LOCUS       NM_029018               1498 bp    mRNA    linear   ROD 05-FEB-2024
DEFINITION  Mus musculus CD200 receptor 3 (Cd200r3), transcript variant 3,
            mRNA.
ACCESSION   NM_029018
VERSION     NM_029018.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1498)
  AUTHORS   Kojima,T., Obata,K., Mukai,K., Sato,S., Takai,T., Minegishi,Y. and
            Karasuyama,H.
  TITLE     Mast cells and basophils are selectively activated in vitro and in
            vivo through CD200R3 in an IgE-independent manner
  JOURNAL   J Immunol 179 (10), 7093-7100 (2007)
   PUBMED   17982101
  REMARK    GeneRIF: CD200R3 functions as an activating receptor on mast cells
            and basophils to regulate IgE-independent immune responses in
            cooperation with an inhibitory receptor CD200R
REFERENCE   2  (bases 1 to 1498)
  AUTHORS   Hatherley,D., Cherwinski,H.M., Moshref,M. and Barclay,A.N.
  TITLE     Recombinant CD200 protein does not bind activating proteins closely
            related to CD200 receptor
  JOURNAL   J Immunol 175 (4), 2469-2474 (2005)
   PUBMED   16081818
REFERENCE   3  (bases 1 to 1498)
  AUTHORS   Voehringer,D., Rosen,D.B., Lanier,L.L. and Locksley,R.M.
  TITLE     CD200 receptor family members represent novel DAP12-associated
            activating receptors on basophils and mast cells
  JOURNAL   J Biol Chem 279 (52), 54117-54123 (2004)
   PUBMED   15471863
  REMARK    GeneRIF: during parasitic helminth infection, we identified CD200
            receptor-like 3 as a transcript highly expressed in basophils and
            mast cells
REFERENCE   4  (bases 1 to 1498)
  AUTHORS   Gorczynski,R.M., Chen,Z., Clark,D.A., Kai,Y., Lee,L., Nachman,J.,
            Wong,S. and Marsden,P.
  TITLE     Structural and functional heterogeneity in the CD200R family of
            immunoregulatory molecules and their expression at the
            feto-maternal interface
  JOURNAL   Am J Reprod Immunol 52 (2), 147-163 (2004)
   PUBMED   15274657
REFERENCE   5  (bases 1 to 1498)
  AUTHORS   Gorczynski,R., Chen,Z., Kai,Y., Lee,L., Wong,S. and Marsden,P.A.
  TITLE     CD200 is a ligand for all members of the CD200R family of
            immunoregulatory molecules
  JOURNAL   J Immunol 172 (12), 7744-7749 (2004)
   PUBMED   15187158
REFERENCE   6  (bases 1 to 1498)
  AUTHORS   Rosenblum,M.D., Olasz,E., Woodliff,J.E., Johnson,B.D., Konkol,M.C.,
            Gerber,K.A., Orentas,R.J., Sandford,G. and Truitt,R.L.
  TITLE     CD200 is a novel p53-target gene involved in apoptosis-associated
            immune tolerance
  JOURNAL   Blood 103 (7), 2691-2698 (2004)
   PUBMED   14644999
  REMARK    GeneRIF: Expression of the immunoregulatory protein CD200 increases
            as murine dendritic cells undergo apoptosis.
REFERENCE   7  (bases 1 to 1498)
  AUTHORS   Wright,G.J., Cherwinski,H., Foster-Cuevas,M., Brooke,G.,
            Puklavec,M.J., Bigler,M., Song,Y., Jenmalm,M., Gorman,D.,
            McClanahan,T., Liu,M.R., Brown,M.H., Sedgwick,J.D., Phillips,J.H.
            and Barclay,A.N.
  TITLE     Characterization of the CD200 receptor family in mice and humans
            and their interactions with CD200
  JOURNAL   J Immunol 171 (6), 3034-3046 (2003)
   PUBMED   12960329
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124600.5, AY230199.1 and AK040868.1.
            
            On Jun 5, 2008 this sequence version replaced NM_029018.3.
            
            Transcript Variant: This variant (3) uses a different 3' terminal
            exon, compared to variant 1. It encodes isoform 3 which is shorter
            and has a distinct C-terminus, compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK040868.1, AY230199.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164133, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                AC124600.5         172351-172378       c
            29-1475             AY230199.1         3-1449
            1476-1498           AK040868.1         1466-1488
FEATURES             Location/Qualifiers
     source          1..1498
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 29.25 cM"
     gene            1..1498
                     /gene="Cd200r3"
                     /gene_synonym="4733401I18Rik; 4833409J19Rik; mCD200RLb"
                     /note="CD200 receptor 3"
                     /db_xref="GeneID:74603"
                     /db_xref="MGI:MGI:1921853"
     exon            1..159
                     /gene="Cd200r3"
                     /gene_synonym="4733401I18Rik; 4833409J19Rik; mCD200RLb"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..923
                     /gene="Cd200r3"
                     /gene_synonym="4733401I18Rik; 4833409J19Rik; mCD200RLb"
                     /note="isoform 3 precursor is encoded by transcript
                     variant 3; cell surface glycoprotein CD200 receptor 3;
                     CD200 cell surface glycoprotein receptor 3; CD200RLb;
                     CD200 receptor-like 3; cell surface glycoprotein OX2
                     receptor 3; CD200 cell surface glycoprotein receptor-like
                     3; CD200 cell surface glycoprotein receptor-like b"
                     /codon_start=1
                     /product="cell surface glycoprotein CD200 receptor 3
                     isoform 3 precursor"
                     /protein_id="NP_083294.2"
                     /db_xref="CCDS:CCDS49857.1"
                     /db_xref="GeneID:74603"
                     /db_xref="MGI:MGI:1921853"
                     /translation="MHALGRTLALMLLIFITILVPESSCSVKGREEIPPDDSFPFSDD
                     NIFPDGVGVTMEIEIITPVSVQIGIKAQLFCHPSPSKEATLRIWEITPRDWPSCRLPY
                     RAELQQISKKICTERGTTRVPAHHQSSDLPIKSMALKHDGHYSCRIETTDGIFQERHS
                     IQVPGENRTVVCEAIASKPAMQILWTPDEDCVTKSKSHNDTMIVRSKCHREKNNGHSV
                     FCFISHLTDNWILSMEQNRGTTSILPSLLSILYVKLAVTVLIVGFAFFQKRNYFRWI"
     exon            160..270
                     /gene="Cd200r3"
                     /gene_synonym="4733401I18Rik; 4833409J19Rik; mCD200RLb"
                     /inference="alignment:Splign:2.1.0"
     exon            271..588
                     /gene="Cd200r3"
                     /gene_synonym="4733401I18Rik; 4833409J19Rik; mCD200RLb"
                     /inference="alignment:Splign:2.1.0"
     exon            589..807
                     /gene="Cd200r3"
                     /gene_synonym="4733401I18Rik; 4833409J19Rik; mCD200RLb"
                     /inference="alignment:Splign:2.1.0"
     exon            808..913
                     /gene="Cd200r3"
                     /gene_synonym="4733401I18Rik; 4833409J19Rik; mCD200RLb"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1498
                     /gene="Cd200r3"
                     /gene_synonym="4733401I18Rik; 4833409J19Rik; mCD200RLb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtcggtgaa ctgagcataa acaaagttga ccaagctgga gtcactgatt ccactcagag
       61 ggttacgatt tgtgcttaac ctgactccac tccagatgca tgctttgggg aggactctgg
      121 ctttgatgtt actcatcttc atcactattt tggtgcctga gtcaagttgt tcagtgaaag
      181 gacgggagga gatcccaccg gatgattcat ttcctttttc agatgataat atcttccctg
      241 atggagtggg cgtcaccatg gagattgaga ttatcactcc agtgtctgta cagataggta
      301 tcaaggctca gcttttctgt catcctagtc catcaaaaga agcaacactt agaatatggg
      361 aaataactcc cagagactgg ccttcctgca gactacccta cagagcagag ttgcagcaga
      421 tcagtaaaaa aatctgtact gagagaggaa ccactagggt ccctgcacat caccagagtt
      481 ctgaccttcc catcaaatca atggccctca agcatgatgg gcattactca tgtcggatag
      541 aaacaacaga tgggattttc caagagagac atagcatcca agtgccaggg gaaaatagaa
      601 ctgtagtttg tgaggcaatt gcaagcaagc ctgctatgca gatcttgtgg actccagatg
      661 aggactgtgt cactaagagt aaatcacaca atgacaccat gattgtcagg agcaagtgcc
      721 acagggagaa aaacaatggc cacagtgtgt tctgctttat ctcccatttg actgataact
      781 ggattctctc catggaacag aatcgaggta caaccagcat cctgccttcc ttgctgagca
      841 ttctctatgt gaaactggct gtaactgttc tcatcgtagg atttgctttt ttccagaaga
      901 gaaattattt caggtggatc taaagacctt gaagaagcca catctacatt gactgaaaac
      961 agtgtcatga ctgtggagag acggaatata gaatgaaacc aatgtcttca taggccatct
     1021 acactagcca tttactttca acctctacat ctgacctcaa attcctgtga caattaggca
     1081 aagctcctgg aatgtgagca gacctcttgc ctccaccaat gcaaagtcta agactgctac
     1141 agcatctggg acatttagag aagattcaca taattttttg taggccagtt acctagtgtc
     1201 ctaccaatat atttcctagt aaaagttcac gtgccttctt ccacagtgga gcatgttact
     1261 caggggaaac tgaatctgtg ctctggatct ttggtcattc acatttggct catcctaaat
     1321 gatctcttat tcctttggac ttcaagctat gttttagtga caaaatcact aatggccaag
     1381 gttgaatttc tctctcaact tagcagaggc ttgttcaaaa agaaaacatc ttttacccac
     1441 ttagctttag tatttgtgga cctgcaaaat aaactaaaaa aaaaaacaat tttaagag
//
