LOCUS       NM_054042               2660 bp    mRNA    linear   ROD 12-AUG-2024
DEFINITION  Mus musculus CD248 antigen, endosialin (Cd248), mRNA.
ACCESSION   NM_054042
VERSION     NM_054042.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2660)
  AUTHORS   Hong,Y.K., Cheng,T.L., Hsu,C.K., Lee,F.T., Chang,B.I., Wang,K.C.,
            Chang,L.Y., Wu,H.L. and Lai,C.H.
  TITLE     Regulation of matrix reloading by tumor endothelial marker 1
            protects against abdominal aortic aneurysm
  JOURNAL   Int J Biol Sci 20 (10), 3691-3709 (2024)
   PUBMED   39113704
  REMARK    GeneRIF: Regulation of matrix reloading by tumor endothelial marker
            1 protects against abdominal aortic aneurysm.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2660)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2660)
  AUTHORS   Wu,J., Zhang,Q., Wu,J., Yang,Z., Liu,X., Lou,C., Wang,X., Peng,J.,
            Zhang,J., Shang,Z., Xiao,J., Wang,N., Zhang,R., Zhou,J., Wang,Y.,
            Hu,Z., Zhang,R., Zhang,J. and Zeng,Z.
  TITLE     IL-8 from CD248-expressing cancer-associated fibroblasts generates
            cisplatin resistance in non-small cell lung cancer
  JOURNAL   J Cell Mol Med 28 (4), e18185 (2024)
   PUBMED   38396325
  REMARK    GeneRIF: IL-8 from CD248-expressing cancer-associated fibroblasts
            generates cisplatin resistance in non-small cell lung cancer.
REFERENCE   4  (bases 1 to 2660)
  AUTHORS   Hong,Y.K., Lin,Y.C., Cheng,T.L., Lai,C.H., Chang,Y.H., Huang,Y.L.,
            Hung,C.Y., Wu,C.H., Hung,K.S., Ku,Y.C., Ho,Y.T., Tang,M.J.,
            Lin,S.W., Shi,G.Y., McGrath,J.A., Wu,H.L. and Hsu,C.K.
  TITLE     TEM1/endosialin/CD248 promotes pathologic scarring and TGF-beta
            activity through its receptor stability in dermal fibroblasts
  JOURNAL   J Biomed Sci 31 (1), 12 (2024)
   PUBMED   38254097
  REMARK    GeneRIF: TEM1/endosialin/CD248 promotes pathologic scarring and
            TGF-beta activity through its receptor stability in dermal
            fibroblasts.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2660)
  AUTHORS   Benedet,P.O., Safikhan,N.S., Pereira,M.J., Lum,B.M.,
            Botezelli,J.D., Kuo,C.H., Wu,H.L., Craddock,B.P., Miller,W.T.,
            Eriksson,J.W., Yue,J.T.Y. and Conway,E.M.
  TITLE     CD248 promotes insulin resistance by binding to the insulin
            receptor and dampening its insulin-induced autophosphorylation
  JOURNAL   EBioMedicine 99, 104906 (2024)
   PUBMED   38061240
  REMARK    GeneRIF: CD248 promotes insulin resistance by binding to the
            insulin receptor and dampening its insulin-induced
            autophosphorylation.
REFERENCE   6  (bases 1 to 2660)
  AUTHORS   MacFadyen,J., Savage,K., Wienke,D. and Isacke,C.M.
  TITLE     Endosialin is expressed on stromal fibroblasts and CNS pericytes in
            mouse embryos and is downregulated during development
  JOURNAL   Gene Expr Patterns 7 (3), 363-369 (2007)
   PUBMED   16965941
  REMARK    GeneRIF: In the embryo when analysed by confocal microscopy
            endosialin on vessels does not colocalise with endothelial cells
            expressing CD31, rather, endosialin is restricted to closely
            associated perivascular cells that also express the pericyte marker
            NG2.
REFERENCE   7  (bases 1 to 2660)
  AUTHORS   Rupp,C., Dolznig,H., Puri,C., Sommergruber,W., Kerjaschki,D.,
            Rettig,W.J. and Garin-Chesa,P.
  TITLE     Mouse endosialin, a C-type lectin-like cell surface receptor:
            expression during embryonic development and induction in
            experimental cancer neoangiogenesis
  JOURNAL   Cancer Immun 6, 10 (2006)
   PUBMED   16875435
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2660)
  AUTHORS   Nanda,A., Karim,B., Peng,Z., Liu,G., Qiu,W., Gan,C., Vogelstein,B.,
            St Croix,B., Kinzler,K.W. and Huso,D.L.
  TITLE     Tumor endothelial marker 1 (Tem1) functions in the growth and
            progression of abdominal tumors
  JOURNAL   Proc Natl Acad Sci U S A 103 (9), 3351-3356 (2006)
   PUBMED   16492758
  REMARK    GeneRIF: Tem1 have significant implications for the mechanisms
            underlying tumor invasiveness and for models that evaluate this
            process
REFERENCE   9  (bases 1 to 2660)
  AUTHORS   Opavsky,R., Haviernik,P., Jurkovicova,D., Garin,M.T.,
            Copeland,N.G., Gilbert,D.J., Jenkins,N.A., Bies,J., Garfield,S.,
            Pastorekova,S., Oue,A. and Wolff,L.
  TITLE     Molecular characterization of the mouse Tem1/endosialin gene
            regulated by cell density in vitro and expressed in normal tissues
            in vivo
  JOURNAL   J Biol Chem 276 (42), 38795-38807 (2001)
   PUBMED   11489895
REFERENCE   10 (bases 1 to 2660)
  AUTHORS   Carson-Walter,E.B., Watkins,D.N., Nanda,A., Vogelstein,B.,
            Kinzler,K.W. and St Croix,B.
  TITLE     Cell surface tumor endothelial markers are conserved in mice and
            humans
  JOURNAL   Cancer Res 61 (18), 6649-6655 (2001)
   PUBMED   11559528
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC046318.1.
            
            On Jun 19, 2003 this sequence version replaced NM_054042.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC046318.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2660
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 4.24 cM"
     gene            1..2660
                     /gene="Cd248"
                     /gene_synonym="2610111G01Rik; Cd164l1; Tem1"
                     /note="CD248 antigen, endosialin"
                     /db_xref="GeneID:70445"
                     /db_xref="MGI:MGI:1917695"
     exon            1..2563
                     /gene="Cd248"
                     /gene_synonym="2610111G01Rik; Cd164l1; Tem1"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..2346
                     /gene="Cd248"
                     /gene_synonym="2610111G01Rik; Cd164l1; Tem1"
                     /note="tumor endothelial marker 1; CD164 sialomucin-like
                     1; endosialin"
                     /codon_start=1
                     /product="endosialin precursor"
                     /protein_id="NP_473383.1"
                     /db_xref="CCDS:CCDS29448.1"
                     /db_xref="GeneID:70445"
                     /db_xref="MGI:MGI:1917695"
                     /translation="MLLRLLLAWVAAVPALGQVPWTPEPRAACGPSSCYALFPRRRTF
                     LEAWRACRELGGNLATPRTPEEAQRVDSLVGVGPANGLLWIGLQRQARQCQPQRPLRG
                     FIWTTGDQDTAFTNWAQPATEGPCPAQRCAALEASGEHRWLEGSCTLAVDGYLCQFGF
                     EGACPALPLEVGQAGPAVYTTPFNLVSSEFEWLPFGSVAAVQCQAGRGASLLCVKQPS
                     GGVGWSQTGPLCPGTGCGPDNGGCEHECVEEVDGAVSCRCSEGFRLAADGHSCEDPCA
                     QAPCEQQCEPGGPQGYSCHCRLGFRPAEDDPHRCVDTDECQIAGVCQQMCVNYVGGFE
                     CYCSEGHELEADGISCSPAGAMGAQASQDLRDELLDDGEEGEDEEEPWEDFDGTWTEE
                     QGILWLAPTHPPDFGLPYRPNFPQDGEPQRLHLEPTWPPPLSAPRGPYHSSVVSATRP
                     MVISATRPTLPSAHKTSVISATRPPLSPVHPPAMAPATPPAVFSEHQIPKIKANYPDL
                     PFGHKPGITSATHPARSPPYQPPIISTNYPQVFPPHQAPMSPDTHTITYLPPVPPHLD
                     PGDTTSKAHQHPLLPDAPGIRTQAPQLSVSALQPPLPTNSRSSVHETPVPAANQPPAF
                     PSSPLPPQRPTNQTSSISPTHSYSRAPLVPREGVPSPKSVPQLPSVPSTAAPTALAES
                     GLAGQSQRDDRWLLVALLVPTCVFLVVLLALGIVYCTRCGSHAPNKRITDCYRWVTHA
                     GNKSSTEPMPPRGSLTGVQTCRTSV"
     regulatory      2536..2541
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cd248"
                     /gene_synonym="2610111G01Rik; Cd164l1; Tem1"
                     /note="hexamer: AATAAA"
     polyA_site      2563
                     /gene="Cd248"
                     /gene_synonym="2610111G01Rik; Cd164l1; Tem1"
                     /note="major polyA site"
ORIGIN      
        1 gtcaagagca gcggcaggcc cgagccgggc cagtcggggg gcgtcgcgat gctgctgcgc
       61 ctgctgctgg cctgggtggc cgcggtgccc gcactgggcc aggtcccctg gacgccggag
      121 cctcgagccg cgtgcggccc cagcagctgc tacgcgctct ttccccggcg ccgcacattc
      181 ctggaagctt ggcgggcgtg ccgcgaattg gggggcaacc tggccacacc gcggacccca
      241 gaggaggccc agcgtgtgga cagcctggtg ggggtcgggc cggccaacgg gctgctatgg
      301 attgggttgc agcggcaggc taggcaatgc cagccgcagc gcccactgcg gggcttcata
      361 tggaccacgg gagaccagga caccgccttc accaactggg cccagccggc tacggaagga
      421 ccctgcccag cccagcgctg tgcagccctt gaggccagcg gagagcatcg ctggctcgaa
      481 ggctcgtgca cactggctgt cgatggctac ctctgccagt ttggttttga gggtgcctgc
      541 cctgccttgc cgcttgaggt gggtcaggcc ggtcccgctg tctacaccac acccttcaac
      601 ctggtttcca gcgagttcga atggctgccc tttggctccg tggcagctgt gcagtgccaa
      661 gctggcaggg gagcttctct gctgtgcgtg aaacagcctt caggtggcgt gggctggtcc
      721 cagactggcc cgctgtgccc agggactggc tgtggtcctg acaatggggg ttgcgaacat
      781 gagtgtgtgg aagaggtgga cggtgctgtg tcctgccgct gcagtgaagg cttccgtcta
      841 gcagcagatg ggcacagttg tgaagacccc tgtgcccagg ccccctgtga gcagcagtgt
      901 gaacctggag ggccacaagg ctatagctgc cactgtcgcc ttggcttccg gccagctgag
      961 gatgatccac accgctgcgt ggacacggat gagtgccaga ttgctggtgt gtgccagcag
     1021 atgtgtgtca actatgttgg tggctttgag tgttactgca gcgagggtca cgagcttgag
     1081 gcagatggta tcagctgtag ccctgcagga gccatgggtg cccaggcttc ccaggatctc
     1141 agagatgagt tgctggatga tggagaagaa ggggaggatg aagaggagcc ctgggaggac
     1201 tttgatggca cctggacaga ggaacagggg atcctatggc tggcacctac acatccacct
     1261 gactttggcc tgccctatag gcccaacttc ccacaggatg gagagcctca gagattgcac
     1321 ctggagccta cctggccacc cccacttagt gcccccaggg gcccctacca ctcctcagtg
     1381 gtgtctgcca cacggcccat ggtgatctct gccactcgac ccacactacc ttctgcccac
     1441 aagacctctg ttatttcagc tacacgccca cccctgagcc ctgtccaccc acctgccatg
     1501 gcccctgcca cacctccagc tgtgttctct gagcaccaga tccccaaaat caaggccaat
     1561 tatccagacc tgccttttgg ccacaagcct gggataacct cggccactca cccagcacgg
     1621 tctcctccgt accagccccc cattatctca accaactatc cccaagtctt ccctccccac
     1681 caggccccta tgtctccaga tacccacact atcacttatt tgcctccagt cccccctcac
     1741 cttgatcctg gggataccac ttctaaagcc catcaacacc ctttgctccc agatgctcca
     1801 ggtatcagaa cccaggcccc ccagctttct gtctcagctc tccagccccc tcttcctacc
     1861 aactccaggt cttctgtcca tgaaactcct gtgcctgctg ccaaccagcc cccagccttc
     1921 ccttcttctc ccctcccccc tcagaggccc actaaccaga cctcatctat cagccctaca
     1981 cattcctatt ccagagcccc tctagtccca agggaaggag ttcccagtcc caaatcagtg
     2041 ccacagctgc cctcggtgcc ctccacagca gctccaacag ccctggcaga gtcaggtctt
     2101 gcaggccaaa gccaaaggga tgaccgctgg ctgctggtgg cactcctggt gccaacatgt
     2161 gtcttcttgg tggtgctgct tgccctgggc attgtgtact gcactcgctg tggctcccac
     2221 gcacccaaca agcggatcac ggactgctat cgctgggtca cacatgctgg gaacaagagc
     2281 tcaacagaac ccatgccccc cagaggcagc cttacagggg tacagacctg tagaaccagt
     2341 gtgtgatggg gtgcagatgc ccctttgtgg gatagaagaa aaggacttgc tttggacaca
     2401 tggctgagac cacaccaagg acttatgggg gctgcccagc tgacagagga ggttctgttc
     2461 tttgagccca gcatccatgg caaaggacac accaggactc caggacctca aggggtgggt
     2521 gctgggatct tctccaataa atggggtgcc aacctcaccc aaaaaaaaaa aaaaaaaaaa
     2581 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     2641 aaaaaaaaaa aaaaaaaaaa
//
