LOCUS       NM_027987               2348 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus CD300 molecule like family member G (Cd300lg),
            transcript variant 4, mRNA.
ACCESSION   NM_027987 XM_126512
VERSION     NM_027987.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2348)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2348)
  AUTHORS   Shintani,A., Fukai,S., Nobusawa,R., Taniguchi,K., Hatatani,T.,
            Nagai,H., Sakai,T., Yoshimura,T., Miyasaka,M. and Hayasaka,H.
  TITLE     Dach1 transcription factor regulates the expression of peripheral
            node addressin and lymphocyte trafficking in lymph nodes
  JOURNAL   Curr Res Immunol 3, 175-185 (2022)
   PUBMED   36045707
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2348)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2348)
  AUTHORS   Umemoto,E., Takeda,A., Jin,S., Luo,Z., Nakahogi,N., Hayasaka,H.,
            Lee,C.M., Tanaka,T. and Miyasaka,M.
  TITLE     Dynamic changes in endothelial cell adhesion molecule
            nepmucin/CD300LG expression under physiological and pathological
            conditions
  JOURNAL   PLoS One 8 (12), e83681 (2013)
   PUBMED   24376728
  REMARK    GeneRIF: nepmucin/CD300LG expression in microvascular endothelial
            cells
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2348)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   6  (bases 1 to 2348)
  AUTHORS   Jin,S., Umemoto,E., Tanaka,T., Shimomura,Y., Tohya,K., Kunizawa,K.,
            Yang,B.G., Jang,M.H., Hirata,T. and Miyasaka,M.
  TITLE     Nepmucin/CLM-9, an Ig domain-containing sialomucin in vascular
            endothelial cells, promotes lymphocyte transendothelial migration
            in vitro
  JOURNAL   FEBS Lett 582 (20), 3018-3024 (2008)
   PUBMED   18675811
  REMARK    GeneRIF: These results suggest that endothelial nepmucin promotes
            lymphocyte transendothelial migration using multiple adhesion
            pathways.
REFERENCE   7  (bases 1 to 2348)
  AUTHORS   Takatsu,H., Hase,K., Ohmae,M., Ohshima,S., Hashimoto,K.,
            Taniura,N., Yamamoto,A. and Ohno,H.
  TITLE     CD300 antigen like family member G: A novel Ig receptor like
            protein exclusively expressed on capillary endothelium
  JOURNAL   Biochem Biophys Res Commun 348 (1), 183-191 (2006)
   PUBMED   16876123
REFERENCE   8  (bases 1 to 2348)
  AUTHORS   Umemoto,E., Tanaka,T., Kanda,H., Jin,S., Tohya,K., Otani,K.,
            Matsutani,T., Matsumoto,M., Ebisuno,Y., Jang,M.H., Fukuda,M.,
            Hirata,T. and Miyasaka,M.
  TITLE     Nepmucin, a novel HEV sialomucin, mediates L-selectin-dependent
            lymphocyte rolling and promotes lymphocyte adhesion under flow
  JOURNAL   J Exp Med 203 (6), 1603-1614 (2006)
   PUBMED   16754720
  REMARK    GeneRIF: nepmucin may serve as a dual-functioning in peripheral
            node addressin in endothial venules mediating both lymphocyte
            rolling and binding via different functional domains.
REFERENCE   9  (bases 1 to 2348)
  AUTHORS   Chung,D.H., Humphrey,M.B., Nakamura,M.C., Ginzinger,D.G.,
            Seaman,W.E. and Daws,M.R.
  TITLE     CMRF-35-like molecule-1, a novel mouse myeloid receptor, can
            inhibit osteoclast formation
  JOURNAL   J Immunol 171 (12), 6541-6548 (2003)
   PUBMED   14662855
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB630327.1, BC116906.1, BB150844.2 and AK009375.1.
            
            [WARNING] On May 8, 2024 this sequence was replaced by NM_027987.4.
            
            On May 27, 2009 this sequence version replaced NM_027987.2.
            
            Transcript Variant: This variant (4) lacks an exon and a segment in
            the CDS, as compared to variant 1. The reading frame is not
            affected and the resulting isoform (4) lacks an internal segment,
            as compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB243066.1, AK171982.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-53                BB630327.1         1-53
            54-1299             BC116906.1         1-1246
            1300-1412           BB150844.2         567-679
            1413-2348           AK009375.1         1374-2309
FEATURES             Location/Qualifiers
     source          1..2348
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 65.48 cM"
     gene            1..2348
                     /gene="Cd300lg"
                     /gene_synonym="2310016B05Rik; Clm9; D11Ertd736e"
                     /note="CD300 molecule like family member G"
                     /db_xref="GeneID:52685"
                     /db_xref="MGI:MGI:1289168"
     exon            1..123
                     /gene="Cd300lg"
                     /gene_synonym="2310016B05Rik; Clm9; D11Ertd736e"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..944
                     /gene="Cd300lg"
                     /gene_synonym="2310016B05Rik; Clm9; D11Ertd736e"
                     /note="isoform 4 precursor is encoded by transcript
                     variant 4; CMRF-35-like molecule-9; CMRF35-like molecule
                     9; nepmucin; CLM-9; CD300 antigen like family member G"
                     /codon_start=1
                     /product="CMRF35-like molecule 9 isoform 4 precursor"
                     /protein_id="NP_082263.2"
                     /db_xref="CCDS:CCDS25484.1"
                     /db_xref="GeneID:52685"
                     /db_xref="MGI:MGI:1289168"
                     /translation="MRPLVLLWGCLVLPGYEALKGPKEISGFEGDTVSLRCTYVEKMK
                     EHRKYWCRQGGILVSRCGDIVYANQDQEVTRGRMSIRDSPQELSMTVIMRDLTLKDSG
                     KYWCGIDRLGRDESFEVTLIVFPGSSRPVVWLPLTTPQDSRAVASSVSKPSVSIPMVR
                     MMAPVLILLSLLLAAGLIAFGSHMLRWRKKAWLATETQKNEKVYLETSLPGNGWTTED
                     STIDLAVTPECLRNLNPSAVPSPETQNLSQSTEEEEAARSLDDDKEDVMAPPPLQMSA
                     EELAFSEFISV"
     exon            124..456
                     /gene="Cd300lg"
                     /gene_synonym="2310016B05Rik; Clm9; D11Ertd736e"
                     /inference="alignment:Splign:2.1.0"
     exon            457..538
                     /gene="Cd300lg"
                     /gene_synonym="2310016B05Rik; Clm9; D11Ertd736e"
                     /inference="alignment:Splign:2.1.0"
     exon            539..651
                     /gene="Cd300lg"
                     /gene_synonym="2310016B05Rik; Clm9; D11Ertd736e"
                     /inference="alignment:Splign:2.1.0"
     exon            652..704
                     /gene="Cd300lg"
                     /gene_synonym="2310016B05Rik; Clm9; D11Ertd736e"
                     /inference="alignment:Splign:2.1.0"
     exon            705..824
                     /gene="Cd300lg"
                     /gene_synonym="2310016B05Rik; Clm9; D11Ertd736e"
                     /inference="alignment:Splign:2.1.0"
     exon            825..2348
                     /gene="Cd300lg"
                     /gene_synonym="2310016B05Rik; Clm9; D11Ertd736e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1395..1400
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cd300lg"
                     /gene_synonym="2310016B05Rik; Clm9; D11Ertd736e"
                     /note="hexamer: ATTAAA"
     polyA_site      1419
                     /gene="Cd300lg"
                     /gene_synonym="2310016B05Rik; Clm9; D11Ertd736e"
                     /note="major polyA site"
ORIGIN      
        1 ccttcctggc tccagcccgg cagaagctaa agctcagaag agctcccaat tgcaggcaac
       61 tgcagtgtcc agcacccacc atgaggcctc tggtcctgct atggggctgc ctggtgctcc
      121 caggttatga agccctgaag ggtccaaagg agatcagtgg atttgaaggt gacaccgtgt
      181 ccctgcggtg tacctacgtg gagaagatga aggagcacag gaagtattgg tgccggcagg
      241 gtggcatcct ggtgtcacgc tgcggtgaca ttgtctacgc aaatcaggac caggaggtga
      301 ctcgaggcag gatgtccatc cgagacagtc cccaagagct ctcgatgacc gtgatcatga
      361 gggaccttac cctgaaggat tcagggaagt actggtgtgg gattgacaga ctgggccgcg
      421 atgagtcttt tgaggttaca ctcattgtct ttccagggag ctcccgtcca gtcgtctggc
      481 tgccccttac cacgccacag gactccaggg ctgtagccag cagtgtctcc aagcccagtg
      541 tgtccatccc gatggtccgc atgatggccc cagtcctgat actcttgtcc ctgctgttgg
      601 ctgcaggact aattgccttt ggcagccaca tgctccggtg gagaaagaaa gcttggctgg
      661 ccacagagac acagaagaac gagaaggtct accttgaaac ctcgctgcca gggaacggct
      721 ggaccactga agactcgacg atagaccttg cagtgactcc tgaatgtctc agaaacctca
      781 acccttctgc tgtgccctct cctgagacac agaacctcag tcagtctaca gaggaggaag
      841 aggcagctcg ttccctggac gacgacaagg aggacgtgat ggcaccccct cccttgcaga
      901 tgtctgcgga ggaactggcc ttctctgagt tcatctctgt gtaattgcag aatgccccgt
      961 ggtcggccag ggattgtgaa gctgaacagc tgagttctca tgaattcttg ggttctactc
     1021 acagtccacg gctctgtcca ccttccttcc ggctctcttt catgccccag atggagaagt
     1081 gtcttggtcc ctgaagcccg gatggtactt aacaagtcca gccagaggct ggaacctccc
     1141 gcatattcta atccctggga agagttaatg ggtgtgtggg ccttcatcgg ggcctggcca
     1201 ggctccatgg ataaaggctg agtttgtgtg cgttccagga aattccctgg gcatggatgc
     1261 ccagcaacag tcccacctcc catcctcgga agatcccacc ttcacctccc tctaattctt
     1321 ctgcatcaat tgctatggag gagacaacat atgtgtgtct atgaaacacc tgcatcctgg
     1381 cctcttagaa aataattaaa acaaaattct gcagacccat caagactcac caaaccatct
     1441 ctagggcagg gcctgggact ccacagttct gacaagtgac cctgccattc ctacccttgg
     1501 gtctgatgaa tcctcagccc attttagcta gaatcttcct tccttccttc cttccttcct
     1561 tccttccttc cttcctttcc ttcctttcct tcctttcctt cctttcctta ctttccttcc
     1621 tttcttcgtt ccttccttcc ttccctgtgg ggtttcctat atgcttccta gacctagatc
     1681 atgacagtac ggtcccagta ggcacttcct gatgcctctc tggtcaggca cactatggtg
     1741 acagccagcc caaggcagcc agggatcagc tgtctctcca tcctccttcc ccaaggccct
     1801 gtgtcccttg ctttggtagg acactggagg aagtctcgat atcattcctg tccagagtgg
     1861 ttactcctcc atggggtctg gaggctgagg gagaggagga ggaggaggat accagagtgg
     1921 gaaggggggc ggggaaacag aagacactag actctagtta ctagaggaga atactaaatc
     1981 cagtactgtt gagtgaggga aagatggact ggctcaacta ttttttttcc tttttctatt
     2041 ttgttttgaa aagtaagatg ttgggaaggg aggtgttcag aatataaaac agaaatgtag
     2101 ggagaataca aaagaagtgc tgtttctagg atcatatata acctcaccaa accttgttga
     2161 cggctctgcc tgagcttgca ggacccccct cctttcccct ccccttccag tatttgcaga
     2221 tgctccgttt acagaggggt cctctcacca tgcacagccc actacgcatc acacgctgtc
     2281 tcgtcataag catccctccg tgttctacga actttgtaca ataaactttc tcagctgtgt
     2341 agtatttc
//
