LOCUS       NM_027353               3361 bp    mRNA    linear   ROD 26-NOV-2024
DEFINITION  Mus musculus CD2 cytoplasmic tail binding protein 2 (Cd2bp2),
            transcript variant 4, mRNA.
ACCESSION   NM_027353
VERSION     NM_027353.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3361)
  AUTHORS   Bertazzon,M., Hurtado-Pico,A., Plaza-Sirvent,C., Schuster,M.,
            Preussner,M., Kuropka,B., Liu,F., Kirsten,A.Z.A., Schmitt,X.J.,
            Konig,B., Alvaro-Benito,M., Abualrous,E.T., Albert,G.I., Kliche,S.,
            Heyd,F., Schmitz,I. and Freund,C.
  TITLE     The nuclear GYF protein CD2BP2/U5-52K is required for T cell
            homeostasis
  JOURNAL   Front Immunol 15, 1415839 (2024)
   PUBMED   39308865
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3361)
  AUTHORS   Najas,S., Pijuan,I., Esteve-Codina,A., Usieto,S., Martinez,J.D.,
            Zwijsen,A., Arbones,M.L., Marti,E. and Le Dreau,G.
  TITLE     A SMAD1/5-YAP signalling module drives radial glia
            self-amplification and growth of the developing cerebral cortex
  JOURNAL   Development 147 (13) (2020)
   PUBMED   32541003
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3361)
  AUTHORS   Albert,G.I., Schell,C., Kirschner,K.M., Schafer,S., Naumann,R.,
            Muller,A., Kretz,O., Kuropka,B., Girbig,M., Hubner,N., Krause,E.,
            Scholz,H., Huber,T.B., Knobeloch,K.P. and Freund,C.
  TITLE     The GYF domain protein CD2BP2 is critical for embryogenesis and
            podocyte function
  JOURNAL   J Mol Cell Biol 7 (5), 402-414 (2015)
   PUBMED   26082520
REFERENCE   4  (bases 1 to 3361)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   5  (bases 1 to 3361)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122537.4 and AK034689.1.
            
            On Oct 25, 2013 this sequence version replaced NM_027353.3.
            
            Transcript Variant: This variant (4) differs in the 5' UTR compared
            to variant 1. Variants 1-5 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK034689.1, AK154346.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-77                AC122537.4         171070-171146       c
            78-3361             AK034689.1         2-3285
FEATURES             Location/Qualifiers
     source          1..3361
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 69.38 cM"
     gene            1..3361
                     /gene="Cd2bp2"
                     /gene_synonym="1500011B02Rik; 2410024K20Rik"
                     /note="CD2 cytoplasmic tail binding protein 2"
                     /db_xref="GeneID:70233"
                     /db_xref="MGI:MGI:1917483"
     exon            1..149
                     /gene="Cd2bp2"
                     /gene_synonym="1500011B02Rik; 2410024K20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            150..250
                     /gene="Cd2bp2"
                     /gene_synonym="1500011B02Rik; 2410024K20Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             173..1201
                     /gene="Cd2bp2"
                     /gene_synonym="1500011B02Rik; 2410024K20Rik"
                     /note="CD2 tail-binding protein 2; CD2 cytoplasmic
                     domain-binding protein 2; CD2 antigen (cytoplasmic tail)
                     binding protein 2"
                     /codon_start=1
                     /product="CD2 antigen cytoplasmic tail-binding protein 2"
                     /protein_id="NP_081629.1"
                     /db_xref="CCDS:CCDS21859.1"
                     /db_xref="GeneID:70233"
                     /db_xref="MGI:MGI:1917483"
                     /translation="MPKRKVTFQGVGDEDGEDEISVPKKKLVDPVAAAGGPGSRFKGK
                     HSLDSDEEDDDEEGSSKYDILASEDVEGQEAATLPSEGGVRITPFNLQEEMEEGHFDA
                     DGNYFLNQDAQIRDSWLDNIDWVRIKERPPDKHQVSDSEEEDSLGQTPMSAQALLEGL
                     LELLLPRETVAGALRRLGARGGGKGSNSKGTGRPNSPQRLDRLSGLADQMVARGNLGV
                     YQETRERLAMRLKGLGCRAQGSHDPTPPPSLDMFAEEVAEGELETPTPTQREEAESAG
                     DGLMDVMWEYKWENTGDAELYGPFTSAQMQTWVSEGYFPDGVYCRKLDPPGGQFYNSK
                     RIDFELYT"
     exon            251..386
                     /gene="Cd2bp2"
                     /gene_synonym="1500011B02Rik; 2410024K20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            387..544
                     /gene="Cd2bp2"
                     /gene_synonym="1500011B02Rik; 2410024K20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            545..983
                     /gene="Cd2bp2"
                     /gene_synonym="1500011B02Rik; 2410024K20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1090
                     /gene="Cd2bp2"
                     /gene_synonym="1500011B02Rik; 2410024K20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..3361
                     /gene="Cd2bp2"
                     /gene_synonym="1500011B02Rik; 2410024K20Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2973..2978
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cd2bp2"
                     /gene_synonym="1500011B02Rik; 2410024K20Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2996
                     /gene="Cd2bp2"
                     /gene_synonym="1500011B02Rik; 2410024K20Rik"
                     /note="major polyA site"
     regulatory      3011..3016
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cd2bp2"
                     /gene_synonym="1500011B02Rik; 2410024K20Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3033
                     /gene="Cd2bp2"
                     /gene_synonym="1500011B02Rik; 2410024K20Rik"
ORIGIN      
        1 atccgccctt tttgaataga agtgaagcca cttccgggtc ctatgccggt ctccacggtt
       61 tttttccggg tgatgaaggc gggtgccccg gatgtaatac cggcgaaagc atctttcctt
      121 ttcttccccg cctgaccctg ggttcctagc tggaggaaat ccacagccaa tcatgccaaa
      181 gaggaaagtg acttttcagg gtgttggaga tgaggatggt gaagatgaaa tcagtgtgcc
      241 caaaaagaag ctggtggacc ctgtggctgc agcaggtggt cctgggagcc gcttcaaagg
      301 caagcactct ttagacagtg atgaagagga tgatgatgag gaagggtcca gcaaatatga
      361 tatcctggcc tcagaggatg tagaaggtca ggaagcagct actctcccta gtgagggcgg
      421 tgtgaggatc acacccttca acctgcagga agagatggag gaaggccact ttgatgctga
      481 tggcaactac ttcctgaacc aggatgcgca gatccgagac agctggctgg acaacattga
      541 ctgggtgagg atcaaggaac ggccccctga taagcaccag gtttcagact cggaggagga
      601 agacagcctg ggtcagactc caatgagcgc ccaagcactc ctggagggac ttttggagtt
      661 gttgttgcca agagagacag tggctggggc ccttaggcgg ctgggggccc gaggaggagg
      721 caaagggagc aacagcaagg ggactggacg gcccaattcc ccccagcggc tagaccggct
      781 gtctgggtta gctgaccaaa tggtggcacg aggcaacctt ggtgtgtacc aggaaacaag
      841 ggaacggttg gctatgcgac tgaagggttt ggggtgtcgg gcccagggat cccatgaccc
      901 cacacctcca ccctccctgg acatgtttgc tgaggaagta gcagagggtg aactggaaac
      961 cccaacccct acccaaagag aggaggcaga gtcagcagga gatggcctga tggatgtgat
     1021 gtgggagtat aaatgggaga acacggggga cgccgagctg tatggaccct tcaccagtgc
     1081 ccagatgcag acgtgggtga gtgaaggtta cttcccggat ggtgtttatt gtcggaagct
     1141 ggaccctccg ggcggccagt tctacaactc caagcgcatt gattttgagc tgtacacgtg
     1201 agcccgctaa gggccccatg cggcacggca gccccttctt tcttgaactt ggcagaggaa
     1261 gccccagctg ctctgggcag tgaggatatt ggaggccact ttaaagccat tgtttcccaa
     1321 taaaagcctt gactgtgcga tggccaagag ccagggcttc tccatagctc cttttggctt
     1381 cacctggtag gtccctgagc gtttcttccc gagagacttc ctcacttgct tctctctggt
     1441 gtcttggacc acctcagttt tttttcccac ccttggaggc agaggtaggg cccatcagat
     1501 gtcctgtgac tttcctacgt agacaacttc tacttgctgt gtaaaattcc ctccatcact
     1561 cttttctcca gtctcccttg caagtccctg ttctgctgat ctttgacttt taggacctca
     1621 aatgctctgt cctggcagct cccttgtagc tgggacattg ggaagacctt gaaatcctat
     1681 tgagagattc tcttaaacat gcattctctt cttccatagt ctgatttttc tacccctcgc
     1741 ccccctgcag tagcttctgt agcttttagg tgaagtataa acttggtagc acttcaaggt
     1801 tgcttgagcc accatgtgac acagaggggg gcaaagtgca gtggcttatt ggagatgcca
     1861 cagtaataga gagctggcca tggagctaag tctcctgacc ttttttggca taaagctttt
     1921 tcttgcttgg cctttcaggc attgtagtgt acgtttcctg ggctcccaca tctcgggcat
     1981 ggggctggtg cctcgaggaa acagtcggtc tggcccttcc aggaatctgg agtgcagtag
     2041 agggctgtgg gaggcaggca gggcctaagt tttcacccca ccatgctgct ctgctcgcct
     2101 catctgtctc caggaggcgc cccaggagct acaaactgag aacttgggaa gtagttccta
     2161 ggctcagctc gggcttggtg gtgggtattt gatgcagaga cctccaacac atctaacaac
     2221 tagactggtt cctgccagtc tagactgcag ttgccttgac ttcaagaagc ccattagtag
     2281 tagtaggaca tctgatgcag tgagtcactg agacagcaga aaccctccag gcattggtaa
     2341 ggtgttaact gttacagagg aactggcttt ctgaggtacc tggcatcttg ggacgagtga
     2401 aatctagtca ggtggcctga gtgttcacag gtgttggggg atagataccc aggtgtcact
     2461 cagttccctc acgcttggcg agttctcccc ttctctgata acaccaagga gggggcagaa
     2521 tagtgatccc tgaagatacc cacatcctga gctgtgtgaa taccacttta tgagttatgt
     2581 ggcagaggga aagggtaaag tgacattgag gttttgtttt gttttaattt tttgaaatgg
     2641 ggaagggggt cctcactgtg tagccctgac tggcctgctg cctcccaagt gttgagacta
     2701 acgtcatgca ccatggcgct gggcaaaatt aagaaatttt gagactggga gattgattac
     2761 ctttgattat ttgggccatt gtagtcatgg gtccttgctg atccctaatg agagcagagg
     2821 actctgaaag ctggaagtga ggcgtatgtc tcagggtgca ggtgcctgga gagacgggaa
     2881 aagcagaaga cagattcttc tcagacaggt gcagtcccac agtgataacc cagttaaccc
     2941 actttgtact gtaccctcta gagtggtaag ataataaatt tgtgtcaagc tgcttacatt
     3001 gtggtaattt aataaagcac cggtcggaag tgagtctgcg cccagctacg ctctggagag
     3061 ccaccagagt tccttgtctt cccggccaag cactcacctg acccaaccct gcttaggttc
     3121 ggaactgggt ctattctggg tggtaagacc atggactttg ttaagcacaa agccagtaat
     3181 tgtttggatg ggtttttgtt gttttgagac agagtctctc ttggaccctg gctggcctgg
     3241 aattgattat gtagaccagg ctggtcttga atttagagag acccatctgc ctctgcctcc
     3301 caagtgctgg gtaaactgcc ttcctctcca cttcctctcc agtaataaaa ctacaatgtg
     3361 c
//
