LOCUS       NM_130904                880 bp    mRNA    linear   ROD 26-JUN-2024
DEFINITION  Mus musculus CD209d antigen (Cd209d), mRNA.
ACCESSION   NM_130904
VERSION     NM_130904.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 880)
  AUTHORS   Kim,D.S., Park,Y., Choi,J.W., Park,S.H., Cho,M.L. and Kwok,S.K.
  TITLE     Lactobacillus acidophilus Supplementation Exerts a Synergistic
            Effect on Tacrolimus Efficacy by Modulating Th17/Treg Balance in
            Lupus-Prone Mice via the SIGNR3 Pathway
  JOURNAL   Front Immunol 12, 696074 (2021)
   PUBMED   34956169
  REMARK    GeneRIF: Lactobacillus acidophilus Supplementation Exerts a
            Synergistic Effect on Tacrolimus Efficacy by Modulating Th17/Treg
            Balance in Lupus-Prone Mice via the SIGNR3 Pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 880)
  AUTHORS   Malamud,M., Cavallero,G.J., Casabuono,A.C., Lepenies,B.,
            Serradell,M.L.A. and Couto,A.S.
  TITLE     Immunostimulation by Lactobacillus kefiri S-layer proteins with
            distinct glycosylation patterns requires different lectin partners
  JOURNAL   J Biol Chem 295 (42), 14430-14444 (2020)
   PUBMED   32817316
REFERENCE   3  (bases 1 to 880)
  AUTHORS   Erturk-Hasdemir,D., Oh,S.F., Okan,N.A., Stefanetti,G.,
            Gazzaniga,F.S., Seeberger,P.H., Plevy,S.E. and Kasper,D.L.
  TITLE     Symbionts exploit complex signaling to educate the immune system
  JOURNAL   Proc Natl Acad Sci U S A 116 (52), 26157-26166 (2019)
   PUBMED   31811024
REFERENCE   4  (bases 1 to 880)
  AUTHORS   Nzoumbou-Boko,R., De Muylder,G., Semballa,S., Lecordier,L.,
            Dauchy,F.A., Gobert,A.P., Holzmuller,P., Lemesre,J.L.,
            Bras-Goncalves,R., Barnabe,C., Courtois,P., Daulouede,S.,
            Beschin,A., Pays,E. and Vincendeau,P.
  TITLE     Trypanosoma musculi Infection in Mice Critically Relies on Mannose
            Receptor-Mediated Arginase Induction by a TbKHC1 Kinesin H Chain
            Homolog
  JOURNAL   J Immunol 199 (5), 1762-1771 (2017)
   PUBMED   28739879
REFERENCE   5  (bases 1 to 880)
  AUTHORS   Mikulic,J., Bioley,G. and Corthesy,B.
  TITLE     SIgA-Shigella Immune Complexes Interact with Dectin-1 and SIGNR3 to
            Differentially Regulate Mouse Peyer's Patch and Mesenteric Lymph
            Node Dendritic Cell's Responsiveness
  JOURNAL   J Mol Biol 429 (15), 2387-2400 (2017)
   PUBMED   28587925
  REMARK    GeneRIF: The sum of the data suggests that in contrast to IgG-based
            immune complexes boosting immune reactivity of antigen-presenting
            cells, secretory IgA produced during an ongoing immune response
            can, in addition to its known function of immune exclusion,
            modulate mucosal dendritic cell conditioning via specific
            interaction with Dectin-1 and SIGNR3.
REFERENCE   6  (bases 1 to 880)
  AUTHORS   Tanne,A., Ma,B., Boudou,F., Tailleux,L., Botella,H., Badell,E.,
            Levillain,F., Taylor,M.E., Drickamer,K., Nigou,J., Dobos,K.M.,
            Puzo,G., Vestweber,D., Wild,M.K., Marcinko,M., Sobieszczuk,P.,
            Stewart,L., Lebus,D., Gicquel,B. and Neyrolles,O.
  TITLE     A murine DC-SIGN homologue contributes to early host defense
            against Mycobacterium tuberculosis
  JOURNAL   J Exp Med 206 (10), 2205-2220 (2009)
   PUBMED   19770268
REFERENCE   7  (bases 1 to 880)
  AUTHORS   Powlesland,A.S., Ward,E.M., Sadhu,S.K., Guo,Y., Taylor,M.E. and
            Drickamer,K.
  TITLE     Widely divergent biochemical properties of the complete set of
            mouse DC-SIGN-related proteins
  JOURNAL   J Biol Chem 281 (29), 20440-20449 (2006)
   PUBMED   16682406
  REMARK    Erratum:[J Biol Chem. 2006 Sep 1;281(35):25868]
REFERENCE   8  (bases 1 to 880)
  AUTHORS   Leeb,T. and Muller,M.
  TITLE     Comparative human-mouse-rat sequence analysis of the ICAM gene
            cluster on HSA 19p13.2 and a 185-kb porcine region from SSC 2q
  JOURNAL   Gene 343 (2), 239-244 (2004)
   PUBMED   15588578
REFERENCE   9  (bases 1 to 880)
  AUTHORS   Galustian,C., Park,C.G., Chai,W., Kiso,M., Bruening,S.A.,
            Kang,Y.S., Steinman,R.M. and Feizi,T.
  TITLE     High and low affinity carbohydrate ligands revealed for murine
            SIGN-R1 by carbohydrate array and cell binding approaches, and
            differing specificities for SIGN-R3 and langerin
  JOURNAL   Int Immunol 16 (6), 853-866 (2004)
   PUBMED   15136555
REFERENCE   10 (bases 1 to 880)
  AUTHORS   Park,C.G., Takahara,K., Umemoto,E., Yashima,Y., Matsubara,K.,
            Matsuda,Y., Clausen,B.E., Inaba,K. and Steinman,R.M.
  TITLE     Five mouse homologues of the human dendritic cell C-type lectin,
            DC-SIGN
  JOURNAL   Int Immunol 13 (10), 1283-1290 (2001)
   PUBMED   11581173
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF373411.1.
            
            On Nov 2, 2002 this sequence version replaced NM_130904.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF373411.1, AK136586.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..880
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 1.92 cM"
     gene            1..880
                     /gene="Cd209d"
                     /gene_synonym="mSIGNR3; SIGN-R3; SIGNR3"
                     /note="CD209d antigen"
                     /db_xref="GeneID:170779"
                     /db_xref="MGI:MGI:2157947"
     exon            1..62
                     /gene="Cd209d"
                     /gene_synonym="mSIGNR3; SIGN-R3; SIGNR3"
                     /inference="alignment:Splign:2.1.0"
     CDS             17..730
                     /gene="Cd209d"
                     /gene_synonym="mSIGNR3; SIGN-R3; SIGNR3"
                     /note="C-type lectin; dendritic cell surface protein; type
                     II transmembrane protein; DC-SIGNR3; DC-SIGN-related
                     protein 3"
                     /codon_start=1
                     /product="CD209 antigen-like protein D"
                     /protein_id="NP_570974.1"
                     /db_xref="CCDS:CCDS22075.1"
                     /db_xref="GeneID:170779"
                     /db_xref="MGI:MGI:2157947"
                     /translation="MSDSMESKTQQVVIPEDEECLMSGTRYSDISSRLQTKFGIKSLA
                     EYTKQSRNPLVLQLLSFLFLAGLLLIILILVSKVPSSEVQNKIYQELMQLKAEVHDGL
                     CQPCARDWTFFNGSCYFFSKSQRNWHNSTTACQELGAQLVIIETDEEQTFLQQTSKAR
                     GPTWMGLSDMHNEATWHWVDGSPLSPSFTRYWNRGEPNNVGDEDCAEFSGDGWNDLSC
                     DKLLFWICKKVSTSSCTTK"
     exon            63..149
                     /gene="Cd209d"
                     /gene_synonym="mSIGNR3; SIGN-R3; SIGNR3"
                     /inference="alignment:Splign:2.1.0"
     exon            150..239
                     /gene="Cd209d"
                     /gene_synonym="mSIGNR3; SIGN-R3; SIGNR3"
                     /inference="alignment:Splign:2.1.0"
     exon            240..314
                     /gene="Cd209d"
                     /gene_synonym="mSIGNR3; SIGN-R3; SIGNR3"
                     /inference="alignment:Splign:2.1.0"
     exon            315..466
                     /gene="Cd209d"
                     /gene_synonym="mSIGNR3; SIGN-R3; SIGNR3"
                     /inference="alignment:Splign:2.1.0"
     exon            467..576
                     /gene="Cd209d"
                     /gene_synonym="mSIGNR3; SIGN-R3; SIGNR3"
                     /inference="alignment:Splign:2.1.0"
     exon            577..863
                     /gene="Cd209d"
                     /gene_synonym="mSIGNR3; SIGN-R3; SIGNR3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      838..843
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cd209d"
                     /gene_synonym="mSIGNR3; SIGN-R3; SIGNR3"
                     /note="hexamer: AATAAA"
     polyA_site      863
                     /gene="Cd209d"
                     /gene_synonym="mSIGNR3; SIGN-R3; SIGNR3"
                     /note="major polyA site"
ORIGIN      
        1 ccaggcacta gtaaccatga gtgactccat ggaatcaaag acacagcaag tggtcattcc
       61 agaggatgaa gagtgtttga tgagtggcac caggtattct gatatcagct cccgattaca
      121 aacaaaattt ggaatcaaga gtttggcaga gtatacgaag cagagccgca accccttggt
      181 cctgcagctg ctttccttcc tgttcttggc tgggcttctg ctgatcattc tgatcctagt
      241 gtcaaaggtc cccagctcag aggttcagaa caaaatctac caggagctca tgcaactgaa
      301 ggctgaagtt catgatggct tgtgccaacc ctgcgccagg gactggacat tcttcaatgg
      361 aagctgttac ttcttctcca agtcccaaag aaattggcac aactccacca ctgcctgcca
      421 ggaactgggg gcccaactgg tcatcataga gactgatgag gagcagactt tcctgcagca
      481 gacttctaag gctagaggac caacctggat gggtctctca gacatgcata atgaagccac
      541 atggcactgg gtggatggct cacctctgtc acccagcttt acacgctatt ggaatagagg
      601 ggagcccaac aatgtcggtg atgaagattg tgcagagttc tctggggatg gctggaatga
      661 tctcagttgt gataaactac ttttctggat ctgtaagaaa gtttcaacct catcatgcac
      721 caccaaatga aagacctcat ctcagcctct gcatcccaaa ctatgccaag tggatgaacc
      781 tgactcatgt ccctcatgtt cgtgctcctt ctccttgtct tttgacttta ggacgctaat
      841 aaaacaccca tttttctctg tcaaaaaaaa aaaaaaaaaa
//
