LOCUS       NM_133983               3197 bp    mRNA    linear   ROD 02-OCT-2023
DEFINITION  Mus musculus CD276 antigen (Cd276), mRNA.
ACCESSION   NM_133983
VERSION     NM_133983.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3197)
  AUTHORS   Fan X, Huang J, Hu B, Zhou J and Chen L.
  TITLE     Tumor-expressed B7-H3 promotes vasculogenic mimicry formation
            rather than angiogenesis in non-small cell lung cancer
  JOURNAL   J Cancer Res Clin Oncol 149 (11), 8729-8741 (2023)
   PUBMED   37129607
  REMARK    GeneRIF: Tumor-expressed B7-H3 promotes vasculogenic mimicry
            formation rather than angiogenesis in non-small cell lung cancer.
REFERENCE   2  (bases 1 to 3197)
  AUTHORS   Chen H, Duan X, Deng X, Huang Y, Zhou X, Zhang S, Zhang X, Liu P,
            Yang C, Liu G, Ren Q, Xiong Y, Zhu B, Zhang J and Xiang T.
  TITLE     EBV-Upregulated B7-H3 Inhibits NK cell-Mediated Antitumor Function
            and Contributes to Nasopharyngeal Carcinoma Progression
  JOURNAL   Cancer Immunol Res 11 (6), 830-846 (2023)
   PUBMED   36996321
  REMARK    GeneRIF: EBV-Upregulated B7-H3 Inhibits NK cell-Mediated Antitumor
            Function and Contributes to Nasopharyngeal Carcinoma Progression.
REFERENCE   3  (bases 1 to 3197)
  AUTHORS   Zhang D, Yu Y, Ding C, Zhang R, Duan T and Zhou Q.
  TITLE     Decreased B7-H3 promotes unexplained recurrent miscarriage via
            RhoA/ROCK2 signaling pathway and regulates the secretion of
            decidual NK cellsdagger
  JOURNAL   Biol Reprod 108 (3), 504-518 (2023)
   PUBMED   36504380
  REMARK    GeneRIF: Decreased B7-H3 promotes unexplained recurrent miscarriage
            via RhoA/ROCK2 signaling pathway and regulates the secretion of
            decidual NK cellsdagger.
REFERENCE   4  (bases 1 to 3197)
  AUTHORS   Picarda E, Galbo PM Jr, Zong H, Rajan MR, Wallenius V, Zheng D,
            Borgeson E, Singh R, Pessin J and Zang X.
  TITLE     The immune checkpoint B7-H3 (CD276) regulates adipocyte progenitor
            metabolism and obesity development
  JOURNAL   Sci Adv 8 (17), eabm7012 (2022)
   PUBMED   35476450
REFERENCE   5  (bases 1 to 3197)
  AUTHORS   Peuker K, Strigli A, Tauriello DVF, Hendricks A, von Schonfels W,
            Burmeister G, Brosch M, Herrmann A, Kruger S, Nitsche J, Juznic L,
            Geissler MM, Hiergeist A, Gessner A, Wirbel J, Ponnudurai RP,
            Tunger A, Wehner R, Stange DE, Weitz J, Aust DE, Baretton GB,
            Schmitz M, Rocken C, Hampe J, Hinz S, Zeller G, Chavakis T,
            Schafmayer C, Batlle E and Zeissig S.
  TITLE     Microbiota-dependent activation of the myeloid calcineurin-NFAT
            pathway inhibits B7H3- and B7H4-dependent anti-tumor immunity in
            colorectal cancer
  JOURNAL   Immunity 55 (4), 701-717 (2022)
   PUBMED   35364006
  REMARK    GeneRIF: Microbiota-dependent activation of the myeloid
            calcineurin-NFAT pathway inhibits B7H3- and B7H4-dependent
            anti-tumor immunity in colorectal cancer.
REFERENCE   6  (bases 1 to 3197)
  AUTHORS   Prasad DV, Nguyen T, Li Z, Yang Y, Duong J, Wang Y and Dong C.
  TITLE     Murine B7-H3 is a negative regulator of T cells
  JOURNAL   J Immunol 173 (4), 2500-2506 (2004)
   PUBMED   15294965
  REMARK    GeneRIF: B7-H3 serves as a negative regulator of T cell activation
            and function
REFERENCE   7  (bases 1 to 3197)
  AUTHORS   Sun X, Vale M, Leung E, Kanwar JR, Gupta R and Krissansen GW.
  TITLE     Mouse B7-H3 induces antitumor immunity
  JOURNAL   Gene Ther 10 (20), 1728-1734 (2003)
   PUBMED   12939639
REFERENCE   8  (bases 1 to 3197)
  AUTHORS   Suh WK, Gajewska BU, Okada H, Gronski MA, Bertram EM, Dawicki W,
            Duncan GS, Bukczynski J, Plyte S, Elia A, Wakeham A, Itie A, Chung
            S, Da Costa J, Arya S, Horan T, Campbell P, Gaida K, Ohashi PS,
            Watts TH, Yoshinaga SK, Bray MR, Jordana M and Mak TW.
  TITLE     The B7 family member B7-H3 preferentially down-regulates T helper
            type 1-mediated immune responses
  JOURNAL   Nat Immunol 4 (9), 899-906 (2003)
   PUBMED   12925852
  REMARK    GeneRIF: preferentially down-regulates t helper type 1-mediated
            immune responses
REFERENCE   9  (bases 1 to 3197)
  AUTHORS   Ling V, Wu PW, Spaulding V, Kieleczawa J, Luxenberg D, Carreno BM
            and Collins M.
  TITLE     Duplication of primate and rodent B7-H3 immunoglobulin V- and
            C-like domains: divergent history of functional redundancy and exon
            loss
  JOURNAL   Genomics 82 (3), 365-377 (2003)
   PUBMED   12906861
REFERENCE   10 (bases 1 to 3197)
  AUTHORS   Sun M, Richards S, Prasad DV, Mai XM, Rudensky A and Dong C.
  TITLE     Characterization of mouse and human B7-H3 genes
  JOURNAL   J Immunol 168 (12), 6294-6297 (2002)
   PUBMED   12055244
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CT030640.9.
            
            [WARNING] On Oct 4, 2023 this sequence was replaced by NM_133983.5.
            
            On Aug 22, 2007 this sequence version replaced NM_133983.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ832276.1, SRR1660813.48690.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                CT030640.9         128347-128358
            13-286              CT030640.9         142440-142713
            287-625             CT030640.9         145773-146111
            626-922             CT030640.9         147628-147924
            923-1057            CT030640.9         152650-152784
            1058-1099           CT030640.9         154887-154928
            1100-1135           CT030640.9         155826-155861
            1136-3197           CT030640.9         157019-159080
FEATURES             Location/Qualifiers
     source          1..3197
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 31.79 cM"
     gene            1..3197
                     /gene="Cd276"
                     /gene_synonym="6030411F23Rik; B7-H3; B7h3; B7RP-2"
                     /note="CD276 antigen"
                     /db_xref="GeneID:102657"
                     /db_xref="MGI:MGI:2183926"
     exon            1..12
                     /gene="Cd276"
                     /gene_synonym="6030411F23Rik; B7-H3; B7h3; B7RP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            13..286
                     /gene="Cd276"
                     /gene_synonym="6030411F23Rik; B7-H3; B7h3; B7RP-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             208..1158
                     /gene="Cd276"
                     /gene_synonym="6030411F23Rik; B7-H3; B7h3; B7RP-2"
                     /note="B7 homolog 3; costimulatory molecule"
                     /codon_start=1
                     /product="CD276 antigen precursor"
                     /protein_id="NP_598744.1"
                     /db_xref="CCDS:CCDS23244.1"
                     /db_xref="GeneID:102657"
                     /db_xref="MGI:MGI:2183926"
                     /translation="MLRGWGGPSVGVCVRTALGVLCLCLTGAVEVQVSEDPVVALVDT
                     DATLRCSFSPEPGFSLAQLNLIWQLTDTKQLVHSFTEGRDQGSAYSNRTALFPDLLVQ
                     GNASLRLQRVRVTDEGSYTCFVSIQDFDSAAVSLQVAAPYSKPSMTLEPNKDLRPGNM
                     VTITCSSYQGYPEAEVFWKDGQGVPLTGNVTTSQMANERGLFDVHSVLRVVLGANGTY
                     SCLVRNPVLQQDAHGSVTITGQPLTFPPEALWVTVGLSVCLVVLLVALAFVCWRKIKQ
                     SCEEENAGAEDQDGDGEGSKTALRPLKPSENKEDDGQEIA"
     exon            287..625
                     /gene="Cd276"
                     /gene_synonym="6030411F23Rik; B7-H3; B7h3; B7RP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            626..922
                     /gene="Cd276"
                     /gene_synonym="6030411F23Rik; B7-H3; B7h3; B7RP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1057
                     /gene="Cd276"
                     /gene_synonym="6030411F23Rik; B7-H3; B7h3; B7RP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1099
                     /gene="Cd276"
                     /gene_synonym="6030411F23Rik; B7-H3; B7h3; B7RP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1135
                     /gene="Cd276"
                     /gene_synonym="6030411F23Rik; B7-H3; B7h3; B7RP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..3197
                     /gene="Cd276"
                     /gene_synonym="6030411F23Rik; B7-H3; B7h3; B7RP-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggcgcggcg cgccaaagtg acctggtaca gcctggaccc caagctcatc ggctttgtct
       61 ggctggccgc ctggcctctt cccacttgga tttggatgat cctgaggcct ttggaggaac
      121 ttcgagacaa aggcccctct tcctcttcca cgggcaggag cagccattcg ccacggagag
      181 cccagctgtc agctgtctca caggaagatg cttcgaggat ggggtggccc cagtgtgggt
      241 gtgtgtgtgc gcacagcact gggggtgctg tgcctctgcc tcacaggagc tgtggaagtc
      301 caggtctctg aagaccccgt ggtggccctg gtggacacgg atgccaccct acgctgctcc
      361 ttttccccag agcctggctt cagtctggca cagctcaacc tcatctggca gctgacagac
      421 accaaacagc tggtgcacag cttcacggag ggccgggacc aaggcagtgc ctactccaac
      481 cgcacagcgc tcttccctga cctgttggtg caaggcaatg cgtccttgag gctgcagcgc
      541 gtccgagtaa ccgacgaggg cagctacacc tgctttgtga gcatccagga ctttgacagc
      601 gctgctgtta gcctgcaggt ggccgccccc tactcgaagc ccagcatgac cctggagccc
      661 aacaaggacc tacgtccagg gaacatggtg accatcacgt gctctagcta ccagggctat
      721 ccggaggccg aggtgttctg gaaggatgga cagggagtgc ccttgactgg caatgtgacc
      781 acatcccaga tggccaacga gcggggcttg ttcgatgttc acagcgtgct gagggtggtg
      841 ctgggtgcta acggcaccta cagctgcctg gtacgcaacc cggtgttgca gcaagatgct
      901 cacggctcag tcaccatcac agggcagccc ctgacattcc cccctgaggc tctgtgggta
      961 accgtggggc tctctgtctg tcttgtggta ctactggtgg ccctggcttt cgtgtgctgg
     1021 agaaagatca agcagagctg cgaggaggag aatgcaggtg ccgaggacca ggatggagat
     1081 ggagaaggat ccaagacagc tctacggcct ctgaaaccct ctgaaaacaa agaagatgac
     1141 ggacaagaaa ttgcttgatt gggagctgct gcccttccca ggtggggggc ccaccctctg
     1201 gcagtgttga gcttcaatgc gagcccttcc cccaacgaat gggtttgtcc cacagatcta
     1261 cccgttcgtc aaaggacgtg gtccatagac cacccacagc cttacttttc caatggactt
     1321 aattcccatc atcctgcagc ctcatttctc cagtgacacg atacacgaac catcctgcgg
     1381 ccttatttcc cacggacacg acacaaagat gtccctcctc ggtgttcctc cagagtcgtc
     1441 tggtggcctt gtgatacggc gtgaaccttc ttccttctgc cttacgtcta atggacacac
     1501 acgcaccacc cccacaccct tgctcctcca aagccatgca gactgtgtaa ctgctattat
     1561 tctccaaggg gcatcctgtg cagatgaaac cctgctttat ttccctgaag acagctgcac
     1621 agtgacctct tagttcttgc tcccatggcc ctgatgtatc ctagttacca gccctcaacc
     1681 tcagttctga gggtgggatc ccatcgctca gcaaggcttc atcctgacct ccctgccctg
     1741 atctgatctg gccctggctt ttgttgtctc gctccctgac taagtgagat ggggcactct
     1801 cccgcccccg ccccccccag gtcacagata cctacctgca gctgtgcgtg ctggatcacg
     1861 cacatacttg ccttgcatgg tctcctggct gccctgggct gtgcctgttc ttccatagga
     1921 agcaagttct tgtctccctg gttctcaggg cccctcaggg gctcagcctt cagccctgtg
     1981 cttccccatg ttgggaatct ttgttacctt tttcttcttt gtaaattaac atctgataac
     2041 aaccacaggg tccaatggga ctttcacaga cctgccagct agataaataa tgacaacaga
     2101 agtttattaa tattttaaga cttaggcctt ttgctgggca gcctcccaac tattctatcc
     2161 tgactaatcc tggcactatg tcccaccaca tggccaggtc tacctctctg ctccactctc
     2221 catccacctc catgtctgcc agcaaatctc ccgtgattca gttcttctcc cagagtccct
     2281 atctctgccc agaagtacca tcttcgactt cctgcccaac tattggccgt cagctcttca
     2341 ttaaagccga tcagatgtaa ttctagattg ccttaggcag gtgaggaaga aacaagtatt
     2401 tgtaaaatat gagaccagca atgggccata gaaataacag caccagatcc tgccagcatt
     2461 tagccctctg ttggtacaaa attaacaatt gaatatacag agacctactt ccagagtgta
     2521 ccccaacaac aggcgtgagc atggtgctgg gtactagggt cctgctggaa aatcagagac
     2581 cttacctaca gctgggacat gaccttgctt ccgacttacc caccacttct ggatacctca
     2641 ccctcagccc acactatccc tggcctaggg cccagggtag agccagaaac atggagaaag
     2701 catggcccct tgccgtacct ggagaactgg gtattttcca gagtctttat agatgtggac
     2761 tggaaggcag gtggccacag ccgtgcagac ctgggtcagg tcagaaacct atgccatgct
     2821 gggacctact caacagcaga agcatgaaga gggcctgagg acaagaaagg ccttcttacc
     2881 atggtgctat tctggagctg ggatatatac ctggcttgtc tctgactgcc ctggcttctg
     2941 gcagaacttc tgatgtcctc ctgaaggcct ctctcccacc ccagtacctg agaacctgag
     3001 gataatttaa acatgggact ctggccagca cctgggagag acaggtagat ctctgatttt
     3061 tgactcagcc tggtctatcg agtgagttcc aggacatctg gggctacaca gagaaaccat
     3121 cttaaagact aaaaataata aacatgagac tgtaaactgg gtgtattttg ggagaaataa
     3181 atgtcttttt ctttcaa
//
