LOCUS       NM_134158               1139 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Mus musculus CD300C molecule 2 (Cd300c2), mRNA.
ACCESSION   NM_134158
VERSION     NM_134158.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1139)
  AUTHORS   Yonebayashi,S., Tajiri,K., Murakoshi,N., Xu,D., Li,S., Feng,D.,
            Okabe,Y., Yuan,Z., Song,Z., Aonuma,K., Shibuya,A., Aonuma,K. and
            Ieda,M.
  TITLE     MAIR-II deficiency ameliorates cardiac remodelling post-myocardial
            infarction by suppressing TLR9-mediated macrophage activation
  JOURNAL   J Cell Mol Med 24 (24), 14481-14490 (2020)
   PUBMED   33140535
  REMARK    GeneRIF: MAIR-II deficiency ameliorates cardiac remodelling
            post-myocardial infarction by suppressing TLR9-mediated macrophage
            activation.
REFERENCE   2  (bases 1 to 1139)
  AUTHORS   Nakazawa,Y., Ohtsuka,S., Nakahashi-Oda,C. and Shibuya,A.
  TITLE     Cutting Edge: Involvement of the Immunoreceptor CD300c2 on Alveolar
            Macrophages in Bleomycin-Induced Lung Fibrosis
  JOURNAL   J Immunol 203 (12), 3107-3111 (2019)
   PUBMED   31757863
  REMARK    GeneRIF: Our findings demonstrate that CD300c2 contributes to
            BLM-induced inflammatory responses mediated by alveolar
            macrophages.
REFERENCE   3  (bases 1 to 1139)
  AUTHORS   Totsuka,N., Kim,Y.G., Kanemaru,K., Niizuma,K., Umemoto,E.,
            Nagai,K., Tahara-Hanaoka,S., Nakahasi-Oda,C., Honda,S.,
            Miyasaka,M., Shibuya,K. and Shibuya,A.
  TITLE     Toll-like receptor 4 and MAIR-II/CLM-4/LMIR2 immunoreceptor
            regulate VLA-4-mediated inflammatory monocyte migration
  JOURNAL   Nat Commun 5, 4710 (2014)
   PUBMED   25134989
  REMARK    GeneRIF: Toll-like receptor 4 and MAIR-II/CLM-4/LMIR2
            immunoreceptor regulate VLA-4-mediated inflammatory monocyte
            migration.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1139)
  AUTHORS   Nakano-Yokomizo,T., Tahara-Hanaoka,S., Nakahashi-Oda,C.,
            Nabekura,T., Tchao,N.K., Kadosaki,M., Totsuka,N., Kurita,N.,
            Nakamagoe,K., Tamaoka,A., Takai,T., Yasui,T., Kikutani,H.,
            Honda,S., Shibuya,K., Lanier,L.L. and Shibuya,A.
  TITLE     The immunoreceptor adapter protein DAP12 suppresses B
            lymphocyte-driven adaptive immune responses
  JOURNAL   J Exp Med 208 (8), 1661-1671 (2011)
   PUBMED   21727189
  REMARK    GeneRIF: DAP12-coupled MAIR-II negatively regulates B cell-mediated
            adaptive immune responses.
REFERENCE   5  (bases 1 to 1139)
  AUTHORS   Abdallah,B.M., Ditzel,N., Mahmood,A., Isa,A., Traustadottir,G.A.,
            Schilling,A.F., Ruiz-Hidalgo,M.J., Laborda,J., Amling,M. and
            Kassem,M.
  TITLE     DLK1 is a novel regulator of bone mass that mediates estrogen
            deficiency-induced bone loss in mice
  JOURNAL   J Bone Miner Res 26 (7), 1457-1471 (2011)
   PUBMED   21308776
REFERENCE   6  (bases 1 to 1139)
  AUTHORS   Chung,D.H., Humphrey,M.B., Nakamura,M.C., Ginzinger,D.G.,
            Seaman,W.E. and Daws,M.R.
  TITLE     CMRF-35-like molecule-1, a novel mouse myeloid receptor, can
            inhibit osteoclast formation
  JOURNAL   J Immunol 171 (12), 6541-6548 (2003)
   PUBMED   14662855
REFERENCE   7  (bases 1 to 1139)
  AUTHORS   Kumagai,H., Oki,T., Tamitsu,K., Feng,S.Z., Ono,M., Nakajima,H.,
            Bao,Y.C., Kawakami,Y., Nagayoshi,K., Copeland,N.G., Gilbert,D.J.,
            Jenkins,N.A., Kawakami,T. and Kitamura,T.
  TITLE     Identification and characterization of a new pair of
            immunoglobulin-like receptors LMIR1 and 2 derived from murine bone
            marrow-derived mast cells
  JOURNAL   Biochem Biophys Res Commun 307 (3), 719-729 (2003)
   PUBMED   12893283
  REMARK    GeneRIF: Molecular cloning and characterization of leukocyte
            mono-immunoglobulin-like receptor1 and 2 derived from mast cells
            [LMIR1] [LMIR2]
REFERENCE   8  (bases 1 to 1139)
  AUTHORS   Yotsumoto,K., Okoshi,Y., Shibuya,K., Yamazaki,S.,
            Tahara-Hanaoka,S., Honda,S., Osawa,M., Kuroiwa,A., Matsuda,Y.,
            Tenen,D.G., Iwama,A., Nakauchi,H. and Shibuya,A.
  TITLE     Paired activating and inhibitory immunoglobulin-like receptors,
            MAIR-I and MAIR-II, regulate mast cell and macrophage activation
  JOURNAL   J Exp Med 198 (2), 223-233 (2003)
   PUBMED   12874256
REFERENCE   9  (bases 1 to 1139)
  AUTHORS   Clark,G.J., Fitzpatrick,S., Kuo,B., Modra,C., Jamriska,L. and
            Hart,D.N.
  TITLE     CMRF-35A, CMRF-35H: potential new CD
  JOURNAL   J Biol Regul Homeost Agents 16 (3), 233-235 (2002)
   PUBMED   12456026
  REMARK    GeneRIF: structure and tissue distribution
            Review article
REFERENCE   10 (bases 1 to 1139)
  AUTHORS   Luo,K., Zhang,W., Sui,L., Li,N., Zhang,M., Ma,X., Zhang,L. and
            Cao,X.
  TITLE     DIgR1, a novel membrane receptor of the immunoglobulin gene
            superfamily, is preferentially expressed by antigen-presenting
            cells
  JOURNAL   Biochem Biophys Res Commun 287 (1), 35-41 (2001)
   PUBMED   11549249
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY048685.1.
            
            [WARNING] On May 7, 2024 this sequence was replaced by NM_134158.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY048685.1, BC006801.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1139
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 80.57 cM"
     gene            1..1139
                     /gene="Cd300c2"
                     /gene_synonym="Cd300c; Cd300d; CLM-4; CLM4; DIgR1; Igsf7;
                     Lmir2; MAIR-II"
                     /note="CD300C molecule 2"
                     /db_xref="GeneID:140497"
                     /db_xref="MGI:MGI:2153249"
     exon            1..394
                     /gene="Cd300c2"
                     /gene_synonym="Cd300c; Cd300d; CLM-4; CLM4; DIgR1; Igsf7;
                     Lmir2; MAIR-II"
                     /inference="alignment:Splign:2.1.0"
     CDS             334..1020
                     /gene="Cd300c2"
                     /gene_synonym="Cd300c; Cd300d; CLM-4; CLM4; DIgR1; Igsf7;
                     Lmir2; MAIR-II"
                     /note="Cd300C antigen; immunoglobulin superfamily, member
                     7; Cd300D antigen; leukocyte mono-Ig-like receptor 2;
                     CMRF35-like molecule; myeloid-associated
                     immunoglobulin-like receptor II; dendritic cell-derived
                     immunoglobulin receptor 1; CLM; MAIR-2; dendritic
                     cell-derived Ig-like receptor 1; myeloid-associated
                     immunoglobulin-like receptor 2; CMRF-35-like molecule 4"
                     /codon_start=1
                     /product="CMRF-35-like molecule 4 precursor"
                     /protein_id="NP_598919.1"
                     /db_xref="CCDS:CCDS25616.1"
                     /db_xref="GeneID:140497"
                     /db_xref="MGI:MGI:2153249"
                     /translation="MIPRVIRLWLPSALFLSQVPGCVPLHGPSTITGAVGESLSVSCQ
                     YEEKFKTKDKFWCRGSLKVLCKDIVKTSSSEEVRNGRVTIRDHPDNLTFTVTYESLTL
                     EDADTYMCAVDISLFDGSLGFDKYFKIELSVVPSEDPVTGSSLESGRDILESPTSSVG
                     HTHPSVTTDDTIPAPCPQPRSLRSSLYFWVLVSLKLFLFLSMLGAVLWVNRPQRCSGG
                     SSSRPCYENQ"
     exon            395..751
                     /gene="Cd300c2"
                     /gene_synonym="Cd300c; Cd300d; CLM-4; CLM4; DIgR1; Igsf7;
                     Lmir2; MAIR-II"
                     /inference="alignment:Splign:2.1.0"
     exon            752..872
                     /gene="Cd300c2"
                     /gene_synonym="Cd300c; Cd300d; CLM-4; CLM4; DIgR1; Igsf7;
                     Lmir2; MAIR-II"
                     /inference="alignment:Splign:2.1.0"
     exon            873..1139
                     /gene="Cd300c2"
                     /gene_synonym="Cd300c; Cd300d; CLM-4; CLM4; DIgR1; Igsf7;
                     Lmir2; MAIR-II"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caacctgacc ggaaatggaa atgcccctcc agggctctgg caggagcagg gaagccctcg
       61 ggtaagggct aggtgacaga tggcaccctc aatccacagc agtggttgtc cccacttatt
      121 ctgtgtggta ggaaccaaag cctctaaggc ctggagtatt aacagagccc ttcctgctac
      181 tgttcatctg gagcctcacg taagagcacg agaccaggaa gcagaggaca gaaaggagaa
      241 ctaggcaaga gaacattcta ctgtctagac tgagacagat ccttctccac tcttggccct
      301 gatgtgggca caggtgacag cggagctgaa gaaatgattc ccagagtaat aagattgtgg
      361 ctgccttcag ctctgttcct ctctcaggtc ccaggctgtg tcccactgca tggccccagc
      421 actatcacag gcgctgttgg ggaatcgctc agtgtgtcat gtcaatacga ggagaaattc
      481 aagactaagg acaaattctg gtgcagaggg tcactgaagg tactctgtaa agatattgtc
      541 aagaccagca gctcagaaga agttaggaat ggccgagtga ccatcaggga ccatccagac
      601 aacctcacct tcacagtgac ctatgagagc ctcaccctgg aggatgcaga cacctacatg
      661 tgtgcggtgg atatatcact ttttgatggc tccttggggt tcgataagta cttcaagatt
      721 gagttgtctg tggttccaag tgaggaccca gtcacaggtt cgagccttga gagtggtaga
      781 gatatcctgg aatcccccac atcctcagtt gggcacactc atcccagtgt gaccacagat
      841 gacacaattc ctgctccctg ccctcagcct cggtctcttc ggagcagcct ctacttctgg
      901 gtcctggtgt ctctgaagtt gttcctgttc ctgagcatgc ttggtgctgt cctctgggtg
      961 aacaggcctc agaggtgctc tgggggaagc agctctcggc cctgttatga gaaccagtga
     1021 agtctgttga catcaaggcc ctgtccctaa acacagctcc tctggtggct gaggacagcc
     1081 agtaaataca tatttcttga gaatgctctg agacttttag aagattctct gtggtgtat
//
