LOCUS       NM_013706                531 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus CD52 antigen (Cd52), mRNA.
ACCESSION   NM_013706
VERSION     NM_013706.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 531)
  AUTHORS   Mao,R., Yang,F., Zhang,Y., Liu,H., Guo,P., Liu,Y. and Zhang,T.
  TITLE     High expression of CD52 in adipocytes: a potential therapeutic
            target for obesity with type 2 diabetes
  JOURNAL   Aging (Albany NY) 13 (8), 11043-11060 (2021)
   PUBMED   33705353
  REMARK    GeneRIF: High expression of CD52 in adipocytes: a potential
            therapeutic target for obesity with type 2 diabetes.
REFERENCE   2  (bases 1 to 531)
  AUTHORS   Rashidi,M., Bandala-Sanchez,E., Lawlor,K.E., Zhang,Y., Neale,A.M.,
            Vijayaraj,S.L., O'Donoghue,R., Wentworth,J.M., Adams,T.E.,
            Vince,J.E. and Harrison,L.C.
  TITLE     CD52 inhibits Toll-like receptor activation of NF-kappaB and
            triggers apoptosis to suppress inflammation
  JOURNAL   Cell Death Differ 25 (2), 392-405 (2018)
   PUBMED   29244050
REFERENCE   3  (bases 1 to 531)
  AUTHORS   Chen,J.Q., Mori,H., Cardiff,R.D., Trott,J.F., Hovey,R.C.,
            Hubbard,N.E., Engelberg,J.A., Tepper,C.G., Willis,B.J., Khan,I.H.,
            Ravindran,R.K., Chan,S.R., Schreiber,R.D. and Borowsky,A.D.
  TITLE     Abnormal Mammary Development in 129:STAT1-Null Mice is
            Stroma-Dependent
  JOURNAL   PLoS One 10 (6), e0129895 (2015)
   PUBMED   26075897
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 531)
  AUTHORS   Liu,K.X., Edwards,B., Lee,S., Finelli,M.J., Davies,B., Davies,K.E.
            and Oliver,P.L.
  TITLE     Neuron-specific antioxidant OXR1 extends survival of a mouse model
            of amyotrophic lateral sclerosis
  JOURNAL   Brain 138 (Pt 5), 1167-1181 (2015)
   PUBMED   25753484
REFERENCE   5  (bases 1 to 531)
  AUTHORS   Bandala-Sanchez,E., Zhang,Y., Reinwald,S., Dromey,J.A., Lee,B.H.,
            Qian,J., Bohmer,R.M. and Harrison,L.C.
  TITLE     T cell regulation mediated by interaction of soluble CD52 with the
            inhibitory receptor Siglec-10
  JOURNAL   Nat Immunol 14 (7), 741-748 (2013)
   PUBMED   23685786
  REMARK    GeneRIF: Soluble CD52 is used by certain CD4-positive cells to
            suppress target celss via the inhibitory receptor Siglec-10.
REFERENCE   6  (bases 1 to 531)
  AUTHORS   Egashira,M., Kitamura,D., Watanabe,T. and Niikawa,N.
  TITLE     The human HCLS1 gene maps to chromosome 3q13 by fluorescence in
            situ hybridization
  JOURNAL   Cytogenet Cell Genet 72 (2-3), 175-176 (1996)
   PUBMED   8978766
REFERENCE   7  (bases 1 to 531)
  AUTHORS   Chen,C. and Nabavi,N.
  TITLE     In vitro induction of T cell anergy by blocking B7 and early T cell
            costimulatory molecule ETC-1/B7-2
  JOURNAL   Immunity 1 (2), 147-154 (1994)
   PUBMED   7534198
REFERENCE   8  (bases 1 to 531)
  AUTHORS   Kirchhoff,C.
  TITLE     A major messenger ribonucleic acid of the rodent epididymis encodes
            a small glycosylphosphatidylinositol-anchored lymphocyte surface
            antigen
  JOURNAL   Biol Reprod 50 (4), 896-902 (1994)
   PUBMED   7515288
REFERENCE   9  (bases 1 to 531)
  AUTHORS   Hemmerich,P., von Mikecz,A., Neumann,F., Sozeri,O.,
            Wolff-Vorbeck,G., Zoebelein,R. and Krawinkel,U.
  TITLE     Structural and functional properties of ribosomal protein L7 from
            humans and rodents
  JOURNAL   Nucleic Acids Res 21 (2), 223-231 (1993)
   PUBMED   8441630
REFERENCE   10 (bases 1 to 531)
  AUTHORS   Kubota,H., Okazaki,H., Onuma,M., Kano,S., Hattori,M. and Minato,N.
  TITLE     Identification and gene cloning of a new
            phosphatidylinositol-linked antigen expressed on mature
            lymphocytes. Down-regulation by lymphocyte activation
  JOURNAL   J Immunol 145 (11), 3924-3931 (1990)
   PUBMED   2147207
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK155728.1 and BC027495.1.
            
            On Oct 31, 2007 this sequence version replaced NM_013706.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AI021439.1, AK155728.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                AK155728.1         2-51
            51-531              BC027495.1         1-481
FEATURES             Location/Qualifiers
     source          1..531
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 66.5 cM"
     gene            1..531
                     /gene="Cd52"
                     /gene_synonym="B7; B7-Ag; CAMPATH-1; CLS1; MB7"
                     /note="CD52 antigen"
                     /db_xref="GeneID:23833"
                     /db_xref="MGI:MGI:1346088"
     exon            1..140
                     /gene="Cd52"
                     /gene_synonym="B7; B7-Ag; CAMPATH-1; CLS1; MB7"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..314
                     /gene="Cd52"
                     /gene_synonym="B7; B7-Ag; CAMPATH-1; CLS1; MB7"
                     /note="CAMPATH-1 antigen; lymphocyte differentiation
                     antigen B7"
                     /codon_start=1
                     /product="CAMPATH-1 antigen precursor"
                     /protein_id="NP_038734.1"
                     /db_xref="CCDS:CCDS38909.1"
                     /db_xref="GeneID:23833"
                     /db_xref="MGI:MGI:1346088"
                     /translation="MKSFLLFLTIILLVVIQIQTGSLGQATTAASGTNKNSTSTKKTP
                     LKSGASSIIDAGACSFLFFANTLMCLFYLS"
     exon            141..503
                     /gene="Cd52"
                     /gene_synonym="B7; B7-Ag; CAMPATH-1; CLS1; MB7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      482..487
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cd52"
                     /gene_synonym="B7; B7-Ag; CAMPATH-1; CLS1; MB7"
                     /note="hexamer: AATAAA"
     polyA_site      503
                     /gene="Cd52"
                     /gene_synonym="B7; B7-Ag; CAMPATH-1; CLS1; MB7"
                     /note="major polyA site"
ORIGIN      
        1 tgcagaaaaa gcagccaggt tcaaagtggc ctgcagactg tcctgaactc atctctcaaa
       61 gctgctacag agcccaggaa gatttcagga tgaagagctt cctcctcttc ctcactatca
      121 ttcttctggt tgtgattcag atacaaacag gatccttggg acaagccact acggccgctt
      181 ctggtactaa caaaaacagc acctccacca aaaaaacccc cttaaagagt ggggcctcat
      241 ccatcatcga tgcgggtgcc tgcagtttcc tcttctttgc caatacctta atgtgcctct
      301 tctacctcag ctgaggtgaa ggcgcagctt ctgaagcccc gtgctccacc cactgctgcc
      361 accatcagta gcgagagaca tcccaaccca cgggaagggt tgatagcaga tatccaagga
      421 ggctaaagtt gacagccaat ggccggaatg ggagcggggc cgtgacaccc agctagggca
      481 caataaagtt atacttatgc ttaaaaaaaa aaaaaaaaaa aaaaaaaaaa a
//
