LOCUS       NM_007648               1457 bp    mRNA    linear   ROD 21-AUG-2024
DEFINITION  Mus musculus CD3 antigen, epsilon polypeptide (Cd3e), mRNA.
ACCESSION   NM_007648
VERSION     NM_007648.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1457)
  AUTHORS   Janusova,S., Paprckova,D., Michalik,J., Uleri,V., Drobek,A.,
            Salyova,E., Chorfi,L., Neuwirth,A., Andreyeva,A., Prochazka,J.,
            Sedlacek,R., Draber,P. and Stepanek,O.
  TITLE     ABIN1 is a negative regulator of effector functions in cytotoxic T
            cells
  JOURNAL   EMBO Rep 25 (8), 3456-3485 (2024)
   PUBMED   38877170
REFERENCE   2  (bases 1 to 1457)
  AUTHORS   Grammer,C., Komorowska,J.A. and Swann,J.B.
  TITLE     Vhl safeguards thymic epithelial cell identity and thymopoietic
            capacity by constraining Hif1a activity during development
  JOURNAL   iScience 27 (7), 110258 (2024)
   PUBMED   39040069
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1457)
  AUTHORS   Deng,S., Zhang,Y., Wang,H., Liang,W., Xie,L., Li,N., Fang,Y.,
            Wang,Y., Liu,J., Chi,H., Sun,Y., Ye,R., Shan,L., Shi,J., Shen,Z.,
            Wang,Y., Wang,S., Brosseau,J.P., Wang,F., Liu,G., Quan,Y. and Xu,J.
  TITLE     ITPRIPL1 binds CD3epsilon to impede T cell activation and enable
            tumor immune evasion
  JOURNAL   Cell 187 (9), 2305-2323 (2024)
   PUBMED   38614099
REFERENCE   4  (bases 1 to 1457)
  AUTHORS   Zhu,Y., Wang,Q., Xie,X., Ma,C., Qiao,Y., Zhang,Y., Wu,Y., Gao,Y.,
            Jiang,J., Liu,X., Chen,J., Li,C. and Ge,G.
  TITLE     ZBTB7B is a permissive regulator of hepatocellular carcinoma
            initiation by repressing c-Jun expression and function
  JOURNAL   Cell Death Dis 15 (1), 55 (2024)
   PUBMED   38225233
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1457)
  AUTHORS   Tokifuji,Y., Hayabuchi,H., Sasaki,T., Hara-Chikuma,M., Hirota,K.,
            Takahashi,H., Amagai,M., Yoshimura,A. and Chikuma,S.
  TITLE     Targeting abatacept-resistant T-helper-17 cells by aldehyde
            dehydrogenase inhibition
  JOURNAL   iScience 27 (1), 108646 (2023)
   PUBMED   38226171
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1457)
  AUTHORS   Morse,H.C. 3rd.
  TITLE     Genetic nomenclature for loci controlling surface antigens of mouse
            hemopoietic cells
  JOURNAL   J Immunol 149 (10), 3129-3134 (1992)
   PUBMED   1431091
  REMARK    Review article
            Erratum:[J Immunol 1993 Mar 15;150(6):2563]
REFERENCE   7  (bases 1 to 1457)
  AUTHORS   Charmley,P., Nguyen,J., Wei,S. and Gatti,R.A.
  TITLE     Genetic linkage analysis and homology relationships of genes
            located on human chromosome 11q
  JOURNAL   Genomics 10 (3), 608-617 (1991)
   PUBMED   1679745
REFERENCE   8  (bases 1 to 1457)
  AUTHORS   Letourneur,F., Mattei,M.G. and Malissen,B.
  TITLE     The mouse CD3-gamma, -delta, and -epsilon genes reside within 50
            kilobases on chromosome 9, whereas CD3-zeta maps to chromosome 1,
            band H
  JOURNAL   Immunogenetics 29 (4), 265-268 (1989)
   PUBMED   2522910
REFERENCE   9  (bases 1 to 1457)
  AUTHORS   Miller,R.D., Ozaki,J.H., Riblet,R.J. and Gold,D.P.
  TITLE     Genetic mapping of mouse T3d and T3e between Apoa1 and Ncam
  JOURNAL   Immunogenetics 30 (6), 511-514 (1989)
   PUBMED   2512252
REFERENCE   10 (bases 1 to 1457)
  AUTHORS   Gold,D.P., van Dongen,J.J., Morton,C.C., Bruns,G.A., van den
            Elsen,P., Geurts van Kessel,A.H. and Terhorst,C.
  TITLE     The gene encoding the epsilon subunit of the T3/T-cell receptor
            complex maps to chromosome 11 in humans and to chromosome 9 in mice
  JOURNAL   Proc Natl Acad Sci U S A 84 (6), 1664-1668 (1987)
   PUBMED   2882512
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122305.4.
            
            On Jun 16, 2018 this sequence version replaced NM_007648.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: J02990.1, BB635082.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                AC122305.4         19613-19658         c
            47-148              AC122305.4         19395-19496         c
            149-166             AC122305.4         17223-17240         c
            167-181             AC122305.4         15559-15573         c
            182-397             AC122305.4         12185-12400         c
            398-565             AC122305.4         11026-11193         c
            566-612             AC122305.4         10482-10528         c
            613-1457            AC122305.4         8790-9634           c
FEATURES             Location/Qualifiers
     source          1..1457
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 24.84 cM"
     gene            1..1457
                     /gene="Cd3e"
                     /gene_synonym="CD3; CD3epsilon; T3e"
                     /note="CD3 antigen, epsilon polypeptide"
                     /db_xref="GeneID:12501"
                     /db_xref="MGI:MGI:88332"
     exon            1..46
                     /gene="Cd3e"
                     /gene_synonym="CD3; CD3epsilon; T3e"
                     /inference="alignment:Splign:2.1.0"
     exon            47..148
                     /gene="Cd3e"
                     /gene_synonym="CD3; CD3epsilon; T3e"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..669
                     /gene="Cd3e"
                     /gene_synonym="CD3; CD3epsilon; T3e"
                     /note="T-cell surface glycoprotein CD3 epsilon chain;
                     T-cell surface antigen T3/Leu-4 epsilon chain"
                     /codon_start=1
                     /product="T-cell surface glycoprotein CD3 epsilon chain
                     precursor"
                     /protein_id="NP_031674.1"
                     /db_xref="CCDS:CCDS23125.1"
                     /db_xref="GeneID:12501"
                     /db_xref="MGI:MGI:88332"
                     /translation="MRWNTFWGILCLSLLAVGTCQDDAENIEYKVSISGTSVELTCPL
                     DSDENLKWEKNGQELPQKHDKHLVLQDFSEVEDSGYYVCYTPASNKNTYLYLKARVCE
                     YCVEVDLTAVAIIIIVDICITLGLLMVIYYWSKNRKAKAKPVTRGTGAGSRPRGQNKE
                     RPPPVPNPDYEPIRKGQRDLYSGLNQRAV"
     exon            149..166
                     /gene="Cd3e"
                     /gene_synonym="CD3; CD3epsilon; T3e"
                     /inference="alignment:Splign:2.1.0"
     exon            167..181
                     /gene="Cd3e"
                     /gene_synonym="CD3; CD3epsilon; T3e"
                     /inference="alignment:Splign:2.1.0"
     exon            182..397
                     /gene="Cd3e"
                     /gene_synonym="CD3; CD3epsilon; T3e"
                     /inference="alignment:Splign:2.1.0"
     exon            398..565
                     /gene="Cd3e"
                     /gene_synonym="CD3; CD3epsilon; T3e"
                     /inference="alignment:Splign:2.1.0"
     exon            566..612
                     /gene="Cd3e"
                     /gene_synonym="CD3; CD3epsilon; T3e"
                     /inference="alignment:Splign:2.1.0"
     exon            613..1457
                     /gene="Cd3e"
                     /gene_synonym="CD3; CD3epsilon; T3e"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agacacctgc ctcccctgtc tgcgtctggt gccttcttca gaaatgaagt aatgagctgg
       61 ctgcgtccgc catcttggta gagagagcat tctgagagga tgcggtggaa cactttctgg
      121 ggcatcctgt gcctcagcct cctagctgtt ggcacttgcc aggacgatgc cgagaacatt
      181 gaatacaaag tctccatctc aggaaccagt gtagagttga cgtgccctct agacagtgac
      241 gagaacttaa aatgggaaaa aaatggccaa gagctgcctc agaagcatga taagcacctg
      301 gtgctccagg atttctcgga agtcgaggac agtggctact acgtctgcta cacaccagcc
      361 tcaaataaaa acacgtactt gtacctgaaa gctcgagtgt gtgagtactg tgtggaggtg
      421 gacctgacag cagtagccat aatcatcatt gttgacatct gtatcactct gggcttgctg
      481 atggtcattt attactggag caagaatagg aaggccaagg ccaagcctgt gacccgagga
      541 accggtgctg gtagcaggcc cagagggcaa aacaaggagc ggccaccacc tgttcccaac
      601 ccagactatg agcccatccg caaaggccag cgggacctgt attctggcct gaatcagaga
      661 gcagtctgac agataggaga gacatcgcct tctgtggacc cagatccagc cctccgagca
      721 ccctgctact ccttgttctc tggacagact gcagactcca cagcttgctc ttcagcctcc
      781 tggtgaacac gtgtcctaga accttgctct cctgcctcct ctgctagtag ccagtgctgg
      841 gacattgctg actcaacagc ctttgaaaga atcaggctgc tcagattgtc tgccagccac
      901 cttgtgggga tacttttttc agccgccctg ctgccagctc cccgctgcct caccagtgtc
      961 ctctctgcct cagttccttt cctctcctaa ttggccctca tagctaagcc ctttcctaca
     1021 gctttctgtt ttttcttttt ctttcttttt aggttttctt tcttttcttt tttattcctt
     1081 tttatttaat cttttttttt taaacactcc agattttatt cccttcccgg cccatcctcc
     1141 gactgttaca caccccatac ctcctccctg cccccttgtc tctacgagaa tgtcccccac
     1201 ccccatcccc cacctgcttt ctggtttttg gtttttggtt tgtttttttt ttttaaactc
     1261 tgtgttttac actcttctct gggatggatt ctgtaatcat tggcacaggt cctgccccat
     1321 ttatagatcc tggcccagcc cctgccacag gtgcctctcc agatttcccc ttagatcctc
     1381 ggatggtcat ctccatctcc atgaatacac cagccccctc tctgctaatg caaaaggcaa
     1441 taaagtgtat tggctgg
//
