LOCUS       NM_013487               1330 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus CD3 antigen, delta polypeptide (Cd3d), mRNA.
ACCESSION   NM_013487
VERSION     NM_013487.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1330)
  AUTHORS   Chora,A.F., Marques,S., Goncalves,J.L., Lima,P., Gomes da Costa,D.,
            Fernandez-Ruiz,D., Marreiros,M.I., Ruivo,P., Carvalho,T.,
            Ribeiro,R.M., Serre,K., Heath,W.R., Silva-Santos,B., Tate,A.T. and
            Mota,M.M.
  TITLE     Interplay between liver and blood stages of Plasmodium infection
            dictates malaria severity via gammadelta T cells and IL-17-promoted
            stress erythropoiesis
  JOURNAL   Immunity 56 (3), 592-605 (2023)
   PUBMED   36804959
REFERENCE   2  (bases 1 to 1330)
  AUTHORS   Hosseini,S., Moody,S.C., Fietz,D., Indumathy,S., Schuppe,H.C.,
            Hedger,M.P. and Loveland,K.L.
  TITLE     The changing landscape of immune cells in the fetal mouse testis
  JOURNAL   Histochem Cell Biol 158 (4), 345-368 (2022)
   PUBMED   35829816
REFERENCE   3  (bases 1 to 1330)
  AUTHORS   He,T., Mortensen,X., Wang,P. and Tian,N.
  TITLE     The effects of immune protein CD3zeta development and degeneration
            of retinal neurons after optic nerve injury
  JOURNAL   PLoS One 12 (4), e0175522 (2017)
   PUBMED   28441398
  REMARK    GeneRIF: Mutation of Cd3d not only impairs the proper development
            of amacrine cells expressing Cd3d but also those not expressing
            Cd3d . In contrast to effects of Major histocompatibility complex
            and its receptor, PirB, on other neurons, mutation of Cd3d has no
            effect on retinal ganglion cells death and starburst amacrine cells
            degeneration after optic nerve crush.
            Erratum:[PLoS One. 2018 Jun 1;13(6):e0198770. doi:
            10.1371/journal.pone.0198770.. PMID: 29856870]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1330)
  AUTHORS   Vasilopoulou,E., Kolatsi-Joannou,M., Lindenmeyer,M.T., White,K.E.,
            Robson,M.G., Cohen,C.D., Sebire,N.J., Riley,P.R., Winyard,P.J. and
            Long,D.A.
  TITLE     Loss of endogenous thymosin beta4 accelerates glomerular disease
  JOURNAL   Kidney Int 90 (5), 1056-1070 (2016)
   PUBMED   27575556
REFERENCE   5  (bases 1 to 1330)
  AUTHORS   Munoz-Ruiz,M., Ribot,J.C., Grosso,A.R., Goncalves-Sousa,N.,
            Pamplona,A., Pennington,D.J., Regueiro,J.R., Fernandez-Malave,E.
            and Silva-Santos,B.
  TITLE     TCR signal strength controls thymic differentiation of discrete
            proinflammatory gammadelta T cell subsets
  JOURNAL   Nat Immunol 17 (6), 721-727 (2016)
   PUBMED   27043412
REFERENCE   6  (bases 1 to 1330)
  AUTHORS   Morse,H.C. 3rd.
  TITLE     Genetic nomenclature for loci controlling surface antigens of mouse
            hemopoietic cells
  JOURNAL   J Immunol 149 (10), 3129-3134 (1992)
   PUBMED   1431091
  REMARK    Review article
            Erratum:[J Immunol 1993 Mar 15;150(6):2563]
REFERENCE   7  (bases 1 to 1330)
  AUTHORS   Hearne,C.M., McAleer,M.A., Love,J.M., Aitman,T.J., Cornall,R.J.,
            Ghosh,S., Knight,A.M., Prins,J.B. and Todd,J.A.
  TITLE     Additional microsatellite markers for mouse genome mapping
  JOURNAL   Mamm Genome 1 (4), 273-282 (1991)
   PUBMED   1794058
REFERENCE   8  (bases 1 to 1330)
  AUTHORS   Letourneur,F., Mattei,M.G. and Malissen,B.
  TITLE     The mouse CD3-gamma, -delta, and -epsilon genes reside within 50
            kilobases on chromosome 9, whereas CD3-zeta maps to chromosome 1,
            band H
  JOURNAL   Immunogenetics 29 (4), 265-268 (1989)
   PUBMED   2522910
REFERENCE   9  (bases 1 to 1330)
  AUTHORS   Miller,R.D., Ozaki,J.H., Riblet,R.J. and Gold,D.P.
  TITLE     Genetic mapping of mouse T3d and T3e between Apoa1 and Ncam
  JOURNAL   Immunogenetics 30 (6), 511-514 (1989)
   PUBMED   2512252
REFERENCE   10 (bases 1 to 1330)
  AUTHORS   Saito,H., Koyama,T., Georgopoulos,K., Clevers,H., Haser,W.G.,
            LeBien,T., Tonegawa,S. and Terhorst,C.
  TITLE     Close linkage of the mouse and human CD3 gamma- and delta-chain
            genes suggests that their transcription is controlled by common
            regulatory elements
  JOURNAL   Proc Natl Acad Sci U S A 84 (24), 9131-9134 (1987)
   PUBMED   2827170
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK042172.1, BC062807.1, BB237678.2 and BY576367.1.
            
            On Apr 25, 2009 this sequence version replaced NM_013487.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK042172.1, AK154064.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-590               AK042172.1         3-592
            591-699             BC062807.1         496-604
            700-1126            AK042172.1         702-1128
            1127-1248           BB237678.2         37-158
            1249-1318           BY576367.1         330-399
            1319-1330           AK042172.1         1317-1328
FEATURES             Location/Qualifiers
     source          1..1330
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 24.84 cM"
     gene            1..1330
                     /gene="Cd3d"
                     /gene_synonym="T3d"
                     /note="CD3 antigen, delta polypeptide"
                     /db_xref="GeneID:12500"
                     /db_xref="MGI:MGI:88331"
     exon            1..155
                     /gene="Cd3d"
                     /gene_synonym="T3d"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..622
                     /gene="Cd3d"
                     /gene_synonym="T3d"
                     /note="T-cell surface glycoprotein CD3 delta chain; T-cell
                     receptor T3 delta chain"
                     /codon_start=1
                     /product="T-cell surface glycoprotein CD3 delta chain
                     precursor"
                     /protein_id="NP_038515.3"
                     /db_xref="CCDS:CCDS23124.1"
                     /db_xref="GeneID:12500"
                     /db_xref="MGI:MGI:88331"
                     /translation="MEHSGILASLILIAVLPQGSPFKIQVTEYEDKVFVTCNTSVMHL
                     DGTVEGWFAKNKTLNLGKGVLDPRGIYLCNGTEQLAKVVSSVQVHYRMCQNCVELDSG
                     TMAGVIFIDLIATLLLALGVYCFAGHETGRPSGAAEVQALLKNEQLYQPLRDREDTQY
                     SRLGGNWPRNKKS"
     exon            156..374
                     /gene="Cd3d"
                     /gene_synonym="T3d"
                     /inference="alignment:Splign:2.1.0"
     exon            375..506
                     /gene="Cd3d"
                     /gene_synonym="T3d"
                     /inference="alignment:Splign:2.1.0"
     exon            507..550
                     /gene="Cd3d"
                     /gene_synonym="T3d"
                     /inference="alignment:Splign:2.1.0"
     exon            551..1330
                     /gene="Cd3d"
                     /gene_synonym="T3d"
                     /inference="alignment:Splign:2.1.0"
     regulatory      676..681
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cd3d"
                     /gene_synonym="T3d"
                     /note="hexamer: AATAAA"
     polyA_site      699
                     /gene="Cd3d"
                     /gene_synonym="T3d"
                     /note="major polyA site"
ORIGIN      
        1 tttttctgaa tacccatgag tctgttggcg gaggatagtg ctaaccctgg ctgatcatcc
       61 tgtggcttgc ctctatttgt tgcatgattc cctctggaag atggaacaca gcgggattct
      121 ggctagtctg atactgattg ctgttctccc ccaagggagc cccttcaaga tacaagtgac
      181 cgaatatgag gacaaagtat ttgtgacctg caataccagc gtcatgcatc tagatggaac
      241 ggtggaagga tggtttgcaa agaataaaac actcaacttg ggcaaaggcg ttctggaccc
      301 acgagggata tatctgtgta atgggacaga gcagctggca aaggtggtgt cttctgtgca
      361 agtccattac cgaatgtgcc agaactgtgt ggagctagac tcgggcacca tggctggtgt
      421 catcttcatt gacctcatcg caactctgct cctggctttg ggcgtctact gctttgcagg
      481 acatgagacc ggaaggcctt ctggggctgc tgaggttcaa gcactgctga agaatgagca
      541 gctgtatcag cctcttcgag atcgtgaaga tacccagtac agccgtcttg gagggaactg
      601 gccccggaac aagaaatctt aagatggagg tttctcaaag tgccatagca acggcgcctt
      661 cccctgtgat caaccaataa agacgtttcc ttccgtcggc aggcgcctgt gttttccaaa
      721 gcatggattg agagttgtct tagcttggct gagttctgcc cacccgtggc ccctcacttc
      781 tggcttcctc tcctcagacc cagacaggca gtacgaggga cagcttccca tcctggcccc
      841 ttggcatttc taaccctgtg ggtttcctgt gggcagggtc agcccagcca ctctgcttca
      901 ttgcctgttg gttccagtcc ctatcataac aacttccggg attttgctgc cttaccacag
      961 cccaaagcag gctgtggtgt ttagaagctg agccacaaag aagtttccat gacatcatga
     1021 atgggggtgg cagagaagaa tattggggct cagagggtgt gtgtgtgtgt gtgtgtgtgt
     1081 gtgtgagtga gagagagaga gagagagaga gagagagaga gagagagaga cagacagaga
     1141 gacagagaga cagaaagaca gaaagacaga aagacagaga cagagctgtc aagaattttc
     1201 ttctcacttc gtgggttctg gggattgtac taaggtcatg aggcttgtgt ggcaagcacc
     1261 cttacccact gagccatctt gcctgccctc atcctcaaat taattaaaaa taaagaacat
     1321 gatgaattcc
//
