LOCUS       NM_018729               3758 bp    mRNA    linear   ROD 07-OCT-2024
DEFINITION  Mus musculus CD244 molecule A (Cd244a), transcript variant 1, mRNA.
ACCESSION   NM_018729 NM_176981 XM_916191
VERSION     NM_018729.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3758)
  AUTHORS   Li,R., Galindo,C.C., Davidson,D., Guo,H., Zhong,M.C., Qian,J.,
            Li,B., Ruzsics,Z., Lau,C.M., O'Sullivan,T.E., Vidal,S.M., Sun,J.C.
            and Veillette,A.
  TITLE     Suppression of adaptive NK cell expansion by macrophage-mediated
            phagocytosis inhibited by 2B4-CD48
  JOURNAL   Cell Rep 43 (3), 113800 (2024)
   PUBMED   38386559
  REMARK    GeneRIF: Suppression of adaptive NK cell expansion by
            macrophage-mediated phagocytosis inhibited by 2B4-CD48.
REFERENCE   2  (bases 1 to 3758)
  AUTHORS   Gaur,P., Seaf,M., Trabelsi,N., Marcu,O., Gafarov,D.,
            Schueler-Furman,O., Mandelboim,O., Ben-Zimra,M. and
            Levi-Schaffer,F.
  TITLE     2B4: A potential target in Staphylococcus aureus associated
            allergic inflammation
  JOURNAL   Clin Exp Immunol 215 (1), 37-46 (2024)
   PUBMED   37583293
  REMARK    GeneRIF: 2B4: A potential target in Staphylococcus aureus
            associated allergic inflammation.
REFERENCE   3  (bases 1 to 3758)
  AUTHORS   Xu,X., Zheng,G., Ren,Y., He,X., Peng,B., Hu,X. and Liu,W.
  TITLE     A novel 2B4 receptor leads to worse pregnancy outcomes by
            facilitating TNF-alpha and IFN-gamma production in dNK cells during
            Toxoplasma gondii infection
  JOURNAL   Parasit Vectors 15 (1), 337 (2022)
   PUBMED   36153598
  REMARK    GeneRIF: A novel 2B4 receptor leads to worse pregnancy outcomes by
            facilitating TNF-alpha and IFN-gamma production in dNK cells during
            Toxoplasma gondii infection.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3758)
  AUTHORS   Li,D., Xiong,W., Wang,Y., Feng,J., He,Y., Du,J., Wang,J., Yang,M.,
            Zeng,H., Yang,Y.G., Wu,N., Chen,S. and Dong,Z.
  TITLE     SLAMF3 and SLAMF4 are immune checkpoints that constrain macrophage
            phagocytosis of hematopoietic tumors
  JOURNAL   Sci Immunol 7 (67), eabj5501 (2022)
   PUBMED   35061505
  REMARK    GeneRIF: SLAMF3 and SLAMF4 are immune checkpoints that constrain
            macrophage phagocytosis of hematopoietic tumors.
REFERENCE   5  (bases 1 to 3758)
  AUTHORS   Chen,C.W., Xue,M., Zhang,W., Xie,J., Coopersmith,C.M. and Ford,M.L.
  TITLE     2B4 but not PD-1 blockade improves mortality in septic animals with
            preexisting malignancy
  JOURNAL   JCI Insight 4 (22), 127867 (2019)
   PUBMED   31723059
  REMARK    GeneRIF: 2B4 but not PD-1 blockade improves mortality in septic
            animals with preexisting malignancy.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3758)
  AUTHORS   Boles,K.S., Nakajima,H., Colonna,M., Chuang,S.S., Stepp,S.E.,
            Bennett,M., Kumar,V. and Mathew,P.A.
  TITLE     Molecular characterization of a novel human natural killer cell
            receptor homologous to mouse 2B4
  JOURNAL   Tissue Antigens 54 (1), 27-34 (1999)
   PUBMED   10458320
REFERENCE   7  (bases 1 to 3758)
  AUTHORS   Kubota,K., Katoh,H., Muguruma,K. and Koyama,K.
  TITLE     Characterization of a surface membrane molecule expressed by
            natural killer cells in most inbred mouse strains: monoclonal
            antibody C9.1 identifies an allelic form of the 2B4 antigen
  JOURNAL   Immunology 96 (3), 491-497 (1999)
   PUBMED   10233732
  REMARK    Erratum:[Immunology. 2003 Oct;110(2):287]
REFERENCE   8  (bases 1 to 3758)
  AUTHORS   Moriggl,R., Topham,D.J., Teglund,S., Sexl,V., McKay,C., Wang,D.,
            Hoffmeyer,A., van Deursen,J., Sangster,M.Y., Bunting,K.D.,
            Grosveld,G.C. and Ihle,J.N.
  TITLE     Stat5 is required for IL-2-induced cell cycle progression of
            peripheral T cells
  JOURNAL   Immunity 10 (2), 249-259 (1999)
   PUBMED   10072077
REFERENCE   9  (bases 1 to 3758)
  AUTHORS   Latchman,Y., McKay,P.F. and Reiser,H.
  TITLE     Identification of the 2B4 molecule as a counter-receptor for CD48
  JOURNAL   J Immunol 161 (11), 5809-5812 (1998)
   PUBMED   9834056
REFERENCE   10 (bases 1 to 3758)
  AUTHORS   Mathew,P.A., Garni-Wagner,B.A., Land,K., Takashima,A., Stoneman,E.,
            Bennett,M. and Kumar,V.
  TITLE     Cloning and characterization of the 2B4 gene encoding a molecule
            associated with non-MHC-restricted killing mediated by activated
            natural killer cells and T cells
  JOURNAL   J Immunol 151 (10), 5328-5337 (1993)
   PUBMED   8228228
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY207581.1, AF082803.1, AK137505.1 and AC083892.19.
            
            On Jan 13, 2007 this sequence version replaced NM_018729.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK155548.1, AK089530.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-338               BY207581.1         2-339
            339-831             AF082803.1         333-825
            832-2002            AK137505.1         798-1968
            2003-3758           AC083892.19        62665-64420         c
FEATURES             Location/Qualifiers
     source          1..3758
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 79.52 cM"
     gene            1..3758
                     /gene="Cd244a"
                     /gene_synonym="2B4; C9.1; Cd244; F730046O15Rik; Ly90;
                     NAIL; NKR2B4; Nmrk; SLAMF4"
                     /note="CD244 molecule A"
                     /db_xref="GeneID:18106"
                     /db_xref="MGI:MGI:109294"
     exon            1..193
                     /gene="Cd244a"
                     /gene_synonym="2B4; C9.1; Cd244; F730046O15Rik; Ly90;
                     NAIL; NKR2B4; Nmrk; SLAMF4"
                     /inference="alignment:Splign:2.1.0"
     CDS             133..1326
                     /gene="Cd244a"
                     /gene_synonym="2B4; C9.1; Cd244; F730046O15Rik; Ly90;
                     NAIL; NKR2B4; Nmrk; SLAMF4"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; NK cell receptor 2B4; natural killer cell
                     receptor 2B4; NK cell type I receptor protein 2B4; non-MHC
                     restricted killing associated; SLAM family member 4;
                     signaling lymphocytic activation molecule 4; CD244 natural
                     killer cell receptor 2B4"
                     /codon_start=1
                     /product="natural killer cell receptor 2B4 isoform 1
                     precursor"
                     /protein_id="NP_061199.2"
                     /db_xref="CCDS:CCDS35778.1"
                     /db_xref="GeneID:18106"
                     /db_xref="MGI:MGI:109294"
                     /translation="MLGQAVLFTTFLLLRAHQGQDCPDSSEEVVGVSGKPVQLRPSNI
                     QTKDVSVQWKKTEQGSHRKIEILNWYNDGPSWSNVSFSDIYGFDYGDFALSIKSAKLQ
                     DSGHYLLEITNTGGKVCNKNFQLLILDHVETPNLKAQWKPWTNGTCQLFLSCLVTKDD
                     NVSYALYRGSTLISNQRNSTHWENQIDASSLHTYTCNVSNRASWANHTLNFTHGCQSV
                     PSNFRFLPFGVIIVILVTLFLGAIICFCVWTKKRKQLQFSPKEPLTIYEYVKDSRASR
                     DQQGCSRASGSPSAVQEDGRGQRELDRRVSEVLEQLPQQTFPGDRGTMYSMIQCKPSD
                     STSQEKCTVYSVVQPSRKSGSKKRNQNSSLSCTVYEEVGNPWLKAHNPARLSRRELEN
                     FDVYS"
     exon            194..517
                     /gene="Cd244a"
                     /gene_synonym="2B4; C9.1; Cd244; F730046O15Rik; Ly90;
                     NAIL; NKR2B4; Nmrk; SLAMF4"
                     /inference="alignment:Splign:2.1.0"
     exon            518..793
                     /gene="Cd244a"
                     /gene_synonym="2B4; C9.1; Cd244; F730046O15Rik; Ly90;
                     NAIL; NKR2B4; Nmrk; SLAMF4"
                     /inference="alignment:Splign:2.1.0"
     exon            794..898
                     /gene="Cd244a"
                     /gene_synonym="2B4; C9.1; Cd244; F730046O15Rik; Ly90;
                     NAIL; NKR2B4; Nmrk; SLAMF4"
                     /inference="alignment:Splign:2.1.0"
     exon            899..1053
                     /gene="Cd244a"
                     /gene_synonym="2B4; C9.1; Cd244; F730046O15Rik; Ly90;
                     NAIL; NKR2B4; Nmrk; SLAMF4"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1125
                     /gene="Cd244a"
                     /gene_synonym="2B4; C9.1; Cd244; F730046O15Rik; Ly90;
                     NAIL; NKR2B4; Nmrk; SLAMF4"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1188
                     /gene="Cd244a"
                     /gene_synonym="2B4; C9.1; Cd244; F730046O15Rik; Ly90;
                     NAIL; NKR2B4; Nmrk; SLAMF4"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1245
                     /gene="Cd244a"
                     /gene_synonym="2B4; C9.1; Cd244; F730046O15Rik; Ly90;
                     NAIL; NKR2B4; Nmrk; SLAMF4"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..3758
                     /gene="Cd244a"
                     /gene_synonym="2B4; C9.1; Cd244; F730046O15Rik; Ly90;
                     NAIL; NKR2B4; Nmrk; SLAMF4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1867..1872
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cd244a"
                     /gene_synonym="2B4; C9.1; Cd244; F730046O15Rik; Ly90;
                     NAIL; NKR2B4; Nmrk; SLAMF4"
                     /note="hexamer: ATTAAA"
     polyA_site      1886
                     /gene="Cd244a"
                     /gene_synonym="2B4; C9.1; Cd244; F730046O15Rik; Ly90;
                     NAIL; NKR2B4; Nmrk; SLAMF4"
ORIGIN      
        1 agttgaggaa attgtggctg gacaggcagt gaggtagttc tgctgtgtcc tgctgacagt
       61 tagctgcgag cctattgaca tctgagcacc tggagaagac agggcccccg tagtctgctc
      121 tgtcctgtgg tgatgttggg gcaagctgtc ctgttcacaa cctttctgct cctcagggct
      181 catcagggcc aagactgccc agattcttct gaagaagtgg ttggtgtctc aggaaagcct
      241 gtccagctga ggccttccaa catacagaca aaagatgttt ctgttcaatg gaagaagaca
      301 gaacagggct cacacagaaa aattgagatc ctgaattggt ataatgatgg tcccagttgg
      361 tcaaatgtat cttttagtga tatctatggt tttgattatg gggattttgc tcttagtatc
      421 aagtcagcta agctgcaaga cagtggtcac tacctgctgg agatcaccaa cacaggcgga
      481 aaagtgtgca ataagaactt ccagcttctt atacttgatc atgttgagac ccctaacctg
      541 aaggcccagt ggaagccctg gactaatggg acttgtcaac tgtttttgtc ctgcttggtg
      601 accaaggatg acaatgtgag ctacgctttg tacagaggga gcactctgat ctccaatcaa
      661 aggaatagta cccactggga gaaccagatt gacgccagca gcctgcacac atacacctgc
      721 aacgttagca acagagccag ctgggcaaac cacaccctga acttcaccca tggctgtcaa
      781 agtgtccctt cgaatttcag atttctgccc tttggggtga tcatcgtgat tctagttaca
      841 ttatttctcg gggccatcat ttgtttctgt gtgtggacta agaagaggaa gcagttacag
      901 ttcagcccta aggaaccttt gacaatatat gaatatgtca aggactcacg agccagcagg
      961 gatcaacaag gatgctctag ggcctctgga tctccctcgg ctgtccagga agatgggagg
     1021 ggacaaagag aattggacag gcgtgtttct gaggtgctgg agcagttgcc acagcagact
     1081 ttccctggag atagaggcac catgtactct atgatacagt gcaagccttc tgattccaca
     1141 tcacaagaaa aatgtacagt atattcagta gtccagcctt ccaggaagtc tggatccaag
     1201 aagaggaacc agaactcttc cttaagttgt accgtgtacg aggaggttgg aaacccatgg
     1261 ctcaaagctc acaaccctgc caggctgagc cgcagagagc tggagaactt tgatgtctac
     1321 tcctagttgt tagcagtggc ctcatcctgt gtcatgcagc atcattgact ttggaaggaa
     1381 gcacactgaa ggatgcttaa gtccgtatgt gtccgtagac cagcttctag gctggagaga
     1441 atgtagttta ttaacattga aggatgctga gtctgtatgt gtctgtggac cagcttttag
     1501 gctgaagaga atgtagttta ttaacattga aggatgctga gtctgtatgt gtctgtggac
     1561 cagcttctag gctgaagaga atgtagttta ttaacattga agaatgctga gtctgtatat
     1621 gtctgtggac cagcttctag gctggagatg atgtagttta ttcgtggttt atattttata
     1681 ttttattatc tttcttttta gacaggatct gacatagctt ggcatggcct gaatttgctg
     1741 agtagccaag aatgacttta aacctttggt cctcctgcct acacttccta gggtttggaa
     1801 tcacagtcat gtaacactgt gtatagcttg gaaaaaattt ctaacagcca ctgtatgatc
     1861 aaggtcatta aaaaatatca cccaagctta tagatcagat aggaatgggt agataggttg
     1921 tattggccag attttgagcc attgtaatct atgatttatg ttttatttta tttttattat
     1981 caattatata atttaaaata gtatggtgct gtataaatgt gaggtagagg aagatcccct
     2041 tcttctggtt ctctaatatg ttatctacca ccaccccacc acctccaaga ccattatggg
     2101 atgcctgtat tctagaccct gcccaccttc caaagcaagt acagtgagag atgatggtga
     2161 ttcagaggaa aaggaagcac aggtcctctt tgaagctgtg atgtctggct gtgagctggc
     2221 tggcagttct cccacagagg caggaacccc tgatcacccc acatcgttgt ttctgaccgg
     2281 ttgttcacaa gggaaagtgc aaagaagtga aattagatgg tgcagttcaa acagatctct
     2341 ggatccaaga atcacccagt gtgtacatca tcctgataag aggtggttaa caccagtgtt
     2401 gcccacagta tgatggttgg cttacaaagt cctatcacag aaatctatct tgtcattgac
     2461 atctttgtct tcagccttac cttcttcatg acagtttttc actgtatagc tctggatggt
     2521 ctgaaactca ctatgcagac cagactggcc tcaagcctag agtgatccac ctgcttgtgc
     2581 cttccaaatg ccagcatcag tgccgtgtac taccacaccc agccgatttt gtcttctttg
     2641 tagacatctc tcagaaacca tagccttcca aatctagaat cccgagcagt ggtccctgtg
     2701 atacatctgg agaaagggct cacaccatag gtatccaagt tcagagttct gagaagtgtt
     2761 tcccatgata taccctgaag gaagggctca aatagttgat tgctgaagat gaggcagtca
     2821 actactgcat accatgctct ctctctttag actagctcct tcagcagtgt aggattagca
     2881 agcccaaggc tggatgagct ctggaaagca acaagtatga actgagagag gactcactcc
     2941 aaaagtgttt tttttttttg aagagagggt ctcactatcc caccctggct ttcctgattc
     3001 tcactgtgta aaccacgctg ccttcaaact cacagagatc ctcttgtctc tgctggaatg
     3061 aaaggcaaac agcaccattc ctggctcaga gtctcagtct tgttcttcaa gagtgtcatc
     3121 ctgtgcttat catgggaatg tgacatgaaa ccttattctc actcagaggc aatgccagtc
     3181 ctttgcctgg agcaaactga taagcttctc tatactcagt gtgtatgggt cactgattaa
     3241 tattcactag catggctgtt taaattctgc tggaagtgga gcagactctc tggccagatg
     3301 tcagtcttgt tcacacagag atagcagaga gccagaagac gaggcctact ccgcctcatg
     3361 aagggcattc aagccatggg ctcatttatg cttcacctaa tccttcatcc ctgtacatgc
     3421 ctagcaggct ggcatcctcc taggtagaaa tacagacaga gcacatctta aagcacgtgc
     3481 caagtaatga gtatattcaa aaagagtctg tggtcttgag gcagttactg ggagtggagt
     3541 caaggtgatt ggtaagcaga gacaataaga gatgatggag aagctgggtg gtgctggcac
     3601 atgtcttcaa ttccagcatc caggaggcag aggcaggtgg acttctgtga gttggaggcc
     3661 agcatagtct atagagtgag ttccaggaca gataatgctg cacagagaaa ccctgtctca
     3721 atccctaacc ccagaaaaat aaaagaaatg atggagag
//
