LOCUS       NM_019421               2209 bp    mRNA    linear   ROD 07-OCT-2024
DEFINITION  Mus musculus CD320 antigen (Cd320), transcript variant 1, mRNA.
ACCESSION   NM_019421
VERSION     NM_019421.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2209)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2209)
  AUTHORS   Jonnalagadda,D., Kihara,Y., Groves,A., Ray,M., Saha,A.,
            Ellington,C., Lee-Okada,H.C., Furihata,T., Yokomizo,T.,
            Quadros,E.V., Rivera,R. and Chun,J.
  TITLE     FTY720 requires vitamin B12-TCN2-CD320 signaling in astrocytes to
            reduce disease in an animal model of multiple sclerosis
  JOURNAL   Cell Rep 42 (12), 113545 (2023)
   PUBMED   38064339
REFERENCE   3  (bases 1 to 2209)
  AUTHORS   Tscherner,A.K., McClatchie,T., Macaulay,A.D. and Baltz,J.M.
  TITLE     Relationship of quantitative reverse transcription polymerase chain
            reaction (RT-PCR) to RNA Sequencing (RNAseq) transcriptome
            identifies mouse preimplantation embryo reference genesdagger
  JOURNAL   Biol Reprod 109 (5), 601-617 (2023)
   PUBMED   37669129
REFERENCE   4  (bases 1 to 2209)
  AUTHORS   Boachie,J., Adaikalakoteswari,A., Goljan,I., Samavat,J.,
            Cagampang,F.R. and Saravanan,P.
  TITLE     Intracellular and Tissue Levels of Vitamin B12 in Hepatocytes Are
            Modulated by CD320 Receptor and TCN2 Transporter
  JOURNAL   Int J Mol Sci 22 (6), 3089 (2021)
   PUBMED   33803025
  REMARK    GeneRIF: Intracellular and Tissue Levels of Vitamin B12 in
            Hepatocytes Are Modulated by CD320 Receptor and TCN2 Transporter.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2209)
  AUTHORS   Wang,B., Shen,Y., Zhai,L., Xia,X., Gu,H.M., Wang,M., Zhao,Y.,
            Chang,X., Alabi,A., Xing,S., Deng,S., Liu,B., Wang,G., Qin,S. and
            Zhang,D.W.
  TITLE     Atherosclerosis-associated hepatic secretion of VLDL but not PCSK9
            is dependent on cargo receptor protein Surf4
  JOURNAL   J Lipid Res 62, 100091 (2021)
   PUBMED   34118252
  REMARK    GeneRIF: Atherosclerosis-associated hepatic secretion of VLDL but
            not PCSK9 is dependent on cargo receptor protein Surf4.
REFERENCE   6  (bases 1 to 2209)
  AUTHORS   Andrade,N., Komnenovic,V., Blake,S.M., Jossin,Y., Howell,B.,
            Goffinet,A., Schneider,W.J. and Nimpf,J.
  TITLE     ApoER2/VLDL receptor and Dab1 in the rostral migratory stream
            function in postnatal neuronal migration independently of Reelin
  JOURNAL   Proc Natl Acad Sci U S A 104 (20), 8508-8513 (2007)
   PUBMED   17494763
  REMARK    GeneRIF: These data demonstrate a cell-autonomous function of
            ApoER2, and most likely VLDLR and Dab1, in postnatal migration of
            neuroblasts in the forebrain, which is suggested to depend on
            ligands other than Reelin.
REFERENCE   7  (bases 1 to 2209)
  AUTHORS   MacDougall,E.D., Kramer,F., Polinsky,P., Barnhart,S., Askari,B.,
            Johansson,F., Varon,R., Rosenfeld,M.E., Oka,K., Chan,L.,
            Schwartz,S.M. and Bornfeldt,K.E.
  TITLE     Aggressive very low-density lipoprotein (VLDL) and LDL lowering by
            gene transfer of the VLDL receptor combined with a low-fat diet
            regimen induces regression and reduces macrophage content in
            advanced atherosclerotic lesions in LDL receptor-deficient mice
  JOURNAL   Am J Pathol 168 (6), 2064-2073 (2006)
   PUBMED   16723719
  REMARK    GeneRIF: VLDL and LDL lowering by gene transfer of the VLDL
            receptor combined with a low-fat diet regimen induces regression
            and reduces macrophage content in advanced atherosclerotic lesions
            in LDL receptor-deficient mice
REFERENCE   8  (bases 1 to 2209)
  AUTHORS   Iwasaki,T., Takahashi,S., Takahashi,M., Zenimaru,Y., Kujiraoka,T.,
            Ishihara,M., Nagano,M., Suzuki,J., Miyamori,I., Naiki,H., Sakai,J.,
            Fujino,T., Miller,N.E., Yamamoto,T.T. and Hattori,H.
  TITLE     Deficiency of the very low-density lipoprotein (VLDL) receptors in
            streptozotocin-induced diabetic rats: insulin dependency of the
            VLDL receptor
  JOURNAL   Endocrinology 146 (8), 3286-3294 (2005)
   PUBMED   15878964
  REMARK    GeneRIF: Diabetic rats showed severe hyperlipidemia on d 21 and 28,
            with a dramatic decline in VLDL-R protein in skeletal muscle
            (>90%), heart (approximately 50%) and a loss of adipose tissues
            itself.
REFERENCE   9  (bases 1 to 2209)
  AUTHORS   Sinagra,M., Verrier,D., Frankova,D., Korwek,K.M., Blahos,J.,
            Weeber,E.J., Manzoni,O.J. and Chavis,P.
  TITLE     Reelin, very-low-density lipoprotein receptor, and apolipoprotein E
            receptor 2 control somatic NMDA receptor composition during
            hippocampal maturation in vitro
  JOURNAL   J Neurosci 25 (26), 6127-6136 (2005)
   PUBMED   15987942
  REMARK    GeneRIF: Reelin binds several receptors, including the VLDL
            receptor in cultured hippocampus neurons.
REFERENCE   10 (bases 1 to 2209)
  AUTHORS   Abe,K., Yuzuriha,M., Sugimoto,M., Ko,M.S., Brathwaite,M., Waeltz,P.
            and Nagaraja,R.
  TITLE     Gene content of the 750-kb critical region for mouse embryonic
            ectoderm lethal tcl-w5
  JOURNAL   Mamm Genome 15 (4), 265-276 (2004)
   PUBMED   15112104
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK078151.1 and AK140204.1.
            
            On Feb 25, 2006 this sequence version replaced NM_019421.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK140204.1, AK088189.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                AK078151.1         2-15
            15-1386             AK140204.1         2-1373
            1387-1844           AK078151.1         1388-1845
            1845-2209           AK140204.1         1832-2196
FEATURES             Location/Qualifiers
     source          1..2209
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 17.98 cM"
     gene            1..2209
                     /gene="Cd320"
                     /gene_synonym="425O18-1; 8D6; D17Ertd716e; NG29; TCblR;
                     VLDL"
                     /note="CD320 antigen"
                     /db_xref="GeneID:54219"
                     /db_xref="MGI:MGI:1860083"
     exon            1..201
                     /gene="Cd320"
                     /gene_synonym="425O18-1; 8D6; D17Ertd716e; NG29; TCblR;
                     VLDL"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..863
                     /gene="Cd320"
                     /gene_synonym="425O18-1; 8D6; D17Ertd716e; NG29; TCblR;
                     VLDL"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; putative VLDL lipoprotein receptor;
                     transcobalamin receptor"
                     /codon_start=1
                     /product="CD320 antigen isoform 1 precursor"
                     /protein_id="NP_062294.3"
                     /db_xref="CCDS:CCDS28632.1"
                     /db_xref="GeneID:54219"
                     /db_xref="MGI:MGI:1860083"
                     /translation="MARGGAGRAVALGLVLRLLFGLRTGLEAAPAPAHTRVQVSGSRA
                     DSCPTDTFQCLTSGYCVPLSWRCDGDQDCSDGSDEEDCRIESCAQNGQCQPQSALPCS
                     CDNISGCSDVSDKNLNCSRPPCQESELHCILDDVCIPHTWRCDGHPDCLDSSDELSCD
                     TDTEIDKIFQEENATTTRISTTMENETSFRNVTFTSAGDSSRNPSAYGVIAAAGVLSA
                     ILVSATLLILLRLRGQGYLPPPGLLVAVKESLLLSERKTSLI"
     exon            202..327
                     /gene="Cd320"
                     /gene_synonym="425O18-1; 8D6; D17Ertd716e; NG29; TCblR;
                     VLDL"
                     /inference="alignment:Splign:2.1.0"
     exon            328..558
                     /gene="Cd320"
                     /gene_synonym="425O18-1; 8D6; D17Ertd716e; NG29; TCblR;
                     VLDL"
                     /inference="alignment:Splign:2.1.0"
     exon            559..720
                     /gene="Cd320"
                     /gene_synonym="425O18-1; 8D6; D17Ertd716e; NG29; TCblR;
                     VLDL"
                     /inference="alignment:Splign:2.1.0"
     exon            721..2209
                     /gene="Cd320"
                     /gene_synonym="425O18-1; 8D6; D17Ertd716e; NG29; TCblR;
                     VLDL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1168..1173
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cd320"
                     /gene_synonym="425O18-1; 8D6; D17Ertd716e; NG29; TCblR;
                     VLDL"
                     /note="hexamer: ATTAAA"
     polyA_site      1188
                     /gene="Cd320"
                     /gene_synonym="425O18-1; 8D6; D17Ertd716e; NG29; TCblR;
                     VLDL"
                     /note="major polyA site"
ORIGIN      
        1 gtgtgcgcgt gcgcgagaat cagcgcgtcc ttctgactga gcggctgcgg ctggagcgga
       61 gcagttcggc tagctgttgg atggcgcggg gcggagctgg gcgggcagtg gccctgggcc
      121 tggtgctgcg gctcctcttt ggtctcagaa caggcctaga ggccgctccg gctccggccc
      181 atacccgggt ccaagtctcc ggctctagag ctgactcctg cccgacagac accttccagt
      241 gtcttaccag tggctattgt gtgccccttt cctggcgctg tgatggggac caggactgct
      301 ctgatggcag tgacgaggaa gactgtagga ttgagtcatg tgctcagaat gggcagtgcc
      361 aaccacagtc tgcccttcct tgctcctgtg acaacatcag tggttgctct gatgtctctg
      421 acaagaacct caactgcagc cgcccaccct gtcaggagag tgagctgcat tgcatactgg
      481 atgatgtctg tattccacac acgtggcgct gtgatggcca cccagactgt cttgactcca
      541 gtgatgagct cagctgtgac actgacacag aaattgataa gatattccag gaggagaatg
      601 ccacaactac aaggatttct acgaccatgg agaatgagac ctctttcagg aatgtaacat
      661 ttacctctgc tggggactca tcccgaaacc caagtgccta tggggttatt gcagctgctg
      721 gggtgttgag tgccatcctg gtttcggcca cccttctcat attgctacgc ctccgaggtc
      781 agggttatct gcccccacca gggctgttgg tggctgtgaa ggagtcgctg ctgctgtcag
      841 aaaggaaaac ctctctgatc tgaggacaca tggttaccac ctggccctga gtgcagtcag
      901 actgggacaa aggagccgtg aaacacgcaa ggagcttctg gcttctcagc tttgagacct
      961 gggctctttg gagcacagag aactttgatt tttaagcttc tacagatatg gtcctagaga
     1021 ctggggtcct cagacactcc cgctgtatgt ggtgagcttg gctggaaact tgccatagcc
     1081 aggactgagg ggctggcccc aggacgctct caagaaatgg ggctactgtg gtttagacac
     1141 tcctgctgct cacattgatg ggtggctatt aaagtttctt cacccctctg tctgcctcta
     1201 gcctgtttcc cttggcctgg gcagcctatg gtctcggctg gatctccttc taccttttaa
     1261 aagggagtct tcagccaaga ggtctgtgtc ctggacattt cctcctatac tctactttta
     1321 taaagtgagg acgagtattg agtccacact caacattaac agtgggctta ataggagaag
     1381 agacctgaag taatgtttcc ttattgggca ttcctttgtc atggcttctt ctgtgacatg
     1441 gaagctgggc taacctgatt tgaacttggc tatcccctgt tttttcaggg ctataatccc
     1501 agcagttggg aaggggagat aggagaatta gaagtaatag gcttgatgta catgcctgta
     1561 attctagcac tggggaggtt gaggcctgaa gagctggagt tcaaggaatg tctgtgctat
     1621 tcagggagac cttatttcct ttcttcccca gatgcagttg gttgatgttt tatgagacag
     1681 ttctgttcta ggctgacagg ttgtttactg tctagcaatg agttagcccc gggaggtagg
     1741 gaagggctgt ccccatgtca taactgaagc ccaagatacc tgaacatgga catacagaaa
     1801 acaagaaaat attgttaata caacttgact tctgagtaac aaggccagag ctcttcccag
     1861 actctcaaat tcctaagtaa aatggtgggg actgttagaa tgcctccaac aggcagagga
     1921 gaggccttcc tggtatctct agctcctagt aacctccagg cccatgatga gtattggagc
     1981 tctgaggctg tacaagtaag aggacctgaa ttcagatccc cagtacccta taggaagttg
     2041 gatttgccta tgatcttatt actgcgggtg ggcatgagca caggaagatc ccggggactt
     2101 gctggggaga tagtgtagcc tgagagttta agattcagtg agaaaccttg tttcaaaaaa
     2161 taaaggggag ggactgggga tatgtctcag tgattaaaac acctgttgc
//
