LOCUS       NM_001113391            1686 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus CD247 antigen (Cd247), transcript variant zeta, mRNA.
ACCESSION   NM_001113391
VERSION     NM_001113391.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1686)
  AUTHORS   Du,R., Wang,P. and Tian,N.
  TITLE     CD3zeta-Mediated Signaling Protects Retinal Ganglion Cells in
            Glutamate Excitotoxicity of the Retina
  JOURNAL   Cells 13 (12), 1006 (2024)
   PUBMED   38920637
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1686)
  AUTHORS   Jin,Y., Yuan,H., Mehta,I., Ezenwa,O. and Morel,P.A.
  TITLE     Alternatively Spliced Variants of Murine CD247 Influence T Cell
            Development and Activation, Revealing the Importance of the CD3zeta
            C-Terminal Region
  JOURNAL   J Immunol 212 (4), 541-550 (2024)
   PUBMED   38117282
  REMARK    GeneRIF: Alternatively Spliced Variants of Murine CD247 Influence T
            Cell Development and Activation, Revealing the Importance of the
            CD3zeta C-Terminal Region.
REFERENCE   3  (bases 1 to 1686)
  AUTHORS   Gaud,G., Achar,S., Bourassa,F.X.P., Davies,J., Hatzihristidis,T.,
            Choi,S., Kondo,T., Gossa,S., Lee,J., Juneau,P., Taylor,N.,
            Hinrichs,C.S., McGavern,D.B., Francois,P., Altan-Bonnet,G. and
            Love,P.E.
  TITLE     CD3zeta ITAMs enable ligand discrimination and antagonism by
            inhibiting TCR signaling in response to low-affinity peptides
  JOURNAL   Nat Immunol 24 (12), 2121-2134 (2023)
   PUBMED   37945821
  REMARK    GeneRIF: CD3zeta ITAMs enable ligand discrimination and antagonism
            by inhibiting TCR signaling in response to low-affinity peptides.
            Erratum:[Nat Immunol. 2024 Mar;25(3):579. doi:
            10.1038/s41590-023-01725-5.. PMID: 38057618]
REFERENCE   4  (bases 1 to 1686)
  AUTHORS   Bovolenta,E.R., Garcia-Cuesta,E.M., Horndler,L., Ponomarenko,J.,
            Schamel,W.W., Mellado,M., Castro,M., Abia,D. and van Santen,H.M.
  TITLE     A set point in the selection of the alphabetaTCR T cell repertoire
            imposed by pre-TCR signaling strength
  JOURNAL   Proc Natl Acad Sci U S A 119 (22), e2201907119 (2022)
   PUBMED   35617435
REFERENCE   5  (bases 1 to 1686)
  AUTHORS   Morita,M., Mizui,M., Masuyama,S., Tsokos,G.C. and Isaka,Y.
  TITLE     Reduction of Cell Surface T-Cell Receptor by Non-Mitogenic CD3
            Antibody to Mitigate Murine Lupus
  JOURNAL   Front Immunol 13, 855812 (2022)
   PUBMED   35419004
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1686)
  AUTHORS   Hoopes,C.W., Taketo,M., Ozato,K., Liu,Q., Howard,T.A., Linney,E.
            and Seldin,M.F.
  TITLE     Mapping of the mouse Rxr loci encoding nuclear retinoid X receptors
            RXR alpha, RXR beta, and RXR gamma
  JOURNAL   Genomics 14 (3), 611-617 (1992)
   PUBMED   1358808
REFERENCE   7  (bases 1 to 1686)
  AUTHORS   Oakey,R.J., Watson,M.L. and Seldin,M.F.
  TITLE     Construction of a physical map on mouse and human chromosome 1:
            comparison of 13 Mb of mouse and 11 Mb of human DNA
  JOURNAL   Hum Mol Genet 1 (8), 613-620 (1992)
   PUBMED   1301170
REFERENCE   8  (bases 1 to 1686)
  AUTHORS   Love,P.E., Tremblay,M.L. and Westphal,H.
  TITLE     Targeting of the T-cell receptor zeta-chain gene in embryonic stem
            cells: strategies for generating multiple mutations in a single
            gene
  JOURNAL   Proc Natl Acad Sci U S A 89 (20), 9929-9933 (1992)
   PUBMED   1409721
REFERENCE   9  (bases 1 to 1686)
  AUTHORS   Lerner,A., Diener,A.C., Reinherz,E.L. and Clayton,L.K.
  TITLE     Human genomic sequences corresponding to murine CD3 eta-related
            transcripts: lack of conservation or expression of homologous human
            products
  JOURNAL   Eur J Immunol 22 (8), 2135-2140 (1992)
   PUBMED   1322304
REFERENCE   10 (bases 1 to 1686)
  AUTHORS   Clayton,L.K., D'Adamio,L., Howard,F.D., Sieh,M., Hussey,R.E.,
            Koyasu,S. and Reinherz,E.L.
  TITLE     CD3 eta and CD3 zeta are alternatively spliced products of a common
            genetic locus and are transcriptionally and/or
            post-transcriptionally regulated during T-cell development
  JOURNAL   Proc Natl Acad Sci U S A 88 (12), 5202-5206 (1991)
   PUBMED   1828894
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK138774.1, BC052824.1, BM240376.1 and AC093371.6.
            
            On Jan 5, 2011 this sequence version replaced NM_001113391.1.
            
            Transcript Variant: This variant (zeta) encodes the shortest
            isoform (zeta).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: J04967.1, AK017904.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-87                AK138774.1         2-88
            88-1535             BC052824.1         9-1456
            1536-1642           BM240376.1         2-108               c
            1643-1686           AC093371.6         141613-141656       c
FEATURES             Location/Qualifiers
     source          1..1686
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 73.14 cM"
     gene            1..1686
                     /gene="Cd247"
                     /gene_synonym="4930549J05Rik; A430104F18Rik; Cd3; Cd3-eta;
                     Cd3-zeta; Cd3h; Cd3z; Cd3zeta; T3z; Tcrk; Tcrz"
                     /note="CD247 antigen"
                     /db_xref="GeneID:12503"
                     /db_xref="MGI:MGI:88334"
     exon            1..206
                     /gene="Cd247"
                     /gene_synonym="4930549J05Rik; A430104F18Rik; Cd3; Cd3-eta;
                     Cd3-zeta; Cd3h; Cd3z; Cd3zeta; T3z; Tcrk; Tcrz"
                     /inference="alignment:Splign:2.1.0"
     CDS             149..643
                     /gene="Cd247"
                     /gene_synonym="4930549J05Rik; A430104F18Rik; Cd3; Cd3-eta;
                     Cd3-zeta; Cd3h; Cd3z; Cd3zeta; T3z; Tcrk; Tcrz"
                     /note="isoform zeta precursor is encoded by transcript
                     variant zeta; T-cell surface glycoprotein CD3 zeta chain;
                     T-cell receptor T3 eta chain; CD3-zeta/eta; CD3 antigen,
                     zeta polypeptide"
                     /codon_start=1
                     /product="CD247 antigen isoform zeta precursor"
                     /protein_id="NP_001106862.1"
                     /db_xref="CCDS:CCDS48427.1"
                     /db_xref="GeneID:12503"
                     /db_xref="MGI:MGI:88334"
                     /translation="MKWKVSVLACILHVRFPGAEAQSFGLLDPKLCYLLDGILFIYGV
                     IITALYLRAKFSRSAETAANLQDPNQLYNELNLGRREEYDVLEKKRARDPEMGGKQQR
                     RRNPQEGVYNALQKDKMAEAYSEIGTKGERRRGKGHDGLYQGLSTATKDTYDALHMQT
                     LAPR"
     exon            207..310
                     /gene="Cd247"
                     /gene_synonym="4930549J05Rik; A430104F18Rik; Cd3; Cd3-eta;
                     Cd3-zeta; Cd3h; Cd3z; Cd3zeta; T3z; Tcrk; Tcrz"
                     /inference="alignment:Splign:2.1.0"
     exon            311..367
                     /gene="Cd247"
                     /gene_synonym="4930549J05Rik; A430104F18Rik; Cd3; Cd3-eta;
                     Cd3-zeta; Cd3h; Cd3z; Cd3zeta; T3z; Tcrk; Tcrz"
                     /inference="alignment:Splign:2.1.0"
     exon            368..448
                     /gene="Cd247"
                     /gene_synonym="4930549J05Rik; A430104F18Rik; Cd3; Cd3-eta;
                     Cd3-zeta; Cd3h; Cd3z; Cd3zeta; T3z; Tcrk; Tcrz"
                     /inference="alignment:Splign:2.1.0"
     exon            449..484
                     /gene="Cd247"
                     /gene_synonym="4930549J05Rik; A430104F18Rik; Cd3; Cd3-eta;
                     Cd3-zeta; Cd3h; Cd3z; Cd3zeta; T3z; Tcrk; Tcrz"
                     /inference="alignment:Splign:2.1.0"
     exon            485..541
                     /gene="Cd247"
                     /gene_synonym="4930549J05Rik; A430104F18Rik; Cd3; Cd3-eta;
                     Cd3-zeta; Cd3h; Cd3z; Cd3zeta; T3z; Tcrk; Tcrz"
                     /inference="alignment:Splign:2.1.0"
     exon            542..577
                     /gene="Cd247"
                     /gene_synonym="4930549J05Rik; A430104F18Rik; Cd3; Cd3-eta;
                     Cd3-zeta; Cd3h; Cd3z; Cd3zeta; T3z; Tcrk; Tcrz"
                     /inference="alignment:Splign:2.1.0"
     exon            578..1686
                     /gene="Cd247"
                     /gene_synonym="4930549J05Rik; A430104F18Rik; Cd3; Cd3-eta;
                     Cd3-zeta; Cd3h; Cd3z; Cd3zeta; T3z; Tcrk; Tcrz"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1621..1626
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cd247"
                     /gene_synonym="4930549J05Rik; A430104F18Rik; Cd3; Cd3-eta;
                     Cd3-zeta; Cd3h; Cd3z; Cd3zeta; T3z; Tcrk; Tcrz"
                     /note="hexamer: AATAAA"
     polyA_site      1634
                     /gene="Cd247"
                     /gene_synonym="4930549J05Rik; A430104F18Rik; Cd3; Cd3-eta;
                     Cd3-zeta; Cd3h; Cd3z; Cd3zeta; T3z; Tcrk; Tcrz"
                     /note="major polyA site"
     polyA_site      1643
                     /gene="Cd247"
                     /gene_synonym="4930549J05Rik; A430104F18Rik; Cd3; Cd3-eta;
                     Cd3-zeta; Cd3h; Cd3z; Cd3zeta; T3z; Tcrk; Tcrz"
ORIGIN      
        1 ctcaaaggcc cacagtcctc cacttcctgg ggtgtcagcc acagaacaaa gccagcagag
       61 actccatcag cgcctccttt tctcctcatc ctcccaggca tagctgcctc tgcctctgcc
      121 tctgggtacc atcccaggga agcagaagat gaagtggaaa gtgtctgttc tcgcctgcat
      181 cctccacgtg cggttcccag gagcagaggc acagagcttt ggtctgctgg atcccaaact
      241 ctgctacttg ctagatggaa tcctcttcat ctacggagtc atcatcacag ccctgtacct
      301 gagagcaaaa ttcagcagga gtgcagagac tgctgccaac ctgcaggacc ccaaccagct
      361 ctacaatgag ctcaatctag ggcgaagaga ggaatatgac gtcttggaga agaagcgggc
      421 tcgggatcca gagatgggag gcaaacagca gaggaggagg aacccccagg aaggcgtata
      481 caatgcactg cagaaagaca agatggcaga agcctacagt gagatcggca caaaaggcga
      541 gaggcggaga ggcaaggggc acgatggcct ttaccagggt ctcagcactg ccaccaagga
      601 cacctatgat gccctgcata tgcagaccct ggcccctcgc taacagccag ggcatttctc
      661 cctcacgggc ttcacctgct gatgtcactt gtgaaggaca gaggacaaag cccccctcag
      721 tttattcatt tcccagccac catttcatga cgaggatggt tctctcactt gccacatttg
      781 tcttcttcag ttccagagca ctgaacacag aacgtcatcc ctggactctc taaagggaga
      841 gccacccttg ctcttccacc ccagccctgc tcttgggtct tctggcaggc tcctctcctt
      901 gcagagccca gccctagcta ggagttgggg gtggagggtg gggcactaac acactccctc
      961 ctgcagctag ctgagttcag tttgctttgt aaagtcccca gagaagccct aggtactgtg
     1021 tgtattgttc tatgggtatt gactcgctcc gctcctgctg taaatttggc ttctgttgtc
     1081 acactttgca gtgttgaggt aacatgtaat taggccacat tgtgaaaggc agagaggcag
     1141 gtacaaggga gtccaggtaa atgccagcca gaggtggctc aaagaaggga agcaacacac
     1201 aaggaaggtt cctagccaca ggggaacagt aacaaggggc ctctttccat caagagtact
     1261 ttccacatct cccagccttt gtgccaggca ctccaggaac ggtaagatgt cttaccttca
     1321 tgaagaccat gcttttaaga gtgcaaataa cttgtgtaca aactgacaca gaaaatagga
     1381 tgggccatta ccgccaacga caagggagca agagaaaagg gagcaagtcc tgccttcttc
     1441 caggaactcg gttcatccct gtcaggtggc aggaagaccc agaccaccca ggtctgcaac
     1501 gttcccagtg acaatcagtg gccggcaagg tcattgtgtc attaaagtgc ctgtacccat
     1561 ggatggggaa ccctctgatc gcctgggttt tttaatttat accagcttgc tattttgcat
     1621 aataaacact ttgctaaaaa tgatctttga agccttattt cagtggtgaa gcctggggta
     1681 gcaatg
//
