LOCUS       NM_178687               2487 bp    mRNA    linear   ROD 06-DEC-2024
DEFINITION  Mus musculus CD226 antigen (Cd226), transcript variant 1, mRNA.
ACCESSION   NM_178687
VERSION     NM_178687.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2487)
  AUTHORS   Qiao,W., Duan,C., Ma,J., Hu,W., Xie,Y., Yang,L., Wang,T., Wu,S.,
            Li,X., Wang,Y., Cheng,K., Zhang,Y., Zhang,Y. and Zhuang,R.
  TITLE     Costimulatory Molecule CD226 Regulates Atopic Dermatitis in a Mouse
            Model
  JOURNAL   J Invest Dermatol 144 (8), 1743-1753 (2024)
   PUBMED   38325579
  REMARK    GeneRIF: Costimulatory Molecule CD226 Regulates Atopic Dermatitis
            in a Mouse Model.
REFERENCE   2  (bases 1 to 2487)
  AUTHORS   Ma,P. and Sun,W.
  TITLE     Integrated single-cell and bulk sequencing analyses with
            experimental validation identify the prognostic and immunological
            implications of CD226 in pan-cancer
  JOURNAL   J Cancer Res Clin Oncol 149 (16), 14597-14617 (2023)
   PUBMED   37580402
  REMARK    GeneRIF: Integrated single-cell and bulk sequencing analyses with
            experimental validation identify the prognostic and immunological
            implications of CD226 in pan-cancer.
REFERENCE   3  (bases 1 to 2487)
  AUTHORS   Ma,J., Hu,W., Liu,Y., Duan,C., Zhang,D., Wang,Y., Cheng,K.,
            Yang,L., Wu,S., Jin,B., Zhang,Y. and Zhuang,R.
  TITLE     CD226 maintains regulatory T cell phenotype stability and
            metabolism by the mTOR/Myc pathway under inflammatory conditions
  JOURNAL   Cell Rep 42 (10), 113306 (2023)
   PUBMED   37864795
  REMARK    GeneRIF: CD226 maintains regulatory T cell phenotype stability and
            metabolism by the mTOR/Myc pathway under inflammatory conditions.
REFERENCE   4  (bases 1 to 2487)
  AUTHORS   Hou,Y., Wang,Y., Tang,K., Yang,Y., Wang,Y., Liu,R., Wu,B., Chen,X.,
            Fu,Z., Zhao,F. and Chen,L.
  TITLE     CD226 deficiency attenuates cardiac early pathological remodeling
            and dysfunction via decreasing inflammatory macrophage proportion
            and macrophage glycolysis in STZ-induced diabetic mice
  JOURNAL   FASEB J 37 (8), e23047 (2023)
   PUBMED   37392373
  REMARK    GeneRIF: CD226 deficiency attenuates cardiac early pathological
            remodeling and dysfunction via decreasing inflammatory macrophage
            proportion and macrophage glycolysis in STZ-induced diabetic mice.
REFERENCE   5  (bases 1 to 2487)
  AUTHORS   Zhang,D., Liu,Y., Ma,J., Xu,Z., Duan,C., Wang,Y., Li,X., Han,J. and
            Zhuang,R.
  TITLE     Competitive binding of CD226/TIGIT with poliovirus receptor
            regulates macrophage polarization and is involved in vascularized
            skin graft rejection
  JOURNAL   Am J Transplant 23 (7), 920-934 (2023)
   PUBMED   37054890
  REMARK    GeneRIF: Competitive binding of CD226/TIGIT with poliovirus
            receptor regulates macrophage polarization and is involved in
            vascularized skin graft rejection.
REFERENCE   6  (bases 1 to 2487)
  AUTHORS   Tahara-Hanaoka,S., Shibuya,K., Kai,H., Miyamoto,A., Morikawa,Y.,
            Ohkochi,N., Honda,S. and Shibuya,A.
  TITLE     Tumor rejection by the poliovirus receptor family ligands of the
            DNAM-1 (CD226) receptor
  JOURNAL   Blood 107 (4), 1491-1496 (2006)
   PUBMED   16249389
  REMARK    GeneRIF: DNAM-1 ligands stimulate innate immunity by in dendritic
            and natural killer cells, which efficiently prime cell-mediated
            tumor-specific immunity.
REFERENCE   7  (bases 1 to 2487)
  AUTHORS   Dardalhon,V., Schubart,A.S., Reddy,J., Meyers,J.H., Monney,L.,
            Sabatos,C.A., Ahuja,R., Nguyen,K., Freeman,G.J., Greenfield,E.A.,
            Sobel,R.A. and Kuchroo,V.K.
  TITLE     CD226 is specifically expressed on the surface of Th1 cells and
            regulates their expansion and effector functions
  JOURNAL   J Immunol 175 (3), 1558-1565 (2005)
   PUBMED   16034094
  REMARK    GeneRIF: CD226 is a costimulatory molecule that plays an important
            role in activation and effector functions of T helper type 1 (Th1)
            cells.
REFERENCE   8  (bases 1 to 2487)
  AUTHORS   Tahara-Hanaoka,S., Miyamoto,A., Hara,A., Honda,S., Shibuya,K. and
            Shibuya,A.
  TITLE     Identification and characterization of murine DNAM-1 (CD226) and
            its poliovirus receptor family ligands
  JOURNAL   Biochem Biophys Res Commun 329 (3), 996-1000 (2005)
   PUBMED   15752754
  REMARK    GeneRIF: We demonstrated that ligand binding of murine DNAM-1
            induced a costimulatory signal in antigen-specific CD8+ T cells.
REFERENCE   9  (bases 1 to 2487)
  AUTHORS   Tian,F., Li,D., Xia,H., Liu,X., Jia,W., Sun,C., Sun,K. and Jin,B.
  TITLE     Isolation of cDNAs encoding gibbon and monkey platelet and T cell
            activation antigen 1 (PTA1)
  JOURNAL   DNA Seq 10 (3), 155-161 (1999)
   PUBMED   10647817
REFERENCE   10 (bases 1 to 2487)
  AUTHORS   Sherrington,P.D., Scott,J.L., Jin,B., Simmons,D., Dorahy,D.J.,
            Lloyd,J., Brien,J.H., Aebersold,R.H., Adamson,J., Zuzel,M. and
            Burns,G.F.
  TITLE     TLiSA1 (PTA1) activation antigen implicated in T cell
            differentiation and platelet activation is a member of the
            immunoglobulin superfamily exhibiting distinctive regulation of
            expression
  JOURNAL   J Biol Chem 272 (35), 21735-21744 (1997)
   PUBMED   9268302
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC116387.7 and AK140349.1.
            
            On Jan 20, 2006 this sequence version replaced NM_178687.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK140349.1, AF416980.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849388
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-112               AC116387.7         162850-162961       c
            113-1606            AK140349.1         1-1494
            1607-2487           AC116387.7         90061-90941         c
FEATURES             Location/Qualifiers
     source          1..2487
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 59.05 cM"
     gene            1..2487
                     /gene="Cd226"
                     /gene_synonym="DNAM-1; DNAM1; Pta1; TLiSA1"
                     /note="CD226 antigen"
                     /db_xref="GeneID:225825"
                     /db_xref="MGI:MGI:3039602"
     exon            1..213
                     /gene="Cd226"
                     /gene_synonym="DNAM-1; DNAM1; Pta1; TLiSA1"
                     /inference="alignment:Splign:2.1.0"
     exon            214..285
                     /gene="Cd226"
                     /gene_synonym="DNAM-1; DNAM1; Pta1; TLiSA1"
                     /inference="alignment:Splign:2.1.0"
     CDS             240..1241
                     /gene="Cd226"
                     /gene_synonym="DNAM-1; DNAM1; Pta1; TLiSA1"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; platelet and T cell activation antigen 1"
                     /codon_start=1
                     /product="CD226 antigen isoform a precursor"
                     /protein_id="NP_848802.2"
                     /db_xref="CCDS:CCDS29392.1"
                     /db_xref="GeneID:225825"
                     /db_xref="MGI:MGI:3039602"
                     /translation="MAYVTWLLAILHVHKALCEETLWDTTVRLSETMTLECVYPLTHN
                     LTQVEWTKNTGTKTVSIAVYNPNHNMHIESNYLHRVHFLNSTVGFRNMSLSFYNASEA
                     DIGIYSCLFHAFPNGPWEKKIKVVWSDSFEIAAPSDSYLSAEPGQDVTLTCQLPRTWP
                     VQQVIWEKVQPHQVDILASCNLSQETRYTSKYLRQTRSNCSQGSMKSILIIPNAMAAD
                     SGLYRCRSEAITGKNKSFVIRLIITDGGTNKHFILPIVGGLVSLLLVILIIIIFILYN
                     RKRRRQVRIPLKEPRDKQSKVATNCRSPTSPIQSTDDEKEDIYVNYPTFSRRPKPRL"
     exon            286..624
                     /gene="Cd226"
                     /gene_synonym="DNAM-1; DNAM1; Pta1; TLiSA1"
                     /inference="alignment:Splign:2.1.0"
     exon            625..972
                     /gene="Cd226"
                     /gene_synonym="DNAM-1; DNAM1; Pta1; TLiSA1"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1069
                     /gene="Cd226"
                     /gene_synonym="DNAM-1; DNAM1; Pta1; TLiSA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1127
                     /gene="Cd226"
                     /gene_synonym="DNAM-1; DNAM1; Pta1; TLiSA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..2487
                     /gene="Cd226"
                     /gene_synonym="DNAM-1; DNAM1; Pta1; TLiSA1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1342..1347
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cd226"
                     /gene_synonym="DNAM-1; DNAM1; Pta1; TLiSA1"
                     /note="hexamer: ATTAAA"
     polyA_site      1361
                     /gene="Cd226"
                     /gene_synonym="DNAM-1; DNAM1; Pta1; TLiSA1"
                     /note="major polyA site"
ORIGIN      
        1 acacagaaga cttcttgact tcaggagaca ctgctgtatg aaacagtgct tgctatcagt
       61 ggctgctgga agaggctgtg gtggaaagaa aacctcaact gcaggccaga gttggttccc
      121 caaaagaggc aaactcccag tgctagccag aggctaggaa gctctaagca acccacttat
      181 ctgcaaggag agttacgccc aaagagcatc aagtccaacc tcctgaactg tttccagaga
      241 tggcttatgt tacttggctt ttggctattc ttcatgtgca caaagcactg tgtgaagaga
      301 cattgtggga cacaacagtt cggctttctg agactatgac tctggaatgt gtatatccat
      361 tgacgcataa cttaacccag gtggagtgga ccaagaacac tggcacaaag acagtgagca
      421 tagcagttta caaccctaac cataatatgc atatagaatc taactacctc catagagtac
      481 acttcctaaa ctcaacagtg gggttccgca acatgagcct ttccttttac aatgcctcag
      541 aagcagacat tggcatctac tcctgcttgt ttcatgcttt cccaaatgga ccttgggaaa
      601 agaagataaa agtagtctgg tcagatagtt ttgagatagc agcaccctcg gatagctacc
      661 tgtctgcaga acctggacaa gatgtcacac tcacttgcca gcttccaagg acttggccag
      721 tgcaacaagt catatgggaa aaagtccagc cccatcaggt agacatctta gcttcctgta
      781 acctatctca agagacaaga tacacttcaa agtacctaag acaaacaagg agcaactgta
      841 gccaggggag catgaagagc atcctcatca ttccaaatgc catggccgct gactcaggac
      901 tttacagatg tcgctcagag gccattacag gaaaaaacaa gtcctttgtc ataaggctga
      961 tcataactga tggtggaacc aataaacatt ttatccttcc catcgttgga gggttagttt
     1021 cactgttact tgtcatccta attatcatca ttttcatttt atataacagg aagagacgga
     1081 gacaggtgag aattccactt aaagagccca gggataaaca gagtaaggta gccaccaact
     1141 gcagaagtcc tacttctccc atccagtcta cagatgatga aaaagaggac atttatgtaa
     1201 actatccaac tttctctcga agaccaaaac caagactcta agctgctctt ttggcctgaa
     1261 cacattagtg atgacttcta tggcatggaa ttttacccat gatttcctta ccactaggat
     1321 ctacattgat aaaaaaaatt gattaaattt atttcatctc atatatagaa gtactttatt
     1381 acctggaaac attcttaata gagattcatt agaaaaccca aatctaatgt tcatgtgttc
     1441 aaggaacctt cttccattat gtaacagaac agtctagaga agattaagga ccacatggct
     1501 ttcttgctct acttgaaatt aattgtgagc ataagcttgt ttctggagtc ttcttacatt
     1561 gttggttcta cttacatact actggtccaa ctctcatgct gtttctctca gatgttccca
     1621 tgatggttgc caaggacact tgatagaaag actactggtt aaacacaata aacaaagttc
     1681 attattcact tattagcaag aaggtagcat tatcataaag gattagatga cttaagttag
     1741 ctataggttc aagacctgga ctaaagtatt acttggaaat tctgagtatt gctaaaaagg
     1801 aggatgaaag ggacctagaa gttgagttat tactaaaaac tttgagtgcg aagatattac
     1861 tcattaacca gataacaagt gaatatgctg tagcatcaac ataattcaaa agagtaaaga
     1921 aatggctagg aatgaggtag ttgtgtaatt atttcttctc ttactagttt caaataaatt
     1981 catctctaat tctatagaga attcttgcct cccattcagg actggccttc tatacagtga
     2041 gatggtccag taagaaataa tttttattag tgttttttct attttgagaa ttattttaat
     2101 atatatttta atatataaac ttgtgagtta aatttttttt ttgcaaaatt agcacatgaa
     2161 aagagattga tggttttaag tagtagaaca cagtagtgta ggaatctgag agcagagagt
     2221 ttgggagggg gtgaagagaa aacaacatca ccaaatagtg atatataaga gaaaatctgt
     2281 gcttcagagt ttgatcaggg ccatctctcc caactctgct ggaactgaga gaatgcacct
     2341 gatgttgtct ccattttaga tagagaaaaa aaaaacccga atatttataa aactaaataa
     2401 aactatagtt acctcaaaac tatggggatc actataacat agaatagaat agaatagaat
     2461 agaatagaat agaatagaat agaatag
//
