LOCUS       NM_013488               3086 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus CD4 antigen (Cd4), mRNA.
ACCESSION   NM_013488
VERSION     NM_013488.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3086)
  AUTHORS   Al-Omari,A.A., Cook,K.W., Symonds,P., Skinner,A., Wright,A.,
            Zhu,Y., Coble,V.L., Mohammed,O.J., Choudhury,R.H., Uddin,N.,
            Ranglani,P., Parry,A., Adams,S.E., Lynn,G.M., Durrant,L.G. and
            Brentville,V.A.
  TITLE     Modi-2 a vaccine stimulating CD4 responses to homocitrullinated
            self epitopes as therapy for solid cancers
  JOURNAL   NPJ Vaccines 9 (1), 236 (2024)
   PUBMED   39604380
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3086)
  AUTHORS   Cordeiro,B., Ahn,J.J., Gawde,S., Ucciferri,C., Alvarez-Sanchez,N.,
            Revelo,X.S., Stickle,N., Massey,K., Brooks,D.G., Guthridge,J.M.,
            Pardo,G., Winer,D.A., Axtell,R.C. and Dunn,S.E.
  TITLE     Obesity intensifies sex-specific interferon signaling to
            selectively worsen central nervous system autoimmunity in females
  JOURNAL   Cell Metab 36 (10), 2298-2314 (2024)
   PUBMED   39168127
REFERENCE   3  (bases 1 to 3086)
  AUTHORS   Mahadevan,K.K., Dyevoich,A.M., Chen,Y., Li,B., Sugimoto,H.,
            Sockwell,A.M., McAndrews,K.M., Sthanam,L.K., Wang,H., Shalapour,S.,
            Watowich,S.S. and Kalluri,R.
  TITLE     Type I conventional dendritic cells facilitate immunotherapy in
            pancreatic cancer
  JOURNAL   Science 384 (6703), eadh4567 (2024)
   PUBMED   38935717
REFERENCE   4  (bases 1 to 3086)
  AUTHORS   Jash,A., Pridmore,T., Collins,J.B., Hay,A.M., Hudson,K.E.,
            Luckey,C.J. and Zimring,J.C.
  TITLE     Complement C3 and marginal zone B cells promote IgG-mediated
            enhancement of RBC alloimmunization in mice
  JOURNAL   J Clin Invest 134 (8), e167665 (2024)
   PUBMED   38618959
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3086)
  AUTHORS   Chang,Y., Bach,L., Hasiuk,M., Wen,L., Elmzzahi,T., Tsui,C.,
            Gutierrez-Melo,N., Steffen,T., Utzschneider,D.T., Raj,T.,
            Jost,P.J., Heink,S., Cheng,J., Burton,O.T., Zeitrag,J.,
            Alterauge,D., Dahlstrom,F., Becker,J.C., Kastl,M., Symeonidis,K.,
            van Uelft,M., Becker,M., Reschke,S., Krebs,S., Blum,H.,
            Abdullah,Z., Paeschke,K., Ohnmacht,C., Neumann,C., Liston,A.,
            Meissner,F., Korn,T., Hasenauer,J., Heissmeyer,V., Beyer,M.,
            Kallies,A., Jeker,L.T. and Baumjohann,D.
  TITLE     TGF-beta specifies TFH versus TH17 cell fates in murine CD4+ T
            cells through c-Maf
  JOURNAL   Sci Immunol 9 (93), eadd4818 (2024)
   PUBMED   38427718
  REMARK    Erratum:[Sci Immunol. 2024 May 31;9(95):eadp3365. doi:
            10.1126/sciimmunol.adq3365.. PMID: 38820142]
REFERENCE   6  (bases 1 to 3086)
  AUTHORS   Wineman,J.P., Gilmore,G.L., Gritzmacher,C., Torbett,B.E. and
            Muller-Sieburg,C.E.
  TITLE     CD4 is expressed on murine pluripotent hematopoietic stem cells
  JOURNAL   Blood 80 (7), 1717-1724 (1992)
   PUBMED   1391941
REFERENCE   7  (bases 1 to 3086)
  AUTHORS   Ludwig,T., Ruther,U., Metzger,R., Copeland,N.G., Jenkins,N.A.,
            Lobel,P. and Hoflack,B.
  TITLE     Gene and pseudogene of the mouse cation-dependent mannose
            6-phosphate receptor. Genomic organization, expression, and
            chromosomal localization
  JOURNAL   J Biol Chem 267 (17), 12211-12219 (1992)
   PUBMED   1376319
REFERENCE   8  (bases 1 to 3086)
  AUTHORS   Mori,T., Gou,M.W., Yoshida,H., Saito,S. and Mori,E.
  TITLE     Expression of the signal transducing regions of CD4-like and lck
            genes in murine egg
  JOURNAL   Biochem Biophys Res Commun 182 (2), 527-533 (1992)
   PUBMED   1370884
REFERENCE   9  (bases 1 to 3086)
  AUTHORS   Seldin,M.F., Mattei,M.G. and Hendy,G.N.
  TITLE     Localization of mouse parathyroid hormone-like peptide gene (Pthlh)
            to distal chromosome 6 using interspecific backcross mice and in
            situ hybridization
  JOURNAL   Cytogenet Cell Genet 60 (3-4), 252-254 (1992)
   PUBMED   1354597
REFERENCE   10 (bases 1 to 3086)
  AUTHORS   Potter,M., Pumphrey,J.G. and Bailey,D.W.
  TITLE     Genetics of susceptibility to plasmacytoma induction. I. BALB/cAnN
            (C), C57BL/6N (B6), C57BL/Ka (BK), (C times B6)F1, (C times BK)F1,
            and C times B recombinant-inbred strains
  JOURNAL   J Natl Cancer Inst 54 (6), 1413-1417 (1975)
   PUBMED   1133851
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK153707.1, AK161775.1 and BX639790.1.
            
            On Feb 16, 2018 this sequence version replaced NM_013488.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X04836.1, AK153966.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                AK153707.1         2-68
            68-3073             AK161775.1         1-3006
            3074-3086           BX639790.1         6-18                c
FEATURES             Location/Qualifiers
     source          1..3086
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 59.17 cM"
     gene            1..3086
                     /gene="Cd4"
                     /gene_synonym="L3T4; Ly-4"
                     /note="CD4 antigen"
                     /db_xref="GeneID:12504"
                     /db_xref="MGI:MGI:88335"
     exon            1..121
                     /gene="Cd4"
                     /gene_synonym="L3T4; Ly-4"
                     /inference="alignment:Splign:2.1.0"
     exon            122..212
                     /gene="Cd4"
                     /gene_synonym="L3T4; Ly-4"
                     /inference="alignment:Splign:2.1.0"
     CDS             161..1534
                     /gene="Cd4"
                     /gene_synonym="L3T4; Ly-4"
                     /note="T-cell surface antigen T4/Leu-3; T-cell
                     differentiation antigen L3T4; T-cell surface glycoprotein
                     CD4"
                     /codon_start=1
                     /product="T-cell surface glycoprotein CD4 precursor"
                     /protein_id="NP_038516.1"
                     /db_xref="CCDS:CCDS20535.1"
                     /db_xref="GeneID:12504"
                     /db_xref="MGI:MGI:88335"
                     /translation="MCRAISLRRLLLLLLQLSQLLAVTQGKTLVLGKEGESAELPCES
                     SQKKITVFTWKFSDQRKILGQHGKGVLIRGGSPSQFDRFDSKKGAWEKGSFPLIINKL
                     KMEDSQTYICELENRKEEVELWVFKVTFSPGTSLLQGQSLTLTLDSNSKVSNPLTECK
                     HKKGKVVSGSKVLSMSNLRVQDSDFWNCTVTLDQKKNWFGMTLSVLGFQSTAITAYKS
                     EGESAEFSFPLNFAEENGWGELMWKAEKDSFFQPWISFSIKNKEVSVQKSTKDLKLQL
                     KETLPLTLKIPQVSLQFAGSGNLTLTLDKGTLHQEVNLVVMKVAQLNNTLTCEVMGPT
                     SPKMRLTLKQENQEARVSEEQKVVQVVAPETGLWQCLLSEGDKVKMDSRIQVLSRGVN
                     QTVFLACVLGGSFGFLGFLGLCILCCVRCRHQQRQAARMSQIKRLLSEKKTCQCPHRM
                     QKSHNLI"
     exon            213..380
                     /gene="Cd4"
                     /gene_synonym="L3T4; Ly-4"
                     /inference="alignment:Splign:2.1.0"
     exon            381..542
                     /gene="Cd4"
                     /gene_synonym="L3T4; Ly-4"
                     /inference="alignment:Splign:2.1.0"
     exon            543..779
                     /gene="Cd4"
                     /gene_synonym="L3T4; Ly-4"
                     /inference="alignment:Splign:2.1.0"
     exon            780..1115
                     /gene="Cd4"
                     /gene_synonym="L3T4; Ly-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1316
                     /gene="Cd4"
                     /gene_synonym="L3T4; Ly-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1435
                     /gene="Cd4"
                     /gene_synonym="L3T4; Ly-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1436..1503
                     /gene="Cd4"
                     /gene_synonym="L3T4; Ly-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1504..3086
                     /gene="Cd4"
                     /gene_synonym="L3T4; Ly-4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3064..3069
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cd4"
                     /gene_synonym="L3T4; Ly-4"
                     /note="hexamer: AATAAA"
     polyA_site      3083
                     /gene="Cd4"
                     /gene_synonym="L3T4; Ly-4"
                     /note="major polyA site"
ORIGIN      
        1 acgaacatct gtgaaggcaa agcaagactc tcttcttcac taggtacctg tttgcaaagt
       61 ctcgagccct catatacaca cacctgtgca agaagcagag tgaaggaagg actggccaga
      121 ggctcagatt cccaaccaac aagagctcaa ggagaccacc atgtgccgag ccatctctct
      181 taggcgcttg ctgctgctgc tgctgcagct gtcacaactc ctagctgtca ctcaagggaa
      241 gacgctggtg ctggggaagg aaggggaatc agcagaactg ccctgcgaga gttcccagaa
      301 gaagatcaca gtcttcacct ggaagttctc tgaccagagg aagattctgg ggcagcatgg
      361 caaaggtgta ttaattagag gaggttcgcc ttcgcagttt gatcgttttg attccaaaaa
      421 aggggcatgg gagaaaggat cgtttcctct catcatcaat aaacttaaga tggaagactc
      481 tcagacttat atctgtgagc tggagaacag gaaagaggag gtggagttgt gggtgttcaa
      541 agtgaccttc agtccgggta ccagcctgtt gcaagggcag agcctgaccc tgaccttgga
      601 tagcaactct aaggtctcta accccttgac agagtgcaaa cacaaaaagg gtaaagttgt
      661 cagtggttcc aaagttctct ccatgtccaa cctaagggtt caggacagcg acttctggaa
      721 ctgcaccgtg accctggacc agaaaaagaa ctggttcggc atgacactct cagtgctggg
      781 ttttcagagc acagctatca cggcctataa gagtgaggga gagtcagcgg agttctcctt
      841 cccactcaac tttgcagagg aaaacgggtg gggagagctg atgtggaagg cagagaagga
      901 ttctttcttc cagccctgga tctccttctc cataaagaac aaagaggtgt ccgtacaaaa
      961 gtccaccaaa gacctcaagc tccagctgaa ggaaacgctc ccactcaccc tcaagatacc
     1021 ccaggtctcg cttcagtttg ctggttctgg caacctgact ctgactctgg acaaagggac
     1081 actgcatcag gaagtgaacc tggtggtgat gaaagtggct cagctcaaca atactttgac
     1141 ctgtgaggtg atgggaccta cctctcccaa gatgagactg accctgaagc aggagaacca
     1201 ggaggccagg gtctctgagg agcagaaagt agttcaagtg gtggcccctg agacagggct
     1261 gtggcagtgt ctactgagtg aaggtgataa ggtcaagatg gactccagga tccaggtttt
     1321 atccagaggg gtgaaccaga cagtgttcct ggcttgcgtg ctgggtggct ccttcggctt
     1381 tctgggtttc cttgggctct gcatcctctg ctgtgtcagg tgccggcacc aacagcgcca
     1441 ggcagcacga atgtctcaga tcaagaggct cctcagtgag aagaagacct gccagtgccc
     1501 ccaccggatg cagaagagcc ataatctcat ctgaggccta ggccccacct gcagcccacc
     1561 acctgcgtcc tgtctcatcg cccgaggcct ggggaccaga tgaatgtagc agacacgctg
     1621 cctccggcct tctgctctcc tcttccacaa ccggccacgg tttccctccc tctgttccca
     1681 agcctgtctg tctgcagagc ttgccctctg cgtttcagac actcaagcac accccatcag
     1741 cttatttatt cttcgctgct gcctttctgc cagagcctcg gcccttctcg gactaaggtc
     1801 ctggaacctt tttccagctg tctgcttgga tcaaagggca gtgtatagca cctggcacgg
     1861 atggtgggac tggtgtctgg aaatacacag cacagtttac gagagggctc tgggaccaag
     1921 ctgagtgggg cagggagggc cgggaggttg tgcatgtcac acatgaagca tgtcaggggc
     1981 aaatgaagac tgagaggctg cgggagtcag cctcagcttc ccatgatgcc tgcttctctt
     2041 ttgaatttgc aagaccagac tcacattcta accagtgcac caacacacat ccaagccaca
     2101 cacctgtcca tatatccaaa cagcatatct taattcataa gccactttaa tgtcccaggc
     2161 attcgaccct tacaaaaacc ttacaagtgg atgagcggta aaaagcctca tgaactgagt
     2221 ggaaggagag gattaactct tgaaagttgt cccctatgta tgtaccatga ccctcatgtg
     2281 tacacaacac acacacacac acacacacat acacacacga acacacgcat gttgcacaca
     2341 tgcatgcacg ctgaaatcct acaagctgac agtgatgact aagatggcag agataaccag
     2401 tcatccctag tgaaatggaa cttggttgaa tgactaccca aggttaccca gctaacaagt
     2461 gctgatgtca gggccaaccc agggctcctg atccctagag ccaagccact acatggaaca
     2521 cagggatgaa taccacacag atctctggag ctagttccag gccctcggta tacacacaca
     2581 cacacacaca cacacacact ggagcgcagc ccctggcaga gatcttgaga ggatggagga
     2641 gccattctgg tttcaaatcc ctccttgatc actgctgttc tcaccccccc ctccttcccc
     2701 caaaacccta gttctcttag agtgaggctg ggagagatgc acagagacct gccgcagtgt
     2761 gtgcagagcc tgggaagtgg accatgctgg ggtcctttat ggagagagca ttgtggcagg
     2821 tggctgtgcc ttccatccag gaggtcaggg gtctaagggc tctccctgag agtcttgatc
     2881 tgtttctcat agatccacag cctcctctgc ctctgtcgtt tgcctgcttc agcacttcct
     2941 tccccttttt tcctcttttc ttcccagctg gcctcttcta gaaacatccc ttccccactt
     3001 ctcttcatta ttcacttctt atttttgccc actccccact cctgcttcct gagctgacag
     3061 aaaaataaag gctataaata aaatgc
//
