LOCUS       NM_170758               1937 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus CD300A molecule (Cd300a), transcript variant 1, mRNA.
ACCESSION   NM_170758
VERSION     NM_170758.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1937)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1937)
  AUTHORS   Puzzovio,P.G., Levy,B.D. and Levi-Schaffer,F.
  TITLE     CD300a Regulates Mouse Macrophage Functionality in Allergic
            Inflammation
  JOURNAL   Int Arch Allergy Immunol 184 (7), 720-726 (2023)
   PUBMED   36928079
  REMARK    GeneRIF: CD300a Regulates Mouse Macrophage Functionality in
            Allergic Inflammation.
REFERENCE   3  (bases 1 to 1937)
  AUTHORS   Nakazawa,Y., Nishiyama,N., Koizumi,H., Kanemaru,K.,
            Nakahashi-Oda,C. and Shibuya,A.
  TITLE     Tumor-derived extracellular vesicles regulate tumor-infiltrating
            regulatory T cells via the inhibitory immunoreceptor CD300a
  JOURNAL   Elife 10, e61999 (2021)
   PUBMED   34751648
  REMARK    GeneRIF: Tumor-derived extracellular vesicles regulate
            tumor-infiltrating regulatory T cells via the inhibitory
            immunoreceptor CD300a.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1937)
  AUTHORS   Nakahashi-Oda,C., Fujiyama,S., Nakazawa,Y., Kanemaru,K., Wang,Y.,
            Lyu,W., Shichita,T., Kitaura,J., Abe,F. and Shibuya,A.
  TITLE     CD300a blockade enhances efferocytosis by infiltrating myeloid
            cells and ameliorates neuronal deficit after ischemic stroke
  JOURNAL   Sci Immunol 6 (64), eabe7915 (2021)
   PUBMED   34652960
  REMARK    GeneRIF: CD300a blockade enhances efferocytosis by infiltrating
            myeloid cells and ameliorates neuronal deficit after ischemic
            stroke.
REFERENCE   5  (bases 1 to 1937)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1937)
  AUTHORS   Enomoto,Y., Yamanishi,Y., Izawa,K., Kaitani,A., Takahashi,M.,
            Maehara,A., Oki,T., Takamatsu,R., Kajikawa,M., Takai,T.,
            Kitamura,T. and Kitaura,J.
  TITLE     Characterization of leukocyte mono-immunoglobulin-like receptor 7
            (LMIR7)/CLM-3 as an activating receptor: its similarities to and
            differences from LMIR4/CLM-5
  JOURNAL   J Biol Chem 285 (46), 35274-35283 (2010)
   PUBMED   20817736
REFERENCE   7  (bases 1 to 1937)
  AUTHORS   Bachelet,I., Munitz,A., Moretta,A., Moretta,L. and Levi-Schaffer,F.
  TITLE     The inhibitory receptor IRp60 (CD300a) is expressed and functional
            on human mast cells
  JOURNAL   J Immunol 175 (12), 7989-7995 (2005)
   PUBMED   16339535
  REMARK    GeneRIF: in a murine model of allergic peritonitis, neutralization
            of the murine homolog of IRp60, LMIR1, led to a significantly
            augmented release of inflammatory mediators and eosinophilic
            infiltration.
REFERENCE   8  (bases 1 to 1937)
  AUTHORS   Chung,D.H., Humphrey,M.B., Nakamura,M.C., Ginzinger,D.G.,
            Seaman,W.E. and Daws,M.R.
  TITLE     CMRF-35-like molecule-1, a novel mouse myeloid receptor, can
            inhibit osteoclast formation
  JOURNAL   J Immunol 171 (12), 6541-6548 (2003)
   PUBMED   14662855
REFERENCE   9  (bases 1 to 1937)
  AUTHORS   Kumagai,H., Oki,T., Tamitsu,K., Feng,S.Z., Ono,M., Nakajima,H.,
            Bao,Y.C., Kawakami,Y., Nagayoshi,K., Copeland,N.G., Gilbert,D.J.,
            Jenkins,N.A., Kawakami,T. and Kitamura,T.
  TITLE     Identification and characterization of a new pair of
            immunoglobulin-like receptors LMIR1 and 2 derived from murine bone
            marrow-derived mast cells
  JOURNAL   Biochem Biophys Res Commun 307 (3), 719-729 (2003)
   PUBMED   12893283
  REMARK    GeneRIF: Molecular cloning and characterization of leukocyte
            mono-immunoglobulin-like receptor1 and 2 derived from mast cells
            [LMIR1] [LMIR2]
REFERENCE   10 (bases 1 to 1937)
  AUTHORS   Yotsumoto,K., Okoshi,Y., Shibuya,K., Yamazaki,S.,
            Tahara-Hanaoka,S., Honda,S., Osawa,M., Kuroiwa,A., Matsuda,Y.,
            Tenen,D.G., Iwama,A., Nakauchi,H. and Shibuya,A.
  TITLE     Paired activating and inhibitory immunoglobulin-like receptors,
            MAIR-I and MAIR-II, regulate mast cell and macrophage activation
  JOURNAL   J Exp Med 198 (2), 223-233 (2003)
   PUBMED   12874256
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL669969.14.
            
            On Jan 13, 2018 this sequence version replaced NM_170758.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK045869.1, AB091766.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-394               AL669969.14        91412-91805
            395-751             AL669969.14        94609-94965
            752-872             AL669969.14        96029-96149
            873-970             AL669969.14        99093-99190
            971-1008            AL669969.14        100716-100753
            1009-1119           AL669969.14        101124-101234
            1120-1937           AL669969.14        102500-103317
FEATURES             Location/Qualifiers
     source          1..1937
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 80.54 cM"
     gene            1..1937
                     /gene="Cd300a"
                     /gene_synonym="B230315M08Rik; Clm8; LMIR1; MAIR-1; MAIR-I;
                     MAIR-Ia; mcpir1; MMAC8; Pigr4"
                     /note="CD300A molecule"
                     /db_xref="GeneID:217303"
                     /db_xref="MGI:MGI:2443411"
     exon            1..394
                     /gene="Cd300a"
                     /gene_synonym="B230315M08Rik; Clm8; LMIR1; MAIR-1; MAIR-I;
                     MAIR-Ia; mcpir1; MMAC8; Pigr4"
                     /inference="alignment:Splign:2.1.0"
     exon            395..751
                     /gene="Cd300a"
                     /gene_synonym="B230315M08Rik; Clm8; LMIR1; MAIR-1; MAIR-I;
                     MAIR-Ia; mcpir1; MMAC8; Pigr4"
                     /inference="alignment:Splign:2.1.0"
     exon            752..872
                     /gene="Cd300a"
                     /gene_synonym="B230315M08Rik; Clm8; LMIR1; MAIR-1; MAIR-I;
                     MAIR-Ia; mcpir1; MMAC8; Pigr4"
                     /inference="alignment:Splign:2.1.0"
     exon            873..970
                     /gene="Cd300a"
                     /gene_synonym="B230315M08Rik; Clm8; LMIR1; MAIR-1; MAIR-I;
                     MAIR-Ia; mcpir1; MMAC8; Pigr4"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1008
                     /gene="Cd300a"
                     /gene_synonym="B230315M08Rik; Clm8; LMIR1; MAIR-1; MAIR-I;
                     MAIR-Ia; mcpir1; MMAC8; Pigr4"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1119
                     /gene="Cd300a"
                     /gene_synonym="B230315M08Rik; Clm8; LMIR1; MAIR-1; MAIR-I;
                     MAIR-Ia; mcpir1; MMAC8; Pigr4"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1937
                     /gene="Cd300a"
                     /gene_synonym="B230315M08Rik; Clm8; LMIR1; MAIR-1; MAIR-I;
                     MAIR-Ia; mcpir1; MMAC8; Pigr4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1909..1914
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cd300a"
                     /gene_synonym="B230315M08Rik; Clm8; LMIR1; MAIR-1; MAIR-I;
                     MAIR-Ia; mcpir1; MMAC8; Pigr4"
                     /note="hexamer: AATAAA"
     polyA_site      1937
                     /gene="Cd300a"
                     /gene_synonym="B230315M08Rik; Clm8; LMIR1; MAIR-1; MAIR-I;
                     MAIR-Ia; mcpir1; MMAC8; Pigr4"
                     /note="major polyA site"
ORIGIN      
        1 gaggagtgac tgggtgccag tcagaatgaa acctggccct gcaccctgag ccagacgcaa
       61 gcaggggtca tcaggctgtc atggcagcct ggcagtcatg agatcagagc ctcacggggg
      121 gttcatcagc tcgcctcggc tccttccgat tcttttagtt tctcccgtag ctccaggaac
      181 agaactgagg aaagtcggaa gcaaaacagc tagacacaaa gaaaagcaga agtgggcgtc
      241 tcagagactg gccgtccccc agcgggactg aaccgtggag cgtccagccg tggcctgcct
      301 gccggtgacc cgtgtgtggg agaaatgacc caactggcct cagctgtgtg gctgcccaca
      361 ctgttgctgc tgctgctgct tttttggctt ccaggctgtg tccctctgca tggtcccagc
      421 accatgtcag gaagtgtagg tgaatccctg agtgtgtcat gtcgatatga ggagaaattc
      481 aagactaagg acaaatactg gtgcagagtg tcacttaaga tactatgtaa agatattgtc
      541 aagaccagca gctcagaaga agctaggagt ggccgagtga ccatcaggga ccatccagac
      601 aacctcacct ttacagtgac ctatgagagc ctcaccctgg aggatgcaga cacctacatg
      661 tgtgcggtgg atatatcact ttttgatggc tccttggggt tcgataagta cttcaagatt
      721 gagttgtctg tggttccaag tgaggaccca gtttcatctc caggaccaac actagagaca
      781 cctgtggtgt ccaccagtct gcctaccaag ggtcccgccc taggatccaa cacagagggc
      841 caccgtgaac atgactattc ccagggcttg aggctcccag cgctgttgtc tgtgttagct
      901 ctcctgctgt ttctgttggt ggggacctct ctgctggcct ggaggatgtt ccagaagcgg
      961 ctggtcaaag ctgataggca tccagagctg tcccagaacc tcagacaggc ttctgagcag
     1021 aatgagtgcc agtatgtgaa tttgcagctg cacacgtggt ctctgaggga agagccggtg
     1081 ctaccaagtc aggtagaagt ggtggaatat agcacattgg cattacccca ggaagagctt
     1141 cactattcat ccgtggcatt caactcccag aggcaggatt ctcacgccaa tggagattct
     1201 cttcatcaac ctcaggacca gaaagcagag tacagtgaga tccagaagcc cagaaaagga
     1261 ctctctgacc tttacctgtg actccttgtc acctgatcct ctcagtggtg actaccaggt
     1321 tccaaggctc cctgctggct gctgccctca atgtcatgag cctcagtggc ttcactaaag
     1381 atgagcagga gccagggctc tgtgggcaca gtctcatccc actggctctc tcctcttagc
     1441 ctgtattttg ttctgcctct gggtgtggaa gacatcgatg ctgctctttt ggggctctgg
     1501 gaattgacat ggttcgtata gaacggtact tgtgttagtt agctttgtag tgtcagtcca
     1561 ggaagaacat ctgtggtcac tgggaaagtg ggggacccat gagactacaa aggaagggga
     1621 gtcatggagg tactaaacac caactccttc atctcacaga gaaaaaaacc taagctctga
     1681 ggacaaaagc ctggcccgtg gcaccaaggt caggggcaaa ttcctctgga ctcattttta
     1741 tttttatttt ttgttttttg agacagggtc tctctgtgta gctttggctg tcctggaact
     1801 cactctgtaa accagaatgg cctcagactc acaaagatct gcctgcctct gcctccaaag
     1861 gtgtgtgcca caatgcctgg cttctctgaa ttcttaagta aaagatgaaa taaagtttat
     1921 aatatctttt aaaaaaa
//
