LOCUS       NM_007645               1226 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus CD37 antigen (Cd37), transcript variant 3, mRNA.
ACCESSION   NM_007645
VERSION     NM_007645.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1226)
  AUTHORS   Hoeger,S., Drake,L.A. and Drake,J.R.
  TITLE     Proximity-Based Labeling Identifies MHC Class II and CD37 as B Cell
            Receptor-Proximal Proteins with Immunological Functions
  JOURNAL   Immunohorizons 8 (4), 326-338 (2024)
   PUBMED   38625120
  REMARK    GeneRIF: Proximity-Based Labeling Identifies MHC Class II and CD37
            as B Cell Receptor-Proximal Proteins with Immunological Functions.
REFERENCE   2  (bases 1 to 1226)
  AUTHORS   Peeters,R., Cuenca-Escalona,J., Zaal,E.A., Hoekstra,A.T.,
            Balvert,A.C.G., Vidal-Manrique,M., Blomberg,N., van Deventer,S.J.,
            Stienstra,R., Jellusova,J., Giera,M., Hannibal,L.,
            Spiekerkoetter,U., Ter Beest,M., Berkers,C.R. and van Spriel,A.B.
  TITLE     Fatty acid metabolism in aggressive B-cell lymphoma is inhibited by
            tetraspanin CD37
  JOURNAL   Nat Commun 13 (1), 5371 (2022)
   PUBMED   36100608
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1226)
  AUTHORS   de Winde,C.M., Matthews,A.L., van Deventer,S., van der Schaaf,A.,
            Tomlinson,N.D., Jansen,E., Eble,J.A., Nieswandt,B.,
            McGettrick,H.M., Figdor,C.G., Tomlinson,M.G., Acton,S.E. and van
            Spriel,A.B.
  TITLE     C-type lectin-like receptor 2 (CLEC-2)-dependent dendritic cell
            migration is controlled by tetraspanin CD37
  JOURNAL   J Cell Sci 131 (19) (2018)
   PUBMED   30185523
  REMARK    GeneRIF: tetraspanin CD37 controls CLEC-2 membrane organization and
            provides new molecular insights into the mechanisms underlying
            CLEC-2-dependent dendritic cell migration.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1226)
  AUTHORS   Rops,A.L.W.M.M., Jansen,E., van der Schaaf,A., Pieterse,E.,
            Rother,N., Hofstra,J., Dijkman,H.B.P.M., van de Logt,A.E.,
            Wetzels,J., van der Vlag,J. and van Spriel,A.B.
  TITLE     Interleukin-6 is essential for glomerular immunoglobulin A
            deposition and the development of renal pathology in Cd37-deficient
            mice
  JOURNAL   Kidney Int 93 (6), 1356-1366 (2018)
   PUBMED   29551516
  REMARK    GeneRIF: CD37 may protect against IgA nephropathy by inhibition of
            the IL-6 pathway.
REFERENCE   5  (bases 1 to 1226)
  AUTHORS   de Winde,C.M., Veenbergen,S., Young,K.H., Xu-Monette,Z.Y.,
            Wang,X.X., Xia,Y., Jabbar,K.J., van den Brand,M., van der
            Schaaf,A., Elfrink,S., van Houdt,I.S., Gijbels,M.J., van de
            Loo,F.A., Bennink,M.B., Hebeda,K.M., Groenen,P.J., van
            Krieken,J.H., Figdor,C.G. and van Spriel,A.B.
  TITLE     Tetraspanin CD37 protects against the development of B cell
            lymphoma
  JOURNAL   J Clin Invest 126 (2), 653-666 (2016)
   PUBMED   26784544
  REMARK    GeneRIF: this study identifies CD37 as a tumor suppressor that
            directly protects against B cell lymphomagenesis
REFERENCE   6  (bases 1 to 1226)
  AUTHORS   Knobeloch,K.P., Wright,M.D., Ochsenbein,A.F., Liesenfeld,O.,
            Lohler,J., Zinkernagel,R.M., Horak,I. and Orinska,Z.
  TITLE     Targeted inactivation of the tetraspanin CD37 impairs
            T-cell-dependent B-cell response under suboptimal costimulatory
            conditions
  JOURNAL   Mol Cell Biol 20 (15), 5363-5369 (2000)
   PUBMED   10891477
REFERENCE   7  (bases 1 to 1226)
  AUTHORS   Stubbs,L., Carver,E.A., Shannon,M.E., Kim,J., Geisler,J.,
            Generoso,E.E., Stanford,B.G., Dunn,W.C., Mohrenweiser,H.,
            Zimmermann,W., Watt,S.M. and Ashworth,L.K.
  TITLE     Detailed comparative map of human chromosome 19q and related
            regions of the mouse genome
  JOURNAL   Genomics 35 (3), 499-508 (1996)
   PUBMED   8812484
REFERENCE   8  (bases 1 to 1226)
  AUTHORS   Tomlinson,M.G. and Wright,M.D.
  TITLE     Characterisation of mouse CD37: cDNA and genomic cloning
  JOURNAL   Mol Immunol 33 (10), 867-872 (1996)
   PUBMED   8845018
REFERENCE   9  (bases 1 to 1226)
  AUTHORS   Butler,A., Rochelle,J.M., Seldin,M.F. and Whitehead,A.S.
  TITLE     The gene encoding the mouse serum amyloid A protein, apo-SAA5, maps
            to proximal chromosome 7
  JOURNAL   Immunogenetics 42 (2), 153-155 (1995)
   PUBMED   7607707
REFERENCE   10 (bases 1 to 1226)
  AUTHORS   Wright,M.D., Rochelle,J.M., Tomlinson,M.G., Seldin,M.F. and
            Williams,A.F.
  TITLE     Gene structure, chromosomal localization, and protein sequence of
            mouse CD53 (Cd53): evidence that the transmembrane 4 superfamily
            arose by gene duplication
  JOURNAL   Int Immunol 5 (2), 209-216 (1993)
   PUBMED   8452817
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC150897.2.
            
            On Apr 27, 2007 this sequence version replaced NM_007645.3.
            
            Transcript Variant: This variant (3) differs in the 5' UTR and
            coding sequence compared to variant 1. The resulting isoform (3) is
            shorter at the N-terminus compared to isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK155966.1, CT010217.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-180               AC150897.2         107611-107790
            181-253             AC150897.2         107878-107950
            254-378             AC150897.2         109166-109290
            379-453             AC150897.2         109374-109448
            454-558             AC150897.2         110231-110335
            559-795             AC150897.2         110807-111043
            796-879             AC150897.2         111683-111766
            880-1226            AC150897.2         112472-112818
FEATURES             Location/Qualifiers
     source          1..1226
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 29.2 cM"
     gene            1..1226
                     /gene="Cd37"
                     /gene_synonym="Tspan26"
                     /note="CD37 antigen"
                     /db_xref="GeneID:12493"
                     /db_xref="MGI:MGI:88330"
     exon            1..180
                     /gene="Cd37"
                     /gene_synonym="Tspan26"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..957
                     /gene="Cd37"
                     /gene_synonym="Tspan26"
                     /note="isoform 3 is encoded by transcript variant 3;
                     leukocyte antigen CD37"
                     /codon_start=1
                     /product="leukocyte antigen CD37 isoform 3"
                     /protein_id="NP_031671.1"
                     /db_xref="CCDS:CCDS21237.1"
                     /db_xref="GeneID:12493"
                     /db_xref="MGI:MGI:88330"
                     /translation="MSAQESCLSLIKYFLFVFNLFFFVLGGLIFCFGTWILIDKTSFV
                     SFVGLSFVPLQTWSKVLAVSGVLTMALALLGCVGALKELRCLLGLYFGMLLLLFATQI
                     TLGILISTQRVRLERRVQELVLRTIQSYRTNPDETAAEESWDYAQFQLRCCGWQSPRD
                     WNKAQMLKANESEEPFVPCSCYNSTATNDSTVFDKLFFSQLSRLGPRAKLRQTADICA
                     LPAKAHIYREGCAQSLQKWLHNNIISIVGICLGVGLLELGFMTLSIFLCRNLDHVYDR
                     LARYR"
     exon            181..253
                     /gene="Cd37"
                     /gene_synonym="Tspan26"
                     /inference="alignment:Splign:2.1.0"
     exon            254..378
                     /gene="Cd37"
                     /gene_synonym="Tspan26"
                     /inference="alignment:Splign:2.1.0"
     exon            379..453
                     /gene="Cd37"
                     /gene_synonym="Tspan26"
                     /inference="alignment:Splign:2.1.0"
     exon            454..558
                     /gene="Cd37"
                     /gene_synonym="Tspan26"
                     /inference="alignment:Splign:2.1.0"
     exon            559..795
                     /gene="Cd37"
                     /gene_synonym="Tspan26"
                     /inference="alignment:Splign:2.1.0"
     exon            796..879
                     /gene="Cd37"
                     /gene_synonym="Tspan26"
                     /inference="alignment:Splign:2.1.0"
     exon            880..1226
                     /gene="Cd37"
                     /gene_synonym="Tspan26"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1197..1202
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cd37"
                     /gene_synonym="Tspan26"
                     /note="hexamer: AATAAA"
     polyA_site      1221
                     /gene="Cd37"
                     /gene_synonym="Tspan26"
                     /note="major polyA site"
ORIGIN      
        1 tttgtgcctc tcagtctctg tctttctttg cccactattc cccttccccc ctgcggccaa
       61 cacctcttct gtctgggttt ctcgagtggg tcattcccca tctaggcgaa gatgtccgcc
      121 caagagagtt gcctcagcct catcaagtac ttcctcttcg ttttcaacct cttcttcttt
      181 gtactaggcg gcctgatttt ctgcttcggc acctggatcc tcattgacaa gaccagcttc
      241 gtgtcctttg tgggtttgtc cttcgtgcca ctgcagactt ggtccaaggt cctggctgtc
      301 tcaggtgtcc tcaccatggc cctggctctc ctgggctgtg tgggggctct aaaggagctg
      361 cgctgtctcc tgggcctgta ttttggaatg ctgctgctcc tgtttgccac acagattacc
      421 ctgggcatcc tcatttccac tcagcgggtc cggctggagc gaagggtgca ggaattggtg
      481 ttgaggacga tccagagcta ccgcacgaat ccggatgaga cagcagccga ggagagttgg
      541 gactatgcac agttccagct gcgctgctgc ggctggcaat ctccgcggga ctggaacaag
      601 gcccagatgc tgaaagcgaa cgagtctgag gagccctttg tgccctgctc ctgctacaac
      661 tccacggcga ccaatgactc caccgtcttt gataagctct ttttctccca gctaagccgg
      721 ttggggccgc gggcgaagct gaggcagact gctgacatat gtgcactccc tgcaaaagct
      781 cacatctacc gtgagggctg cgcgcagagc ctccagaagt ggctgcacaa caatatcatc
      841 tccatagtgg gaatctgtct gggagtcggt cttcttgagc tcggcttcat gacgctctca
      901 atattcctgt gtagaaatct ggatcacgtc tatgaccggc tggcccggta ccgctaggcc
      961 ccagcccacc catcggcacc cacgcacctc catgcagtca ggaaatgttt ccttcctggt
     1021 tggtcacagg cttggagccc atgcctcagg cctcatcccc tggggaccca gctgtctgcc
     1081 ctatcgacag ccttcacttt ccccacatgg ccagggactt ttgtgcccag cttccttccc
     1141 ttcctggctc cctcctcccc acaccatctg tctgccacct cccacatgac acctcaaata
     1201 aatccccttt gggtttttgg cttttt
//
