LOCUS       NM_010778               1887 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus CD46 antigen, complement regulatory protein (Cd46),
            transcript variant 1, mRNA.
ACCESSION   NM_010778
VERSION     NM_010778.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1887)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1887)
  AUTHORS   Geng,X., Xue,J., Zheng,H., Suo,L., Zeng,H., Zhao,M., Song,S.,
            Liu,Y., Zhao,C. and Yang,P.
  TITLE     The association between CD46 expression in B cells and the
            pathogenesis of airway allergy
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (1), 166845 (2024)
   PUBMED   37579982
  REMARK    GeneRIF: The association between CD46 expression in B cells and the
            pathogenesis of airway allergy.
REFERENCE   3  (bases 1 to 1887)
  AUTHORS   Esposito,P., Rodriguez,C., Gandelman,M., Liang,J. and Ismail,N.
  TITLE     CD46 expression in the central nervous system of male and female
            pubescent mice
  JOURNAL   J Neuroimmunol 385, 578234 (2023)
   PUBMED   37944208
  REMARK    GeneRIF: CD46 expression in the central nervous system of male and
            female pubescent mice.
REFERENCE   4  (bases 1 to 1887)
  AUTHORS   Lu,M., Dravid,P., Zhang,Y., Trivedi,S., Li,A., Harder,O., Kc,M.,
            Chaiwatpongsakorn,S., Zani,A., Kenney,A., Zeng,C., Cai,C., Ye,C.,
            Liang,X., Shimamura,M., Liu,S.L., Mejias,A., Ramilo,O.,
            Boyaka,P.N., Qiu,J., Martinez-Sobrido,L., Yount,J.S., Peeples,M.E.,
            Kapoor,A., Niewiesk,S. and Li,J.
  TITLE     A safe and highly efficacious measles virus-based vaccine
            expressing SARS-CoV-2 stabilized prefusion spike
  JOURNAL   Proc Natl Acad Sci U S A 118 (12) (2021)
   PUBMED   33688034
REFERENCE   5  (bases 1 to 1887)
  AUTHORS   Collin,G.B., Gogna,N., Chang,B., Damkham,N., Pinkney,J., Hyde,L.F.,
            Stone,L., Naggert,J.K., Nishina,P.M. and Krebs,M.P.
  TITLE     Mouse Models of Inherited Retinal Degeneration with Photoreceptor
            Cell Loss
  JOURNAL   Cells 9 (4), 931 (2020)
   PUBMED   32290105
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1887)
  AUTHORS   Liszewski,M.K., Leung,M., Cui,W., Subramanian,V.B., Parkinson,J.,
            Barlow,P.N., Manchester,M. and Atkinson,J.P.
  TITLE     Dissecting sites important for complement regulatory activity in
            membrane cofactor protein (MCP; CD46)
  JOURNAL   J Biol Chem 275 (48), 37692-37701 (2000)
   PUBMED   10960475
REFERENCE   7  (bases 1 to 1887)
  AUTHORS   Evlashev,A., Moyse,E., Valentin,H., Azocar,O.,
            Trescol-Biemont,M.C., Marie,J.C., Rabourdin-Combe,C. and Horvat,B.
  TITLE     Productive measles virus brain infection and apoptosis in CD46
            transgenic mice
  JOURNAL   J Virol 74 (3), 1373-1382 (2000)
   PUBMED   10627548
REFERENCE   8  (bases 1 to 1887)
  AUTHORS   Nomura,M., Tsujimura,A., Shida,K., Matsumoto,M., Matsuda,Y.,
            Toyoshima,K. and Seya,T.
  TITLE     Membrane and secretory forms of mouse membrane cofactor protein
            (CD46) generated from a single gene through alternative splicing
  JOURNAL   Immunogenetics 50 (5-6), 245-254 (1999)
   PUBMED   10630288
REFERENCE   9  (bases 1 to 1887)
  AUTHORS   Miwa,T., Nonaka,M., Okada,N., Wakana,S., Shiroishi,T. and Okada,H.
  TITLE     Molecular cloning of rat and mouse membrane cofactor protein (MCP,
            CD46): preferential expression in testis and close linkage between
            the mouse Mcp and Cr2 genes on distal chromosome 1
  JOURNAL   Immunogenetics 48 (6), 363-371 (1998)
   PUBMED   9799332
REFERENCE   10 (bases 1 to 1887)
  AUTHORS   Tsujimura,A., Shida,K., Kitamura,M., Nomura,M., Takeda,J.,
            Tanaka,H., Matsumoto,M., Matsumiya,K., Okuyama,A., Nishimune,Y.,
            Okabe,M. and Seya,T.
  TITLE     Molecular cloning of a murine homologue of membrane cofactor
            protein (CD46): preferential expression in testicular germ cells
  JOURNAL   Biochem J 330 (Pt 1) (Pt 1), 163-168 (1998)
   PUBMED   9461505
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK006632.1, AB010919.1, AC139206.5 and BE634816.1.
            
            On Aug 27, 2015 this sequence version replaced NM_010778.3.
            
            Transcript Variant: This variant (1) encodes the protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK006632.1, BC150660.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AK006632.1         2-4
            4-1159              AB010919.1         1-1156
            1160-1425           AC139206.5         153790-154055       c
            1426-1887           BE634816.1         1-462               c
FEATURES             Location/Qualifiers
     source          1..1887
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 98.41 cM"
     gene            1..1887
                     /gene="Cd46"
                     /gene_synonym="Mcp"
                     /note="CD46 antigen, complement regulatory protein"
                     /db_xref="GeneID:17221"
                     /db_xref="MGI:MGI:1203290"
     exon            1..150
                     /gene="Cd46"
                     /gene_synonym="Mcp"
                     /inference="alignment:Splign:2.1.0"
     exon            151..339
                     /gene="Cd46"
                     /gene_synonym="Mcp"
                     /inference="alignment:Splign:2.1.0"
     exon            340..442
                     /gene="Cd46"
                     /gene_synonym="Mcp"
                     /inference="alignment:Splign:2.1.0"
     exon            443..531
                     /gene="Cd46"
                     /gene_synonym="Mcp"
                     /inference="alignment:Splign:2.1.0"
     exon            532..729
                     /gene="Cd46"
                     /gene_synonym="Mcp"
                     /inference="alignment:Splign:2.1.0"
     exon            730..912
                     /gene="Cd46"
                     /gene_synonym="Mcp"
                     /inference="alignment:Splign:2.1.0"
     exon            913..960
                     /gene="Cd46"
                     /gene_synonym="Mcp"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1002
                     /gene="Cd46"
                     /gene_synonym="Mcp"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1038
                     /gene="Cd46"
                     /gene_synonym="Mcp"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1099
                     /gene="Cd46"
                     /gene_synonym="Mcp"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1875
                     /gene="Cd46"
                     /gene_synonym="Mcp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1192..1197
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cd46"
                     /gene_synonym="Mcp"
                     /note="hexamer: ATTATA"
     polyA_site      1214
                     /gene="Cd46"
                     /gene_synonym="Mcp"
                     /note="major polyA site"
     regulatory      1853..1858
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cd46"
                     /gene_synonym="Mcp"
                     /note="hexamer: ATTAAA"
     polyA_site      1875
                     /gene="Cd46"
                     /gene_synonym="Mcp"
ORIGIN      
        1 agtttccctt tcagtctggt aacatgacgg cggcgcctct tatgccagac tcaacgcacc
       61 cctgtcgcag aaggaagagc tacactttct tctggtgctc cttgggcgtc tatgctgagg
      121 cccttctgtt tctgctgtct catttatctg atgcctgtga actaccacgg ccatttgaag
      181 ctatggaact caagggtaca cctaaactct tttatgccgt tggagagaaa atagaatata
      241 agtgtaaaaa aggatacctg tatctgtctc catacctgat gattgctacc tgtgagccaa
      301 atcatacatg ggtccctatt tcagatgctg gttgtattaa agttcaatgt actatgttac
      361 aagacccttc atttggcaaa gtatactaca tagatggcag cttttcatgg ggtgctcgag
      421 ctaaatttac ttgtatggaa ggttattacg tagttggtat gtcagttcta cactgtgtgc
      481 ttaaaggtga tgatgaagca tactggaatg gctatccccc acattgtgaa aagatttatt
      541 gtttaccacc tccaaaaata aaaaatggaa cacataccct tactgatata aatgtattca
      601 aataccatga agcagtaagt tacagttgtg atcctacccc agggccagat aagttttccc
      661 ttgttggaac aagcatgata ttctgtgctg gccataacac ctggagtaac agccctccgg
      721 agtgtaaagt ggtaaaatgt ccaaatccag tactacaaaa tggaagactg atatcaggag
      781 ctggcgaaat attttcctat caatcaacag tgatgtttga gtgtttgcaa ggattttaca
      841 tggaaggcag tagcatggtg atctgtagtg ctaataactc ttgggagcca tctatcccaa
      901 aatgtcttaa aggtcctagg cctactcatc ctaccaagcc tccagtttat aattatacag
      961 gatatcctag tccccgtgaa ggaatattta gccaagaatt agatgcatgg attattgctt
     1021 tgattgttat tacgtcaatt gttggagttt ttatactttg tctcattgtg ctcaggtgtt
     1081 ttgagcacag gaagaaaaca aatgtatctg cagcaagatg aaaatctcat gtgtggaagt
     1141 cattactgtt ccatttttga aaactggatc ttcaagtctg gcaaacgcaa aattatatat
     1201 ttgcaggagc ttcatttgtg gtaatgtgtg tgtttctagt gtaaatcaaa tctgtgttta
     1261 taaatacaat ctgtatctaa cctctctact ataacctcac atttcagccc ctgcagctca
     1321 ccaagggttc tcagtatcca accatgagtg cctgtgtact aagcagaatg ttctgcctgt
     1381 gacatggtat ttgcaggaag aaggtcacat ttccaagcag acaccaaacc ctgtccagtt
     1441 ggagctctta tccccatgcc tcacactttc actgcacata atggctgtga attaaccaca
     1501 tctgtgcctt ccacactcag tctgtcacct gaaatgctta atattctctc taaatccatg
     1561 tacctctaac gccaatgcat gtcctaccag tcctgtgaag ctctaactcc tcaggttctt
     1621 tatctttatt ggttagcctt aagttagcca catttaagag tctgtataca tgtgcctaat
     1681 aggagatgta attttcatat cacttgaacg tattcatagg tctcaaaaaa caaagtaaaa
     1741 cctgtgtaac taataggaca tgatgatttt tatgtgaaaa taaaaatgtg acagtcaact
     1801 ctccatataa agaggataac agcttaaaga aaatcagagt ttaattctac ctattaaaaa
     1861 ccaaattttc aaagaaaaaa aaaaaaa
//
