LOCUS       NM_172050               1950 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus CD300E molecule (Cd300e), mRNA.
ACCESSION   NM_172050
VERSION     NM_172050.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1950)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1950)
  AUTHORS   Isobe,M., Izawa,K., Sugiuchi,M., Sakanishi,T., Kaitani,A.,
            Takamori,A., Maehara,A., Matsukawa,T., Takahashi,M., Yamanishi,Y.,
            Oki,T., Uchida,S., Uchida,K., Ando,T., Maeda,K., Nakano,N.,
            Yagita,H., Takai,T., Ogawa,H., Okumura,K., Kitamura,T. and
            Kitaura,J.
  TITLE     The CD300e molecule in mice is an immune-activating receptor
  JOURNAL   J Biol Chem 293 (10), 3793-3805 (2018)
   PUBMED   29358324
  REMARK    GeneRIF: Data (including data from studies conducted with cells
            from knockout mice) suggest that Cd300e on the surface of monocytes
            or mast cells recognizes the ligand sphingomyelin and thereby
            regulates non-classical and intermediate immunologic functions
            through FcRgamma and DAP12. (Cd300e = CD300 antigen like family
            member E; FcRgamma = Fc receptor subunit gamma; DAP12 =
            DNAX-activation protein-12)
REFERENCE   3  (bases 1 to 1950)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   4  (bases 1 to 1950)
  AUTHORS   Chung,D.H., Humphrey,M.B., Nakamura,M.C., Ginzinger,D.G.,
            Seaman,W.E. and Daws,M.R.
  TITLE     CMRF-35-like molecule-1, a novel mouse myeloid receptor, can
            inhibit osteoclast formation
  JOURNAL   J Immunol 171 (12), 6541-6548 (2003)
   PUBMED   14662855
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL607025.21.
            
            On Sep 20, 2016 this sequence version replaced NM_172050.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC034097.2, BG245629.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                AL607025.21        138311-138365       c
            56-403              AL607025.21        131572-131919       c
            404-506             AL607025.21        130802-130904       c
            507-1950            AL607025.21        128243-129686       c
FEATURES             Location/Qualifiers
     source          1..1950
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 80.58 cM"
     gene            1..1950
                     /gene="Cd300e"
                     /gene_synonym="Cd300le; CLM2; TREM5"
                     /note="CD300E molecule"
                     /db_xref="GeneID:217306"
                     /db_xref="MGI:MGI:2387602"
     exon            1..55
                     /gene="Cd300e"
                     /gene_synonym="Cd300le; CLM2; TREM5"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..606
                     /gene="Cd300e"
                     /gene_synonym="Cd300le; CLM2; TREM5"
                     /note="CD300 antigen like family member E; CMRF35-like
                     molecule 2; CMRF-35-like molecule-1; immune receptor
                     expressed on myeloid cells 2; CD300e antigen"
                     /codon_start=1
                     /product="CMRF35-like molecule 2 precursor"
                     /protein_id="NP_742047.1"
                     /db_xref="CCDS:CCDS25618.1"
                     /db_xref="GeneID:217306"
                     /db_xref="MGI:MGI:2387602"
                     /translation="MRLCAGLLLLCFQGCLSLTGPGSVSGYVGGSLRVQCQYSPSYKG
                     YMKYWCRGPHDTTCKTIVETDGSEKEKRSGPVSIRDHASNSTITVIMEDLSEDNAGSY
                     WCKIQTSFIWDSWSRDPSVSVRVNVFPATTPTLPATTAILPLVNSGQNLRISTNVMFI
                     FQLWSLLSSIQFQVLVFLKLPLFLSMLCAIFWVNRL"
     exon            56..403
                     /gene="Cd300e"
                     /gene_synonym="Cd300le; CLM2; TREM5"
                     /inference="alignment:Splign:2.1.0"
     exon            404..506
                     /gene="Cd300e"
                     /gene_synonym="Cd300le; CLM2; TREM5"
                     /inference="alignment:Splign:2.1.0"
     exon            507..1950
                     /gene="Cd300e"
                     /gene_synonym="Cd300le; CLM2; TREM5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1932..1937
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cd300e"
                     /gene_synonym="Cd300le; CLM2; TREM5"
                     /note="hexamer: AATAAA"
     polyA_site      1950
                     /gene="Cd300e"
                     /gene_synonym="Cd300le; CLM2; TREM5"
                     /note="major polyA site"
ORIGIN      
        1 cagtgaggca ggaggatgag gctatgtgca ggtctgctcc ttctctgctt ccaaggttgt
       61 ttgtctctga cgggccctgg ctctgtgtct ggctacgtag gaggctctct ccgtgtgcag
      121 tgtcaatata gtccatcata taagggctat atgaaatact ggtgccgagg accgcatgac
      181 acgacatgta aaactattgt agaaaccgac ggaagtgaga aagaaaagag gagtggcccg
      241 gtgtccatca gagaccatgc ttcgaactcc accatcacag tgatcatgga ggacctcagc
      301 gaagacaatg ctgggtctta ctggtgcaag attcagactt cctttatctg ggattcgtgg
      361 tcacgtgatc catcggtcag tgtaagggtg aatgtttttc cagccacaac tcctacactc
      421 ccagccacaa ctgctatcct cccactagtg aattctgggc agaacctgag gattagtact
      481 aatgtgatgt tcatcttcca actgtggtcc ctgctcagca gcatccagtt ccaggtcctg
      541 gtcttcctga agctgcctct gtttctgagc atgctctgtg ctatcttctg ggtgaacaga
      601 ctttaggggg ttcctggggg caatgtagag tgacccatcc aagaactatg aagtgaagca
      661 tcccaggaat gccctgggag gaactcagcc ctgcatgcag actggacttc attgttctgt
      721 gtctcaaagg tggggagggg gtgggggctg attatcagag tcttggattt cagactcctg
      781 tggtgtcctc agcataacag agagaacaag actgggagta aaggcactgg gagttaatcc
      841 cagcactgga gaggaagaac ctagtaagtc tctgagttaa aggccagcct agtctatata
      901 ctgagttcct ggacagccag ggataaataa tagactctgt ctcaaagaca cccacaaaag
      961 cgggaacaag actctcccgg ggccctctgt tagaggtctg cctttccctt ctccaaattt
     1021 cctggattct gctctcatgt cagctccaaa ggataagaat cttctagaag tttcttgaac
     1081 agaagtctag ctccttgatc ttctcagtgc cataaaaaca tcccaggaca ttgtctccga
     1141 tggcaacaat catctcctta ctacagagac gagtttcctg agaaacatgt ccctcacaca
     1201 cttggcttgc aggctgttgc cccctttcta gaacaatcct aaaggatttg gcttctggta
     1261 gagcatttca actgccaact ctcccaagca cacagagagg tcaactagga gtctagaggt
     1321 gtgggctcgc agaataaatg tttagggttg gggagaaagg cacagggaga gggattatca
     1381 ggttcctaga ggtaggtgaa attaccaggt gagtgctcag caccaaggac agagctcaca
     1441 aggcgcggga agactgctaa gctaagcgtt cagaaccacg gacagagacc taagaagctc
     1501 ttagaccacc aactatgccc gtttcagcag cacagcagcc actgctgttc tcagcgtttt
     1561 tcacacgaat tcatttacat gtgtgtttag ctatgcagct ttatcctaca catgcatcca
     1621 ggtaacgacc atcacagtca aaacagagga ttgttccacc atcacaagtc ctccttcatg
     1681 ccagtctgcc tcattactgc ccactagaga acactgatct ctggctgact ctggctctgt
     1741 cactttgaga atgttctaga aagagaagca tttcagtggt atgtcaagta caaggcctct
     1801 gggatccaca caagcagatg ttcttggaaa tcatccattc ctctttatta ctgagcatta
     1861 ttcattgtat acattcatta cagtttgttt aactccttat tcagttaact atttgggtca
     1921 tttccattac aaataaaact attatccaca
//
