LOCUS       NM_133238               1484 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus CD209a antigen (Cd209a), mRNA.
ACCESSION   NM_133238
VERSION     NM_133238.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1484)
  AUTHORS   Zhang,X., Sun,K., Tang,C., Cen,L., Li,S., Zhu,W., Liu,P., Chen,Y.,
            Yu,C. and Li,L.
  TITLE     LECT2 modulates dendritic cell function after Helicobacter pylori
            infection via the CD209a receptor
  JOURNAL   J Gastroenterol Hepatol 38 (4), 625-633 (2023)
   PUBMED   36740832
  REMARK    GeneRIF: LECT2 modulates dendritic cell function after Helicobacter
            pylori infection via the CD209a receptor.
REFERENCE   2  (bases 1 to 1484)
  AUTHORS   Pirgova,G., Chauveau,A., MacLean,A.J., Cyster,J.G. and Arnon,T.I.
  TITLE     Marginal zone SIGN-R1+ macrophages are essential for the maturation
            of germinal center B cells in the spleen
  JOURNAL   Proc Natl Acad Sci U S A 117 (22), 12295-12305 (2020)
   PUBMED   32424104
  REMARK    GeneRIF: Marginal zone SIGN-R1(+) macrophages are essential for the
            maturation of germinal center B cells in the spleen.
REFERENCE   3  (bases 1 to 1484)
  AUTHORS   Palomino-Segura,M., Perez,L., Farsakoglu,Y., Virgilio,T.,
            Latino,I., D'Antuono,R., Chatziandreou,N., Pizzagalli,D.U.,
            Wang,G., Garcia-Sastre,A., Sallusto,F., Carroll,M.C., Neyrolles,O.
            and Gonzalez,S.F.
  TITLE     Protection against influenza infection requires early recognition
            by inflammatory dendritic cells through C-type lectin receptor
            SIGN-R1
  JOURNAL   Nat Microbiol 4 (11), 1930-1940 (2019)
   PUBMED   31358982
  REMARK    GeneRIF: Study showed that SIGN-R1 participates in the recognition
            of influenza virus by interacting with N-linked glycans present in
            glycoproteins of the virion envelope.
REFERENCE   4  (bases 1 to 1484)
  AUTHORS   Chen,W., Ma,L., Li,R., Huang,S., Xie,R., Chen,Y., Zhao,B., Fei,J.,
            Qu,H., Chen,H., Mao,E. and Chen,E.Z.
  TITLE     DC-SIGN Expression in Intestinal Epithelial Cells Regulates
            Sepsis-Associated Acute Intestinal Injury Via Activating
            ERK1/2-NF-kappaB/P65 Signaling
  JOURNAL   Shock 52 (4), 434-442 (2019)
   PUBMED   30335674
  REMARK    GeneRIF: Sepsis-induced DC-SIGN expression in IECs plays a
            significant role in regulating acute intestinal injury and systemic
            inflammatory response. The inhibition of DC-SIGN exhibited
            protective effects on sepsis-associated organ injury and systemic
            inflammation.
REFERENCE   5  (bases 1 to 1484)
  AUTHORS   Schetters,S.T.T., Kruijssen,L.J.W., Crommentuijn,M.H.W., Kalay,H.,
            Ochando,J., den Haan,J.M.M., Garcia-Vallejo,J.J. and van Kooyk,Y.
  TITLE     Mouse DC-SIGN/CD209a as Target for Antigen Delivery and Adaptive
            Immunity
  JOURNAL   Front Immunol 9, 990 (2018)
   PUBMED   29867967
  REMARK    GeneRIF: mouse DC-SIGN shows partly overlapping similarities to
            human DC-SIGN; mDC-SIGN is expressed on GM-CSF cultured bone
            marrow-derived dendritic cells and macrophages
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1484)
  AUTHORS   Schjetne,K.W., Thompson,K.M., Aarvak,T., Fleckenstein,B.,
            Sollid,L.M. and Bogen,B.
  TITLE     A mouse C kappa-specific T cell clone indicates that DC-SIGN is an
            efficient target for antibody-mediated delivery of T cell epitopes
            for MHC class II presentation
  JOURNAL   Int Immunol 14 (12), 1423-1430 (2002)
   PUBMED   12456590
  REMARK    GeneRIF: DC-SIGN-specific mAb are channeled into the MHC class II
            presentation pathway
REFERENCE   7  (bases 1 to 1484)
  AUTHORS   Geijtenbeek,T.B., Groot,P.C., Nolte,M.A., van Vliet,S.J.,
            Gangaram-Panday,S.T., van Duijnhoven,G.C., Kraal,G., van
            Oosterhout,A.J. and van Kooyk,Y.
  TITLE     Marginal zone macrophages express a murine homologue of DC-SIGN
            that captures blood-borne antigens in vivo
  JOURNAL   Blood 100 (8), 2908-2916 (2002)
   PUBMED   12351402
  REMARK    GeneRIF: isolation of a murine homologue of DC-SIGN that is
            identical to the previously reported murine homologue mSIGNR1;
            expressed in marginal zone macrophages
REFERENCE   8  (bases 1 to 1484)
  AUTHORS   Park,C.G., Takahara,K., Umemoto,E., Yashima,Y., Matsubara,K.,
            Matsuda,Y., Clausen,B.E., Inaba,K. and Steinman,R.M.
  TITLE     Five mouse homologues of the human dendritic cell C-type lectin,
            DC-SIGN
  JOURNAL   Int Immunol 13 (10), 1283-1290 (2001)
   PUBMED   11581173
REFERENCE   9  (bases 1 to 1484)
  AUTHORS   Caminschi,I., Lucas,K.M., O'Keeffe,M.A., Hochrein,H., Laabi,Y.,
            Brodnicki,T.C., Lew,A.M., Shortman,K. and Wright,M.D.
  TITLE     Molecular cloning of a C-type lectin superfamily protein
            differentially expressed by CD8alpha(-) splenic dendritic cells
  JOURNAL   Mol Immunol 38 (5), 365-373 (2001)
   PUBMED   11684292
REFERENCE   10 (bases 1 to 1484)
  AUTHORS   Katz,L.C.
  TITLE     Somatosensory development. A new level of refinement
  JOURNAL   Curr Biol 4 (9), 831-834 (1994)
   PUBMED   7820555
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY049062.1.
            
            On Apr 28, 2009 this sequence version replaced NM_133238.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY049062.1, AK054139.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1484              AY049062.1         1-1484
FEATURES             Location/Qualifiers
     source          1..1484
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 1.92 cM"
     gene            1..1484
                     /gene="Cd209a"
                     /gene_synonym="CD209; CDSIGN; CIRE; DC-SIGN; DC-SIGN1;
                     Dcsign; SIGN-R1; SIGNR5"
                     /note="CD209a antigen"
                     /db_xref="GeneID:170786"
                     /db_xref="MGI:MGI:2157942"
     exon            1..124
                     /gene="Cd209a"
                     /gene_synonym="CD209; CDSIGN; CIRE; DC-SIGN; DC-SIGN1;
                     Dcsign; SIGN-R1; SIGNR5"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..795
                     /gene="Cd209a"
                     /gene_synonym="CD209; CDSIGN; CIRE; DC-SIGN; DC-SIGN1;
                     Dcsign; SIGN-R1; SIGNR5"
                     /note="dendritic cell-specific ICAM-3-grabbing
                     non-integrin"
                     /codon_start=1
                     /product="CD209 antigen-like protein A"
                     /protein_id="NP_573501.1"
                     /db_xref="CCDS:CCDS22073.1"
                     /db_xref="GeneID:170786"
                     /db_xref="MGI:MGI:2157942"
                     /translation="MSDSKEMGKRQLRPLDEELLTSSHTRHSIKGFGFQTNSGFSSFT
                     GCLVHSQVPLALQVLFLAVCSVLLVVILVKVYKIPSSQEENNQMNVYQELTQLKAGVD
                     RLCRSCPWDWTHFQGSCYFFSVAQKSWNDSATACHNVGAQLVVIKSDEEQNFLQQTSK
                     KRGYTWMGLIDMSKESTWYWVDGSPLTLSFMKYWSKGEPNNLGEEDCAEFRDDGWNDT
                     KCTNKKFWICKKLSTSCPSK"
     exon            125..211
                     /gene="Cd209a"
                     /gene_synonym="CD209; CDSIGN; CIRE; DC-SIGN; DC-SIGN1;
                     Dcsign; SIGN-R1; SIGNR5"
                     /inference="alignment:Splign:2.1.0"
     exon            212..301
                     /gene="Cd209a"
                     /gene_synonym="CD209; CDSIGN; CIRE; DC-SIGN; DC-SIGN1;
                     Dcsign; SIGN-R1; SIGNR5"
                     /inference="alignment:Splign:2.1.0"
     exon            302..382
                     /gene="Cd209a"
                     /gene_synonym="CD209; CDSIGN; CIRE; DC-SIGN; DC-SIGN1;
                     Dcsign; SIGN-R1; SIGNR5"
                     /inference="alignment:Splign:2.1.0"
     exon            383..534
                     /gene="Cd209a"
                     /gene_synonym="CD209; CDSIGN; CIRE; DC-SIGN; DC-SIGN1;
                     Dcsign; SIGN-R1; SIGNR5"
                     /inference="alignment:Splign:2.1.0"
     exon            535..644
                     /gene="Cd209a"
                     /gene_synonym="CD209; CDSIGN; CIRE; DC-SIGN; DC-SIGN1;
                     Dcsign; SIGN-R1; SIGNR5"
                     /inference="alignment:Splign:2.1.0"
     exon            645..1484
                     /gene="Cd209a"
                     /gene_synonym="CD209; CDSIGN; CIRE; DC-SIGN; DC-SIGN1;
                     Dcsign; SIGN-R1; SIGNR5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1453..1458
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cd209a"
                     /gene_synonym="CD209; CDSIGN; CIRE; DC-SIGN; DC-SIGN1;
                     Dcsign; SIGN-R1; SIGNR5"
                     /note="hexamer: AATAAA"
     polyA_site      1482
                     /gene="Cd209a"
                     /gene_synonym="CD209; CDSIGN; CIRE; DC-SIGN; DC-SIGN1;
                     Dcsign; SIGN-R1; SIGNR5"
                     /note="major polyA site"
ORIGIN      
        1 ctaagtaaga ttcaaggagg tggcaaataa aagctgtagt ctctgtcaga ttctggcact
       61 gagaagtggc tgtgaaacat gagtgattct aaggaaatgg ggaagaggca gcttcgccct
      121 ctggatgagg aactgctgac atccagccac accaggcact ccatcaaagg ctttggcttc
      181 caaacaaatt ctggattcag tagcttcaca gggtgcctgg tccacagtca agtccccttg
      241 gcactgcagg tgctcttcct agctgtttgt tctgtgctgc tggttgtcat ccttgtcaaa
      301 gtctacaaaa tacccagttc tcaggaagaa aacaatcaga tgaatgtcta ccaagaactg
      361 acccagttga aggctggcgt agatcgactg tgccgctcct gcccctggga ctggacgcac
      421 ttccaaggaa gctgttactt cttctctgtg gcccagaagt cctggaatga ttctgccact
      481 gcctgccaca atgtgggggc tcaacttgtg gtcatcaaga gtgatgaaga gcagaacttt
      541 ctacaacaaa cttctaagaa gagaggctac acttggatgg ggctcattga catgagcaag
      601 gagtctacat ggtactgggt agatggttca cctctgactc tcagtttcat gaagtattgg
      661 agtaaaggag aacctaacaa cctgggagag gaagactgtg cagagttcag agatgacggc
      721 tggaatgaca ccaaatgtac taacaagaaa ttctggatct gcaaaaagct ttcaacttcc
      781 tgccctagca agtgatggcc aactccctcc accatctcca cagtcccaaa accctgccaa
      841 atggcagaac tttacccata gctatgccag tttattctac ttgtctgtga ccattgataa
      901 ccttgacaag atctgtaaga ctttattctg gcaggtagct tgtctcctgc attgctccta
      961 ggtccagttt gtctcctgga ccattaatgt atagtctcct gatgtctgca ggttctcttt
     1021 gggttagtgg ttgtggctct ggtccacctt tgacatttaa tgaagtaaac agacatgagg
     1081 tgtccttaaa tgggttcctt tcatctcctc tgtcttcctt tctgagtaga gaccacatat
     1141 tgccatgtgc aattgatcct gagtactcac acctactaaa ttttaattca tctaccctgc
     1201 acacctttct atgggaccct tctctgattt caggagctca acctatagac taaaagcaca
     1261 agagaaccaa ttccttaact attagtcatg atcagaaatt attgtgttaa ttctctgact
     1321 ccatctctac ccctgggtgg acatggtgag cctcaatgtt atagacctcc caaatttttt
     1381 ggaggattta taatttttat tgaacttact cattaacaat tgtatacata tgtatgtata
     1441 aatataagta taaataaaca ttctgatttt tgccatcctt catc
//
