LOCUS       NM_021325               1850 bp    mRNA    linear   ROD 14-OCT-2024
DEFINITION  Mus musculus CD200 receptor 1 (Cd200r1), mRNA.
ACCESSION   NM_021325
VERSION     NM_021325.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1850)
  AUTHORS   Lin,S., Shu,Y., Shen,R., Zhou,Y., Pan,H., He,L., Fang,F., Zhu,X.,
            Wang,X., Wang,Y., Xu,W. and Ding,J.
  TITLE     The regulation of NFKB1 on CD200R1 expression and their potential
            roles in Parkinson's disease
  JOURNAL   J Neuroinflammation 21 (1), 229 (2024)
   PUBMED   39294682
  REMARK    GeneRIF: The regulation of NFKB1 on CD200R1 expression and their
            potential roles in Parkinson's disease.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1850)
  AUTHORS   Qian,H., Gao,F., Wu,X., Lin,D., Huang,Y., Chen,A., Deng,J.,
            Gong,C., Chen,X. and Zheng,X.
  TITLE     Activation of the CD200/CD200R1 axis attenuates neuroinflammation
            and improves postoperative cognitive dysfunction via the
            PI3K/Akt/NF-kappaB signaling pathway in aged mice
  JOURNAL   Inflamm Res 72 (12), 2127-2144 (2023)
   PUBMED   37902837
  REMARK    GeneRIF: Activation of the CD200/CD200R1 axis attenuates
            neuroinflammation and improves postoperative cognitive dysfunction
            via the PI3K/Akt/NF-kappaB signaling pathway in aged mice.
REFERENCE   3  (bases 1 to 1850)
  AUTHORS   Pfeifer,C.W., Walsh,J.T., Santeford,A., Lin,J.B., Beatty,W.L.,
            Terao,R., Liu,Y.A., Hase,K., Ruzycki,P.A. and Apte,R.S.
  TITLE     Dysregulated CD200-CD200R signaling in early diabetes modulates
            microglia-mediated retinopathy
  JOURNAL   Proc Natl Acad Sci U S A 120 (45), e2308214120 (2023)
   PUBMED   37903272
  REMARK    GeneRIF: Dysregulated CD200-CD200R signaling in early diabetes
            modulates microglia-mediated retinopathy.
REFERENCE   4  (bases 1 to 1850)
  AUTHORS   Linley,H., Ogden,A., Jaigirdar,S., Buckingham,L., Cox,J.,
            Priestley,M. and Saunders,A.
  TITLE     CD200R1 promotes interleukin-17 production by group 3 innate
            lymphoid cells by enhancing signal transducer and activator of
            transcription 3 activation
  JOURNAL   Mucosal Immunol 16 (2), 167-179 (2023)
   PUBMED   36623588
  REMARK    GeneRIF: CD200R1 promotes interleukin-17 production by group 3
            innate lymphoid cells by enhancing signal transducer and activator
            of transcription 3 activation.
REFERENCE   5  (bases 1 to 1850)
  AUTHORS   Pannunzio,B., Amo-Aparicio,J., Julian,C., Lopez-Vales,R.,
            Peluffo,H. and Lago,N.
  TITLE     CD200R1 Contributes to Successful Functional Reinnervation after a
            Sciatic Nerve Injury
  JOURNAL   Cells 11 (11), 1786 (2022)
   PUBMED   35681481
  REMARK    GeneRIF: CD200R1 Contributes to Successful Functional Reinnervation
            after a Sciatic Nerve Injury.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1850)
  AUTHORS   Gorczynski,R.M., Chen,Z., Clark,D.A., Kai,Y., Lee,L., Nachman,J.,
            Wong,S. and Marsden,P.
  TITLE     Structural and functional heterogeneity in the CD200R family of
            immunoregulatory molecules and their expression at the
            feto-maternal interface
  JOURNAL   Am J Reprod Immunol 52 (2), 147-163 (2004)
   PUBMED   15274657
REFERENCE   7  (bases 1 to 1850)
  AUTHORS   Gorczynski,R., Chen,Z., Kai,Y., Lee,L., Wong,S. and Marsden,P.A.
  TITLE     CD200 is a ligand for all members of the CD200R family of
            immunoregulatory molecules
  JOURNAL   J Immunol 172 (12), 7744-7749 (2004)
   PUBMED   15187158
REFERENCE   8  (bases 1 to 1850)
  AUTHORS   Wright,G.J., Cherwinski,H., Foster-Cuevas,M., Brooke,G.,
            Puklavec,M.J., Bigler,M., Song,Y., Jenmalm,M., Gorman,D.,
            McClanahan,T., Liu,M.R., Brown,M.H., Sedgwick,J.D., Phillips,J.H.
            and Barclay,A.N.
  TITLE     Characterization of the CD200 receptor family in mice and humans
            and their interactions with CD200
  JOURNAL   J Immunol 171 (6), 3034-3046 (2003)
   PUBMED   12960329
  REMARK    GeneRIF: The CD200 receptor gene family resembles the signal
            regulatory proteins and killer Ig-related receptors in having
            receptor family members with potential activatory and inhibitory
            functions that may play important roles in immune regulation and
            balance.
REFERENCE   9  (bases 1 to 1850)
  AUTHORS   Vieites,J.M., de la Torre,R., Ortega,M.A., Montero,T., Peco,J.M.,
            Sanchez-Pozo,A., Gil,A. and Suarez,A.
  TITLE     Characterization of human cd200 glycoprotein receptor gene located
            on chromosome 3q12-13
  JOURNAL   Gene 311, 99-104 (2003)
   PUBMED   12853143
REFERENCE   10 (bases 1 to 1850)
  AUTHORS   Wright,G.J., Puklavec,M.J., Willis,A.C., Hoek,R.M., Sedgwick,J.D.,
            Brown,M.H. and Barclay,A.N.
  TITLE     Lymphoid/neuronal cell surface OX2 glycoprotein recognizes a novel
            receptor on macrophages implicated in the control of their function
  JOURNAL   Immunity 13 (2), 233-242 (2000)
   PUBMED   10981966
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122217.4.
            
            On Oct 5, 2022 this sequence version replaced NM_021325.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK154722.1, BC052682.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-295               AC122217.4         162749-163043       c
            296-358             AC122217.4         140013-140075       c
            359-673             AC122217.4         138960-139274       c
            674-925             AC122217.4         138597-138848       c
            926-1025            AC122217.4         135995-136094       c
            1026-1071           AC122217.4         135426-135471       c
            1072-1850           AC122217.4         133843-134621       c
FEATURES             Location/Qualifiers
     source          1..1850
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 29.08 cM"
     gene            1..1850
                     /gene="Cd200r1"
                     /gene_synonym="CD200R; Mox2r; OX2R"
                     /note="CD200 receptor 1"
                     /db_xref="GeneID:57781"
                     /db_xref="MGI:MGI:1889024"
     exon            1..295
                     /gene="Cd200r1"
                     /gene_synonym="CD200R; Mox2r; OX2R"
                     /inference="alignment:Splign:2.1.0"
     CDS             232..1212
                     /gene="Cd200r1"
                     /gene_synonym="CD200R; Mox2r; OX2R"
                     /note="antigen identified by monoclonal antibody MRC OX-2
                     receptor; cell surface glycoprotein CD200 receptor 1;
                     CD200 cell surface glycoprotein receptor; cell surface
                     glycoprotein OX2 receptor 1; Orexin receptor 2"
                     /codon_start=1
                     /product="cell surface glycoprotein CD200 receptor 1
                     precursor"
                     /protein_id="NP_067300.1"
                     /db_xref="CCDS:CCDS28189.1"
                     /db_xref="GeneID:57781"
                     /db_xref="MGI:MGI:1889024"
                     /translation="MFCFWRTSALAVLLIWGVFVAGSSCTDKNQTTQNNSSSPLTQVN
                     TTVSVQIGTKALLCCFSIPLTKAVLITWIIKLRGLPSCTIAYKVDTKTNETSCLGRNI
                     TWASTPDHSPELQISAVTLQHEGTYTCETVTPEGNFEKNYDLQVLVPPEVTYFPEKNR
                     SAVCEAMAGKPAAQISWSPDGDCVTTSESHSNGTVTVRSTCHWEQNNVSDVSCIVSHL
                     TGNQSLSIELSRGGNQSLRPYIPYIIPSIIILIIIGCICLLKISGFRKCKLPKLEATS
                     AIEEDEMQPYASYTEKSNPLYDTVTKVEAFPVSQGEVNGTDCLTLSAIGI"
     exon            296..358
                     /gene="Cd200r1"
                     /gene_synonym="CD200R; Mox2r; OX2R"
                     /inference="alignment:Splign:2.1.0"
     exon            359..673
                     /gene="Cd200r1"
                     /gene_synonym="CD200R; Mox2r; OX2R"
                     /inference="alignment:Splign:2.1.0"
     exon            674..925
                     /gene="Cd200r1"
                     /gene_synonym="CD200R; Mox2r; OX2R"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1025
                     /gene="Cd200r1"
                     /gene_synonym="CD200R; Mox2r; OX2R"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1071
                     /gene="Cd200r1"
                     /gene_synonym="CD200R; Mox2r; OX2R"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1850
                     /gene="Cd200r1"
                     /gene_synonym="CD200R; Mox2r; OX2R"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1832..1837
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cd200r1"
                     /gene_synonym="CD200R; Mox2r; OX2R"
                     /note="hexamer: AACAAA"
     polyA_site      1850
                     /gene="Cd200r1"
                     /gene_synonym="CD200R; Mox2r; OX2R"
                     /note="major polyA site"
ORIGIN      
        1 attgctgtgt caagtcccag agaagtttct tctcttccaa gccagactaa agcacgcgag
       61 tggaaggagt tggcaggcag gacggggctg ctccctgcgg atgggttaag aggtgcgcta
      121 ccacgcagaa gccaacccga gagaagaggg atccgggtta tggtcactgc tgctccctta
      181 cctctgagga gaaaaagtac cgagtgagcg gcggaaaacc agaaaaccga aatgttttgc
      241 ttttggagaa cttctgccct agcagtgctc ttaatatggg gggtctttgt ggctgggtca
      301 agttgtactg ataagaatca aacaacacag aacaacagtt catctcctct gacacaagtg
      361 aacactacag tgtctgtaca gataggtaca aaggctctgc tctgctgctt ttctattcca
      421 ctgacaaaag cagtattaat cacatggata ataaagctca gaggcctgcc atcctgcaca
      481 atagcataca aagtagatac aaagaccaat gaaaccagct gcttgggcag gaacatcacc
      541 tgggcctcca cacctgacca cagtcctgaa cttcagatca gtgcagtgac cctccagcat
      601 gaggggactt acacatgtga gacagtaaca cctgaaggga attttgaaaa aaactatgac
      661 ctccaagtgc tggtgccccc tgaagtaacc tactttccag agaaaaacag atctgcagtc
      721 tgtgaggcaa tggcaggcaa gcctgctgca cagatctctt ggtctccaga tggggactgt
      781 gtcactacga gtgaatcaca cagcaatggc actgtgactg tcaggagcac atgccactgg
      841 gagcagaaca atgtgtctga tgtgtcctgc attgtctctc atttgactgg taaccaatct
      901 ctgtccatag aactgagtag aggtggtaac caatcattac gaccatatat tccatacatc
      961 ataccatcaa ttatcatttt gatcatcata ggatgcattt gtcttttgaa aatcagtggc
     1021 ttcagaaaat gcaaattgcc aaaattagaa gctacttcag ctattgagga ggatgaaatg
     1081 cagccttatg ctagctatac agagaagagc aatccactct atgatactgt gactaaggtg
     1141 gaggcatttc cagtatcaca aggcgaagtc aatggcacag actgccttac tttgtcggcc
     1201 attggaatct agaaccaaga aaaaagaagt caagagacat cataattact gctttgcttt
     1261 ctttaaaatt cgacaatgga aggactactt ggaaattagc tcttccaaag ctattaaaaa
     1321 gcacaaatgt tctaatgaaa ttgcatttaa attctatcat tggaagtttg gaatctctgc
     1381 tgctacctgt taattttagg aagaactgat ttaattatta caaagaaagc acatggttat
     1441 ggtgaaatat caagttgtgc aataaagtat gatgaaaact gagtttcctc aagaaataac
     1501 tgcaggagga acaatcatca ctaaagaatt tcatgtgagt tcttacaaaa aaattcctat
     1561 gtatacatga ctatggtatg tgtgtccaat tacatgttta tttacaaatg tgtatatatg
     1621 cacacatttg cttttcagga catctccttg taaaaaacac actggagttt tggatttata
     1681 aaagcttata aagtgagcat tggagatatt tttatatcag cataagtaaa tctacctcat
     1741 tctttttaat ggctacatag aattctcctg tatgattaca ttgtaattta attaatcatg
     1801 gcccttggat tttgtgttgt gtgtggtatt aaacaaaacc atgtagaata
//
