LOCUS       NM_001169153            1885 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus CD300 molecule like family member F (Cd300lf),
            transcript variant 1, mRNA.
ACCESSION   NM_001169153
VERSION     NM_001169153.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1885)
  AUTHORS   Evans,F., Ali-Ruiz,D., Rego,N., Negro-Demontel,M.L., Lago,N.,
            Cawen,F.A., Pannunzio,B., Sanchez-Molina,P., Reyes,L., Paolino,A.,
            Rodriguez-Duarte,J., Perez-Torrado,V., Chicote-Gonzalez,A.,
            Quijano,C., Marmisolle,I., Mulet,A.P., Schlapp,G., Meikle,M.N.,
            Bresque,M., Crispo,M., Savio,E., Malagelada,C., Escande,C. and
            Peluffo,H.
  TITLE     CD300f immune receptor contributes to healthy aging by regulating
            inflammaging, metabolism, and cognitive decline
  JOURNAL   Cell Rep 42 (10), 113269 (2023)
   PUBMED   37864797
REFERENCE   2  (bases 1 to 1885)
  AUTHORS   Ali-Ruiz,D., Vitureira,N. and Peluffo,H.
  TITLE     Microglial CD300f immune receptor contributes to the maintenance of
            neuron viability in vitro and after a penetrating brain injury
  JOURNAL   Sci Rep 13 (1), 16796 (2023)
   PUBMED   37798310
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1885)
  AUTHORS   Kennedy,E.A., Aggarwal,S., Dhar,A., Karst,S.M., Wilen,C.B. and
            Baldridge,M.T.
  TITLE     Age-associated features of norovirus infection analysed in mice
  JOURNAL   Nat Microbiol 8 (6), 1095-1107 (2023)
   PUBMED   37188813
REFERENCE   4  (bases 1 to 1885)
  AUTHORS   Strine,M.S., Alfajaro,M.M., Graziano,V.R., Song,J., Hsieh,L.L.,
            Hill,R., Guo,J., VanDussen,K.L., Orchard,R.C., Baldridge,M.T.,
            Lee,S. and Wilen,C.B.
  TITLE     Tuft-cell-intrinsic and -extrinsic mediators of norovirus tropism
            regulate viral immunity
  JOURNAL   Cell Rep 41 (6), 111593 (2022)
   PUBMED   36351394
REFERENCE   5  (bases 1 to 1885)
  AUTHORS   Hayman,D.J., Modebadze,T., Charlton,S., Cheung,K., Soul,J., Lin,H.,
            Hao,Y., Miles,C.G., Tsompani,D., Jackson,R.M., Briggs,M.D.,
            Pirog,K.A., Clark,I.M., Barter,M.J., Clowry,G.J., LeBeau,F.E.N. and
            Young,D.A.
  TITLE     Increased hippocampal excitability in miR-324-null mice
  JOURNAL   Sci Rep 11 (1), 10452 (2021)
   PUBMED   34001919
  REMARK    GeneRIF: Increased hippocampal excitability in miR-324-null mice.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1885)
  AUTHORS   Can,I., Tahara-Hanaoka,S., Hitomi,K., Nakano,T., Nakahashi-Oda,C.,
            Kurita,N., Honda,S., Shibuya,K. and Shibuya,A.
  TITLE     Caspase-independent cell death by CD300LF (MAIR-V), an inhibitory
            immunoglobulin-like receptor on myeloid cells
  JOURNAL   J Immunol 180 (1), 207-213 (2008)
   PUBMED   18097021
  REMARK    GeneRIF: These results indicate that CD300LF mediates caspase and
            endoplasmic reticulum stress-independent cell death by a novel
            mechanism.
REFERENCE   7  (bases 1 to 1885)
  AUTHORS   Izawa,K., Kitaura,J., Yamanishi,Y., Matsuoka,T., Oki,T.,
            Shibata,F., Kumagai,H., Nakajima,H., Maeda-Yamamoto,M.,
            Hauchins,J.P., Tybulewicz,V.L.J., Takai,T. and Kitamura,T.
  TITLE     Functional analysis of activating receptor LMIR4 as a counterpart
            of inhibitory receptor LMIR3
  JOURNAL   J Biol Chem 282 (25), 17997-18008 (2007)
   PUBMED   17438331
  REMARK    GeneRIF: the innate immune system is at least in part regulated by
            the qualitative and quantitative balance of the paired receptors
            LMIR3 and LMIR4
REFERENCE   8  (bases 1 to 1885)
  AUTHORS   Shi,L., Luo,K., Xia,D., Chen,T., Chen,G., Jiang,Y., Li,N. and
            Cao,X.
  TITLE     DIgR2, dendritic cell-derived immunoglobulin receptor 2, is one
            representative of a family of IgSF inhibitory receptors and
            mediates negative regulation of dendritic cell-initiated
            antigen-specific T-cell responses
  JOURNAL   Blood 108 (8), 2678-2686 (2006)
   PUBMED   16794255
  REMARK    GeneRIF: DIgR2 is a functionally inhibitory receptor and can
            mediate negative signaling to regulate DC-initiated
            antigen-specific T-cell responses.
REFERENCE   9  (bases 1 to 1885)
  AUTHORS   Chung,D.H., Humphrey,M.B., Nakamura,M.C., Ginzinger,D.G.,
            Seaman,W.E. and Daws,M.R.
  TITLE     CMRF-35-like molecule-1, a novel mouse myeloid receptor, can
            inhibit osteoclast formation
  JOURNAL   J Immunol 171 (12), 6541-6548 (2003)
   PUBMED   14662855
REFERENCE   10 (bases 1 to 1885)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK089313.1, CK790587.1, BM227747.2 and AI414341.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and it encodes the longer protein (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK089313.1, AB292061.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1045              AK089313.1         1-1045
            1046-1627           CK790587.1         76-657
            1628-1880           BM227747.2         1-253               c
            1881-1885           AI414341.1         1-5                 c
FEATURES             Location/Qualifiers
     source          1..1885
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 80.59 cM"
     gene            1..1885
                     /gene="Cd300lf"
                     /gene_synonym="CLIM1; CLM-1; CLM1; Digr2; F730004D16Rik;
                     IgSF13; IREM1; LMIR3; Pigr3"
                     /note="CD300 molecule like family member F"
                     /db_xref="GeneID:246746"
                     /db_xref="MGI:MGI:2442359"
     exon            1..154
                     /gene="Cd300lf"
                     /gene_synonym="CLIM1; CLM-1; CLM1; Digr2; F730004D16Rik;
                     IgSF13; IREM1; LMIR3; Pigr3"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..1125
                     /gene="Cd300lf"
                     /gene_synonym="CLIM1; CLM-1; CLM1; Digr2; F730004D16Rik;
                     IgSF13; IREM1; LMIR3; Pigr3"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; CMRF35-like molecule 1; DC-derived Ig-like
                     receptor 2; CMRF-35-like molecule 1; leukocyte
                     mono-Ig-like receptor 3; MAIR-5; MAIR-V;
                     myeloid-associated immunoglobulin-like receptor 5; CD300
                     antigen like family member F"
                     /codon_start=1
                     /product="CMRF35-like molecule 1 isoform 1 precursor"
                     /protein_id="NP_001162624.1"
                     /db_xref="CCDS:CCDS48980.1"
                     /db_xref="GeneID:246746"
                     /db_xref="MGI:MGI:2442359"
                     /translation="MHLSLLVPFLFWITGCCTAEDPVTGPEEVSGQEQGSLTVQCRYT
                     SGWKDYKKYWCQGVPQRSCKTLVETDASEQLVKKNRVSIRDNQRDFIFTVTMEDLRMS
                     DAGIYWCGITKGGLDPMFKVTVNIGPAIQVPITVPTMPPITSTTTIFTVTTTVKETSM
                     FPTLTSYYSDNGHGGGDSGGGEDGVGDGFLDLSVLLPVISAVLLLLLLVASLFAWRMV
                     RRQKKAAGPPSEQAQSLEGDLCYADLSLKQPRTSPGSSWKKGSSMSSSGKDHQEEVEY
                     VTMAPFPREEVSYAALTLAGLGQEPTYGNTGCPITHVPRTGLEEETTEYSSIRRPLPA
                     AMP"
     exon            155..496
                     /gene="Cd300lf"
                     /gene_synonym="CLIM1; CLM-1; CLM1; Digr2; F730004D16Rik;
                     IgSF13; IREM1; LMIR3; Pigr3"
                     /inference="alignment:Splign:2.1.0"
     exon            497..626
                     /gene="Cd300lf"
                     /gene_synonym="CLIM1; CLM-1; CLM1; Digr2; F730004D16Rik;
                     IgSF13; IREM1; LMIR3; Pigr3"
                     /inference="alignment:Splign:2.1.0"
     exon            627..781
                     /gene="Cd300lf"
                     /gene_synonym="CLIM1; CLM-1; CLM1; Digr2; F730004D16Rik;
                     IgSF13; IREM1; LMIR3; Pigr3"
                     /inference="alignment:Splign:2.1.0"
     exon            782..804
                     /gene="Cd300lf"
                     /gene_synonym="CLIM1; CLM-1; CLM1; Digr2; F730004D16Rik;
                     IgSF13; IREM1; LMIR3; Pigr3"
                     /inference="alignment:Splign:2.1.0"
     exon            805..948
                     /gene="Cd300lf"
                     /gene_synonym="CLIM1; CLM-1; CLM1; Digr2; F730004D16Rik;
                     IgSF13; IREM1; LMIR3; Pigr3"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1885
                     /gene="Cd300lf"
                     /gene_synonym="CLIM1; CLM-1; CLM1; Digr2; F730004D16Rik;
                     IgSF13; IREM1; LMIR3; Pigr3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1861..1866
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cd300lf"
                     /gene_synonym="CLIM1; CLM-1; CLM1; Digr2; F730004D16Rik;
                     IgSF13; IREM1; LMIR3; Pigr3"
                     /note="hexamer: AATAAA"
     polyA_site      1885
                     /gene="Cd300lf"
                     /gene_synonym="CLIM1; CLM-1; CLM1; Digr2; F730004D16Rik;
                     IgSF13; IREM1; LMIR3; Pigr3"
                     /note="major polyA site"
ORIGIN      
        1 gaggaagtgc cgagtgagag tgagggaaac cacaggacca ggagacgcag gagtggagca
       61 tgtagcctgt tctcgctggc aggctccacc aaggtgaccc ggtgtgagaa gatgcatttg
      121 tcattgctgg tcccctttct cttctggatc acaggctgct gcacggctga ggatccagtc
      181 acaggtccag aggaggtgag cggtcaggag cagggctcct tgacagtgca gtgccgatat
      241 acctcaggct ggaaggatta caagaagtac tggtgccaag gagttcctca gagatcatgt
      301 aagactcttg ttgaaaccga tgcatcagag cagctggtga agaagaaccg tgtgtccatc
      361 agggacaacc agagagactt catcttcaca gtgaccatgg aggatctgag gatgagcgat
      421 gctggcattt actggtgtgg aattacgaaa ggtggacttg atcccatgtt taaagttact
      481 gtgaacattg gcccagcaat ccaagtaccc attacagtgc caaccatgcc ccccatcacc
      541 tccaccacca ccatcttcac agtgacaacc acagtaaaag agaccagcat gtttccaacg
      601 ctgactagct actactctga taacgggcat ggcggtggtg acagtggcgg tggtgaagat
      661 ggcgtcggtg atgggtttct ggatctcagt gtgctcctcc cagtcatctc tgcagtcctg
      721 ttgcttctcc tgttggtggc ctcgctcttt gcttggagga tggtgaggag acagaagaaa
      781 gctgctgggc caccatcaga gcaggcacag tctctggagg gtgatctctg ttatgcagac
      841 ctgtccctga agcagcccag aacctcccct ggctcctctt ggaaaaaggg ctcctccatg
      901 tcctcctctg gcaaggacca ccaagaggaa gtggaatatg tcaccatggc tccctttccc
      961 agggaggagg tttcatatgc cgctctgact ttggccggct tgggtcagga gcctacttat
     1021 ggcaatactg gctgccccat cacccacgtt cccaggacag gccttgaaga ggagaccaca
     1081 gagtacagca gcatcaggag gcccttgcct gcagccatgc cttaatcttg gtctctgaag
     1141 gcggcttgga gcatggatct ttacatctgc ctctgtacct gcttccttac ccggcccagc
     1201 tggtgactgg aactctgtcc atccgtctct catggccatc agctctacct tgcttgagct
     1261 tggagttcaa cctcagggag ttccagggaa ttaaggctcc ttccacatcc ccacttatag
     1321 ccaatgtacc ttggaaggta ccaggcaggc tgcttcaggg atgctgtgta aatcgtatca
     1381 acgatgacaa taatagcaat caacctttat ttattgtttt tcatatgggt ttcccccgcc
     1441 cctcccccca ggacattttc atcctcatac ccataatctg taaattattt tatacaaaga
     1501 aagataagta catatgtgtt taagttagag ttttgagatg agtctgtatt atccaagtag
     1561 gcccaaaata taaccacaag ggtctgtttt aaggaggaag agagagagag agagagtgag
     1621 agagagagag agagagagag agagagagag agagagagag agagagagaa agagagagaa
     1681 caacagaagc agaaggtgga gggatgcaga aggagtcagg atgttgcaca tccagcagcc
     1741 agcaaggcca agtatcagac tgttctgttc cgtgagcgga gcactgggtg gcgattaggt
     1801 ctgccagtgt caagggttgg gtggagttga attgattgtg tactttcaga attgtagaag
     1861 aataaagttg tattgttttt attta
//
