LOCUS       NM_021893               3653 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus CD274 antigen (Cd274), mRNA.
ACCESSION   NM_021893
VERSION     NM_021893.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3653)
  AUTHORS   Lin,F., Yin,S., Zhang,Z., Yu,Y., Fang,H., Liang,Z., Zhu,R.,
            Zhou,H., Li,J., Cao,K., Guo,W., Qin,S., Zhang,Y., Lu,C., Li,H.,
            Liu,S., Zhang,H., Ye,B., Lin,J., Li,Y., Kang,X., Xi,J.J. and
            Chen,P.R.
  TITLE     Multimodal targeting chimeras enable integrated immunotherapy
            leveraging tumor-immune microenvironment
  JOURNAL   Cell 187 (26), 7470-7491 (2024)
   PUBMED   39504957
REFERENCE   2  (bases 1 to 3653)
  AUTHORS   Ogishi,M., Kitaoka,K., Good-Jacobson,K.L., Rinchai,D., Zhang,B.,
            Wang,J., Gies,V., Rao,G., Nguyen,T., Avery,D.T., Khan,T.,
            Smithmyer,M.E., Mackie,J., Yang,R., Arias,A.A., Asano,T.,
            Ponsin,K., Chaldebas,M., Zhang,P., Peel,J.N., Bohlen,J., Levy,R.,
            Pelham,S.J., Lei,W.T., Han,J.E., Fagniez,I., Chrabieh,M., Laine,C.,
            Langlais,D., Gruber,C., Al Ali,F., Rahman,M., Aytekin,C.,
            Benson,B., Dufort,M.J., Domingo-Vila,C., Moriya,K., Shlomchik,M.,
            Uzel,G., Gray,P.E., Suan,D., Preece,K., Chua,I., Okada,S.,
            Chikuma,S., Kiyonari,H., Tree,T.I., Bogunovic,D., Gros,P., Marr,N.,
            Speake,C., Oram,R.A., Beziat,V., Bustamante,J., Abel,L.,
            Boisson,B., Korganow,A.S., Ma,C.S., Johnson,M.B., Chamoto,K.,
            Boisson-Dupuis,S., Honjo,T., Casanova,J.L. and Tangye,S.G.
  TITLE     Impaired development of memory B cells and antibody responses in
            humans and mice deficient in PD-1 signaling
  JOURNAL   Immunity 57 (12), 2790-2807 (2024)
   PUBMED   39603236
REFERENCE   3  (bases 1 to 3653)
  AUTHORS   Lazar-Molnar,E., Yan,Q., Cao,E., Ramagopal,U., Nathenson,S.G. and
            Almo,S.C.
  TITLE     Crystal structure of the complex between programmed death-1 (PD-1)
            and its ligand PD-L2
  JOURNAL   Proc Natl Acad Sci U S A 105 (30), 10483-10488 (2008)
   PUBMED   18641123
REFERENCE   4  (bases 1 to 3653)
  AUTHORS   Habicht,A., Dada,S., Jurewicz,M., Fife,B.T., Yagita,H., Azuma,M.,
            Sayegh,M.H. and Guleria,I.
  TITLE     A link between PDL1 and T regulatory cells in fetomaternal
            tolerance
  JOURNAL   J Immunol 179 (8), 5211-5219 (2007)
   PUBMED   17911606
  REMARK    GeneRIF: Interactions between PD-L1 and T regulatory cells regulate
            the maternal alloimmune response against paternal antigens on the
            fetus.
REFERENCE   5  (bases 1 to 3653)
  AUTHORS   Carter,L.L., Leach,M.W., Azoitei,M.L., Cui,J., Pelker,J.W.,
            Jussif,J., Benoit,S., Ireland,G., Luxenberg,D., Askew,G.R.,
            Milarski,K.L., Groves,C., Brown,T., Carito,B.A., Percival,K.,
            Carreno,B.M., Collins,M. and Marusic,S.
  TITLE     PD-1/PD-L1, but not PD-1/PD-L2, interactions regulate the severity
            of experimental autoimmune encephalomyelitis
  JOURNAL   J Neuroimmunol 182 (1-2), 124-134 (2007)
   PUBMED   17182110
REFERENCE   6  (bases 1 to 3653)
  AUTHORS   Guleria,I., Khosroshahi,A., Ansari,M.J., Habicht,A., Azuma,M.,
            Yagita,H., Noelle,R.J., Coyle,A., Mellor,A.L., Khoury,S.J. and
            Sayegh,M.H.
  TITLE     A critical role for the programmed death ligand 1 in fetomaternal
            tolerance
  JOURNAL   J Exp Med 202 (2), 231-237 (2005)
   PUBMED   16027236
REFERENCE   7  (bases 1 to 3653)
  AUTHORS   Dong,H., Zhu,G., Tamada,K., Flies,D.B., van Deursen,J.M. and
            Chen,L.
  TITLE     B7-H1 determines accumulation and deletion of intrahepatic CD8(+) T
            lymphocytes
  JOURNAL   Immunity 20 (3), 327-336 (2004)
   PUBMED   15030776
  REMARK    GeneRIF: B7-H1 regulates the accumulation and deletion of
            intrahepatic CD8(+) T cells which resulted in accelerated liver
            damage in experimental autoimmune hepatitis.
REFERENCE   8  (bases 1 to 3653)
  AUTHORS   Tamura,H., Dong,H., Zhu,G., Sica,G.L., Flies,D.B., Tamada,K. and
            Chen,L.
  TITLE     B7-H1 costimulation preferentially enhances CD28-independent
            T-helper cell function
  JOURNAL   Blood 97 (6), 1809-1816 (2001)
   PUBMED   11238124
REFERENCE   9  (bases 1 to 3653)
  AUTHORS   Latchman,Y., Wood,C.R., Chernova,T., Chaudhary,D., Borde,M.,
            Chernova,I., Iwai,Y., Long,A.J., Brown,J.A., Nunes,R.,
            Greenfield,E.A., Bourque,K., Boussiotis,V.A., Carter,L.L.,
            Carreno,B.M., Malenkovich,N., Nishimura,H., Okazaki,T., Honjo,T.,
            Sharpe,A.H. and Freeman,G.J.
  TITLE     PD-L2 is a second ligand for PD-1 and inhibits T cell activation
  JOURNAL   Nat Immunol 2 (3), 261-268 (2001)
   PUBMED   11224527
REFERENCE   10 (bases 1 to 3653)
  AUTHORS   Freeman,G.J., Long,A.J., Iwai,Y., Bourque,K., Chernova,T.,
            Nishimura,H., Fitz,L.J., Malenkovich,N., Okazaki,T., Byrne,M.C.,
            Horton,H.F., Fouser,L., Carter,L., Ling,V., Bowman,M.R.,
            Carreno,B.M., Collins,M., Wood,C.R. and Honjo,T.
  TITLE     Engagement of the PD-1 immunoinhibitory receptor by a novel B7
            family member leads to negative regulation of lymphocyte activation
  JOURNAL   J Exp Med 192 (7), 1027-1034 (2000)
   PUBMED   11015443
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC119228.10, BY193530.1,
            AF317088.1 and AI645624.1.
            
            On Dec 9, 2009 this sequence version replaced NM_021893.2.
            
            Summary: The protein encoded by this gene is an immune inhibitory
            receptor ligand that is expressed by hematopoietic and
            non-hematopoietic cells, such as T cells and B cells and various
            types of tumor cells. The encoded protein is a type I transmembrane
            protein that has immunoglobulin V-like and C-like domains.
            Interaction of this ligand with its receptor inhibits T-cell
            activation and cytokine production. During infection or
            inflammation of normal tissue, this interaction is important for
            preventing autoimmunity by maintaining homeostasis of the immune
            response. In tumor microenvironments, this interaction provides an
            immune escape for tumor cells through cytotoxic T-cell
            inactivation. Mice deficient for this gene display a variety of
            phenotypes including decreased allogeneic fetal survival rates and
            severe experimental autoimmune encephalomyelitis. [provided by
            RefSeq, Sep 2015].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC066841.1, AK154403.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 AC119228.10        135454-135459
            7-83                BY193530.1         3-79
            84-956              AF317088.1         1-873
            957-3364            AC119228.10        153429-155836
            3365-3653           AI645624.1         1-289               c
FEATURES             Location/Qualifiers
     source          1..3653
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 23.88 cM"
     gene            1..3653
                     /gene="Cd274"
                     /gene_synonym="A530045L16Rik; B7h1; Pdcd1l1; Pdcd1lg1;
                     Pdl1"
                     /note="CD274 antigen"
                     /db_xref="GeneID:60533"
                     /db_xref="MGI:MGI:1926446"
     exon            1..69
                     /gene="Cd274"
                     /gene_synonym="A530045L16Rik; B7h1; Pdcd1l1; Pdcd1lg1;
                     Pdl1"
                     /inference="alignment:Splign:2.1.0"
     exon            70..135
                     /gene="Cd274"
                     /gene_synonym="A530045L16Rik; B7h1; Pdcd1l1; Pdcd1lg1;
                     Pdl1"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..956
                     /gene="Cd274"
                     /gene_synonym="A530045L16Rik; B7h1; Pdcd1l1; Pdcd1lg1;
                     Pdl1"
                     /note="programmed cell death 1 ligand 1; B7 homolog 1;
                     PDCD1 ligand 1"
                     /codon_start=1
                     /product="programmed cell death 1 ligand 1 precursor"
                     /protein_id="NP_068693.1"
                     /db_xref="CCDS:CCDS29735.1"
                     /db_xref="GeneID:60533"
                     /db_xref="MGI:MGI:1926446"
                     /translation="MRIFAGIIFTACCHLLRAFTITAPKDLYVVEYGSNVTMECRFPV
                     ERELDLLALVVYWEKEDEQVIQFVAGEEDLKPQHSNFRGRASLPKDQLLKGNAALQIT
                     DVKLQDAGVYCCIISYGGADYKRITLKVNAPYRKINQRISVDPATSEHELICQAEGYP
                     EAEVIWTNSDHQPVSGKRSVTTSRTEGMLLNVTSSLRVNATANDVFYCTFWRSQPGQN
                     HTAELIIPELPATHPPQNRTHWVLLGSILLFLIVVSTVLLFLRKQVRMLDVEKCGVED
                     TSSKNRNDTQFEET"
     exon            136..477
                     /gene="Cd274"
                     /gene_synonym="A530045L16Rik; B7h1; Pdcd1l1; Pdcd1lg1;
                     Pdl1"
                     /inference="alignment:Splign:2.1.0"
     exon            478..762
                     /gene="Cd274"
                     /gene_synonym="A530045L16Rik; B7h1; Pdcd1l1; Pdcd1lg1;
                     Pdl1"
                     /inference="alignment:Splign:2.1.0"
     exon            763..873
                     /gene="Cd274"
                     /gene_synonym="A530045L16Rik; B7h1; Pdcd1l1; Pdcd1lg1;
                     Pdl1"
                     /inference="alignment:Splign:2.1.0"
     exon            874..933
                     /gene="Cd274"
                     /gene_synonym="A530045L16Rik; B7h1; Pdcd1l1; Pdcd1lg1;
                     Pdl1"
                     /inference="alignment:Splign:2.1.0"
     exon            934..3639
                     /gene="Cd274"
                     /gene_synonym="A530045L16Rik; B7h1; Pdcd1l1; Pdcd1lg1;
                     Pdl1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3617..3622
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cd274"
                     /gene_synonym="A530045L16Rik; B7h1; Pdcd1l1; Pdcd1lg1;
                     Pdl1"
                     /note="hexamer: AATAAA"
     polyA_site      3639
                     /gene="Cd274"
                     /gene_synonym="A530045L16Rik; B7h1; Pdcd1l1; Pdcd1lg1;
                     Pdl1"
                     /note="major polyA site"
ORIGIN      
        1 gaaatcgtgg tccccaagcc tcatgccagg ctgcacttgc acgtcgcggg ccagtctcct
       61 cgcctgcaga tagttcccaa aacatgagga tatttgctgg cattatattc acagcctgct
      121 gtcacttgct acgggcgttt actatcacgg ctccaaagga cttgtacgtg gtggagtatg
      181 gcagcaacgt cacgatggag tgcagattcc ctgtagaacg ggagctggac ctgcttgcgt
      241 tagtggtgta ctgggaaaag gaagatgagc aagtgattca gtttgtggca ggagaggagg
      301 accttaagcc tcagcacagc aacttcaggg ggagagcctc gctgccaaag gaccagcttt
      361 tgaagggaaa tgctgccctt cagatcacag acgtcaagct gcaggacgca ggcgtttact
      421 gctgcataat cagctacggt ggtgcggact acaagcgaat cacgctgaaa gtcaatgccc
      481 cataccgcaa aatcaaccag agaatttccg tggatccagc cacttctgag catgaactaa
      541 tatgtcaggc cgagggttat ccagaagctg aggtaatctg gacaaacagt gaccaccaac
      601 ccgtgagtgg gaagagaagt gtcaccactt cccggacaga ggggatgctt ctcaatgtga
      661 ccagcagtct gagggtcaac gccacagcga atgatgtttt ctactgtacg ttttggagat
      721 cacagccagg gcaaaaccac acagcggagc tgatcatccc agaactgcct gcaacacatc
      781 ctccacagaa caggactcac tgggtgcttc tgggatccat cctgttgttc ctcattgtag
      841 tgtccacggt cctcctcttc ttgagaaaac aagtgagaat gctagatgtg gagaaatgtg
      901 gcgttgaaga tacaagctca aaaaaccgaa atgatacaca attcgaggag acgtaagcag
      961 tgttgaaccc tctgatcgtc gattggcagc ttgtggtctg tgaaagaaag ggcccatggg
     1021 acatgagtcc aaagactcaa gatggaacct gagggagaga accaagaaag tgttgggaga
     1081 ggagcctgga acaacggaca ttttttccag ggagacactg ctaagcaagt tgcccatcag
     1141 tcgtcttggg aaatggattg agggttcctg gcttagcagc tggtccttgc acagtgacct
     1201 tttcctctgc tcagtgccgg gatgagagat ggagtcatga gtgttgaaga ataagtgcct
     1261 tctatttatt ttgagtctgt gtgttctcac tttgggcatg taattatgac tggtgaattc
     1321 tgacgacatg atagatctta agatgtagtc accaaactca actgctgctt agcatcctcc
     1381 gtaactactg atacaagcag ggaacacaga ggtcacctgc ttggtttgac aggctcttgc
     1441 tgtctgactc aaataatctt tatttttcag tcctcaaggc tcttcgatag cagttgttct
     1501 gtatcagcct tataggtgtc aggtatagca ctcaacatct catctcatta caatagcaac
     1561 cctcatcacc atagcaacag ctaacctctg ttatcctcac ttcatagcca ggaagctgag
     1621 cgactaagtc acttgcccac agagtatcag ctctcagatt tctgttcttc agccactgtc
     1681 ctttcaggat agaatttgtc gttaagaaat taatttaaaa actgattatt gagtagcatt
     1741 gtatatcaat cacaacatgc cttgtgcact gtgctggcct ctgagcataa agatgtacgc
     1801 cggagtaccg gtcggacatg tttatgtgtg ttaaatactc agagaaatgt tcattaacaa
     1861 ggagcttgca ttttagagac actggaaagt aactccagtt cattgtctag cattacattt
     1921 acctcatttg ctatccttgc catacagtct cttgttctcc atgaagtgtc atgaatcttg
     1981 ttgaatagtt cttttatttt ttaaatgttt ctatttaaat gatattgaca tctgaggcga
     2041 tagctcagtt ggtaaaaccc tttcctcaca agtgtgaaac cctgagtctt atccctagaa
     2101 cccacataaa aaacagttgc gtatgtttgt gcatgctttt gatcccagca ctagggaggc
     2161 agaggcaggc agatcctgag ctctcattga ccacccagcc tagcctacat ggttagctcc
     2221 aggcctacag gagctggcag agcctgaaaa acgatgccta gacacacaca cacacacaca
     2281 cacacacaca cacacacaca cacaccatgt actcatagac ctaagtgcac cctcctacac
     2341 atgcacacac atacaattca aacacaaatc aacagggaat tgtctcagaa tggtccccaa
     2401 gacaaagaag aagaaaaaca ccaaaccagc tctattccct cagcctatcc tctctactcc
     2461 ttcctagaag caactactat tgtttttgta tataaattta cccaacgaca gttaatatgt
     2521 agaatatata ttaaagtgtc tgtcaatata tattatctct ttctttcttt cttcctttct
     2581 ttctttcttt ctttctttct ttctttcttt ctttctttct ttcttccttc cttccttcct
     2641 tccttccttc cttccttcct ttctttcttt ctttcttttt ttctgtctat ctgtacctaa
     2701 atggttgctc actatgcatt ttctgtgctc ttcgcccttt ttatttaatg tatggatatt
     2761 tatgctgctt ccagaatgga tctaaagctc tttgtttcta ggttttctcc cccatccttc
     2821 taggcatctc tcacactgtc taggccagac accatgtctg ctgcctgaat ctgtagacac
     2881 catttataaa gcacgtactc accgagtttg tatttggctt gttctgtgtc tgattaaagg
     2941 gagaccatga gtccccaggg tacactgagt taccccagta ccaaggggga gccttgtttg
     3001 tgtctccatg gcagaagcag gcctggagcc attttggttt cttccttgac ttctctcaaa
     3061 cacagacgcc tcacttgctc attacaggtt ctcctttggg aatgtcagca ttgctccttg
     3121 actgctggct gccctggaag gagcccatta gctctgtgtg agcccttgac agctactgcc
     3181 tctccttacc acaggggcct ctaagatact gttacctaga ggtcttgagg atctgtgttc
     3241 tctgggggga ggaaaggagg aggaacccag aactttctta cagttttcct tgttctgtca
     3301 catgtcaaga ctgaaggaac aggctgggct acgtagtgag atcctgtctc aaaggaaaga
     3361 cgagcatagc cgaacccccg gtggaacccc ctctgttacc tgttcacaca agcttattga
     3421 tgagtctcat gttaatgtct tgtttgtatg aagtttaaga aaatatcggg ttgggcaaca
     3481 cattctattt attcatttta tttgaaatct taatgccatc tcatggtgtt ggattggtgt
     3541 ggcactttat tcttttgtgt tgtgtataac cataaatttt attttgcatc agattgtcaa
     3601 tgtattgcat taatttaata aatattttta tttattaaaa aaaaaaaaaa aaa
//
