LOCUS       NM_026972               2068 bp    mRNA    linear   ROD 26-JUN-2024
DEFINITION  Mus musculus CD209b antigen (Cd209b), transcript variant 1, mRNA.
ACCESSION   NM_026972
VERSION     NM_026972.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2068)
  AUTHORS   Seeling,M., Pohnl,M., Kara,S., Horstmann,N., Riemer,C., Wohner,M.,
            Liang,C., Bruckner,C., Eiring,P., Werner,A., Biburger,M.,
            Altmann,L., Schneider,M., Amon,L., Lehmann,C.H.K., Lee,S., Kunz,M.,
            Dudziak,D., Schett,G., Bauerle,T., Lux,A., Tuckermann,J.,
            Vogtle,T., Nieswandt,B., Sauer,M., Bockmann,R.A. and Nimmerjahn,F.
  TITLE     Immunoglobulin G-dependent inhibition of inflammatory bone
            remodeling requires pattern recognition receptor Dectin-1
  JOURNAL   Immunity 56 (5), 1046-1063 (2023)
   PUBMED   36948194
REFERENCE   2  (bases 1 to 2068)
  AUTHORS   Pirgova,G., Chauveau,A., MacLean,A.J., Cyster,J.G. and Arnon,T.I.
  TITLE     Marginal zone SIGN-R1+ macrophages are essential for the maturation
            of germinal center B cells in the spleen
  JOURNAL   Proc Natl Acad Sci U S A 117 (22), 12295-12305 (2020)
   PUBMED   32424104
REFERENCE   3  (bases 1 to 2068)
  AUTHORS   Zhang,Y., Zhang,S., He,Y., Sun,Z., Cai,W., Lv,Y., Jiang,L., Li,Q.,
            Zhu,S., Li,W., Ye,C., Wu,B., Xue,Y., Chen,H., Cai,H. and Chen,T.
  TITLE     Murine SIGNR1 (CD209b) Contributes to the Clearance of
            Uropathogenic Escherichia coli During Urinary Tract Infections
  JOURNAL   Front Cell Infect Microbiol 9, 457 (2020)
   PUBMED   31998663
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2068)
  AUTHORS   Palomino-Segura,M., Perez,L., Farsakoglu,Y., Virgilio,T.,
            Latino,I., D'Antuono,R., Chatziandreou,N., Pizzagalli,D.U.,
            Wang,G., Garcia-Sastre,A., Sallusto,F., Carroll,M.C., Neyrolles,O.
            and Gonzalez,S.F.
  TITLE     Protection against influenza infection requires early recognition
            by inflammatory dendritic cells through C-type lectin receptor
            SIGN-R1
  JOURNAL   Nat Microbiol 4 (11), 1930-1940 (2019)
   PUBMED   31358982
REFERENCE   5  (bases 1 to 2068)
  AUTHORS   Camara,A., Cordeiro,O.G., Alloush,F., Sponsel,J., Chypre,M.,
            Onder,L., Asano,K., Tanaka,M., Yagita,H., Ludewig,B., Flacher,V.
            and Mueller,C.G.
  TITLE     Lymph Node Mesenchymal and Endothelial Stromal Cells Cooperate via
            the RANK-RANKL Cytokine Axis to Shape the Sinusoidal Macrophage
            Niche
  JOURNAL   Immunity 50 (6), 1467-1481 (2019)
   PUBMED   31201093
REFERENCE   6  (bases 1 to 2068)
  AUTHORS   Taylor,P.R., Brown,G.D., Herre,J., Williams,D.L., Willment,J.A. and
            Gordon,S.
  TITLE     The role of SIGNR1 and the beta-glucan receptor (dectin-1) in the
            nonopsonic recognition of yeast by specific macrophages
  JOURNAL   J Immunol 172 (2), 1157-1162 (2004)
   PUBMED   14707091
  REMARK    GeneRIF: Dendritic cell-specific ICAM-3-grabbing nonintegrin
            homolog SIGNR1 has been identified as a major mannose receptor for
            fungal and other pathogens present on murine resident peritoneal
            macrophages.
REFERENCE   7  (bases 1 to 2068)
  AUTHORS   Geijtenbeek,T.B., Groot,P.C., Nolte,M.A., van Vliet,S.J.,
            Gangaram-Panday,S.T., van Duijnhoven,G.C., Kraal,G., van
            Oosterhout,A.J. and van Kooyk,Y.
  TITLE     Marginal zone macrophages express a murine homologue of DC-SIGN
            that captures blood-borne antigens in vivo
  JOURNAL   Blood 100 (8), 2908-2916 (2002)
   PUBMED   12351402
  REMARK    GeneRIF: isolation of a murine homologue of DC-SIGN that is
            identical to the previously reported murine homologue mSIGNR1;
            expressed in marginal zone macrophages
REFERENCE   8  (bases 1 to 2068)
  AUTHORS   Parent,S.A., Zhang,T., Chrebet,G., Clemas,J.A., Figueroa,D.J.,
            Ky,B., Blevins,R.A., Austin,C.P. and Rosen,H.
  TITLE     Molecular characterization of the murine SIGNR1 gene encoding a
            C-type lectin homologous to human DC-SIGN and DC-SIGNR
  JOURNAL   Gene 293 (1-2), 33-46 (2002)
   PUBMED   12137941
REFERENCE   9  (bases 1 to 2068)
  AUTHORS   Baribaud,F., Pohlmann,S., Sparwasser,T., Kimata,M.T., Choi,Y.K.,
            Haggarty,B.S., Ahmad,N., Macfarlan,T., Edwards,T.G., Leslie,G.J.,
            Arnason,J., Reinhart,T.A., Kimata,J.T., Littman,D.R., Hoxie,J.A.
            and Doms,R.W.
  TITLE     Functional and antigenic characterization of human, rhesus macaque,
            pigtailed macaque, and murine DC-SIGN
  JOURNAL   J Virol 75 (21), 10281-10289 (2001)
   PUBMED   11581396
REFERENCE   10 (bases 1 to 2068)
  AUTHORS   Park,C.G., Takahara,K., Umemoto,E., Yashima,Y., Matsubara,K.,
            Matsuda,Y., Clausen,B.E., Inaba,K. and Steinman,R.M.
  TITLE     Five mouse homologues of the human dendritic cell C-type lectin,
            DC-SIGN
  JOURNAL   Int Immunol 13 (10), 1283-1290 (2001)
   PUBMED   11581173
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF424803.1, AF373409.1 and AK138999.1.
            
            On Dec 7, 2013 this sequence version replaced NM_026972.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK138999.1, AF373409.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on expression, longest
                                                protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                AF424803.1         9-30
            23-1218             AF373409.1         1-1196
            1219-1887           AK138999.1         1193-1861
            1888-2068           AF424803.1         1744-1924
FEATURES             Location/Qualifiers
     source          1..2068
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 1.92 cM"
     gene            1..2068
                     /gene="Cd209b"
                     /gene_synonym="1810030I22Rik; DC-SIGNR1; mSIGNR1; OtB7;
                     SIGNR1"
                     /note="CD209b antigen"
                     /db_xref="GeneID:69165"
                     /db_xref="MGI:MGI:1916415"
     exon            1..95
                     /gene="Cd209b"
                     /gene_synonym="1810030I22Rik; DC-SIGNR1; mSIGNR1; OtB7;
                     SIGNR1"
                     /inference="alignment:Splign:2.1.0"
     exon            96..182
                     /gene="Cd209b"
                     /gene_synonym="1810030I22Rik; DC-SIGNR1; mSIGNR1; OtB7;
                     SIGNR1"
                     /inference="alignment:Splign:2.1.0"
     exon            183..272
                     /gene="Cd209b"
                     /gene_synonym="1810030I22Rik; DC-SIGNR1; mSIGNR1; OtB7;
                     SIGNR1"
                     /inference="alignment:Splign:2.1.0"
     exon            273..353
                     /gene="Cd209b"
                     /gene_synonym="1810030I22Rik; DC-SIGNR1; mSIGNR1; OtB7;
                     SIGNR1"
                     /inference="alignment:Splign:2.1.0"
     exon            354..440
                     /gene="Cd209b"
                     /gene_synonym="1810030I22Rik; DC-SIGNR1; mSIGNR1; OtB7;
                     SIGNR1"
                     /inference="alignment:Splign:2.1.0"
     exon            441..527
                     /gene="Cd209b"
                     /gene_synonym="1810030I22Rik; DC-SIGNR1; mSIGNR1; OtB7;
                     SIGNR1"
                     /inference="alignment:Splign:2.1.0"
     exon            528..614
                     /gene="Cd209b"
                     /gene_synonym="1810030I22Rik; DC-SIGNR1; mSIGNR1; OtB7;
                     SIGNR1"
                     /inference="alignment:Splign:2.1.0"
     exon            615..766
                     /gene="Cd209b"
                     /gene_synonym="1810030I22Rik; DC-SIGNR1; mSIGNR1; OtB7;
                     SIGNR1"
                     /inference="alignment:Splign:2.1.0"
     exon            767..876
                     /gene="Cd209b"
                     /gene_synonym="1810030I22Rik; DC-SIGNR1; mSIGNR1; OtB7;
                     SIGNR1"
                     /inference="alignment:Splign:2.1.0"
     exon            877..2049
                     /gene="Cd209b"
                     /gene_synonym="1810030I22Rik; DC-SIGNR1; mSIGNR1; OtB7;
                     SIGNR1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1204..1209
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cd209b"
                     /gene_synonym="1810030I22Rik; DC-SIGNR1; mSIGNR1; OtB7;
                     SIGNR1"
                     /note="hexamer: GATAAA"
     polyA_site      1228
                     /gene="Cd209b"
                     /gene_synonym="1810030I22Rik; DC-SIGNR1; mSIGNR1; OtB7;
                     SIGNR1"
                     /note="major polyA site"
     regulatory      2027..2032
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cd209b"
                     /gene_synonym="1810030I22Rik; DC-SIGNR1; mSIGNR1; OtB7;
                     SIGNR1"
                     /note="hexamer: AATAAA"
     polyA_site      2049
                     /gene="Cd209b"
                     /gene_synonym="1810030I22Rik; DC-SIGNR1; mSIGNR1; OtB7;
                     SIGNR1"
                     /note="major polyA site"
ORIGIN      
        1 aaaagctgta gtctccagca ttcccatgca ccaggggaca gcggcaacca tgagtgactc
       61 cacagaagcc aagatgcagc ctcttagctc catggacgat gatgagttga tggtcagcgg
      121 cagcaggtat tctattaaaa gctccagact acgaccaaat tctggaatca agtgtttggc
      181 aggatgctcg ggacacagcc aagtcccctt ggtcctgcag ctgctctcct tcctgttctt
      241 ggctgggctc ctgctgatca ttcttttcca agtctccaaa accccaaata ccgagaggca
      301 gaaggaacaa gagaagatcc tccaggaact gacccagctg acagatgagc ttacgtccag
      361 gatccccatc tcccaaggga agaatgagtc catgcaggcg aagatcactg agcaactgat
      421 gcagctgaaa actgaactct tgtccaggat tcccatcttc caggggcaga atgagtccat
      481 acaagagaag atctctgagc aactgatgca gctgaaggct gaacttcttt ccaagatctc
      541 cagcttcccg gtaaaggatg attctaagca ggagaagatc taccaacagc tggtacagat
      601 gaagactgaa ctcttccgcc tgtgtcgact ctgcccctgg gactggacat tcctcctagg
      661 aaattgttac ttcttctcca agtcccagcg gaactggaat gacgccgtca cagcttgcaa
      721 agaagtgaag gctcaactag tcatcatcaa tagtgatgaa gagcagacct tcctgcagca
      781 gacttctaag gctaaaggac caacctggat gggcctgtca gacctgaaga aggaggccac
      841 gtggctctgg gtagatggtt ctactctgtc atccagattc cagaaatatt ggaatagagg
      901 ggagcctaac aacatcggtg aggaagactg tgtcgaattt gctggggatg gctggaatga
      961 ctctaaatgt gaactcaaaa agttctggat ctgcaagaag tctgcaaccc catgcactga
     1021 aggctagctc atctccgctc ctaccttcat gccattctgc caggcacatg gatgtgcctc
     1081 actttcgtgc cagctccttc ttcctgcctg ttggcctcag gatcgtgaaa aaggctctgg
     1141 gattcttctt tttatcagat ttttcatcct ctgcatttat catagtttca tttctgttga
     1201 tgtgataaaa ctctctaacc aaaaacaact aaggcagaaa ggggtttatt ttaccttaca
     1261 ttccagatga gagcagggag gtcaggatgg caggaactta agacaattgg tcacatcaca
     1321 tcaacagcca ggaggagaca gaagtatgtg caagctaacg cacacatttg cttattctca
     1381 gttccatttt cctattccta tagtttagga cccctgccta ggaaatggtg ccattcatag
     1441 ttggctagat gttcccacct ctgttaactt caataagaca agcccccaca gacatgctca
     1501 ctggccaacc caatgcaggc aatacaccat tgagcctctt cccaggtgac tatacgctgt
     1561 gtcaggctga ctatcacaaa gggactcact attgtccttt tgctttcagg tttctctggg
     1621 cttagggctc actgttgtcc ccccacttca gtgcagttac ctgatgtagg atgctttcag
     1681 aatctgggtg ttttccatta acctactcca tcttccttgc tgagacacat acactcaaag
     1741 gtcagaagaa gacattggtg ttctctttga tagctcttta ctcccttgag acaggagttg
     1801 gagttcatta tttttttagc aaggctggtg atctgaaaga tccaacattt ttctgtctcc
     1861 actcacctcc taaatgaagt tacagtcaca tgtggccatg tctggcctct aacaattact
     1921 agggcttcaa ggtcaggccc tctttcttgc acatcagcac tcttatccac taagcatctc
     1981 cccagccatt tgtctattgt caggtagtct agtttactgt tgctgtaata aagtcctgac
     2041 aaaatgcaaa aaaaaaaaaa aaaaaaaa
//
