ttattctggg tcaaaagttc aatttccacc
     2341 cagggcaaaa ttacacaaca ggcatatgac ttctaggaag ttgagatcat tgatggccac
     2401 atgagagatt gctaaccatc tcatgcttac tatgtcaaaa aatatggtgt acttgtctat
     2461 attatgtata tacataacta tattctataa agtaaaaaat tagaacacat ataatgccta
     2521 atttatagaa ctcacaagaa tagaaaataa ttggtttttg ttttagaaat gttctgtaga
     2581 attctctgac ttgctttaag gaaaactggt tattttcgtg gtgctctata gggaaaatat
     2641 ctattgcatt ttctgagtca tataaagagt catgtattcc tctttgttca gactaacact
     2701 tagtggtgac attaccagta agttttcctg cctaatgcct gagctttgtt cttagctcta
     2761 ctttgttctt cactcccaat aaaatgttat ggagttctaa gg
//
