LOCUS       NM_199221               2867 bp    mRNA    linear   ROD 08-JUN-2024
DEFINITION  Mus musculus CD300 molecule like family member B (Cd300lb),
            transcript variant 1, mRNA.
ACCESSION   NM_199221 XM_137898
VERSION     NM_199221.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2867)
  AUTHORS   Avlas,S., Kassis,H., Itan,M., Reichman,H., Dolitzky,A., Hazut,I.,
            Grisaru-Tal,S., Gordon,Y., Tsarfaty,I., Karo-Atar,D., Rozenberg,P.,
            Bitton,A. and Munitz,A.
  TITLE     CD300b regulates intestinal inflammation and promotes repair in
            colitis
  JOURNAL   Front Immunol 14, 1050245 (2023)
   PUBMED   37033950
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2867)
  AUTHORS   Takahashi,M., Izawa,K., Urai,M., Yamanishi,Y., Maehara,A.,
            Isobe,M., Matsukawa,T., Kaitani,A., Takamori,A., Uchida,S.,
            Yamada,H., Nagamine,M., Ando,T., Shimizu,T., Ogawa,H., Okumura,K.,
            Kinjo,Y., Kitamura,T. and Kitaura,J.
  TITLE     The phytosphingosine-CD300b interaction promotes zymosan-induced,
            nitric oxide-dependent neutrophil recruitment
  JOURNAL   Sci Signal 12 (564) (2019)
   PUBMED   30647146
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2867)
  AUTHORS   Voss,O.H., Murakami,Y., Pena,M.Y., Lee,H.N., Tian,L.,
            Margulies,D.H., Street,J.M., Yuen,P.S., Qi,C.F., Krzewski,K. and
            Coligan,J.E.
  TITLE     Lipopolysaccharide-Induced CD300b Receptor Binding to Toll-like
            Receptor 4 Alters Signaling to Drive Cytokine Responses that
            Enhance Septic Shock
  JOURNAL   Immunity 44 (6), 1365-1378 (2016)
   PUBMED   27261276
REFERENCE   4  (bases 1 to 2867)
  AUTHORS   Voce,D.J., Schmitt,A.M., Uppal,A., McNerney,M.E., Bernal,G.M.,
            Cahill,K.E., Wahlstrom,J.S., Nassiri,A., Yu,X., Crawley,C.D.,
            White,K.P., Onel,K., Weichselbaum,R.R. and Yamini,B.
  TITLE     Nfkb1 is a haploinsufficient DNA damage-specific tumor suppressor
  JOURNAL   Oncogene 34 (21), 2807-2813 (2015)
   PUBMED   25043302
REFERENCE   5  (bases 1 to 2867)
  AUTHORS   Phongsisay,V.
  TITLE     Campylobacter jejuni targets immunoglobulin-like receptor LMIR5
  JOURNAL   Mol Immunol 63 (2), 574-578 (2015)
   PUBMED   25172092
  REMARK    GeneRIF: C. jejuni interacted preferentially with LMIR5.
REFERENCE   6  (bases 1 to 2867)
  AUTHORS   Yamanishi,Y., Kitaura,J., Izawa,K., Kaitani,A., Komeno,Y.,
            Nakamura,M., Yamazaki,S., Enomoto,Y., Oki,T., Akiba,H., Abe,T.,
            Komori,T., Morikawa,Y., Kiyonari,H., Takai,T., Okumura,K. and
            Kitamura,T.
  TITLE     TIM1 is an endogenous ligand for LMIR5/CD300b: LMIR5 deficiency
            ameliorates mouse kidney ischemia/reperfusion injury
  JOURNAL   J Exp Med 207 (7), 1501-1511 (2010)
   PUBMED   20566714
  REMARK    GeneRIF: TIM1 is an endogenous ligand for LMIR5.
REFERENCE   7  (bases 1 to 2867)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   8  (bases 1 to 2867)
  AUTHORS   Yamanishi,Y., Kitaura,J., Izawa,K., Matsuoka,T., Oki,T., Lu,Y.,
            Shibata,F., Yamazaki,S., Kumagai,H., Nakajima,H.,
            Maeda-Yamamoto,M., Tybulewicz,V.L., Takai,T. and Kitamura,T.
  TITLE     Analysis of mouse LMIR5/CLM-7 as an activating receptor:
            differential regulation of LMIR5/CLM-7 in mouse versus human cells
  JOURNAL   Blood 111 (2), 688-698 (2008)
   PUBMED   17928527
  REMARK    GeneRIF: although both mouse and human LMIR5 play activatory roles
            in innate immunity cells, the functions of LMIR5 were
            differentially regulated in mouse versus human cells.
REFERENCE   9  (bases 1 to 2867)
  AUTHORS   Martinez-Barriocanal,A. and Sayos,J.
  TITLE     Molecular and functional characterization of CD300b, a new
            activating immunoglobulin receptor able to transduce signals
            through two different pathways
  JOURNAL   J Immunol 177 (5), 2819-2830 (2006)
   PUBMED   16920917
REFERENCE   10 (bases 1 to 2867)
  AUTHORS   Chung,D.H., Humphrey,M.B., Nakamura,M.C., Ginzinger,D.G.,
            Seaman,W.E. and Daws,M.R.
  TITLE     CMRF-35-like molecule-1, a novel mouse myeloid receptor, can
            inhibit osteoclast formation
  JOURNAL   J Immunol 171 (12), 6541-6548 (2003)
   PUBMED   14662855
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL607025.21 and AL669969.14.
            
            On Feb 27, 2019 this sequence version replaced NM_199221.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK170613.1, AK154359.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-163               AL607025.21        10535-10697         c
            164-493             AL607025.21        4620-4949           c
            494-584             AL607025.21        2350-2440           c
            585-2867            AL669969.14        124150-126432       c
FEATURES             Location/Qualifiers
     source          1..2867
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 80.55 cM"
     gene            1..2867
                     /gene="Cd300lb"
                     /gene_synonym="CLM-7; Clm7; Gm253; LMIR5"
                     /note="CD300 molecule like family member B"
                     /db_xref="GeneID:217304"
                     /db_xref="MGI:MGI:2685099"
     exon            1..163
                     /gene="Cd300lb"
                     /gene_synonym="CLM-7; Clm7; Gm253; LMIR5"
                     /inference="alignment:Splign:2.1.0"
     CDS             124..753
                     /gene="Cd300lb"
                     /gene_synonym="CLM-7; Clm7; Gm253; LMIR5"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; CMRF-35-like molecule-7; CMRF35-like molecule
                     7; IREM-3; leukocyte mono-Ig-like receptor 5; immune
                     receptor expressed on myeloid cells 3; CD300 antigen like
                     family member B"
                     /codon_start=1
                     /product="CMRF35-like molecule 7 isoform 1 precursor"
                     /protein_id="NP_954691.3"
                     /db_xref="CCDS:CCDS25614.2"
                     /db_xref="GeneID:217304"
                     /db_xref="MGI:MGI:2685099"
                     /translation="MWLSPALLLLSFPGCLSIQGPALVRGPEQGSVTVQCRYSSRWQT
                     NKKWWCRGASWSTCRVLIRSTGSEKETKSGRLSIRDNQKNHSFQVTMEMLRQNDTDTY
                     WCGIEKFGTDRGTRVKVNVYSVGKDTMSTSNQLPWPTVDGSTDMVSSDLQKRTYYMLL
                     VFVKVPALLILVGAVLWLKRSTQKVPEEQWRHTLCSDLDSELLAKDISP"
     exon            164..493
                     /gene="Cd300lb"
                     /gene_synonym="CLM-7; Clm7; Gm253; LMIR5"
                     /inference="alignment:Splign:2.1.0"
     exon            494..584
                     /gene="Cd300lb"
                     /gene_synonym="CLM-7; Clm7; Gm253; LMIR5"
                     /inference="alignment:Splign:2.1.0"
     exon            585..2867
                     /gene="Cd300lb"
                     /gene_synonym="CLM-7; Clm7; Gm253; LMIR5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2843..2848
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cd300lb"
                     /gene_synonym="CLM-7; Clm7; Gm253; LMIR5"
                     /note="hexamer: ATTAAA"
     polyA_site      2867
                     /gene="Cd300lb"
                     /gene_synonym="CLM-7; Clm7; Gm253; LMIR5"
                     /note="major polyA site"
ORIGIN      
        1 agaggcaacc tggacaaaca gaacgagtca gctgagatct ccagggcttt gggtatcccg
       61 ctgagatttg gatttgctgc tggctgttca tcaaggagtg cagcaaagtg ggaaggcagg
      121 accatgtggc tgtccccagc tttgcttctt ctcagttttc caggctgcct ctccatccaa
      181 ggcccagcat tggtgagggg tccagagcag gggtcagtga ctgtgcaatg tcgctatagc
      241 tcaagatggc aaaccaacaa gaagtggtgg tgccggggag caagctggag cacttgcagg
      301 gtcctcatcc gatccactgg gtcagagaaa gaaacgaaga gcggccggct gtccatcagg
      361 gacaatcaga aaaatcactc attccaggtt accatggaga tgctcaggca aaatgacacg
      421 gacacttact ggtgtggtat tgaaaagttc ggaactgacc gtgggaccag agttaaagtg
      481 aacgtctact cggtgggtaa agataccatg tcgacttcta atcaacttcc ctggcccact
      541 gtggacggca gtacagacat ggtgtcttct gacttgcaga agaggaccta ttacatgctc
      601 ctggtatttg tgaaggtgcc tgccttgctc atcttggttg gtgctgtcct ctggctgaag
      661 aggtcaactc agaaggtccc tgaggaacag tggagacaca ctctctgtag cgatttggac
      721 tctgaacttc tagctaaaga catttctcct tagactgatg gataagcaga gccttcccat
      781 tctggactct catttcagag gagaccagga ccagggaaga aatgtcctta aatcctcggt
      841 gggtggtgac caaggctggt gcctggaagg ctagtccagg catgagctac actctgcata
      901 gcgtggagct acaactcagg atcttcctga agtatcatct caactgcatg accagcacct
      961 cactctctct ttacatcttc atcagcccta ccccatctac ccaccatggt caaccagggt
     1021 gagaatcgat ggaacacagc ccaagctgca gaaagacagc tgtgcgtgcc ctgctggaaa
     1081 agcttatgca gggcctggaa cagaagcaca gaaaagcata agggaccagt ggggtgtcta
     1141 gaccacctat cctatgactc tgtcatagga aactctgtga aagcagagca agcgttcatt
     1201 ctccatgttc tggacactga gcccgcccct agcgtgcact tctgaggaaa ggagaagact
     1261 aacgcctgcc cgacaggccc aggatctaga ttgcagagaa cttgaggatc catgacttag
     1321 ccagcaggtg tgttttgctc caggggtcag gggcagaagg ctgcacagcc ttaaatagat
     1381 ctcagactgg aggcatgcgg gttttaagca aaggttagcc aggagagggc agcagagagc
     1441 tcaggaggca gagagagcca tgtcttccca cctggactcc ccttggccca tactgcatac
     1501 atctgcactg cagaggaagt caggccaagg gtagctcata gagtaactac caacagcacc
     1561 agccaggaag gtagaggcca cgagaatggt cccctgctca cagggttatc tttgactgta
     1621 gttggggtgt ggggaagaaa cttaacatga actctgcctt ttgcgaggtg cttccgttgc
     1681 acagcacaga gctgatgtgc acattgcaaa gacatcatat ctccagaaca gtctcatctt
     1741 gcaagactca gactctaagc ctactgagca atgcctccct tccccacccc gaccccccaa
     1801 cactacctca cctcaccagg ccctggctac caccatctaa cgttttgccc ttgggagttt
     1861 tgctaatgca cccgagtgga atcaagaggt gtctatcgtt ctggggttgc tttgccttag
     1921 catcagtcac gtccccaagg accatccacc ttccagtgga tgacagaatt cctttatgtt
     1981 aaatgctgaa aggcatccca ctgtgtggat ataccacact ttcttcctct gctcatttac
     2041 tcacaggtgt tttgtctgtt cttggccttt gtggataatg ttacagagag catgagtgta
     2101 taggtgaagg tttcacttta agatgctgtc ttcagttctc ttgcctatga ttgtgatggt
     2161 taatcttgat tgtcgatttt gctgggttca gaatcaccta ggagacacac ctccaagcct
     2221 ctctatgatg gtgcttccaa agaagtttaa ctgaggaagg atgacccacc ctgattgtgg
     2281 acactcacca tcccataacc tgggatctca gactgaataa aagggaggaa agagataaag
     2341 caaactgaac atccattggt ccgtctctct ttccttccta agaacaaagt gtggctagcc
     2401 agctcttgac tctggtgcta caaatagatc cgctccagct gccatgcggt ccacaacgtg
     2461 atggactgta gcccttccaa ccatgagcca acacaaacct tccttcctcc cttcagtctc
     2521 ttttctcagg tgttttgtca cagcagtgac acaagtaatt agcatgtata cccaagagta
     2581 ttgctgggtc acgtgacaat cctcattgta atcttttgga atgatctctg tatccttttc
     2641 cgcaatggct acaatgtttt atattcccac caacaggatg taaacattcc aagttctcca
     2701 catacttcat ctacatttac tgttttctgt ctgcttattt gcgattacaa cccttctcca
     2761 ggtgttttaa tttatattat ttccctgata attggagatg ttgggcatct tgctacaccc
     2821 ttaccgttca agtcctttgt ccattaaaaa caattttttt actttaa
//
