LOCUS       NM_001368415            2589 bp    mRNA    linear   ROD 18-FEB-2025
DEFINITION  Mus musculus CD47 antigen (Rh-related antigen, integrin-associated
            signal transducer) (Cd47), transcript variant 1, mRNA.
ACCESSION   NM_001368415 XM_006521811
VERSION     NM_001368415.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2589)
  AUTHORS   Jain,A., Gyori,B.M., Hakim,S., Jain,A., Sun,L., Petrova,V.,
            Bhuiyan,S.A., Zhen,S., Wang,Q., Kawaguchi,R., Bunga,S., Taub,D.G.,
            Ruiz-Cantero,M.C., Tong-Li,C., Andrews,N., Kotoda,M., Renthal,W.,
            Sorger,P.K. and Woolf,C.J.
  TITLE     Nociceptor-immune interactomes reveal insult-specific immune
            signatures of pain
  JOURNAL   Nat Immunol 25 (7), 1296-1305 (2024)
   PUBMED   38806708
REFERENCE   2  (bases 1 to 2589)
  AUTHORS   Turan,A., Tarique,M., Zhang,L., Kazmi,S., Ulker,V., Tedla,M.G.,
            Badal,D., Yolcu,E.S. and Shirwan,H.
  TITLE     Engineering Pancreatic Islets to Transiently Codisplay on Their
            Surface Thrombomodulin and CD47 Immunomodulatory Proteins as a
            Means of Mitigating Instant Blood-Mediated Inflammatory Reaction
            following Intraportal Transplantation
  JOURNAL   J Immunol 212 (12), 1971-1980 (2024)
   PUBMED   38709159
  REMARK    GeneRIF: Engineering Pancreatic Islets to Transiently Codisplay on
            Their Surface Thrombomodulin and CD47 Immunomodulatory Proteins as
            a Means of Mitigating Instant Blood-Mediated Inflammatory Reaction
            following Intraportal Transplantation.
REFERENCE   3  (bases 1 to 2589)
  AUTHORS   Vanhoutte,D., Schips,T.G., Minerath,R.A., Huo,J., Kavuri,N.S.S.,
            Prasad,V., Lin,S.C., Bround,M.J., Sargent,M.A., Adams,C.M. and
            Molkentin,J.D.
  TITLE     Thbs1 regulates skeletal muscle mass in a
            TGFbeta-Smad2/3-ATF4-dependent manner
  JOURNAL   Cell Rep 43 (5), 114149 (2024)
   PUBMED   38678560
REFERENCE   4  (bases 1 to 2589)
  AUTHORS   Moon,S., Han,S., Jang,I.H., Ryu,J., Rha,M.S., Cho,H.J., Yoon,S.S.,
            Nam,K.T., Kim,C.H., Park,M.S., Seong,J.K., Lee,W.J., Yoon,J.H.,
            Chung,Y.W. and Ryu,J.H.
  TITLE     Airway epithelial CD47 plays a critical role in inducing influenza
            virus-mediated bacterial super-infection
  JOURNAL   Nat Commun 15 (1), 3666 (2024)
   PUBMED   38693120
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2589)
  AUTHORS   Xu,L., Wang,X., Zhang,T., Meng,X., Zhao,W., Pi,C. and Yang,Y.G.
  TITLE     Expression of a mutant CD47 protects against phagocytosis without
            inducing cell death or inhibiting angiogenesis
  JOURNAL   Cell Rep Med 5 (3), 101450 (2024)
   PUBMED   38508139
  REMARK    GeneRIF: Expression of a mutant CD47 protects against phagocytosis
            without inducing cell death or inhibiting angiogenesis.
REFERENCE   6  (bases 1 to 2589)
  AUTHORS   Furusawa,T., Yanai,N., Hara,T., Miyajima,A. and Obinata,M.
  TITLE     Integrin-associated protein (IAP, also termed CD47) is involved in
            stroma-supported erythropoiesis
  JOURNAL   J Biochem 123 (1), 101-106 (1998)
   PUBMED   9504415
REFERENCE   7  (bases 1 to 2589)
  AUTHORS   Nishiyama,Y., Tanaka,T., Naitoh,H., Mori,C., Fukumoto,M., Hiai,H.
            and Toyokuni,S.
  TITLE     Overexpression of integrin-associated protein (CD47) in rat kidney
            treated with a renal carcinogen, ferric nitrilotriacetate
  JOURNAL   Jpn J Cancer Res 88 (2), 120-128 (1997)
   PUBMED   9119739
REFERENCE   8  (bases 1 to 2589)
  AUTHORS   Lindberg,F.P., Bullard,D.C., Caver,T.E., Gresham,H.D., Beaudet,A.L.
            and Brown,E.J.
  TITLE     Decreased resistance to bacterial infection and granulocyte defects
            in IAP-deficient mice
  JOURNAL   Science 274 (5288), 795-798 (1996)
   PUBMED   8864123
REFERENCE   9  (bases 1 to 2589)
  AUTHORS   Lindberg,F.P., Gresham,H.D., Schwarz,E. and Brown,E.J.
  TITLE     Molecular cloning of integrin-associated protein: an immunoglobulin
            family member with multiple membrane-spanning domains implicated in
            alpha v beta 3-dependent ligand binding
  JOURNAL   J Cell Biol 123 (2), 485-496 (1993)
   PUBMED   7691831
REFERENCE   10 (bases 1 to 2589)
  AUTHORS   Morse,H.C. 3rd.
  TITLE     Genetic nomenclature for loci controlling surface antigens of mouse
            hemopoietic cells
  JOURNAL   J Immunol 149 (10), 3129-3134 (1992)
   PUBMED   1431091
  REMARK    Review article
            Erratum:[J Immunol 1993 Mar 15;150(6):2563]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP757719.1, AK151922.1 and AC107830.10.
            
            On Feb 12, 2019 this sequence version replaced XM_006521811.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK151922.1, HQ585874.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-47                BP757719.1         67-113
            48-1244             AK151922.1         1-1197
            1245-2589           AC107830.10        89273-90617         c
FEATURES             Location/Qualifiers
     source          1..2589
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 31.23 cM"
     gene            1..2589
                     /gene="Cd47"
                     /gene_synonym="9130415E20Rik; B430305P08Rik; IAP; Itgp"
                     /note="CD47 antigen (Rh-related antigen,
                     integrin-associated signal transducer)"
                     /db_xref="GeneID:16423"
                     /db_xref="MGI:MGI:96617"
     exon            1..172
                     /gene="Cd47"
                     /gene_synonym="9130415E20Rik; B430305P08Rik; IAP; Itgp"
                     /inference="alignment:Splign:2.1.0"
     CDS             127..1038
                     /gene="Cd47"
                     /gene_synonym="9130415E20Rik; B430305P08Rik; IAP; Itgp"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; leukocyte surface antigen CD47; Rh-related
                     antigen; integrin-associated protein"
                     /codon_start=1
                     /product="leukocyte surface antigen CD47 isoform 1
                     precursor"
                     /protein_id="NP_001355344.1"
                     /db_xref="GeneID:16423"
                     /db_xref="MGI:MGI:96617"
                     /translation="MWPLAAALLLGSCCCGSAQLLFSNVNSIEFTSCNETVVIPCIVR
                     NVEAQSTEEMFVKWKLNKSYIFIYDGNKNSTTTDQNFTSAKISVSDLINGIASLKMDK
                     RDAMVGNYTCEVTELSREGKTVIELKNRTVSWFSPNEKILIVIFPILAILLFWGKFGI
                     LTLKYKSSHTNKRIILLLVAGLVLTVIVVVGAILLIPGEKPVKNASGLGLIVISTGIL
                     ILLQYNVFMTAFGMTSFTIAILITQVLGYVLALVGLCLCIMACEPVHGPLLISGLGII
                     ALAELLGLVYMKFVASNQRTIQPPRNR"
     exon            173..520
                     /gene="Cd47"
                     /gene_synonym="9130415E20Rik; B430305P08Rik; IAP; Itgp"
                     /inference="alignment:Splign:2.1.0"
     exon            521..610
                     /gene="Cd47"
                     /gene_synonym="9130415E20Rik; B430305P08Rik; IAP; Itgp"
                     /inference="alignment:Splign:2.1.0"
     exon            611..718
                     /gene="Cd47"
                     /gene_synonym="9130415E20Rik; B430305P08Rik; IAP; Itgp"
                     /inference="alignment:Splign:2.1.0"
     exon            719..811
                     /gene="Cd47"
                     /gene_synonym="9130415E20Rik; B430305P08Rik; IAP; Itgp"
                     /inference="alignment:Splign:2.1.0"
     exon            812..904
                     /gene="Cd47"
                     /gene_synonym="9130415E20Rik; B430305P08Rik; IAP; Itgp"
                     /inference="alignment:Splign:2.1.0"
     exon            905..997
                     /gene="Cd47"
                     /gene_synonym="9130415E20Rik; B430305P08Rik; IAP; Itgp"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1029
                     /gene="Cd47"
                     /gene_synonym="9130415E20Rik; B430305P08Rik; IAP; Itgp"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..2589
                     /gene="Cd47"
                     /gene_synonym="9130415E20Rik; B430305P08Rik; IAP; Itgp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1215..1220
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cd47"
                     /gene_synonym="9130415E20Rik; B430305P08Rik; IAP; Itgp"
                     /note="hexamer: AATAAA"
     polyA_site      1246
                     /gene="Cd47"
                     /gene_synonym="9130415E20Rik; B430305P08Rik; IAP; Itgp"
                     /note="major polyA site"
ORIGIN      
        1 agcctgggcg gccgctcctg cctgtcactg ctgcggcgct gctggtcggt cgtttccctt
       61 gaaggcagca gcggaggcgg cggctgctcc agacacctgc ggcggcgacc ccccggcggc
      121 gcggagatgt ggcccttggc ggcggcgctg ttgctgggct cctgctgctg cggttcagct
      181 caactactgt ttagtaacgt caactccata gagttcactt catgcaatga aactgtggtc
      241 atcccttgca tcgtccgtaa tgtggaggcg caaagcaccg aagaaatgtt tgtgaagtgg
      301 aagttgaaca aatcgtatat tttcatctat gatggaaata aaaatagcac tactacagat
      361 caaaacttta ccagtgcaaa aatctcagtc tcagacttaa tcaatggcat tgcctctttg
      421 aaaatggata agcgcgatgc catggtggga aactacactt gcgaagtgac agagttatcc
      481 agagaaggca aaacagttat agagctgaaa aaccgcacgg tttcgtggtt ttctccaaat
      541 gaaaagatcc tcattgttat tttcccaatt ttggctatac tcctgttctg gggaaagttt
      601 ggtattttaa cactcaaata taaatccagc catacgaata agagaatcat tctgctgctc
      661 gttgccgggc tggtgctcac agtcatcgtg gttgttggag ccatccttct catcccagga
      721 gaaaagcccg tgaagaatgc ttctggactt ggcctcattg taatctctac ggggatatta
      781 atactacttc agtacaatgt gtttatgaca gcttttggaa tgacctcttt caccattgcc
      841 atattgatca ctcaagtgct gggctacgtc cttgctttgg tcgggctgtg tctctgcatc
      901 atggcatgtg agccagtgca cggccccctt ttgatttcag gtttggggat catagctcta
      961 gcagaactac ttggattagt ttatatgaag tttgtcgctt ccaaccagag gactatccaa
     1021 cctcctagga ataggtgaag ggaagtgacg gactgtaact tggaagtcag aaatggaaga
     1081 atacagttgt ctaagcacca ggtcttcacg actcacagct ggaaggaaca gacaacagta
     1141 actgacttcc atccaggaaa acatgtcaca taaatgatta ctaagtttat attcaaagca
     1201 gctgtacttt acataataaa aaaaatatga tgtgctgtgt aaccaattgg aatcccattt
     1261 ttctattgtt tctactcaac taggggcaaa cgtttcaggg gcaacttcca agaatgatgc
     1321 ttgttagatc ctagagtctc tgaacactga gtttaaattg attccgagtg agactcgcca
     1381 agcactaacc tgagggttag ttacccagag atacctatga aaaacagtgg tatccagcaa
     1441 gccttagtaa actcaggttg ccagcagctt tgccacttcc gctgctagct gaataacaag
     1501 actgccactt ctgggtcata gtgatagaga ctgaagtaga aaaacgaatg tggttgggca
     1561 aatcccgtgt ggcccctctg tgtgctatga tattgatggc actggtgtct tcattcttgg
     1621 gggttgccat cattcacaca cacccctttg acatacagtg caccccagtt ttgaatacat
     1681 tttttttgca ccctgtcccg ttctgctact ttgatttgcg ttatgatata tatatatata
     1741 tataatacct tttctcctct ttaaacatgg tcctgtgaca caatagtcag ttgcagaaag
     1801 gagccagact tattcgcaaa gcactgtgct caaactcttc agaaaaaaag gaaaaaaaaa
     1861 aaaagctata gttgtaacat atgtattcca gacctctggt ttaaaggcaa aagaaaaaaa
     1921 atctacagtg tttcttctca tgttttctga tcggaggcat gacaaagcaa gactgaaatc
     1981 tgaactgtgt ctcctgcatg gcaacacgtg tctccgtcag gccctcgcaa ggcccgggga
     2041 gggggttcta cgcctcttgt ctctttgttg catgctgaac actcatcgcc ttcctactgt
     2101 atcctgcctc ctgcagcctc cctcttcctc ctcctcttcc tcttcctcct cttcctcctc
     2161 ctcctcctct tcctccaagt ttgaaaggtc aaacaaaact accacattcc ctacccagtt
     2221 agaagaaaac caccgtcctg acagttgtga tcgcatggag tacttttaga ttattagcac
     2281 ctgtttttac ctcgtttgtg ggcgtgtttg tatgtgcaca tgtatgaagt cggcacatgc
     2341 accttctgta tgggcagagg cgtggcatct acagaagagc agatgccaac tttgtgcttt
     2401 tagtgaatac attaaaaaaa aaaaaccaac ggtccttatt gagtggaatt ctatttgatg
     2461 caaatatttg agctctttaa gactttaaaa ctagataatg tgccaagctt ttaggactgc
     2521 tcaccagtgc cctctgaaga aacaccagta ctttttcctg tttgtgtaat aaaggcatat
     2581 ttgtatttg
//
