LOCUS       NM_207244               1745 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Mus musculus CD200 receptor 4 (Cd200r4), mRNA.
ACCESSION   NM_207244 XM_006522128 XM_156177
VERSION     NM_207244.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1745)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1745)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   3  (bases 1 to 1745)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   4  (bases 1 to 1745)
  AUTHORS   Gorczynski,R.M., Chen,Z., Clark,D.A., Kai,Y., Lee,L., Nachman,J.,
            Wong,S. and Marsden,P.
  TITLE     Structural and functional heterogeneity in the CD200R family of
            immunoregulatory molecules and their expression at the
            feto-maternal interface
  JOURNAL   Am J Reprod Immunol 52 (2), 147-163 (2004)
   PUBMED   15274657
REFERENCE   5  (bases 1 to 1745)
  AUTHORS   Gorczynski,R., Chen,Z., Kai,Y., Lee,L., Wong,S. and Marsden,P.A.
  TITLE     CD200 is a ligand for all members of the CD200R family of
            immunoregulatory molecules
  JOURNAL   J Immunol 172 (12), 7744-7749 (2004)
   PUBMED   15187158
REFERENCE   6  (bases 1 to 1745)
  AUTHORS   Wright,G.J., Cherwinski,H., Foster-Cuevas,M., Brooke,G.,
            Puklavec,M.J., Bigler,M., Song,Y., Jenmalm,M., Gorman,D.,
            McClanahan,T., Liu,M.R., Brown,M.H., Sedgwick,J.D., Phillips,J.H.
            and Barclay,A.N.
  TITLE     Characterization of the CD200 receptor family in mice and humans
            and their interactions with CD200
  JOURNAL   J Immunol 171 (6), 3034-3046 (2003)
   PUBMED   12960329
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122217.4.
            
            On or before Mar 23, 2022 this sequence version replaced
            XM_006522128.4, NM_207244.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189679.78915.1,
                                           SRR5189685.162560.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                AC122217.4         116977-117037       c
            62-293              AC122217.4         107862-108093       c
            294-356             AC122217.4         96684-96746         c
            357-671             AC122217.4         95649-95963         c
            672-920             AC122217.4         95289-95537         c
            921-1035            AC122217.4         90761-90875         c
            1036-1745           AC122217.4         89687-90396         c
FEATURES             Location/Qualifiers
     source          1..1745
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 29.12 cM"
     gene            1..1745
                     /gene="Cd200r4"
                     /gene_synonym="F630107N04Rik; MCD200RLa"
                     /note="CD200 receptor 4"
                     /db_xref="GeneID:239849"
                     /db_xref="MGI:MGI:3036289"
     exon            1..61
                     /gene="Cd200r4"
                     /gene_synonym="F630107N04Rik; MCD200RLa"
                     /inference="alignment:Splign:2.1.0"
     exon            62..293
                     /gene="Cd200r4"
                     /gene_synonym="F630107N04Rik; MCD200RLa"
                     /inference="alignment:Splign:2.1.0"
     CDS             230..1042
                     /gene="Cd200r4"
                     /gene_synonym="F630107N04Rik; MCD200RLa"
                     /note="CD200 cell surface glycoprotein receptor; cell
                     surface glycoprotein CD200 receptor 4; CD200RLa; CD200
                     receptor-like 4; cell surface glycoprotein OX2 receptor 4;
                     CD200 cell surface glycoprotein receptor-like 4; CD200
                     cell surface glycoprotein receptor-like a"
                     /codon_start=1
                     /product="cell surface glycoprotein CD200 receptor 4
                     precursor"
                     /protein_id="NP_997127.1"
                     /db_xref="CCDS:CCDS37346.1"
                     /db_xref="GeneID:239849"
                     /db_xref="MGI:MGI:3036289"
                     /translation="MHALGRIPTLTLLIFINIFVSGSSCTDENQTIQNDSSSSLTQVN
                     TTMSVQMDKKALLCCFSSPLINAVLITWIIKHRHLPSCTIAYNLDKKTNETSCLGRNI
                     TWASTPDHSPELQISAVALQHEGTYTCEIVTPEGNLEKVYDLQVLVPPEVTYFPGKNR
                     TAVCEAMAGKPAAQISWTPDGDCVTKSESHSNGTVTVRSTCHWEQNNVSVVSCLVSHS
                     TGNQSLSIELSQGTMTTPRSLLTILYVKMALLVIILLNVGFAFFQKRNFART"
     exon            294..356
                     /gene="Cd200r4"
                     /gene_synonym="F630107N04Rik; MCD200RLa"
                     /inference="alignment:Splign:2.1.0"
     exon            357..671
                     /gene="Cd200r4"
                     /gene_synonym="F630107N04Rik; MCD200RLa"
                     /inference="alignment:Splign:2.1.0"
     exon            672..920
                     /gene="Cd200r4"
                     /gene_synonym="F630107N04Rik; MCD200RLa"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1035
                     /gene="Cd200r4"
                     /gene_synonym="F630107N04Rik; MCD200RLa"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1745
                     /gene="Cd200r4"
                     /gene_synonym="F630107N04Rik; MCD200RLa"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1721..1726
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cd200r4"
                     /gene_synonym="F630107N04Rik; MCD200RLa"
                     /note="hexamer: ATTAAA"
     polyA_site      1745
                     /gene="Cd200r4"
                     /gene_synonym="F630107N04Rik; MCD200RLa"
                     /note="major polyA site"
ORIGIN      
        1 acacatagcc agaaagatct gctctgctcg tcattggttt ggagcaagag tctgatgacg
       61 ggcttagtca tccaactgga ggcagactgg agatgaagat aaagatagag aaatgaggaa
      121 gaaagtcact cctaaatcgg tgaactgagc ataaacaaag ttgaccaagc tggaatcact
      181 gagtccaccc agggggctac gaattgtgtt tcactaggtt ccactccaga tgcatgctct
      241 ggggaggatt ccgactttga ctttgctgat cttcatcaat atttttgtgt ctgggtcaag
      301 ttgtactgat gagaatcaaa caatacagaa tgacagttca tcttctctga cacaagttaa
      361 cactacaatg tctgtacaga tggataaaaa ggctctgctc tgctgctttt ctagtccact
      421 gataaatgca gtattaatca catggataat aaaacacaga cacctgcctt cctgcacaat
      481 agcatacaac ctagataaaa agaccaatga aaccagctgc ttgggcagga acatcacctg
      541 ggcctccaca cctgaccaca gtcctgaact tcagatcagt gcagtggccc tccagcatga
      601 ggggacttac acatgtgaga tagtaacacc tgaagggaat ttagaaaaag tctatgacct
      661 ccaagtgctg gtgccccctg aggtaaccta ctttccaggg aaaaacagaa ctgcagtctg
      721 tgaggcaatg gcaggcaagc ctgctgcaca gatctcttgg actccagatg gggactgtgt
      781 cactaagagt gagtcacaca gcaatggcac tgtgactgtc aggagcacgt gccactggga
      841 gcagaacaat gtgtctgttg tgtcctgctt agtctctcat tcgactggta atcagtctct
      901 gtccatagaa ctgagtcaag gtacaatgac caccccccgt tccttgctga ccattctcta
      961 tgtgaaaatg gcccttttgg tgattattct tcttaacgta ggatttgctt tcttccagaa
     1021 gagaaatttt gccagaacat gaatatccag atttctggaa gtccattagt ctgaggacac
     1081 aatacaacaa aacagccatt tgcaatcaac tttctcattg caatccagct tacctgtccc
     1141 tgctgtcttc atgtttgtta gacactcatc ttaaaattat taacccagaa gaggttacat
     1201 tttcttcgat tgtgtttgaa tgtgcctttc ttaatattct tatacttgta tttttatatt
     1261 cttactttca catttatact ctccattttt aattaaccag ttgggagata tgtctagcag
     1321 ttataatttt gactctatta tttaatggaa ctggattcat atctttgtca tgtttacaag
     1381 agagacagag aggaagcatt tgtaatgaca gtattttcaa ctctttgtat tgcttcaaaa
     1441 attctgacat gtcatgcaca atagttttat ggatattatg aattgtgtat atttaacatt
     1501 ctattctgat gtacttatca aagagcagct gtctttgaac tatatatgta ggtgggaata
     1561 cttggagtac tttacatgct aaaaggatgg taatgggatg atattacttg tccctccatt
     1621 tttctttgga tggaaatatt gggaatgcat gtattgataa tatttggcat atatttttaa
     1681 ttgttaaata taagtctgtt ccttttatat caggaaaact attaaaaata gattcattca
     1741 tctta
//
