LOCUS       NM_007642               4317 bp    mRNA    linear   ROD 07-AUG-2024
DEFINITION  Mus musculus CD28 antigen (Cd28), mRNA.
ACCESSION   NM_007642
VERSION     NM_007642.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4317)
  AUTHORS   Luo,Z., Tong,C., Cong,P., Mao,S., Xu,Y., Hou,M. and Liu,Y.
  TITLE     Silencing CD28 attenuated chest blast exposure-induced traumatic
            brain injury through the PI3K/AKT/NF-kappaB signaling pathway in
            male mice
  JOURNAL   Brain Res Bull 214, 110987 (2024)
   PUBMED   38830487
  REMARK    GeneRIF: Silencing CD28 attenuated chest blast exposure-induced
            traumatic brain injury through the PI3K/AKT/NF-kappaB signaling
            pathway in male mice.
REFERENCE   2  (bases 1 to 4317)
  AUTHORS   Geels,S.N., Moshensky,A., Sousa,R.S., Murat,C., Bustos,M.A.,
            Walker,B.L., Singh,R., Harbour,S.N., Gutierrez,G., Hwang,M.,
            Mempel,T.R., Weaver,C.T., Nie,Q., Hoon,D.S.B., Ganesan,A.K.,
            Othy,S. and Marangoni,F.
  TITLE     Interruption of the intratumor CD8+ T cell:Treg crosstalk improves
            the efficacy of PD-1 immunotherapy
  JOURNAL   Cancer Cell 42 (6), 1051-1066 (2024)
   PUBMED   38861924
REFERENCE   3  (bases 1 to 4317)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 4317)
  AUTHORS   Obarorakpor,N., Patel,D., Boyarov,R., Amarsaikhan,N., Cepeda,J.R.,
            Eastes,D., Robertson,S., Johnson,T., Yang,K., Tang,Q. and Zhang,L.
  TITLE     Regulatory T cells targeting a pathogenic MHC class II: Insulin
            peptide epitope postpone spontaneous autoimmune diabetes
  JOURNAL   Front Immunol 14, 1207108 (2023)
   PUBMED   37593744
  REMARK    Erratum:[Front Immunol. 2024 Mar 07;15:1391518. doi:
            10.3389/fimmu.2024.1391518. PMID: 38524122]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4317)
  AUTHORS   Zhao,Y., Caron,C., Chan,Y.Y., Lee,C.K., Xu,X., Zhang,J.,
            Masubuchi,T., Wu,C., Bui,J.D. and Hui,E.
  TITLE     cis-B7:CD28 interactions at invaginated synaptic membranes provide
            CD28 co-stimulation and promote CD8+ T cell function and anti-tumor
            immunity
  JOURNAL   Immunity 56 (6), 1187-1203 (2023)
   PUBMED   37160118
  REMARK    GeneRIF: cis-B7:CD28 interactions at invaginated synaptic membranes
            provide CD28 co-stimulation and promote CD8[+] T cell function and
            anti-tumor immunity.
REFERENCE   6  (bases 1 to 4317)
  AUTHORS   Freeman,G.J., Lombard,D.B., Gimmi,C.D., Brod,S.A., Lee,K.,
            Laning,J.C., Hafler,D.A., Dorf,M.E., Gray,G.S., Reiser,H. et al.
  TITLE     CTLA-4 and CD28 mRNA are coexpressed in most T cells after
            activation. Expression of CTLA-4 and CD28 mRNA does not correlate
            with the pattern of lymphokine production
  JOURNAL   J Immunol 149 (12), 3795-3801 (1992)
   PUBMED   1281186
REFERENCE   7  (bases 1 to 4317)
  AUTHORS   Morse,H.C. 3rd.
  TITLE     Genetic nomenclature for loci controlling surface antigens of mouse
            hemopoietic cells
  JOURNAL   J Immunol 149 (10), 3129-3134 (1992)
   PUBMED   1431091
  REMARK    Review article
            Erratum:[J Immunol 1993 Mar 15;150(6):2563]
REFERENCE   8  (bases 1 to 4317)
  AUTHORS   Gross,J.A., Callas,E. and Allison,J.P.
  TITLE     Identification and distribution of the costimulatory receptor CD28
            in the mouse
  JOURNAL   J Immunol 149 (2), 380-388 (1992)
   PUBMED   1320641
REFERENCE   9  (bases 1 to 4317)
  AUTHORS   Colombo,M.P., Martinotti,A., Howard,T.A., Schneider,C.,
            D'Eustachio,P. and Seldin,M.F.
  TITLE     Localization of growth arrest-specific genes on mouse chromosomes
            1, 7, 8, 11, 13, and 16
  JOURNAL   Mamm Genome 2 (2), 130-134 (1992)
   PUBMED   1347472
REFERENCE   10 (bases 1 to 4317)
  AUTHORS   Howard,T.A., Rochelle,J.M. and Seldin,M.F.
  TITLE     Cd28 and Ctla-4, two related members of the Ig supergene family,
            are tightly linked on proximal mouse chromosome 1
  JOURNAL   Immunogenetics 33 (1), 74-76 (1991)
   PUBMED   1671668
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY225764.1, BC064058.1, AK037772.1 and AK030812.1.
            
            On Dec 1, 2007 this sequence version replaced NM_007642.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK030812.1, M34563.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-86                BY225764.1         3-88
            87-1534             BC064058.1         1-1448
            1535-4315           AK037772.1         261-3041
            4316-4317           AK030812.1         4240-4241
FEATURES             Location/Qualifiers
     source          1..4317
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 30.52 cM"
     gene            1..4317
                     /gene="Cd28"
                     /note="CD28 antigen"
                     /db_xref="GeneID:12487"
                     /db_xref="MGI:MGI:88327"
     exon            1..141
                     /gene="Cd28"
                     /inference="alignment:Splign:2.1.0"
     exon            142..498
                     /gene="Cd28"
                     /inference="alignment:Splign:2.1.0"
     exon            499..614
                     /gene="Cd28"
                     /inference="alignment:Splign:2.1.0"
     exon            615..4317
                     /gene="Cd28"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaccttggc agatgtgact tcagttcaca ccacactctg ccttgctcac agaggagggg
       61 ctgcagccct ggccctcatc agaacaatga cactcaggct gctgttcttg gctctcaact
      121 tcttctcagt tcaagtaaca gaaaacaaga ttttggtaaa gcagtcgccc ctgcttgtgg
      181 tagatagcaa cgaggtcagc ctcagctgca ggtattccta caaccttctc gcaaaggaat
      241 tccgggcatc cctgtacaag ggcgtgaaca gcgacgtgga agtctgtgtc gggaatggga
      301 attttaccta tcagccccag tttcgctcga atgccgagtt caactgcgac ggggatttcg
      361 acaacgaaac agtgacgttc cgtctctgga atctgcacgt caatcacaca gatatttact
      421 tctgcaaaat tgagttcatg taccctccgc cttacctaga caacgagagg agcaatggaa
      481 ctattattca cataaaagag aaacatcttt gtcatactca gtcatctcct aagctgtttt
      541 gggcactggt cgtggttgct ggagtcctgt tttgttatgg cttgctagtg acagtggctc
      601 tttgtgttat ctggacaaat agtagaagga acagactcct tcaaagtgac tacatgaaca
      661 tgactccccg gaggcctggg ctcactcgaa agccttacca gccctacgcc cctgccagag
      721 actttgcagc gtaccgcccc tgacagggac ccctatccag aagcccgccg gctggtaccc
      781 gtctacctgc tcatcatcac tgctctggat aggaaaggac agcctcatct tcagccggcc
      841 actttggacc tctactgggc caccaatgcc aactatttta gagtgtctag atctaacatc
      901 atgatcatct tgagactctg gaatgaatga cagaagcttc tatggcagga taaagtctgt
      961 gtggcttgac ccaaactcaa gcttaataca tttattgact tgattgggga agttagagta
     1021 gagcaatcaa aaagatcatt cattcagcct tgggaagtca atttgcaggc tcctggatga
     1081 gccctgcccc gttttcactt gccagcacat ttcagtcatg tggtgtgata gccaaagatg
     1141 ttttggacag agaagaaagg atagaaaaac cttctctttg gctaagttgg tgtttggggt
     1201 ggggataggt tagagtatag tacttaacta tttgaaaaat aatgaaaaca cttttttcac
     1261 tcatgaaatg agccacttag ctcctaaata gtgttttcct gttagtttag aaagttgtgg
     1321 acatattttt ttaatgattt ctgaccattt ttaatcacat tgactcatgg aatggcctca
     1381 aagcaccccc cagtgcttct ttcctcattc ccggtcatgg gaactcagta ttattaatag
     1441 tcacaacatg atttcagaac tagatagccc tcccacacca agaagaatgt gagaggaagt
     1501 aaggtcactt tatgtaaaaa aaaaaaaaaa caaacgcgta cacatatgta tgtatacata
     1561 catacctatg tgcacacaca cacacatata catacacaca aaatgctatg aagagttatc
     1621 tgtttagtag cctgttatag tcaaatcatt ttaagtttca acttcttaca gttgggccac
     1681 ttgttgtcct ttgtggatgg atatctgaaa ttgtgtctat atattgctag tcatgatact
     1741 gtgaacaaaa agggtagtgt tagtatttgt cagggtggta aggatgcatt ccaggaagct
     1801 tcctctgagg aagggaatga ggtcattctt gccatgtatg aaagacatag atgttttcca
     1861 gaaggcacca ttgggagccc cagtataagt tcctttagac tctacagttt agagggattt
     1921 tatatgtcct aggactcagg actccagaac tttgtgggct cagctgcttc ataccatggg
     1981 gatacattga catgaacaat tattttggaa tgtgtcttta gggacgacat caaagttctc
     2041 aagtacctac aagacctgat actggaatga aggtggactt tcttttttgc ttccagttcg
     2101 gatcaactgg aatgtatctg gggaccttga agaacggctg tccagctgtc ttcaccattt
     2161 gtatagtgct ttgaattatt cagaggtttt aaagtcagga agacctggtt taaaaaacat
     2221 ttcattatga gttaaatggc ctcaggcaag tcactgttca tccaagtcta tgactcctca
     2281 actgtaagat ggccacactg aaacttgcta agatcctctg gcctctgcct cccaagagtt
     2341 gggatttcag gagtgcacaa tcatgaccca aactcgtgat aatctctcag cttcaataac
     2401 tttccagcta attggaatat cctgtaatca aacatgaggc atttcccctc cccccactgt
     2461 ttttgtgtat aaagagatct ttaaactttt tttttaatat gaggggtaag aaaagatagg
     2521 aatcttttaa ttctagacag aagatattgt gctttggttt tttttttttt taatggcttc
     2581 tattctgtgc ttttaattaa accagagaag gccaagatta gccctacttg tgtgataaaa
     2641 gaatgctggc ccttgtgatt gcagtcagcc tcttgacaca tagagttctt gaatctaagt
     2701 tataaaatta tatttgaaaa tgacagagct ggagaattta tagaaagggt catagcaaat
     2761 aacaaaccat ttttttttaa acggaaagat ttggtctttg gcaatcaata actttgtttt
     2821 ctaactggaa aaggaggttt actggagatg aatcacacct gaaagttttc atacctcctc
     2881 tgaacacaac cgaaacatag gtgtccaaag cctttcgctc tcggtatgaa ccaacaggcg
     2941 ggttaaaaac actgggtcag agtaaagctt ttgcagtttc agatgtagtg tgtatgaaga
     3001 aaactatgtc acttgctgct attattgtaa gagtctaaga actaaaggtg tgcctgtaat
     3061 ttctaattat gagctcacct atttggtacc gagcatgcca attttaaaga gacccggtgt
     3121 accttatagc tacatccaat gataaaatta ccacactagc acatgcctgt gtttaaactc
     3181 gtgctttaat gtttttctta gggcaggtat gcaccccctt tgcagtgagt tgggagagat
     3241 tttgaaaaag tgtatgacaa acatttttaa cacctttggt ttcctctctc tgtgtctctt
     3301 tgtctctgtc tctctctttc tctcctgtgc atatgtctcc cctccctcac ttctctgtct
     3361 cttcctctct ccctctctct gtctttctct gtgtgtctct ctgtctctgt gtatctctct
     3421 gtctgtctct ttctctgcag attttcaaaa cgttgttttt ctatggaaga aatacaagct
     3481 gtggttggtt tgctacgagt cagtagcagt ttatcagtag gccaatgttt tatctcttgg
     3541 agatttcagt ctgggtttac ccaatgtatt ctctgtaatg tgactgctgg ggacagatat
     3601 aacttgattg agccttcaaa tcatttaggt cttcaatcat ttagtcaacg gagtgagcca
     3661 ctaatctgca atggctattt taatatgcat actgatggtc aaatggatgt ctgatctctc
     3721 atcccagctt tctgtactac catatgggaa ctatatgtaa cttgtatact tacctgaata
     3781 tgttaaattc aactacatgg taagatggac cagaaattgc aatgttcatg tccatatagc
     3841 caccattaac ccaagttaag cacagtagtg tgggttctct caggacttgt gaatgagttt
     3901 atgctctcta caaagacagg tgaagcttaa atctctcttg cactgctatg tttatgcaaa
     3961 tatcaagatt gtttctgtac cagggactta acacattcta ttcatactat tttccctgtc
     4021 tacaatgtta tttcatagat atctacttgg tttgctctta cttccttgac atatttgccc
     4081 aaatgccacc ttcaactgta gttaattacc tgtacaacct gtctccatgc cttgttttat
     4141 tttctctata actctactaa taggtatttt tcttatttat tggtttattg cctgtttttt
     4201 ttcctaaatc tacaccggat ctccaaaggg aaagaactcc atttgctttg attttattgc
     4261 tgtatcccca gtgcctagaa taatgcttag cctgcaataa atatttattc attgact
//
