LOCUS       NM_011616               1305 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Mus musculus CD40 ligand (Cd40lg), mRNA.
ACCESSION   NM_011616
VERSION     NM_011616.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1305)
  AUTHORS   Canesso,M.C.C., Castro,T.B.R., Nakandakari-Higa,S., Lockhart,A.,
            Luehr,J., Bortolatto,J., Parsa,R., Esterhazy,D., Lyu,M., Liu,T.T.,
            Murphy,K.M., Sonnenberg,G.F., Reis,B.S., Victora,G.D. and Mucida,D.
  TITLE     Identification of antigen-presenting cell-T cell interactions
            driving immune responses to food
  JOURNAL   Science, eado5088 (2024) In press
   PUBMED   39700315
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 1305)
  AUTHORS   Chudnovskiy,A., Castro,T.B.R., Nakandakari-Higa,S., Cui,A.,
            Lin,C.H., Sade-Feldman,M., Phillips,B.K., Pae,J., Mesin,L.,
            Bortolatto,J., Schweitzer,L.D., Pasqual,G., Lu,L.F., Hacohen,N. and
            Victora,G.D.
  TITLE     Proximity-dependent labeling identifies dendritic cells that drive
            the tumor-specific CD4+ T cell response
  JOURNAL   Sci Immunol 9 (100), eadq8843 (2024)
   PUBMED   39365874
REFERENCE   3  (bases 1 to 1305)
  AUTHORS   Fisher,J.S., Adan-Barrientos,I., Kumar,N.R. and Lancaster,J.N.
  TITLE     The aged microenvironment impairs BCL6 and CD40L induction in CD4+
            T follicular helper cell differentiation
  JOURNAL   Aging Cell 23 (6), e14140 (2024)
   PUBMED   38481058
  REMARK    GeneRIF: The aged microenvironment impairs BCL6 and CD40L induction
            in CD4[+] T follicular helper cell differentiation.
REFERENCE   4  (bases 1 to 1305)
  AUTHORS   Etesami,N.S., Barker,K.A., Shenoy,A.T., De Ana,C.L., Arafa,E.I.,
            Grifno,G.N., Matschulat,A.M., Vannini,M.E., Pihl,R.M.F.,
            Breen,M.P., Soucy,A.M., Goltry,W.N., Ha,C.T., Betsuyaku,H.,
            Browning,J.L., Varelas,X., Traber,K.E., Jones,M.R., Quinton,L.J.,
            Maglione,P.J., Nia,H.T., Belkina,A.C. and Mizgerd,J.P.
  TITLE     B cells in the pneumococcus-infected lung are heterogeneous and
            require CD4+ T cell help including CD40L to become resident memory
            B cells
  JOURNAL   Front Immunol 15, 1382638 (2024)
   PUBMED   38715601
  REMARK    GeneRIF: B cells in the pneumococcus-infected lung are
            heterogeneous and require CD4[+] T cell help including CD40L to
            become resident memory B cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1305)
  AUTHORS   Calzada-Fraile,D., Iborra,S., Ramirez-Huesca,M., Jorge,I.,
            Dotta,E., Hernandez-Garcia,E., Martin-Cofreces,N.,
            Nistal-Villan,E., Veiga,E., Vazquez,J., Pasqual,G. and
            Sanchez-Madrid,F.
  TITLE     Immune synapse formation promotes lipid peroxidation and MHC-I
            upregulation in licensed dendritic cells for efficient priming of
            CD8+ T cells
  JOURNAL   Nat Commun 14 (1), 6772 (2023)
   PUBMED   37880206
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1305)
  AUTHORS   Covey,L.R., Cleary,A.M., Yellin,M.J., Ware,R., Sullivan,G.,
            Belko,J., Parker,M., Rothman,P., Chess,L. and Lederman,S.
  TITLE     Isolation of cDNAs encoding T-BAM, a surface glycoprotein on CD4+ T
            cells mediating contact-dependent helper function for B cells:
            identity with the CD40-ligand
  JOURNAL   Mol Immunol 31 (6), 471-484 (1994)
   PUBMED   7514269
REFERENCE   7  (bases 1 to 1305)
  AUTHORS   Hasbold,J. and Klaus,G.G.
  TITLE     B cells from CBA/N mice do not proliferate following ligation of
            CD40
  JOURNAL   Eur J Immunol 24 (1), 152-157 (1994)
   PUBMED   7517360
REFERENCE   8  (bases 1 to 1305)
  AUTHORS   Kennedy,M.K., Mohler,K.M., Shanebeck,K.D., Baum,P.R., Picha,K.S.,
            Otten-Evans,C.A., Janeway,C.A. Jr. and Grabstein,K.H.
  TITLE     Induction of B cell costimulatory function by recombinant murine
            CD40 ligand
  JOURNAL   Eur J Immunol 24 (1), 116-123 (1994)
   PUBMED   7517359
REFERENCE   9  (bases 1 to 1305)
  AUTHORS   Farrah,T. and Smith,C.A.
  TITLE     Emerging cytokine family
  JOURNAL   Nature 358 (6381), 26 (1992)
   PUBMED   1377364
REFERENCE   10 (bases 1 to 1305)
  AUTHORS   Armitage,R.J., Fanslow,W.C., Strockbine,L., Sato,T.A.,
            Clifford,K.N., Macduff,B.M., Anderson,D.M., Gimpel,S.D.,
            Davis-Smith,T., Maliszewski,C.R. et al.
  TITLE     Molecular and biological characterization of a murine ligand for
            CD40
  JOURNAL   Nature 357 (6373), 80-82 (1992)
   PUBMED   1374165
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL672128.8.
            
            On Sep 6, 2022 this sequence version replaced NM_011616.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X65453.2, BC119225.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849388 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-223               AL672128.8         138735-138957
            224-355             AL672128.8         140612-140743
            356-410             AL672128.8         144371-144425
            411-473             AL672128.8         146385-146447
            474-1305            AL672128.8         149858-150689
FEATURES             Location/Qualifiers
     source          1..1305
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 31.21 cM"
     gene            1..1305
                     /gene="Cd40lg"
                     /gene_synonym="CD154; CD40-L; Cd40l; gp39; HIGM1; IGM;
                     IMD3; Ly-62; Ly62; T-BAM; Tnfsf5; Tnlg8b; TRAP"
                     /note="CD40 ligand"
                     /db_xref="GeneID:21947"
                     /db_xref="MGI:MGI:88337"
     exon            1..223
                     /gene="Cd40lg"
                     /gene_synonym="CD154; CD40-L; Cd40l; gp39; HIGM1; IGM;
                     IMD3; Ly-62; Ly62; T-BAM; Tnfsf5; Tnlg8b; TRAP"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..850
                     /gene="Cd40lg"
                     /gene_synonym="CD154; CD40-L; Cd40l; gp39; HIGM1; IGM;
                     IMD3; Ly-62; Ly62; T-BAM; Tnfsf5; Tnlg8b; TRAP"
                     /note="T-cell antigen Gp39; TNF-related activation
                     protein; tumor necrosis factor ligand superfamily member
                     5; tumor necrosis factor ligand 8b"
                     /codon_start=1
                     /product="CD40 ligand"
                     /protein_id="NP_035746.2"
                     /db_xref="CCDS:CCDS30152.1"
                     /db_xref="GeneID:21947"
                     /db_xref="MGI:MGI:88337"
                     /translation="MIETYSQPSPRSVATGLPASMKIFMYLLTVFLITQMIGSVLFAV
                     YLHRRLDKVEEEVNLHEDFVFIKKLKRCNKGEGSLSLLNCEEMRRQFEDLVKDITLNK
                     EEKKENSFEMQRGDEDPQIAAHVVSEANSNAASVLQWAKKGYYTMKSNLVMLENGKQL
                     TVKREGLYYVYTQVTFCSNREPSSQRPFIVGLWLKPSSGSERILLKAANTHSSSQLCE
                     QQSVHLGGVFELQAGASVFVNVTEASQVIHRVGFSSFGLLKL"
     exon            224..355
                     /gene="Cd40lg"
                     /gene_synonym="CD154; CD40-L; Cd40l; gp39; HIGM1; IGM;
                     IMD3; Ly-62; Ly62; T-BAM; Tnfsf5; Tnlg8b; TRAP"
                     /inference="alignment:Splign:2.1.0"
     exon            356..410
                     /gene="Cd40lg"
                     /gene_synonym="CD154; CD40-L; Cd40l; gp39; HIGM1; IGM;
                     IMD3; Ly-62; Ly62; T-BAM; Tnfsf5; Tnlg8b; TRAP"
                     /inference="alignment:Splign:2.1.0"
     exon            411..473
                     /gene="Cd40lg"
                     /gene_synonym="CD154; CD40-L; Cd40l; gp39; HIGM1; IGM;
                     IMD3; Ly-62; Ly62; T-BAM; Tnfsf5; Tnlg8b; TRAP"
                     /inference="alignment:Splign:2.1.0"
     exon            474..1305
                     /gene="Cd40lg"
                     /gene_synonym="CD154; CD40-L; Cd40l; gp39; HIGM1; IGM;
                     IMD3; Ly-62; Ly62; T-BAM; Tnfsf5; Tnlg8b; TRAP"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gacagtcttc tcatgctgcc tctgtcccat tcttggtcag aagacaccat ttcagctttc
       61 agtcagcatg atagaaacat acagccaacc ttcccccaga tccgtggcaa ctggacttcc
      121 agcgagcatg aagattttta tgtatttact tactgttttc cttatcaccc aaatgattgg
      181 atctgtgctt tttgctgtgt atcttcatag aagattggat aaggtcgaag aggaagtaaa
      241 ccttcatgaa gattttgtat tcataaaaaa gctaaagaga tgcaacaaag gagaaggatc
      301 tttatccttg ctgaactgtg aggagatgag aaggcaattt gaagaccttg tcaaggatat
      361 aacgttaaac aaagaagaga aaaaagaaaa cagctttgaa atgcaaagag gtgatgagga
      421 tcctcaaatt gcagcacacg ttgtaagcga agccaacagt aatgcagcat ccgttctaca
      481 gtgggccaag aaaggatatt ataccatgaa aagcaacttg gtaatgcttg aaaatgggaa
      541 acagctgacg gttaaaagag aaggactcta ttatgtctac actcaagtca ccttctgctc
      601 taatcgggag ccttcgagtc aacgcccatt catcgtcggc ctctggctga agcccagcag
      661 tggatctgag agaatcttac tcaaggcggc aaatacccac agttcctccc agctttgcga
      721 gcagcagtct gttcacttgg gcggagtgtt tgaattacaa gctggtgctt ctgtgtttgt
      781 caacgtgact gaagcaagcc aagtgatcca cagagttggc ttctcatctt ttggcttact
      841 caaactctga acagtgcgct gtcctaggct gcagcagggc tgatgctggc agtcttccct
      901 atacagcaag tcagttagga cctgccctgt gttgaactgc ctatttataa ccctaggatc
      961 ctcctcatgg agaactattt attatgtacc cccaaggcac atagagctgg aataagagaa
     1021 ttacagggca ggcaaaaatc ccaagggacc ctgctcccta agaacttaca atctgaaaca
     1081 gcaaccccac tgattcagac aaccagaaaa gacaaagcca taatacacag atgacagagc
     1141 tctgatgaaa caacagataa ctaatgagca cagttttgtt gttttatggg tgtgtcgttc
     1201 aatggacagt gtacttgact taccagggaa gatgcagaag ggcaactgtg agcctcagct
     1261 cacaatctgt tatggttgac ctgggctccc tgcggcccta gtagg
//
