LOCUS       NM_001033126            1576 bp    mRNA    linear   ROD 20-SEP-2024
DEFINITION  Mus musculus CD27 antigen (Cd27), transcript variant 1, mRNA.
ACCESSION   NM_001033126 XM_284241
VERSION     NM_001033126.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1576)
  AUTHORS   Englebert,K., Taquin,A., Azouz,A., Acolty,V., Vande Velde,S.,
            Vanhollebeke,M., Innes,H., Boon,L., Keler,T., Leo,O., Goriely,S.,
            Moser,M. and Oldenhove,G.
  TITLE     The CD27/CD70 pathway negatively regulates visceral adipose
            tissue-resident Th2 cells and controls metabolic homeostasis
  JOURNAL   Cell Rep 43 (3), 113824 (2024)
   PUBMED   38386557
  REMARK    GeneRIF: The CD27/CD70 pathway negatively regulates visceral
            adipose tissue-resident Th2 cells and controls metabolic
            homeostasis.
REFERENCE   2  (bases 1 to 1576)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1576)
  AUTHORS   Gong,L., Luo,J., Zhang,Y., Yang,Y., Li,S., Fang,X., Zhang,B.,
            Huang,J., Chow,L.K., Chung,D., Huang,J., Huang,C., Liu,Q., Bai,L.,
            Tiu,Y.C., Wu,P., Wang,Y., Tsao,G.S., Kwong,D.L., Lee,A.W., Dai,W.
            and Guan,X.Y.
  TITLE     Nasopharyngeal carcinoma cells promote regulatory T cell
            development and suppressive activity via CD70-CD27 interaction
  JOURNAL   Nat Commun 14 (1), 1912 (2023)
   PUBMED   37024479
  REMARK    GeneRIF: Nasopharyngeal carcinoma cells promote regulatory T cell
            development and suppressive activity via CD70-CD27 interaction.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1576)
  AUTHORS   Bowakim-Anta,N., Acolty,V., Azouz,A., Yagita,H., Leo,O.,
            Goriely,S., Oldenhove,G. and Moser,M.
  TITLE     Chronic CD27-CD70 costimulation promotes type 1-specific
            polarization of effector Tregs
  JOURNAL   Front Immunol 14, 1023064 (2023)
   PUBMED   36993956
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1576)
  AUTHORS   Wu,R., Ohara,R.A., Jo,S., Liu,T.T., Ferris,S.T., Ou,F., Kim,S.,
            Theisen,D.J., Anderson,D.A. 3rd, Wong,B.W., Gershon,T.,
            Schreiber,R.D., Murphy,T.L. and Murphy,K.M.
  TITLE     Mechanisms of CD40-dependent cDC1 licensing beyond costimulation
  JOURNAL   Nat Immunol 23 (11), 1536-1550 (2022)
   PUBMED   36271147
REFERENCE   6  (bases 1 to 1576)
  AUTHORS   McIndoe,R.A., Bohlman,B., Chi,E., Schuster,E., Lindhardt,M. and
            Hood,L.
  TITLE     Localization of non-Mhc collagen-induced arthritis susceptibility
            loci in DBA/1j mice
  JOURNAL   Proc Natl Acad Sci U S A 96 (5), 2210-2214 (1999)
   PUBMED   10051620
REFERENCE   7  (bases 1 to 1576)
  AUTHORS   Simonart,T., Noel,J.C., Andrei,G., Parent,D., Van Vooren,J.P.,
            Hermans,P., Lunardi-Yskandar,Y., Lambert,C., Dieye,T., Farber,C.M.,
            Liesnard,C., Snoeck,R., Heenen,M. and Boelaert,J.R.
  TITLE     Iron as a potential co-factor in the pathogenesis of Kaposi's
            sarcoma?
  JOURNAL   Int J Cancer 78 (6), 720-726 (1998)
   PUBMED   9833765
REFERENCE   8  (bases 1 to 1576)
  AUTHORS   Gravestein,L.A., Amsen,D., Boes,M., Calvo,C.R., Kruisbeek,A.M. and
            Borst,J.
  TITLE     The TNF receptor family member CD27 signals to Jun N-terminal
            kinase via Traf-2
  JOURNAL   Eur J Immunol 28 (7), 2208-2216 (1998)
   PUBMED   9692890
REFERENCE   9  (bases 1 to 1576)
  AUTHORS   Tesselaar,K., Gravestein,L.A., van Schijndel,G.M., Borst,J. and van
            Lier,R.A.
  TITLE     Characterization of murine CD70, the ligand of the TNF receptor
            family member CD27
  JOURNAL   J Immunol 159 (10), 4959-4965 (1997)
   PUBMED   9366422
REFERENCE   10 (bases 1 to 1576)
  AUTHORS   Gravestein,L.A., Blom,B., Nolten,L.A., de Vries,E., van der
            Horst,G., Ossendorp,F., Borst,J. and Loenen,W.A.
  TITLE     Cloning and expression of murine CD27: comparison with 4-1BB,
            another lymphocyte-specific member of the nerve growth factor
            receptor family
  JOURNAL   Eur J Immunol 23 (4), 943-950 (1993)
   PUBMED   8384562
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AI326735.1, DT924276.1, AA475779.1 and AC140324.3.
            
            On Jul 15, 2006 this sequence version replaced NM_001033126.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC139125.1, SRR5189685.170491.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-74                AI326735.1         1-74
            75-403              DT924276.1         1-329
            404-536             AA475779.1         330-462
            537-583             AC140324.3         148604-148650
            584-811             DT924276.1         330-557
            812-1576            AC140324.3         149779-150543
FEATURES             Location/Qualifiers
     source          1..1576
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 59.32 cM"
     gene            1..1576
                     /gene="Cd27"
                     /gene_synonym="S152; Tnfrsf7; Tp55"
                     /note="CD27 antigen"
                     /db_xref="GeneID:21940"
                     /db_xref="MGI:MGI:88326"
     exon            1..271
                     /gene="Cd27"
                     /gene_synonym="S152; Tnfrsf7; Tp55"
                     /inference="alignment:Splign:2.1.0"
     CDS             136..888
                     /gene="Cd27"
                     /gene_synonym="S152; Tnfrsf7; Tp55"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; CD27L receptor; T-cell activation antigen CD27;
                     tumor necrosis factor receptor superfamily member 7; CD
                     antigen 27"
                     /codon_start=1
                     /product="CD27 antigen isoform a precursor"
                     /protein_id="NP_001028298.1"
                     /db_xref="CCDS:CCDS39639.1"
                     /db_xref="GeneID:21940"
                     /db_xref="MGI:MGI:88326"
                     /translation="MAWPPPYWLCMLGTLVGLSATLAPNSCPDKHYWTGGGLCCRMCE
                     PGTFFVKDCEQDRTAAQCDPCIPGTSFSPDYHTRPHCESCRHCNSGFLIRNCTVTANA
                     ECSCSKNWQCRDQECTECDPPLNPALTRQPSETPSPQPPPTHLPHGTEKPSWPLHRQL
                     PNSTVYSQRSSHRPLCSSDCIRIFVTFSSMFLIFVLGAILFFHQRRNHGPNEDRQAVP
                     EEPCPYSCPREEEGSAIPIQEDYRKPEPAFYP"
     exon            272..403
                     /gene="Cd27"
                     /gene_synonym="S152; Tnfrsf7; Tp55"
                     /inference="alignment:Splign:2.1.0"
     exon            404..583
                     /gene="Cd27"
                     /gene_synonym="S152; Tnfrsf7; Tp55"
                     /inference="alignment:Splign:2.1.0"
     exon            584..646
                     /gene="Cd27"
                     /gene_synonym="S152; Tnfrsf7; Tp55"
                     /inference="alignment:Splign:2.1.0"
     exon            647..766
                     /gene="Cd27"
                     /gene_synonym="S152; Tnfrsf7; Tp55"
                     /inference="alignment:Splign:2.1.0"
     exon            767..1576
                     /gene="Cd27"
                     /gene_synonym="S152; Tnfrsf7; Tp55"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1553..1558
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cd27"
                     /gene_synonym="S152; Tnfrsf7; Tp55"
                     /note="hexamer: AATAAA"
     polyA_site      1576
                     /gene="Cd27"
                     /gene_synonym="S152; Tnfrsf7; Tp55"
                     /note="major polyA site"
ORIGIN      
        1 cagccacaac tgccttcaaa ggtcggttta ccacccaagt ggagtcgcag tggctgctgc
       61 ccagagcaca taggagccac cagtgactcg gtacaagcag ttggggctca gaaaagatct
      121 ccctgggcag gagctatggc atggccacct ccctactggc tctgcatgct ggggaccttg
      181 gtaggactct cagctaccct agccccaaac agctgtccag acaaacacta ctggactggg
      241 ggaggactct gctgccggat gtgtgagcca ggtacattct ttgtgaagga ctgtgaacaa
      301 gacagaacag ctgctcagtg tgatccctgt ataccaggca cctccttctc tccagactac
      361 cacacccggc cccactgcga gagctgcagg cattgtaact ctggttttct tatccgcaac
      421 tgcacagtca ctgccaatgc tgagtgcagc tgttccaaga actggcagtg cagggaccag
      481 gaatgtacag agtgtgaccc tcctctaaac cctgcactga ccagacagcc atctgagacc
      541 ccgagcccac agccaccacc cacccactta cctcatggca cagagaagcc atcctggccc
      601 ctacacaggc agcttcccaa ctcgactgtc tatagccagc ggtcatccca tagacccctg
      661 tgcagctcgg actgcatccg gatctttgtg accttctcca gcatgtttct tatcttcgtc
      721 ctgggtgcaa tcttgttctt ccatcaaaga agaaaccacg ggccaaatga agaccggcag
      781 gcagtgcctg aagagccttg tccttacagc tgccccaggg aagaggaggg cagtgctatc
      841 cctatccagg aggactaccg gaaacccgag cctgctttct acccttgacc gggtgctggt
      901 ggggcccttt ctgacgaggg gccatccaca gagacctcaa tggtggcctg ctcccctgtc
      961 atggtcatca gaaccctttc ctgtgaatac tcaacaaact gcccttctga gaccaacagg
     1021 gacaagagca ggatcccagt gtgtggccca gcaagctggg gagactcagg ctctagctat
     1081 aaagcacact tactctaagt gaaaccgtcc agctgacaaa actacatgcc aggggtggaa
     1141 atggctcacc aagggctcca gagggggctt ggcagtgagg agcacgaagt gttcctccag
     1201 aggaccagag tttgattccc agcactgtca aatggatcga aaccagctgt aactctactt
     1261 tcagagggtc tgacaccttt gacctcctct ggcatctaca aacacaggac ggacacacac
     1321 acacacacac acacacacac acacacacac acgattaaaa ataataattt tttttaaaaa
     1381 aatggaatga gccaccggca ggtgccctgg taccagaagg actgactgcc gtgagagaca
     1441 ctatctacag acacacagac ttcctggcct tggttctgtc ttctctgtaa gttgtgacag
     1501 tgctgtggga aagctgaggc tgagactttc tctcagttga gctaaaacta taaataaatt
     1561 catttgtcta cttcta
//
