LOCUS       NM_144943               1530 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus CD207 antigen (Cd207), mRNA.
ACCESSION   NM_144943
VERSION     NM_144943.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1530)
  AUTHORS   Raquer-McKay,H.M., Maqueda-Alfaro,R.A., Saravanan,S., Arroyo
            Hornero,R., Clausen,B.E., Gottfried-Blackmore,A. and Idoyaga,J.
  TITLE     Monocytes give rise to Langerhans cells that preferentially migrate
            to lymph nodes at steady state
  JOURNAL   Proc Natl Acad Sci U S A 121 (47), e2404927121 (2024)
   PUBMED   39541348
REFERENCE   2  (bases 1 to 1530)
  AUTHORS   Xu,B.L., Ling,S.Q., Zhang,Y., Liu,X.C., Luo,Y. and Yao,X.
  TITLE     [Study the involvement of Langerin in mediating epicutaneous
            sensitization of atopic dermatitis-like mouse model]
  JOURNAL   Zhonghua Yi Xue Za Zhi 103 (38), 3041-3046 (2023)
   PUBMED   37813655
  REMARK    GeneRIF: [Study the involvement of Langerin in mediating
            epicutaneous sensitization of atopic dermatitis-like mouse model].
REFERENCE   3  (bases 1 to 1530)
  AUTHORS   Jaber,Y., Netanely,Y., Naamneh,R., Saar,O., Zubeidat,K., Saba,Y.,
            Georgiev,O., Kles,P., Barel,O., Horev,Y., Yosef,O.,
            Eli-Berchoer,L., Nadler,C., Betser-Cohen,G., Shapiro,H., Elinav,E.,
            Wilensky,A. and Hovav,A.H.
  TITLE     Langerhans cells shape postnatal oral homeostasis in a
            mechanical-force-dependent but microbiota and IL17-independent
            manner
  JOURNAL   Nat Commun 14 (1), 5628 (2023)
   PUBMED   37699897
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1530)
  AUTHORS   Ohkawa,Y., Kanto,N., Nakano,M., Fujinawa,R., Kizuka,Y.,
            Johnson,E.L., Harada,Y., Tamura,J.I. and Taniguchi,N.
  TITLE     Involvement of langerin in the protective function of a keratan
            sulfate-based disaccharide in an emphysema mouse model
  JOURNAL   J Biol Chem 299 (8), 105052 (2023)
   PUBMED   37454739
  REMARK    GeneRIF: Involvement of langerin in the protective function of a
            keratan sulfate-based disaccharide in an emphysema mouse model.
REFERENCE   5  (bases 1 to 1530)
  AUTHORS   Meng,H., Zhao,Y., Li,Y., Fan,H., Yi,X., Meng,X., Wang,P., Fu,F.,
            Wu,S. and Wang,Y.
  TITLE     Evidence for developmental vascular-associated necroptosis and its
            contribution to venous-lymphatic endothelial differentiation
  JOURNAL   Front Cell Dev Biol 11, 1229788 (2023)
   PUBMED   37576598
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1530)
  AUTHORS   Riedl,E., Tada,Y. and Udey,M.C.
  TITLE     Identification and characterization of an alternatively spliced
            isoform of mouse Langerin/CD207
  JOURNAL   J Invest Dermatol 123 (1), 78-86 (2004)
   PUBMED   15191546
  REMARK    GeneRIF: Developmentally regulated expression of Langerin isoforms
            provides a mechanism by which Langerin involvement in antigen
            uptake and processing could be regulated.
REFERENCE   7  (bases 1 to 1530)
  AUTHORS   Geissmann,F., Revy,P., Brousse,N., Lepelletier,Y., Folli,C.,
            Durandy,A., Chambon,P. and Dy,M.
  TITLE     Retinoids regulate survival and antigen presentation by immature
            dendritic cells
  JOURNAL   J Exp Med 198 (4), 623-634 (2003)
   PUBMED   12925678
REFERENCE   8  (bases 1 to 1530)
  AUTHORS   Takahara,K., Omatsu,Y., Yashima,Y., Maeda,Y., Tanaka,S., Iyoda,T.,
            Clausen,B.E., Matsubara,K., Letterio,J., Steinman,R.M., Matsuda,Y.
            and Inaba,K.
  TITLE     Identification and expression of mouse Langerin (CD207) in
            dendritic cells
  JOURNAL   Int Immunol 14 (5), 433-444 (2002)
   PUBMED   11978773
  REMARK    GeneRIF: molecular cloning and expression of Langerin transcripts
            in dendritic cells
            Erratum:[Int Immunol. 2002 Jul;14(7):831. Clusen, Bjoern [corrected
            to Clausen, Bjorn E]]
REFERENCE   9  (bases 1 to 1530)
  AUTHORS   Valladeau,J., Clair-Moninot,V., Dezutter-Dambuyant,C., Pin,J.J.,
            Kissenpfennig,A., Mattei,M.G., Ait-Yahia,S., Bates,E.E.,
            Malissen,B., Koch,F., Fossiez,F., Romani,N., Lebecque,S. and
            Saeland,S.
  TITLE     Identification of mouse langerin/CD207 in Langerhans cells and some
            dendritic cells of lymphoid tissues
  JOURNAL   J Immunol 168 (2), 782-792 (2002)
   PUBMED   11777972
REFERENCE   10 (bases 1 to 1530)
  AUTHORS   Valladeau,J., Ravel,O., Dezutter-Dambuyant,C., Moore,K.,
            Kleijmeer,M., Liu,Y., Duvert-Frances,V., Vincent,C., Schmitt,D.,
            Davoust,J., Caux,C., Lebecque,S. and Saeland,S.
  TITLE     Langerin, a novel C-type lectin specific to Langerhans cells, is an
            endocytic receptor that induces the formation of Birbeck granules
  JOURNAL   Immunity 12 (1), 71-81 (2000)
   PUBMED   10661407
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC090647.6 and AK142731.1.
            
            On Apr 10, 2010 this sequence version replaced NM_144943.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ302711.1, AK142731.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-58                AC090647.6         119017-119074
            59-1528             AK142731.1         1-1470
            1529-1530           AC090647.6         125666-125667
FEATURES             Location/Qualifiers
     source          1..1530
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 35.94 cM"
     gene            1..1530
                     /gene="Cd207"
                     /note="CD207 antigen"
                     /db_xref="GeneID:246278"
                     /db_xref="MGI:MGI:2180021"
     exon            1..140
                     /gene="Cd207"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..1054
                     /gene="Cd207"
                     /note="langerin; Langerhans cell specific c-type lectin"
                     /codon_start=1
                     /product="C-type lectin domain family 4 member K"
                     /protein_id="NP_659192.2"
                     /db_xref="CCDS:CCDS39534.1"
                     /db_xref="GeneID:246278"
                     /db_xref="MGI:MGI:2180021"
                     /translation="MPEAEMKEEAPEAHFTVDKQNISLWPREPPPKQDLSPVLRKPLC
                     ICVAFTCLALVLVTSIVLQAVFYPRLMGKILDVKSDAQMLKGRVDNISTLGSDLKTER
                     GRVDDAEVQMQIVNTTLKRVRSQILSLETSMKIANDQLQILTMSWGEVDSLSAKIPEL
                     KRDLDKASALNTKVQGLQNSLENVNKLLKQQSDILEMVARGWKYFSGNFYYFSRTPKT
                     WYSAEQFCISRKAHLTSVSSESEQKFLYKAADGIPHWIGLTKAGSEGDWYWVDQTSFN
                     KEQSRRFWIPGEPNNAGNNEHCANIRVSALKCWNDGPCDNTFLFICKRPYVQTTE"
     exon            141..257
                     /gene="Cd207"
                     /inference="alignment:Splign:2.1.0"
     exon            258..632
                     /gene="Cd207"
                     /inference="alignment:Splign:2.1.0"
     exon            633..784
                     /gene="Cd207"
                     /inference="alignment:Splign:2.1.0"
     exon            785..903
                     /gene="Cd207"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1530
                     /gene="Cd207"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1512..1517
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cd207"
                     /note="hexamer: AATAAA"
     polyA_site      1530
                     /gene="Cd207"
                     /note="major polyA site"
ORIGIN      
        1 tttcccgttt ctttctggat aaaaaggtcc ttggggagac agatattgag aatttcctat
       61 gccagaggca gagatgaagg aggaggctcc cgaagcgcac ttcacagtgg acaaacagaa
      121 catctctctc tggcctcgag agcctcctcc caagcaagat ctgtctccag ttctaaggaa
      181 acctctctgt atctgcgtgg ccttcacctg cctggcattg gtgctggtca cctccattgt
      241 gcttcaggct gttttctatc ctaggttgat gggcaaaata ttggatgtga agagtgatgc
      301 ccagatgttg aaaggtcgtg tggacaacat cagcaccctg ggttctgatc ttaagactga
      361 aagaggtcgt gtggacgatg ctgaggttca gatgcagata gtgaacacca ccctcaagag
      421 ggtgcgttct cagatcctgt ctttggaaac cagcatgaag atagccaatg atcagctcca
      481 gatattaaca atgagctggg gagaggttga cagtctcagt gccaaaatcc cagaactgaa
      541 aagagatctg gataaagcca gcgccttgaa cacaaaggtc caaggactac agaacagctt
      601 ggagaatgtc aacaagctgc tcaaacaaca gagtgacatt ctggagatgg tggctcgagg
      661 ctggaagtat ttctcgggga acttctatta cttttcacgc accccaaaga cctggtacag
      721 cgcagagcag ttctgtattt ctagaaaagc tcacctgacc tcagtgtcct cagaatcgga
      781 acaaaagttt ctctacaagg cagcagatgg aattccacac tggattggac ttaccaaagc
      841 agggagcgaa ggggactggt actgggtgga ccagacatca ttcaacaagg agcaaagtag
      901 gaggttctgg attccaggtg aacccaacaa cgcagggaac aatgagcact gtgccaatat
      961 cagggtgtct gccctgaagt gctggaacga tggtccctgt gacaatacat ttcttttcat
     1021 ctgcaagagg ccctacgtcc aaacaactga atgacagatc tggcctgagc tcggcatctg
     1081 tggggcaaca gtgacctggc tgaagagatg tctctctccc tgaggctcca agattgctct
     1141 gtactttacg tttttttctt gcttgaaaat tgtcccaaac acagcctgtg gtctttctgt
     1201 cttggctggc agttctctgc tcctggaggc cttggaggag cttgggttaa acgggtgagg
     1261 acctgaagag ggcgtagcag tccttactgc ccaggcgagg caggtcagca caccaaacag
     1321 gttgtttaga ttttcctgat ccttctcaga agccttggct gaccatataa aagctacatt
     1381 caaatatgac cagtatttga ggaggcagac atgcccaaat ttaaccatga tacaatttat
     1441 acaacatgta ttagaacacc tcatggtatg ctcaaaatat gtaaatatgt tgtttttatg
     1501 tgcctattgc aaataaatgt aatattacta
//
