LOCUS       NM_001039151            4409 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus CD44 antigen (Cd44), transcript variant 3, mRNA.
ACCESSION   NM_001039151
VERSION     NM_001039151.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4409)
  AUTHORS   de Haan,S., Corbat,A.A., Cederroth,C.R., Autrum,L.G., Hankeova,S.,
            Driver,E.C., Canlon,B., Kelley,M.W. and Andersson,E.R.
  TITLE     Jag1 represses Notch activation in lateral supporting cells and
            inhibits an outer hair cell fate in the medial cochlea
  JOURNAL   Development 151 (21) (2024)
   PUBMED   39373109
REFERENCE   2  (bases 1 to 4409)
  AUTHORS   Ayten,M., Straub,T., Kaplan,L., Hauck,S.M., Grosche,A. and
            Koch,S.F.
  TITLE     CD44 signaling in Muller cells impacts photoreceptor function and
            survival in healthy and diseased retinas
  JOURNAL   J Neuroinflammation 21 (1), 190 (2024)
   PUBMED   39095775
  REMARK    GeneRIF: CD44 signaling in Muller cells impacts photoreceptor
            function and survival in healthy and diseased retinas.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4409)
  AUTHORS   Tan,Z., Chen,P., Dong,X., Guo,S., Leung,V.Y.L., Cheung,J.P.Y.,
            Chan,D., Richardson,S.M., Hoyland,J.A., To,M.K.T. and Cheah,K.S.E.
  TITLE     Progenitor-like cells contributing to cellular heterogeneity in the
            nucleus pulposus are lost in intervertebral disc degeneration
  JOURNAL   Cell Rep 43 (6), 114342 (2024)
   PUBMED   38865240
REFERENCE   4  (bases 1 to 4409)
  AUTHORS   Bradford,B.M., Walmsley-Rowe,L., Reynolds,J., Verity,N. and
            Mabbott,N.A.
  TITLE     Cell adhesion molecule CD44 is dispensable for reactive astrocyte
            activation during prion disease
  JOURNAL   Sci Rep 14 (1), 13749 (2024)
   PUBMED   38877012
  REMARK    GeneRIF: Cell adhesion molecule CD44 is dispensable for reactive
            astrocyte activation during prion disease.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4409)
  AUTHORS   Weng,X., Jiang,H., Walker,D.J., Zhou,H., Lin,D., Wang,J. and
            Kang,L.
  TITLE     Deletion of CD44 promotes adipogenesis by regulating PPARgamma and
            cell cycle-related pathways
  JOURNAL   J Endocrinol 262 (1), e240079 (2024)
   PUBMED   38692289
  REMARK    GeneRIF: Deletion of CD44 promotes adipogenesis by regulating
            PPARgamma and cell cycle-related pathways.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4409)
  AUTHORS   He,Q., Lesley,J., Hyman,R., Ishihara,K. and Kincade,P.W.
  TITLE     Molecular isoforms of murine CD44 and evidence that the membrane
            proximal domain is not critical for hyaluronate recognition
  JOURNAL   J Cell Biol 119 (6), 1711-1719 (1992)
   PUBMED   1469058
REFERENCE   7  (bases 1 to 4409)
  AUTHORS   Morse,H.C. 3rd.
  TITLE     Genetic nomenclature for loci controlling surface antigens of mouse
            hemopoietic cells
  JOURNAL   J Immunol 149 (10), 3129-3134 (1992)
   PUBMED   1431091
  REMARK    Review article
            Erratum:[J Immunol 1993 Mar 15;150(6):2563]
REFERENCE   8  (bases 1 to 4409)
  AUTHORS   Wang,W., Kobayashi,S. and Uede,T.
  TITLE     Dysregulated expression of cellular adhesion molecules in
            autoimmune-prone mice
  JOURNAL   J Dermatol 19 (11), 831-835 (1992)
   PUBMED   1284074
REFERENCE   9  (bases 1 to 4409)
  AUTHORS   Moen,C.J., Snoek,M., Hart,A.A. and Demant,P.
  TITLE     Scc-1, a novel colon cancer susceptibility gene in the mouse:
            linkage to CD44 (Ly-24, Pgp-1) on chromosome 2
  JOURNAL   Oncogene 7 (3), 563-566 (1992)
   PUBMED   1347918
REFERENCE   10 (bases 1 to 4409)
  AUTHORS   Fleischman,R.A. and Mintz,B.
  TITLE     Prevention of genetic anemias in mice by microinjection of normal
            hematopoietic stem cells into the fetal placenta
  JOURNAL   Proc Natl Acad Sci U S A 76 (11), 5736-5740 (1979)
   PUBMED   42904
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL844155.6 and AK045226.1.
            
            Transcript Variant: This variant (3) lacks several alternate,
            in-frame, exons, compared to variant 1. The resulting protein
            (isoform c) is shorter when it is compared to isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK152099.1, AK144125.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-155               AL844155.6         139813-139967       c
            156-1573            AK045226.1         2-1419
            1574-4409           AL844155.6         49443-52278         c
FEATURES             Location/Qualifiers
     source          1..4409
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 54.13 cM"
     gene            1..4409
                     /gene="Cd44"
                     /gene_synonym="HERMES; Ly-24; Pgp-1"
                     /note="CD44 antigen"
                     /db_xref="GeneID:12505"
                     /db_xref="MGI:MGI:88338"
     exon            1..398
                     /gene="Cd44"
                     /gene_synonym="HERMES; Ly-24; Pgp-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             320..1417
                     /gene="Cd44"
                     /gene_synonym="HERMES; Ly-24; Pgp-1"
                     /note="isoform c precursor is encoded by transcript
                     variant 3; PGP-I; HUTCH-I; ECMR-III; hermes antigen;
                     hyaluronate receptor; lymphocyte antigen 24; phagocytic
                     glycoprotein 1; extracellular matrix receptor III; GP90
                     lymphocyte homing/adhesion receptor; phagocytic
                     glycoprotein I"
                     /codon_start=1
                     /product="CD44 antigen isoform c precursor"
                     /protein_id="NP_001034240.1"
                     /db_xref="CCDS:CCDS16471.1"
                     /db_xref="GeneID:12505"
                     /db_xref="MGI:MGI:88338"
                     /translation="MDKFWWHTAWGLCLLQLSLAHPHQQIDLNVTCRYAGVFHVEKNG
                     RYSISRTEAADLCQAFNSTLPTMDQMKLALSKGFETCRYGFIEGNVVIPRIHPNAICA
                     ANHTGVYILVTSNTSHYDTYCFNASAPPEEDCTSVTDLPNSFDGPVTITIVNRDGTRY
                     SKKGEYRTHQEDIDASNIIDDDVSSGSTIEKSTPESYILHTYLPTEQPTGDQDDSFFI
                     RSTLATRDRDSSKDSRGSSRTVTHGSELAGHSSANQDSGVTTTSGPMRRPQIPEWLII
                     LASLLALALILAVCIAVNSRRRCGQKKKLVINGGNGTVEDRKPSELNGEASKSQEMVH
                     LVNKEPSETPDQCMTADETRNLQSVDMKIGV"
     exon            399..564
                     /gene="Cd44"
                     /gene_synonym="HERMES; Ly-24; Pgp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            565..701
                     /gene="Cd44"
                     /gene_synonym="HERMES; Ly-24; Pgp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            702..770
                     /gene="Cd44"
                     /gene_synonym="HERMES; Ly-24; Pgp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            771..992
                     /gene="Cd44"
                     /gene_synonym="HERMES; Ly-24; Pgp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1061
                     /gene="Cd44"
                     /gene_synonym="HERMES; Ly-24; Pgp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1133
                     /gene="Cd44"
                     /gene_synonym="HERMES; Ly-24; Pgp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1212
                     /gene="Cd44"
                     /gene_synonym="HERMES; Ly-24; Pgp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..4409
                     /gene="Cd44"
                     /gene_synonym="HERMES; Ly-24; Pgp-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4143..4148
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cd44"
                     /gene_synonym="HERMES; Ly-24; Pgp-1"
                     /note="hexamer: ATTAAA"
     polyA_site      4166
                     /gene="Cd44"
                     /gene_synonym="HERMES; Ly-24; Pgp-1"
                     /note="major polyA site"
     regulatory      4385..4390
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cd44"
                     /gene_synonym="HERMES; Ly-24; Pgp-1"
                     /note="hexamer: AATAAA"
     polyA_site      4409
                     /gene="Cd44"
                     /gene_synonym="HERMES; Ly-24; Pgp-1"
                     /note="major polyA site"
ORIGIN      
        1 ggggggcggc cattctcttc tgtccaagag agcagggcag gagtgcaggg gcagtagcga
       61 aagcaggctg gtgtgtcttt aaacttccgt tggctgctta gtcacagccc cctcgctttg
      121 ggtgtgtcct tcgcgcgctc cctccctctt aggtcactca ctctttcaaa gcctggaata
      181 aaaaccacag ccaacttccg aagcggtctc attgcccagc agcccccagc cagtgacagg
      241 ttccattcac cctcgttgcc cttctcccca cgaccctttt ccagaggcga ctagatccct
      301 ccgtttcatc cagcacgcca tggacaagtt ttggtggcac acagcttggg gactttgcct
      361 cttgcagttg agcctggcac atccacatca gcagatcgat ttgaatgtaa cctgccgcta
      421 cgcaggtgta ttccatgtgg agaaaaatgg ccgctacagt atctcccgga ctgaggcagc
      481 tgacctctgc caggctttca acagtacctt acccaccatg gaccaaatga agttggccct
      541 gagcaagggt tttgaaacat gcaggtatgg gttcatagaa ggaaatgtgg taattccgag
      601 gattcatccc aacgctatct gtgcagccaa ccacacagga gtatatatcc tcgtcacgtc
      661 caacacctcc cactatgaca catattgctt caatgcctca gcccctcctg aagaagactg
      721 tacatcagtc acagacctac ccaattcctt cgatggaccg gttaccataa ctattgtcaa
      781 ccgtgatggt actcgctaca gcaagaaggg cgagtataga acacaccaag aagacatcga
      841 tgcttcaaac attatagatg acgatgtcag cagcggctcc accatcgaga agagcacccc
      901 agaaagctac attttgcaca cctaccttcc tactgaacag cctactggag atcaggatga
      961 ctccttcttt atccggagca ccttggccac cagagatcga gactcatcca aggactccag
     1021 ggggagttcc cgcactgtga ctcatggatc cgaattagct ggacactcaa gtgcgaacca
     1081 ggacagtgga gtgaccacaa cttctggtcc tatgaggaga cctcagattc cagaatggct
     1141 catcatcttg gcatctctcc tggcactggc tctgattctt gccgtctgca tcgcggtcaa
     1201 tagtaggaga aggtgtgggc agaagaaaaa gctggtgatc aacggtggca atgggacggt
     1261 ggaagacagg aaacccagtg agctcaacgg ggaggccagc aagtctcagg aaatggtgca
     1321 tttggtgaac aaggaaccat cagagacccc ggaccagtgt atgacagctg acgagacccg
     1381 gaatctgcag agtgtggaca tgaagattgg ggtgtagtgc ctacgccatt aacttgaaaa
     1441 gacagcacga ttggagacgt cattcctggg agctgggacc ctccacagat gcaatgtgct
     1501 actgactatt attattgggg attatgttta gcataaaatt ttctattcct tttttatttt
     1561 atgtcatttt tttagagtct gttccaattt atgaaaatag cattgctttc tgaaatgagg
     1621 gcccaaataa tactccatta agaatttgac ttttccagtt ccttcctagg ggccttgcat
     1681 taccagggta tgctaccata ggcttctacc aaatgcacat tcttggtccc tattgaacct
     1741 tatccctacc caaagtccca gggaacatcc accagctaag gattttcccc agaacctaga
     1801 ttggtctctg ggaggaaatt tgaatgggtc catattgcct ctccagcagt ccaatcctta
     1861 ggcattgctt tccagcgggg tgggagatca ggtgtactgg ttacatactc tctttataga
     1921 ctcccttctg ctggaaaatt ttcagatgct tctgagagat ccccaaaggg tgatgctatt
     1981 tatctttagt aagctattta tctttgtttt tgaaatatca aaccctggag gtcctttgtt
     2041 cagtatgact ttttttttta ttttgtttta ttttgttttg ttttgttttg tttttttagg
     2101 ttactttatc agaagcataa cagggtataa attgattcat aataagtacc ggtccatctt
     2161 ccatcttgac ccgttgtgct gtgatccttc agtttctaaa caagcaaagt ctgagtcttt
     2221 gtagcacatc agtgtggcct tagtatggtc ctcctaagct catgctagag catctgagcc
     2281 tgctgggttc acccagctca atctcattga agatcaggga caggagcact gttttcattc
     2341 caggctctca aaggggtttc tctcctgttc aagaatctga agtgagagta ggcaagcttc
     2401 agtccctttt gtgctttggt gaccaccctt ttctatttct taaagaacac attaagtttt
     2461 tatatcttac aacgtttgtg gtcctgtgtc atagagaatg atcttattag tgatttcaca
     2521 aaacattgtg gtggggactt gtggcgcctt ctcataaaag gagaagccaa cagaaatgaa
     2581 agtgtaaaca tccagcagta gcttgccacg aggaggaggt gtgatgtaca acccccatct
     2641 cactctagcc atggctgtgt ttgttggtgc tttcacaagc gagttggtac ttagaatcag
     2701 ttccctgggg aacccctcaa aaagccacag gactgcccac cactgggatc ttatcatcag
     2761 ataagcaggt ttatggttta gcaaaaggag aatgctgtta ccctcatagt tttcacatat
     2821 tgggcaagtg ttcattcatc tgccaggatg tcccattgct cctggatctt cctaggtatc
     2881 ttgtagaata tattaactct ataaaataag gctgtctcta aaatggaact tcctttctaa
     2941 gggtcccact tttactgttg actaaattta tatgtttagt aggttttttt ttccaataaa
     3001 aacaaacaaa aaaaaaaaaa ggagaaaaaa ttttcacctg agtcaggttt gagtttatat
     3061 caaaagtgga tgtgaagatg ttccttaaag gagatacacg gactttctgg cacaattttg
     3121 agcctcagct ctccttactc atattctagc ctccctcctt ccctgcccat ctctccccca
     3181 gagccatggc tttcatggac tttctctttc tctgtgaata ctataagcca gttccatatt
     3241 tagacacctg gttttcttgt tcaaatagac actagatgat tcttggctat tctccactgg
     3301 tattagaatg tcccctgtcc ttagagctat cctggcctac cacacccaca acaggctccc
     3361 tggggctctt taacctatat gcagcaagcc actctgggat tggtcataaa agggctctgt
     3421 caagctctcc atgacccctt gatgcccttt gagggcacaa gaagagtcat acaagactca
     3481 gagctaaaga taattctcta cccattctaa aaaagtccac tagttgggtt gtggtaggac
     3541 attgcttgcc atagtggtga tgattctggt agcacaatct gactttgagt tactccatga
     3601 ttttgtaaag tattaggagc ccttaaagtg ttcttttgcc atcaactata aatttctcat
     3661 atatcctgga ggctttcctt ctctttgcct tgggtaaaaa tcaaatgagg tgaaagatac
     3721 cttcatgtcc atattttgta tgttctagct agataaaatg gatgtttcag aaaagccttt
     3781 aaaaatcttt atattgacat ccataacacc aaaaactgtc tttttagcta aaatcgaccc
     3841 aagactgtca cagcaaagta gaagaaacag ccatcttctt tggaaaagta aaatgttcat
     3901 aagaacaggg attgcccact atgatgataa tgatgtactg tgtctttgtg taagtcctat
     3961 gtgttgactt ttcaaatata gccaattgct taggtatgta caatgagttt ttctattgtt
     4021 cctttgattt ttcagagacc ccccctttct ttttccagtt tttgtatatt tattgattga
     4081 ctaataataa tgaggaaaac ctgatgtgta cattacccga ttgaaagtgt gtattggaaa
     4141 atattaaaag gttgtaaaaa atggaaccta gggtctctgg tgtgaagggt ctgggaagtg
     4201 gagaggggca gaaagtgatt gtctggatgt ctgaataata tggaagaagt cagaggcagc
     4261 tggcatcctt tgttttgttt tgttttgttt tgttctttta tagccccccc ctcctatttt
     4321 tctttggtgt ttttgttttg tttgtttgat ttttgaaaca ggatctcata gagctcagac
     4381 tggtaataaa ttcaatatgt agccgaaaa
//
