LOCUS       NM_001043317            4097 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus CD22 antigen (Cd22), transcript variant 1, mRNA.
ACCESSION   NM_001043317
VERSION     NM_001043317.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4097)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4097)
  AUTHORS   McGettigan,S.E., Aira,L.E., Kumar,G., Ballet,R., Butcher,E.C.,
            Baumgarth,N. and Debes,G.F.
  TITLE     Secreted IgM modulates IL-10 expression in B cells
  JOURNAL   Nat Commun 15 (1), 324 (2024)
   PUBMED   38182585
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4097)
  AUTHORS   Ma,R., You,F., Tian,S., Zhang,T., Tian,X., Xiang,S., Wu,H.,
            Yang,N., An,G. and Yang,L.
  TITLE     Enhanced efficacy of CD19/CD22 bispecific CAR-T cells with EAAAK
            linker on B-cell malignancies
  JOURNAL   Eur J Haematol 112 (1), 64-74 (2024)
   PUBMED   37671595
  REMARK    GeneRIF: Enhanced efficacy of CD19/CD22 bispecific CAR-T cells with
            EAAAK linker on B-cell malignancies.
REFERENCE   4  (bases 1 to 4097)
  AUTHORS   Ren,H., Pan,Y., Wang,D., Hao,H., Han,R., Qi,C., Zhang,W., He,W.,
            Shi,F.D. and Liu,Q.
  TITLE     CD22 blockade modulates microglia activity to suppress
            neuroinflammation following intracerebral hemorrhage
  JOURNAL   Pharmacol Res 196, 106912 (2023)
   PUBMED   37696483
  REMARK    GeneRIF: CD22 blockade modulates microglia activity to suppress
            neuroinflammation following intracerebral hemorrhage.
REFERENCE   5  (bases 1 to 4097)
  AUTHORS   Wang,X., Liu,M., Zhang,J., Brown,N.K., Zhang,P., Zhang,Y., Liu,H.,
            Du,X., Wu,W., Devenport,M., Tao,W., Mao-Draayer,Y., Chen,G.Y.,
            Chen,Y.E., Zheng,P. and Liu,Y.
  TITLE     CD24-Siglec axis is an innate immune checkpoint against
            metaflammation and metabolic disorder
  JOURNAL   Cell Metab 34 (8), 1088-1103 (2022)
   PUBMED   35921817
REFERENCE   6  (bases 1 to 4097)
  AUTHORS   Law,C.L., Aruffo,A., Chandran,K.A., Doty,R.T. and Clark,E.A.
  TITLE     Ig domains 1 and 2 of murine CD22 constitute the ligand-binding
            domain and bind multiple sialylated ligands expressed on B and T
            cells
  JOURNAL   J Immunol 155 (7), 3368-3376 (1995)
   PUBMED   7561031
REFERENCE   7  (bases 1 to 4097)
  AUTHORS   Kelm,S., Pelz,A., Schauer,R., Filbin,M.T., Tang,S., de
            Bellard,M.E., Schnaar,R.L., Mahoney,J.A., Hartnell,A., Bradfield,P.
            et al.
  TITLE     Sialoadhesin, myelin-associated glycoprotein and CD22 define a new
            family of sialic acid-dependent adhesion molecules of the
            immunoglobulin superfamily
  JOURNAL   Curr Biol 4 (11), 965-972 (1994)
   PUBMED   7533044
REFERENCE   8  (bases 1 to 4097)
  AUTHORS   Law,C.L., Torres,R.M., Sundberg,H.A., Parkhouse,R.M., Brannan,C.I.,
            Copeland,N.G., Jenkins,N.A. and Clark,E.A.
  TITLE     Organization of the murine Cd22 locus. Mapping to chromosome 7 and
            characterization of two alleles
  JOURNAL   J Immunol 151 (1), 175-187 (1993)
   PUBMED   8100843
REFERENCE   9  (bases 1 to 4097)
  AUTHORS   Torres,R.M., Law,C.L., Santos-Argumedo,L., Kirkham,P.A.,
            Grabstein,K., Parkhouse,R.M. and Clark,E.A.
  TITLE     Identification and characterization of the murine homologue of
            CD22, a B lymphocyte-restricted adhesion molecule
  JOURNAL   J Immunol 149 (8), 2641-2649 (1992)
   PUBMED   1401903
REFERENCE   10 (bases 1 to 4097)
  AUTHORS   Symington,F.W., Subbarao,B., Mosier,D.E. and Sprent,J.
  TITLE     Lyb-8.2: A new B cell antigen defined and characterized with a
            monoclonal antibody
  JOURNAL   Immunogenetics 16 (5), 381-391 (1982)
   PUBMED   6984010
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC165340.3 and AK143835.1.
            
            On Oct 17, 2008 this sequence version replaced NM_001043317.1.
            
            Transcript Variant: This variant (1) represents the longer
            protein-coding transcript. Both variants 1 and 2 encode the same
            protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK143835.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849388 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                AC165340.3         203635-203697       c
            64-3238             AK143835.1         2-3176
            3239-4097           AC165340.3         188759-189617       c
FEATURES             Location/Qualifiers
     source          1..4097
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 19.26 cM"
     gene            1..4097
                     /gene="Cd22"
                     /gene_synonym="A530093D23; Lyb-8; Lyb8"
                     /note="CD22 antigen"
                     /db_xref="GeneID:12483"
                     /db_xref="MGI:MGI:88322"
     exon            1..107
                     /gene="Cd22"
                     /gene_synonym="A530093D23; Lyb-8; Lyb8"
                     /inference="alignment:Splign:2.1.0"
     exon            108..196
                     /gene="Cd22"
                     /gene_synonym="A530093D23; Lyb-8; Lyb8"
                     /inference="alignment:Splign:2.1.0"
     exon            197..342
                     /gene="Cd22"
                     /gene_synonym="A530093D23; Lyb-8; Lyb8"
                     /inference="alignment:Splign:2.1.0"
     exon            343..400
                     /gene="Cd22"
                     /gene_synonym="A530093D23; Lyb-8; Lyb8"
                     /inference="alignment:Splign:2.1.0"
     CDS             364..2970
                     /gene="Cd22"
                     /gene_synonym="A530093D23; Lyb-8; Lyb8"
                     /note="B-cell receptor CD22; BL-CAM; siglec-2; T-cell
                     surface antigen Leu-14; B-lymphocyte cell adhesion
                     molecule; sialic acid-binding Ig-like lectin 2"
                     /codon_start=1
                     /product="B-cell receptor CD22 precursor"
                     /protein_id="NP_001036782.1"
                     /db_xref="CCDS:CCDS21114.1"
                     /db_xref="GeneID:12483"
                     /db_xref="MGI:MGI:88322"
                     /translation="MRVHYLWLLLILGHVASARYSSANDWTVDHPQTLFAWEGACIRI
                     PCKYKTPLPKARLDNILLFQNYEFDKATKKFTGTVLYNATKTEKDPESELYLSKQGRV
                     TFLGNRIDNCTLKIHPIRANDSGNLGLRMTAGTERWMEPIHLNVSEKPFQPYIQMPSE
                     IRESQSVTLTCGLNFSCFGYDILLKWFLEDSEITSITSSVTSITSSVTSSIKNVYTES
                     KLTFQPKWTDHGKSVKCQVQHSSKVLSERTVRLDVKYTPKLEIKVNPTEVEKNNSVTM
                     TCRVNSSNPKLRTVAVSWFKDGRPLEDQELEQEQQMSKLILHSVTKDMRGKYRCQASN
                     DIGPGESEEVELTVHYAPEPSRVHIYPSPAEEGQSVELICESLASPSATNYTWYHNRK
                     PIPGDTQEKLRIPKVSPWHAGNYSCLAENRLGHGKIDQEAKLDVHYAPKAVTTVIQSF
                     TPILEGDSVTLVCRYNSSNPDVTSYRWNPQGSGSVLKPGVLRIQKVTWDSMPVSCAAC
                     NHKCSWALPVILNVHYAPRDVKVLKVSPASEIRAGQRVLLQCDFAESNPAEVRFFWKK
                     NGSLVQEGRYLSFGSVSPEDSGNYNCMVNNSIGETLSQAWNLQVLYAPRRLRVSISPG
                     DHVMEGKKATLSCESDANPPISQYTWFDSSGQDLHSSGQKLRLEPLEVQHTGSYRCKG
                     TNGIGTGESPPSTLTVYYSPETIGKRVALGLGFCLTICILAIWGMKIQKKWKQNRSQQ
                     GLQENSSGQSFFVRNKKARRTPLSEGPQSQGCYNPAMDDTVSYAILRFPESDTHNTGD
                     AGTPATQAPPPNNSDSVTYSVIQKRPMGDYENVNPSCPEDESIHYSELVQFGAGKRPQ
                     AKEDVDYVTLKH"
     exon            401..805
                     /gene="Cd22"
                     /gene_synonym="A530093D23; Lyb-8; Lyb8"
                     /inference="alignment:Splign:2.1.0"
     exon            806..1126
                     /gene="Cd22"
                     /gene_synonym="A530093D23; Lyb-8; Lyb8"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1411
                     /gene="Cd22"
                     /gene_synonym="A530093D23; Lyb-8; Lyb8"
                     /inference="alignment:Splign:2.1.0"
     exon            1412..1675
                     /gene="Cd22"
                     /gene_synonym="A530093D23; Lyb-8; Lyb8"
                     /inference="alignment:Splign:2.1.0"
     exon            1676..1933
                     /gene="Cd22"
                     /gene_synonym="A530093D23; Lyb-8; Lyb8"
                     /inference="alignment:Splign:2.1.0"
     exon            1934..2197
                     /gene="Cd22"
                     /gene_synonym="A530093D23; Lyb-8; Lyb8"
                     /inference="alignment:Splign:2.1.0"
     exon            2198..2461
                     /gene="Cd22"
                     /gene_synonym="A530093D23; Lyb-8; Lyb8"
                     /inference="alignment:Splign:2.1.0"
     exon            2462..2558
                     /gene="Cd22"
                     /gene_synonym="A530093D23; Lyb-8; Lyb8"
                     /inference="alignment:Splign:2.1.0"
     exon            2559..2634
                     /gene="Cd22"
                     /gene_synonym="A530093D23; Lyb-8; Lyb8"
                     /inference="alignment:Splign:2.1.0"
     exon            2635..2753
                     /gene="Cd22"
                     /gene_synonym="A530093D23; Lyb-8; Lyb8"
                     /inference="alignment:Splign:2.1.0"
     exon            2754..2838
                     /gene="Cd22"
                     /gene_synonym="A530093D23; Lyb-8; Lyb8"
                     /inference="alignment:Splign:2.1.0"
     exon            2839..4097
                     /gene="Cd22"
                     /gene_synonym="A530093D23; Lyb-8; Lyb8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3647..3652
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cd22"
                     /gene_synonym="A530093D23; Lyb-8; Lyb8"
                     /note="hexamer: ATTAAA"
     polyA_site      3674
                     /gene="Cd22"
                     /gene_synonym="A530093D23; Lyb-8; Lyb8"
                     /note="major polyA site"
ORIGIN      
        1 gaggcccaga gaggaagggg gcgtggccaa gcgtgtgaga cttttcttag ttttcttact
       61 ctcagatcct gctagggatc ctgaagatcg aacacaggag gaaacaggct ttctgggtct
      121 tctgaggtag aagaagcttt tgagtgccag ggaggaaatg atgggaccag gaagctaacc
      181 ttgaggctct cagaaggcca caccaccccc aaccgtggag gcagaaccca gcccacgctc
      241 agcaactgaa ctggctttcc ctacacctgt tcctggtcac ccagaagtcc ttactacctg
      301 tgccctgcgg cctgggagag aaatagcagg agagagaggg aggtcccacc cagacgagac
      361 accatgcgcg tccattacct gtggctcctc ttgatcctag gacacgtggc ttcggctcgg
      421 tacagctcag caaatgattg gaccgttgac catccccaaa ccctctttgc ctgggaggga
      481 gcctgcatca ggattccttg caagtacaaa actccactac ccaaggcacg tctggacaac
      541 atcctccttt ttcagaacta tgagtttgac aaggccacca agaaattcac aggaactgtc
      601 ctgtacaacg ccacaaagac tgagaaggac ccagagtctg agctgtacct ttctaagcaa
      661 gggagagtaa catttctggg gaacagaata gacaattgta ccctgaaaat ccacccgata
      721 cgtgccaatg acagtgggaa tctggggttg aggatgaccg cagggactga acgatggatg
      781 gagcccattc acctcaatgt ctcggagaaa ccgttccaac cttacatcca gatgccatca
      841 gaaatccggg aatcccaaag tgtcactctg acctgtggac tgaatttctc ctgctttggg
      901 tatgacatcc tcttgaagtg gttcctagaa gattctgaga tcacctccat cacctcttct
      961 gtcacctcca tcacctcttc tgtcacctcc tccattaaga atgtctatac agagagcaag
     1021 ctcaccttcc aaccaaagtg gacggaccac ggaaagagtg tgaagtgcca agtccagcac
     1081 tcctccaaag tgctctcaga gcgcactgtg cgtctggatg ttaagtatac cccgaagctg
     1141 gagatcaagg tcaatcccac agaggtggaa aagaacaatt ctgtgaccat gacatgccgg
     1201 gttaacagca gcaacccgaa actcaggacc gtggcggtgt cttggttcaa ggatgggcgc
     1261 cccctagagg atcaggaact ggaacaggaa caacagatgt ccaagctaat tctgcattca
     1321 gtgaccaagg acatgagagg gaaataccgg tgccaggctt ccaacgacat aggcccagga
     1381 gagtcggaag aagtggaact cacggtgcac tatgctccag aaccctccag ggttcacatc
     1441 tacccttccc ccgctgaaga gggacagtca gtagagctga tttgtgagtc actggccagt
     1501 ccaagtgcaa caaactacac ctggtatcac aacaggaaac ctatacctgg agacacccaa
     1561 gagaagctcc gcatccctaa agtctccccg tggcatgctg ggaattactc ttgcttggca
     1621 gagaaccgtc tgggtcatgg aaagatagac caggaagcta agctggatgt ccattatgct
     1681 cccaaggcgg tgaccacagt gattcagagc ttcacaccaa tcctggaagg agacagtgtg
     1741 accctggtct gtaggtacaa ctccagcaat ccagacgtca cctcctacag atggaaccct
     1801 caaggttctg ggagtgtgct caaacccgga gtgctgagga ttcagaaagt gacatgggat
     1861 tccatgcctg tcagctgtgc tgcctgcaac cacaagtgtt cgtgggccct ccctgtcatc
     1921 ctgaatgtcc actacgcccc cagagacgtg aaggtactga aggtaagccc cgcatcagag
     1981 atccgcgctg ggcagcgtgt cctcctccaa tgcgacttcg cagagagcaa cccggcagag
     2041 gtccgcttct tctggaagaa gaatgggagt ctcgtgcagg aagggaggta cctgagcttc
     2101 ggctccgtct ccccagaaga ttctggaaat tataactgca tggtcaacaa ctccatcgga
     2161 gagaccttgt cacaggcctg gaacctccaa gtgctgtatg ctcctcggag gctgcgtgtg
     2221 tccatcagcc ctggggacca tgtgatggag gggaagaagg ccaccttgtc ctgtgagagt
     2281 gatgccaatc cgcccatctc acagtacacc tggtttgact ccagtggcca agacctccac
     2341 tcctcaggcc agaaactgag actggaaccc ctggaggtcc aacacacggg ttcctaccgc
     2401 tgcaaaggga ccaatgggat aggcacagga gagtcaccac ccagcaccct cactgtctac
     2461 tacagtccag agaccatcgg caagcgggtc gccttgggac taggcttctg cctgactatc
     2521 tgcatcctgg ccatctgggg gatgaaaatc cagaaaaaat ggaagcaaaa ccgcagccag
     2581 caggggcttc aggaaaattc cagtggccag agcttttttg tgaggaacaa aaaggctagg
     2641 aggacccctc tctcagaagg cccccaatcc cagggatgct acaatccggc aatggatgac
     2701 accgttagtt atgccatctt gcgctttcca gagagtgaca cgcacaacac tggagatgca
     2761 gggaccccag caacacaggc tcctcctcca aacaacagcg actcggtcac ttactcggtg
     2821 atacagaagc ggcctatggg ggattatgag aatgtgaatc cgagctgccc ggaggatgag
     2881 agcatccatt actcagagct ggttcagttt ggggctggta agcggcccca ggcaaaggaa
     2941 gacgtagact atgtgaccct caagcactga ggtgggtagc agctgctgtt tcaggttctt
     3001 gagcctaaag aagacaactc cttcagctgc tgcagctcag atgctaaggc accggcagct
     3061 ccctgggcac ggactcaggc gtgcatgtgg cgcacgcctt taacgccagc actcaggagg
     3121 cagaggcggg cggatttctg agttcgaggc cagcctgctc tacagagtgg gttccaggac
     3181 agccagggtt tttcaaggaa accctgtatt ggaaaaatga aaaaccaacc aaccaaccaa
     3241 acaaaaaaca acctgtgtct ggccagacct gaccggcctt ctctggctgg tgatcctccc
     3301 tcacgcattg tgccacgtct gcttctccaa ccccaggcac ccaccaccat ctgctccatc
     3361 ctgtgcctca ctgcagctgg atgtgttcct gttgtaatcg tcactaacac ttcttctctg
     3421 accccttgat actctacccc gttcactaat cttactaccc actttctggc cctggggaga
     3481 aatccccagg aaggacagaa gtaaggaagc aagaggcact gtccccagtt ggcttttctt
     3541 ctacaaagat gttggacctt ctgtggagat ggtgccttcc ctcgggggtc ctggacgctg
     3601 agcagacaga acggaatgga catatataat tcaataagtg cttcatatta aaagtggcgc
     3661 agctgtcaca tgaactcctt tgtattggtg attgatcaca ctggaaacat ggagatggag
     3721 atggcttctt ggtgcctaga gggaggggaa aagactcagg gtaatctcat tatcaaatca
     3781 gtccctagag gcaccattgt ctcacagtgt tggtattgaa ctcagggttt catgcatgcg
     3841 agctgtgatg gtttgaatat gcttggccta gggagtggta atattaggag gcgtggcctt
     3901 gttggagtag gtatgtcatt gtgggcatgg gctttagcca gttttctcct agcagccttc
     3961 tcctagcaca tgaagatgta gaactctcag ctcctcctgc accatgccaa cctggatgct
     4021 gccatcctcc tgccttgatg ataatggact gaacctctga acctgtaagc cagccccact
     4081 taaatgtcct tataagc
//
