LOCUS       NM_007646               3009 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus CD38 antigen (Cd38), mRNA.
ACCESSION   NM_007646
VERSION     NM_007646.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3009)
  AUTHORS   Zubiaur,M., Terron-Camero,L.C., Gordillo-Gonzalez,F.,
            Andres-Leon,E., Barroso-Del Jesus,A., Canet-Antequera,L.M., Perez
            Sanchez-Canete,M.M., Martinez-Blanco,A., Dominguez-Pantoja,M.,
            Botia-Sanchez,M., Perez-Cabrera,S., Bello-Iglesias,N., Alcina,A.,
            Abadia-Molina,A.C., Matesanz,F., Zumaquero,E., Merino,R. and
            Sancho,J.
  TITLE     CD38 deficiency leads to a defective short-lived transcriptomic
            response to chronic graft-versus-host disease induction, involving
            purinergic signaling-related genes and distinct transcriptomic
            signatures associated with lupus
  JOURNAL   Front Immunol 16, 1441981 (2025)
   PUBMED   39995666
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3009)
  AUTHORS   Pang,Y., Hu,H., Xu,K., Cao,T., Wang,Z., Nie,J., Zheng,H., Luo,H.,
            Wang,F., Xiong,C., Deng,K.Y., Xin,H.B. and Zhang,X.
  TITLE     CD38 Deficiency Protects Mouse Retinal Ganglion Cells Through
            Activating the NAD+/Sirt1 Pathway in Ischemia-Reperfusion and Optic
            Nerve Crush Models
  JOURNAL   Invest Ophthalmol Vis Sci 65 (5), 36 (2024)
   PUBMED   38776115
  REMARK    GeneRIF: CD38 Deficiency Protects Mouse Retinal Ganglion Cells
            Through Activating the NAD+/Sirt1 Pathway in Ischemia-Reperfusion
            and Optic Nerve Crush Models.
REFERENCE   3  (bases 1 to 3009)
  AUTHORS   Hara-Yokoyama,M., Kukimoto-Niino,M., Terasawa,K., Harumiya,S.,
            Podyma-Inoue,K.A., Hino,N., Sakamoto,K., Itoh,S., Hashii,N.,
            Hiruta,Y., Kawasaki,N., Mishima-Tsumagari,C., Kaitsu,Y.,
            Matsumoto,T., Wakiyama,M., Shirouzu,M., Kasama,T., Takayanagi,H.,
            Utsunomiya-Tate,N., Takatsu,K., Katada,T., Hirabayashi,Y.,
            Yokoyama,S. and Yanagishita,M.
  TITLE     Tetrameric interaction of the ectoenzyme CD38 on the cell surface
            enables its catalytic and raft-association activities
  JOURNAL   Structure 20 (9), 1585-1595 (2012)
   PUBMED   22863568
  REMARK    GeneRIF: The tetrameric interaction underlies the multifaceted
            actions of CD38.
REFERENCE   4  (bases 1 to 3009)
  AUTHORS   Chini,E.N., Chini,C.C., Kato,I., Takasawa,S. and Okamoto,H.
  TITLE     CD38 is the major enzyme responsible for synthesis of nicotinic
            acid-adenine dinucleotide phosphate in mammalian tissues
  JOURNAL   Biochem J 362 (Pt 1), 125-130 (2002)
   PUBMED   11829748
REFERENCE   5  (bases 1 to 3009)
  AUTHORS   Partida-Sanchez,S., Cockayne,D.A., Monard,S., Jacobson,E.L.,
            Oppenheimer,N., Garvy,B., Kusser,K., Goodrich,S., Howard,M.,
            Harmsen,A., Randall,T.D. and Lund,F.E.
  TITLE     Cyclic ADP-ribose production by CD38 regulates intracellular
            calcium release, extracellular calcium influx and chemotaxis in
            neutrophils and is required for bacterial clearance in vivo
  JOURNAL   Nat Med 7 (11), 1209-1216 (2001)
   PUBMED   11689885
REFERENCE   6  (bases 1 to 3009)
  AUTHORS   Fukushi,Y., Kato,I., Takasawa,S., Sasaki,T., Ong,B.H., Sato,M.,
            Ohsaga,A., Sato,K., Shirato,K., Okamoto,H. and Maruyama,Y.
  TITLE     Identification of cyclic ADP-ribose-dependent mechanisms in
            pancreatic muscarinic Ca(2+) signaling using CD38 knockout mice
  JOURNAL   J Biol Chem 276 (1), 649-655 (2001)
   PUBMED   11001947
REFERENCE   7  (bases 1 to 3009)
  AUTHORS   Cockayne,D.A., Muchamuel,T., Grimaldi,J.C., Muller-Steffner,H.,
            Randall,T.D., Lund,F.E., Murray,R., Schuber,F. and Howard,M.C.
  TITLE     Mice deficient for the ecto-nicotinamide adenine dinucleotide
            glycohydrolase CD38 exhibit altered humoral immune responses
  JOURNAL   Blood 92 (4), 1324-1333 (1998)
   PUBMED   9694721
REFERENCE   8  (bases 1 to 3009)
  AUTHORS   Lund,F., Solvason,N., Grimaldi,J.C., Parkhouse,R.M. and Howard,M.
  TITLE     Murine CD38: an immunoregulatory ectoenzyme
  JOURNAL   Immunol Today 16 (10), 469-473 (1995)
   PUBMED   7576049
  REMARK    Review article
REFERENCE   9  (bases 1 to 3009)
  AUTHORS   Santos-Argumedo,L., Lund,F.E., Heath,A.W., Solvason,N., Wu,W.W.,
            Grimaldi,J.C., Parkhouse,R.M. and Howard,M.
  TITLE     CD38 unresponsiveness of xid B cells implicates Bruton's tyrosine
            kinase (btk) as a regular of CD38 induced signal transduction
  JOURNAL   Int Immunol 7 (2), 163-170 (1995)
   PUBMED   7734414
REFERENCE   10 (bases 1 to 3009)
  AUTHORS   Harada,N., Santos-Argumedo,L., Chang,R., Grimaldi,J.C., Lund,F.E.,
            Brannan,C.I., Copeland,N.G., Jenkins,N.A., Heath,A.W.,
            Parkhouse,R.M. et al.
  TITLE     Expression cloning of a cDNA encoding a novel murine B cell
            activation marker. Homology to human CD38
  JOURNAL   J Immunol 151 (6), 3111-3118 (1993)
   PUBMED   8376770
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC140277.3 and AC164004.3.
            
            On Sep 30, 2022 this sequence version replaced NM_007646.5.
            
            Summary: This gene encodes a non-lineage-restricted, type II
            transmembrane glycoprotein that synthesizes and hydrolyzes cyclic
            adenosine 5'-diphosphate-ribose, an intracellular calcium ion
            mobilizing messenger. The release of soluble protein and the
            ability of membrane-bound protein to become internalized indicate
            both extracellular and intracellular functions for the protein.
            This protein has an N-terminal cytoplasmic tail, a single
            membrane-spanning domain, and a C-terminal extracellular region
            with four N-glycosylation sites. Knockout mice deficient for this
            gene display altered humoral immune responses. In addition,
            knockout mice exhibit higher locomotor activity and defects in
            nurturing and social behaviors. [provided by RefSeq, Sep 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK153215.1, BC046312.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-310               AC140277.3         197189-197498
            311-440             AC164004.3         99028-99157
            441-576             AC164004.3         100116-100251
            577-662             AC164004.3         102290-102375
            663-736             AC164004.3         104859-104932
            737-829             AC164004.3         106208-106300
            830-916             AC164004.3         106618-106704
            917-3009            AC164004.3         108975-111067
FEATURES             Location/Qualifiers
     source          1..3009
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 23.85 cM"
     gene            1..3009
                     /gene="Cd38"
                     /gene_synonym="ADPRC 1; Cd38-rs1; I-19"
                     /note="CD38 antigen"
                     /db_xref="GeneID:12494"
                     /db_xref="MGI:MGI:107474"
     exon            1..310
                     /gene="Cd38"
                     /gene_synonym="ADPRC 1; Cd38-rs1; I-19"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..980
                     /gene="Cd38"
                     /gene_synonym="ADPRC 1; Cd38-rs1; I-19"
                     /EC_number="3.2.2.6"
                     /EC_number="2.4.99.20"
                     /note="ADP-ribosyl cyclase 1; NIM-R5 antigen; cADPr
                     hydrolase 1; 2'-phospho-ADP-ribosyl cyclase;
                     2'-phospho-cyclic-ADP-ribose transferase;
                     2'-phospho-ADP-ribosyl
                     cyclase/2'-phospho-cyclic-ADP-ribose transferase; cyclic
                     ADP-ribose hydrolase 1"
                     /codon_start=1
                     /product="ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase
                     1"
                     /protein_id="NP_031672.2"
                     /db_xref="CCDS:CCDS19265.1"
                     /db_xref="GeneID:12494"
                     /db_xref="MGI:MGI:107474"
                     /translation="MANYEFSQVSGDRPGCRLSRKAQIGLGVGLLVLIALVVGIVVIL
                     LRPRSLLVWTGEPTTKHFSDIFLGRCLIYTQILRPEMRDQNCQEILSTFKGAFVSKNP
                     CNITREDYAPLVKLVTQTIPCNKTLFWSKSKHLAHQYTWIQGKMFTLEDTLLGYIADD
                     LRWCGDPSTSDMNYVSCPHWSENCPNNPITVFWKVISQKFAEDACGVVQVMLNGSLRE
                     PFYKNSTFGSVEVFSLDPNKVHKLQAWVMHDIEGASSNACSSSSLNELKMIVQKRNMI
                     FACVDNYRPARFLQCVKNPEHPSCRLNT"
     exon            311..440
                     /gene="Cd38"
                     /gene_synonym="ADPRC 1; Cd38-rs1; I-19"
                     /inference="alignment:Splign:2.1.0"
     exon            441..576
                     /gene="Cd38"
                     /gene_synonym="ADPRC 1; Cd38-rs1; I-19"
                     /inference="alignment:Splign:2.1.0"
     exon            577..662
                     /gene="Cd38"
                     /gene_synonym="ADPRC 1; Cd38-rs1; I-19"
                     /inference="alignment:Splign:2.1.0"
     exon            663..736
                     /gene="Cd38"
                     /gene_synonym="ADPRC 1; Cd38-rs1; I-19"
                     /inference="alignment:Splign:2.1.0"
     exon            737..829
                     /gene="Cd38"
                     /gene_synonym="ADPRC 1; Cd38-rs1; I-19"
                     /inference="alignment:Splign:2.1.0"
     exon            830..916
                     /gene="Cd38"
                     /gene_synonym="ADPRC 1; Cd38-rs1; I-19"
                     /inference="alignment:Splign:2.1.0"
     exon            917..3009
                     /gene="Cd38"
                     /gene_synonym="ADPRC 1; Cd38-rs1; I-19"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2796..2801
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cd38"
                     /gene_synonym="ADPRC 1; Cd38-rs1; I-19"
                     /note="hexamer: AATAAA"
     regulatory      2801..2806
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cd38"
                     /gene_synonym="ADPRC 1; Cd38-rs1; I-19"
                     /note="hexamer: ACTAAA"
     polyA_site      2815
                     /gene="Cd38"
                     /gene_synonym="ADPRC 1; Cd38-rs1; I-19"
                     /note="major polyA site"
     polyA_site      2822
                     /gene="Cd38"
                     /gene_synonym="ADPRC 1; Cd38-rs1; I-19"
                     /note="major polyA site"
     regulatory      2990..2995
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cd38"
                     /gene_synonym="ADPRC 1; Cd38-rs1; I-19"
                     /note="hexamer: ATTAAA"
     polyA_site      3009
                     /gene="Cd38"
                     /gene_synonym="ADPRC 1; Cd38-rs1; I-19"
ORIGIN      
        1 aggctctgac ccagtcagcc ctgtgctctc ttcctgccta gcctgggcca gtcttcggga
       61 gcccaatggc taactatgaa tttagccagg tgtctgggga cagacctggc tgccgcctct
      121 ctaggaaagc ccagatcggt ctcggagtgg gtctcctggt cctgatcgcc ttggtagtag
      181 ggatcgtggt catacttctg aggccgcgct cactcctggt gtggactgga gagcctacca
      241 cgaagcactt ttctgacatc ttcctgggac gctgcctcat ctacactcag atcctccggc
      301 cggagatgag agatcagaac tgccaggaga tactgagtac attcaaagga gcatttgttt
      361 ccaagaaccc ttgcaacatc acaagagaag actacgcccc acttgttaaa ttggtcactc
      421 aaaccatacc atgtaacaag actctctttt ggagcaaatc caaacacctg gcccatcaat
      481 atacttggat ccagggaaag atgttcaccc tggaggacac cctgctgggc tacattgctg
      541 atgatctcag gtggtgtgga gaccctagta cttctgatat gaactatgtc tcttgcccac
      601 attggagtga aaactgtccc aacaacccta ttactgtgtt ctggaaagtg atttcccaaa
      661 agtttgcaga agatgcctgt ggtgtggtcc aagtgatgct caatgggtcc ctccgtgagc
      721 cattttacaa aaacagcacc tttggaagtg tggaagtctt tagtttggac ccaaataagg
      781 ttcataaact acaggcctgg gtgatgcacg acatcgaagg agcttccagt aacgcatgtt
      841 caagctcctc cttaaatgag ctgaagatga ttgtgcagaa aaggaatatg atatttgcct
      901 gcgtggataa ctacaggcct gccaggtttc ttcagtgtgt gaagaaccct gagcacccat
      961 cgtgtagact taatacgtga aggatctgga tcttagatca cctgtagcct ggactgagat
     1021 gaaggggctc agaagcaaca ctggtggaaa gctgaaactg tcagggagaa gcctctacta
     1081 cagtgttaac accagagatg gaagaacttc ccaattctct gtgtactacc aacattcaag
     1141 aaaaattact ccataaacca gagttaaact tctatattgt tatattagtc taactttctc
     1201 atgtggtgct tctgtattgt ttatatattg cttacatcct tttattcctc ttttaatgat
     1261 ctctcttttc tctctctctc tctctctctc tctctctcaa tgaggctgag aatccaacct
     1321 gagaactttc atacatggtg gataagccta tataccactg agctaaatcc tcagcacagc
     1381 tgataacatc atttttgctg aaaaatggcc aatcaaactt cccattagac aaagaaagtc
     1441 aaatgtcaag tatatcgaaa tgaatgaccc tttttttttt ttatgttttt tcattcttcc
     1501 cacagatatt cacatggtaa acctgaggtc atagggtcat tatagggaag gtgctgtgtg
     1561 ggaactaccc acgtgccctg tgctttaatc tttaactcaa cacatccctg ataactttga
     1621 gcattctttt cttttctttt ctttcctttt cttttctttt cttttctttt tctttttttt
     1681 aaacagaaga aaatggagtt tagagagata attgattttc ctaaagtcac attcttaaga
     1741 tcatggttac atctagaatt aaatcagttc tgtcaaagtc cacaacatat gatagttttt
     1801 ttcttttccg agcttttatt gccaaattgg tagtagcctg tgttgtcgtc tagcaaatgc
     1861 tattgcatta gattgaatat aatagaatct gaaatgtgat ctttatggaa gatcacaaaa
     1921 ctaattactt gcaccctctt tctcttccac ttcattcttg gtgcctttta taggcagtca
     1981 agagttaaca tatatttgtt gctaatattg gcaatttatg ttttctatcc tttttttctt
     2041 agatcagtct tgctcagaat cactggtttt gttatgttgt tgttgttgct attgttattg
     2101 ttcttgtctt tttcaaagct caaatcttta actttcctca tttatttatt taattgagct
     2161 ttagtcttta tttttagaaa catagaaatt tcttctagct atctggaata tcttcagttt
     2221 tttgaggcaa atgcttagac cattgatatt tcagtctgtt ttctacacat gtactttagg
     2281 attctaggtt tctccctgag ccctgctttc gatgtaacac tgaatttctg tatgtcttta
     2341 ctggttagtt actttgatag tttgtatatg cttgacccag tgagtggcag gattagaagg
     2401 tatggccttg ctggaatagg tgtgccactg tgggtgtagt cttaagaccc ttaccctagc
     2461 tgcctggagg ccactattcc actaacagcc ttcaaatgaa aatataaaac tctcagctct
     2521 gcctgtgcca tgcctgcctg gatgctgcca tgctcccacc ttgatgataa tggactgaac
     2581 ctctgaacct gtaagccagc cccaatttgt tgtccttata aaagacttgc tttggtcatg
     2641 gtatctgttc acagcagaaa gaacctaact aagacagtta ccattcagtt caaaataatt
     2701 cttgatttta ttgttattta gacatgtgat atttactttt caacatctgg agaattgttt
     2761 aggttttttt tgtgtgtgtg tctttagtag gtattaataa actaaattga gacaactcca
     2821 aagtatttgc ttggtttatt gaaaatagca taaacagagc caggtgcttc tgtattcatg
     2881 ttttgacacc agtttgtgat tgttgaacaa tatatcttat ttctaaactt ttaaaaagct
     2941 acttaaagac attaacttgc tcccttacaa tatgttgatg gttcagtcca ttaaatgctt
     3001 actttgtaa
//
