LOCUS       NM_206535               1750 bp    mRNA    linear   ROD 02-FEB-2024
DEFINITION  Mus musculus Cd200 receptor 2 (Cd200r2), mRNA.
ACCESSION   NM_206535 XM_195003
VERSION     NM_206535.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1750)
  AUTHORS   Gorczynski,R., Yu,K. and Chen,Z.
  TITLE     Anti-CD200R2, anti-IL-9, anti-IL-35, or anti-TGF-beta abolishes
            increased graft survival and Treg induction induced in
            cromolyn-treated CD200R1KO.CD200tg mice
  JOURNAL   Transplantation 97 (1), 39-46 (2014)
   PUBMED   24142033
  REMARK    GeneRIF: Anti-CD200R2, anti-IL-9, anti-IL-35, or anti-TGF-beta
            abolishes increased graft survival and Treg induction induced in
            cromolyn-treated CD200R1KO.CD200tg mice, and suggest combined role
            of mast cells and Tregs.
REFERENCE   2  (bases 1 to 1750)
  AUTHORS   Sato,K., Eizumi,K., Fukaya,T., Fujita,S., Sato,Y., Takagi,H.,
            Yamamoto,M., Yamashita,N., Hijikata,A., Kitamura,H., Ohara,O.,
            Yamasaki,S., Saito,T. and Sato,K.
  TITLE     Naturally occurring regulatory dendritic cells regulate murine
            cutaneous chronic graft-versus-host disease
  JOURNAL   Blood 113 (19), 4780-4789 (2009)
   PUBMED   19228924
REFERENCE   3  (bases 1 to 1750)
  AUTHORS   Gorczynski,R., Khatri,I., Lee,L. and Boudakov,I.
  TITLE     An interaction between CD200 and monoclonal antibody agonists to
            CD200R2 in development of dendritic cells that preferentially
            induce populations of CD4+CD25+ T regulatory cells
  JOURNAL   J Immunol 180 (9), 5946-5955 (2008)
   PUBMED   18424714
  REMARK    GeneRIF: An interaction between CD200 and monoclonal antibody
            agonists to CD200R2 in development of dendritic cells that
            preferentially induce populations of CD4+CD25+ T regulatory cells.
REFERENCE   4  (bases 1 to 1750)
  AUTHORS   Hatherley,D., Cherwinski,H.M., Moshref,M. and Barclay,A.N.
  TITLE     Recombinant CD200 protein does not bind activating proteins closely
            related to CD200 receptor
  JOURNAL   J Immunol 175 (4), 2469-2474 (2005)
   PUBMED   16081818
  REMARK    GeneRIF: The CD200 receptor family consists of both activatory and
            inhibitory members, like several other paired ligand receptors.
REFERENCE   5  (bases 1 to 1750)
  AUTHORS   Gorczynski,R.M., Chen,Z., Clark,D.A., Kai,Y., Lee,L., Nachman,J.,
            Wong,S. and Marsden,P.
  TITLE     Structural and functional heterogeneity in the CD200R family of
            immunoregulatory molecules and their expression at the
            feto-maternal interface
  JOURNAL   Am J Reprod Immunol 52 (2), 147-163 (2004)
   PUBMED   15274657
REFERENCE   6  (bases 1 to 1750)
  AUTHORS   Gorczynski,R., Chen,Z., Kai,Y., Lee,L., Wong,S. and Marsden,P.A.
  TITLE     CD200 is a ligand for all members of the CD200R family of
            immunoregulatory molecules
  JOURNAL   J Immunol 172 (12), 7744-7749 (2004)
   PUBMED   15187158
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY230198.1.
            
            On Mar 22, 2004 this sequence version replaced XM_195003.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY230198.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1750
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 29.17 cM"
     gene            1..1750
                     /gene="Cd200r2"
                     /gene_synonym="Cd200r1l"
                     /note="Cd200 receptor 2"
                     /db_xref="GeneID:271375"
                     /db_xref="MGI:MGI:3042847"
     exon            1..45
                     /gene="Cd200r2"
                     /gene_synonym="Cd200r1l"
                     /inference="alignment:Splign:2.1.0"
     exon            46..277
                     /gene="Cd200r2"
                     /gene_synonym="Cd200r1l"
                     /inference="alignment:Splign:2.1.0"
     CDS             214..963
                     /gene="Cd200r2"
                     /gene_synonym="Cd200r1l"
                     /note="CD200 cell surface glycoprotein receptor; cell
                     surface glycoprotein CD200 receptor 2; CD200RLc; CD200
                     receptor-like 2; cell surface glycoprotein OX2 receptor 2;
                     CD200 cell surface glycoprotein receptor-like 2; CD200
                     cell surface glycoprotein receptor-like c"
                     /codon_start=1
                     /product="cell surface glycoprotein CD200 receptor 2
                     precursor"
                     /protein_id="NP_996258.1"
                     /db_xref="CCDS:CCDS28191.1"
                     /db_xref="GeneID:271375"
                     /db_xref="MGI:MGI:3042847"
                     /translation="MHALGRTPALTLLIFIYNFVSVYTIVSVQMGTKARLCCRSIPLT
                     KAVLITWIIKPRGQPSCIMAYKVETKETNETCLGRNITWASTPDHIPDLQISAVALQH
                     EGNYLCEITTPEGNFHKVYDLQVLVPPEVTYFLGENRTAVCEAMAGKPAAQISWTPDG
                     DCVTKSESHSNGTVTVRSTCHWEQNNVSAVSCIVSHSTGNQSLSIELSRGTTSTTPSL
                     LTILYVKMVLLGIILLKVGFAFFQKRNVTRT"
     exon            278..592
                     /gene="Cd200r2"
                     /gene_synonym="Cd200r1l"
                     /inference="alignment:Splign:2.1.0"
     exon            593..841
                     /gene="Cd200r2"
                     /gene_synonym="Cd200r1l"
                     /inference="alignment:Splign:2.1.0"
     exon            842..956
                     /gene="Cd200r2"
                     /gene_synonym="Cd200r1l"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1750
                     /gene="Cd200r2"
                     /gene_synonym="Cd200r1l"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgctctgctc gttgtcattg gtttggagca agagtctgat gaccggctta gccatccaac
       61 tggaggcaga ctggagataa agataaagac ggaggaataa ggaagaaaag tcactcctga
      121 attggtgaac tgagcataaa caaagctgag caagctggaa tcactgagtc cacccagggg
      181 ttacgaattg tgtttcacta gattccactc cagatgcatg ctttggggag gactccggct
      241 ttgactttgc tgatcttcat ctataatttt gtgtctgtgt acaccatagt gtctgtacag
      301 atgggtacaa aggctcggct ctgctgccgt tctattccac tgacaaaagc agtattaatc
      361 acatggataa taaagcccag aggccagcct tcctgcataa tggcctacaa agtagaaaca
      421 aaggagacca atgaaacctg cttgggcagg aacatcacct gggcctccac acctgaccac
      481 attcctgacc ttcagatcag tgcggtggcc ctccagcatg aggggaatta cttatgtgag
      541 ataacaacac ctgaagggaa tttccataaa gtctatgacc tccaagtgct ggtgccccct
      601 gaagtaacct actttctcgg ggaaaataga actgcagttt gtgaggcaat ggcaggcaag
      661 cctgctgcac agatctcttg gactccagat ggggactgtg tcactaagag tgagtcacac
      721 agcaatggca ctgtgactgt caggagcact tgccactggg agcagaacaa tgtgtctgct
      781 gtgtcctgca ttgtctctca ttcgactggt aatcagtctc tgtccataga actgagtaga
      841 ggtaccacca gcaccacccc ttccttgctg accattctct acgtgaaaat ggtccttttg
      901 gggattattc ttcttaaagt gggatttgct ttcttccaga agagaaatgt taccagaaca
      961 tgaatatcca gatttctgga agctcattag tctgatgaca cataccagaa aacagcattt
     1021 gtaatcaact ttctcattgg aatccagctt acccgtccct gctgtcttca tgtttgttag
     1081 acactcacct ccaaattctt aactgagaag ggctcctgtc taaaggaaat atggggacaa
     1141 attgtggagc atagaccaaa agaaaggcca tccagagact gccccaccta aggacccatc
     1201 ccatatacag acaccaaacc cagacactac tgaagatgct gcgaagcgtt tgctgacagg
     1261 agcctgttat agctgtctcc tgagaggctc agccagagcc tgacaaatac ataggtagat
     1321 gcttgcagcc aacaactgga ctgagcaaaa aatctccatt ggaggagtta gagaaaggac
     1381 tgaagagggt gaaagggttt gcagccccat aggaagaaca acaatatcaa ccaaccagat
     1441 ctcccagagc tcccagggac taaattacca accaaaggct acacatggaa ggacctatgg
     1501 ctccagctgc ttgtgtagca gtggatggcc ttgttgggca tcagtggaag gagaaaccct
     1561 tggtccagta aaggcttgat tccctagtgt aagagaatgc cagggcagtg acgtgggagt
     1621 gagtaggtag gaagcatcct catagatgca ggagaaagga gaatggaaga gggtattctg
     1681 gaggggaaac tggaaaagga gacaacattt gaaatgtaaa tacataaaat atccaataaa
     1741 aaatgtacag
//
